AR059903A1 - Derivados de cromano - Google Patents

Derivados de cromano

Info

Publication number
AR059903A1
AR059903A1 ARP070101061A ARP070101061A AR059903A1 AR 059903 A1 AR059903 A1 AR 059903A1 AR P070101061 A ARP070101061 A AR P070101061A AR P070101061 A ARP070101061 A AR P070101061A AR 059903 A1 AR059903 A1 AR 059903A1
Authority
AR
Argentina
Prior art keywords
group
alkyl group
hydroxy
ulcer
disease
Prior art date
Application number
ARP070101061A
Other languages
English (en)
Inventor
Hirohisa Shimokawa
Tatsuya Yamagishi
Dean Matsumoto
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR059903A1 publication Critical patent/AR059903A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente se refiere a composiciones que contienen dichos compuestos y al método para el tratamiento y el uso, que comprenden dichos compuestos para el tratamiento de una afeccion mediada por la actividad antagonista de la bomba de ácido, tales como, pero no limitado a, enfermedad gastrointestinal, enfermedad gastroesofágica, enfermedad por reflujo gastroesofágico (ERGE), enfermedad por reflujo laringofaríngeo, ulcera péptica, ulcera gástrica, ulcera duodenal, ulceras inducidas por AINE, gastritis, infeccion por Helicobacter pylori, dispepsia, dispepsia funcional, síndrome de Zollinger-Ellison, enfermedad por reflujo no erosivo (ERNE), dolor visceral, cáncer, acidez, náuseas, esofagitis, disfagia, hipersalivacion, trastornos de las vías aéreas y asma. Reivindicacion 1: Un compuesto de formula (1).o una de; sus sales farmacéuticamente aceptable, en la que: -A-B- representa -O-CH2 o -CH2-O-; R1 representa un grupo hidroxi o un resto que se puede convertir en un grupo hidroxi in vivo; R2 representa un grupo alquilo C1-6; R3 y R4 representan de forma independiente un grupo alquilo C1-6 o un grupo cicloalquilo C3-7, y dicho grupo alquilo C1-6 y dicho grupo cicloalquilo C3-7 no están sustituidos o están sustituidos con 1 a 3 sustituyentes seleccionados de forma independiente del grupo que consiste en un átomo de halogeno; un grupo hidroxi, un grupo alcoxi C1-6 y un grupo cicloalquilo C3-7 o R3 y R4 considerados junto con el átomo de nitrogeno al que están unidos, forman un grupo heterocíclico de 4 a 7 miembros que no está sustituido o está sustituido con 1 a 3 sustituyentes seleccionados del grupo que consiste en un grupo hidroxi, un grupo alquilo C1-6, un grupo alcoxi C1-6 y un grupo hidroxi-alquilo C1-6; y R5, R6, R7 y R8 representan de forma independiente un átomo de hidrogeno, un átomo de halogeno o un grupo alquilo C1-6.
ARP070101061A 2006-03-17 2007-03-15 Derivados de cromano AR059903A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78366306P 2006-03-17 2006-03-17
US80487206P 2006-06-15 2006-06-15

Publications (1)

Publication Number Publication Date
AR059903A1 true AR059903A1 (es) 2008-05-07

Family

ID=38255490

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101061A AR059903A1 (es) 2006-03-17 2007-03-15 Derivados de cromano

Country Status (15)

Country Link
US (1) US20070219237A1 (es)
EP (1) EP1996589A1 (es)
JP (1) JP2009530262A (es)
KR (1) KR20080108129A (es)
AR (1) AR059903A1 (es)
BR (1) BRPI0708808A2 (es)
CA (1) CA2645007A1 (es)
GT (1) GT200700022A (es)
MX (1) MX2008011044A (es)
NL (1) NL2000532C2 (es)
PE (1) PE20071313A1 (es)
RU (1) RU2008137145A (es)
TW (1) TW200804380A (es)
UY (1) UY30205A1 (es)
WO (1) WO2007107827A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011016576A1 (en) 2009-08-04 2011-02-10 Takeda Pharmaceutical Company Limited Alanine derivatives as inhibitors of apoptosis proteins
DK3071206T3 (da) 2013-11-22 2021-05-25 CL BioSciences LLC Gastrinantagonister (eg yf476, netazepid) til behandling og forebyggelse af osteoporose
KR101769204B1 (ko) * 2015-08-04 2017-08-17 씨제이헬스케어 주식회사 크로마놀 유도체의 신규한 제조방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191164B1 (en) * 1996-05-15 2001-02-20 Hoechst Aktiengesellschaft Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them
SE9801526D0 (sv) * 1998-04-29 1998-04-29 Astra Ab New compounds
AU2001250850A1 (en) * 2000-03-17 2001-10-03 Dupont Pharmaceuticals Company Beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha
AU2001258771A1 (en) * 2000-05-19 2001-11-26 Takeda Chemical Industries Ltd. -secretase inhibitors
WO2002059099A1 (fr) * 2001-01-26 2002-08-01 Shionogi & Co., Ltd. Composes cycliques presentant un agonisme envers le recepteur de thrombopoietine
SE0102808D0 (sv) * 2001-08-22 2001-08-22 Astrazeneca Ab New compounds
JP2006508142A (ja) * 2002-11-19 2006-03-09 アルタナ　ファルマ　アクチエンゲゼルシャフト ８−置換イミダゾピリジン
DE602005009257D1 (de) * 2004-12-17 2008-10-02 Pfizer Chroman-derivate als säurepumpenantagonisten

Also Published As

Publication number Publication date
WO2007107827A1 (en) 2007-09-27
MX2008011044A (es) 2008-10-09
GT200700022A (es) 2008-02-05
TW200804380A (en) 2008-01-16
PE20071313A1 (es) 2008-01-25
BRPI0708808A2 (pt) 2011-06-14
US20070219237A1 (en) 2007-09-20
CA2645007A1 (en) 2007-09-27
NL2000532C2 (nl) 2008-02-05
UY30205A1 (es) 2007-10-31
KR20080108129A (ko) 2008-12-11
RU2008137145A (ru) 2010-03-27
NL2000532A1 (nl) 2007-09-18
JP2009530262A (ja) 2009-08-27
EP1996589A1 (en) 2008-12-03

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