PE20071313A1 - Derivados de cromano como agentes inhibidores de la bomba de acido - Google Patents

Derivados de cromano como agentes inhibidores de la bomba de acido

Info

Publication number
PE20071313A1
PE20071313A1 PE2007000258A PE2007000258A PE20071313A1 PE 20071313 A1 PE20071313 A1 PE 20071313A1 PE 2007000258 A PE2007000258 A PE 2007000258A PE 2007000258 A PE2007000258 A PE 2007000258A PE 20071313 A1 PE20071313 A1 PE 20071313A1
Authority
PE
Peru
Prior art keywords
alkyl
hydroximethyl
chromen
carboxamide
dihydro
Prior art date
Application number
PE2007000258A
Other languages
English (en)
Inventor
Yukari Matsumoto
Hirohisa Shimokawa
Tatsuya Yamagishi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20071313A1 publication Critical patent/PE20071313A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE CROMANO DE FORMULA (I), DONDE A-B ES -O-CH2- O -CH2-O-; R1 ES OH O UN RESTO QUE SE PUEDE CONVERTIR EN UN GRUPO HIDROXI; R2 ES ALQUILO C1-C6; R3 Y R4 SON ALQUILO C1-C6, CICLOALQUILO C3-C7 OPCIONALMENTE SUSTITUIDOS CON OH, HALOGENO, ALCOXI C1-C6, CICLOALQUILO C3-C7; O R3 Y R4 JUNTO CON EL NITROGENO AL QUE ESTAN UNIDOS FORMAN UN GRUPO HETEROCICLO DE 4 A 7 MIEMBROS OPCIONALMENTE SUSTITUIDO CON OH, ALQUILO C1-C6, ALCOXI C1-C6 O HIDROXIALQUILO C1-C6; R5, R6, R7 Y R8 SON H, HALOGENO O ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS: (S)-(-)-3-(HIDROXIMETIL)-N,N,2-TRIMETIL-8-[(5-METIL-3,4-DIHIDRO-2H-CROMEN-4-IL)AMINO]IMIDAZO[1,2-a]PIRIDINA-6-CARBOXAMIDA, (+)-8-(3,4-DIHIDRO-2H-CROMEN-4-ILAMINO)-3-(HIDROXIMETIL)-N,N,2-TRIMETILIMIDAZO[1,2-a]PIRIDINA-6-CARBOXAMIDA, (S)-(-)-8-[(5,7-DIFLUORO-3,4-DIHIDRO-2H-CROMEN-4-IL)AMINO]-3-(HIDROXIMETIL)-N,N,2-TRIMETILIMIDAZO[1,2-a]PIRIDINA-6-CARBOXAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES SELECTIVOS DE LA BOMBA DE ACIDO Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES GASTROINTESTINALES, REFLUJO GASTROESOFAGICO, GASTRITIS, ENTRE OTRAS
PE2007000258A 2006-03-17 2007-03-09 Derivados de cromano como agentes inhibidores de la bomba de acido PE20071313A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78366306P 2006-03-17 2006-03-17
US80487206P 2006-06-15 2006-06-15

Publications (1)

Publication Number Publication Date
PE20071313A1 true PE20071313A1 (es) 2008-01-25

Family

ID=38255490

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000258A PE20071313A1 (es) 2006-03-17 2007-03-09 Derivados de cromano como agentes inhibidores de la bomba de acido

Country Status (15)

Country Link
US (1) US20070219237A1 (es)
EP (1) EP1996589A1 (es)
JP (1) JP2009530262A (es)
KR (1) KR20080108129A (es)
AR (1) AR059903A1 (es)
BR (1) BRPI0708808A2 (es)
CA (1) CA2645007A1 (es)
GT (1) GT200700022A (es)
MX (1) MX2008011044A (es)
NL (1) NL2000532C2 (es)
PE (1) PE20071313A1 (es)
RU (1) RU2008137145A (es)
TW (1) TW200804380A (es)
UY (1) UY30205A1 (es)
WO (1) WO2007107827A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110034469A1 (en) 2009-08-04 2011-02-10 Takeda Pharmaceutical Company Limited Heterocyclic Compound
JP6502939B2 (ja) 2013-11-22 2019-04-17 シーエル バイオサイエンシズ リミティド ライアビリティ カンパニー 骨粗鬆症の処置及び予防のためのガストリン拮抗薬
KR101769204B1 (ko) * 2015-08-04 2017-08-17 씨제이헬스케어 주식회사 크로마놀 유도체의 신규한 제조방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191164B1 (en) * 1996-05-15 2001-02-20 Hoechst Aktiengesellschaft Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them
SE9801526D0 (sv) * 1998-04-29 1998-04-29 Astra Ab New compounds
JP2003528097A (ja) * 2000-03-17 2003-09-24 ブリストル−マイヤーズ スクイブ ファーマ カンパニー マトリックスメタロプロテアーゼおよびＴＮＦ−α阻害剤としてのβ−アミノ酸誘導体
CA2407088A1 (en) * 2000-05-19 2001-11-22 Takeda Chemical Industries, Ltd. Beta-secretase inhibitors
US7169931B2 (en) * 2001-01-26 2007-01-30 Shionogi & Co., Ltd. Cyclic compounds exhibiting thrombopoietin receptor agonism
SE0102808D0 (sv) * 2001-08-22 2001-08-22 Astrazeneca Ab New compounds
AU2003288071A1 (en) * 2002-11-19 2004-06-15 Altana Pharma Ag 8-substituted imidazopyridines
EA011512B1 (ru) * 2004-12-17 2009-04-28 Ракуалиа Фарма Инк. Производные хромана, полезные в качестве антагонистов кислотной помпы

Also Published As

Publication number Publication date
NL2000532C2 (nl) 2008-02-05
JP2009530262A (ja) 2009-08-27
TW200804380A (en) 2008-01-16
EP1996589A1 (en) 2008-12-03
MX2008011044A (es) 2008-10-09
BRPI0708808A2 (pt) 2011-06-14
WO2007107827A1 (en) 2007-09-27
RU2008137145A (ru) 2010-03-27
NL2000532A1 (nl) 2007-09-18
KR20080108129A (ko) 2008-12-11
UY30205A1 (es) 2007-10-31
US20070219237A1 (en) 2007-09-20
GT200700022A (es) 2008-02-05
AR059903A1 (es) 2008-05-07
CA2645007A1 (en) 2007-09-27

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