ATE512969T1 - Benzimidazolderivate als selektive säurepumpenhemmer - Google Patents
Benzimidazolderivate als selektive säurepumpenhemmerInfo
- Publication number
- ATE512969T1 ATE512969T1 AT07825160T AT07825160T ATE512969T1 AT E512969 T1 ATE512969 T1 AT E512969T1 AT 07825160 T AT07825160 T AT 07825160T AT 07825160 T AT07825160 T AT 07825160T AT E512969 T1 ATE512969 T1 AT E512969T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- disease
- acid pump
- reflux disease
- pharmaceutically acceptable
- Prior art date
Links
- 229940121353 acid pump inhibitor Drugs 0.000 title 1
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000006549 dyspepsia Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000019505 Deglutition disease Diseases 0.000 abstract 1
- 208000007882 Gastritis Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 241000590002 Helicobacter pylori Species 0.000 abstract 1
- 208000005206 Laryngopharyngeal Reflux Diseases 0.000 abstract 1
- 206010028813 Nausea Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010030216 Oesophagitis Diseases 0.000 abstract 1
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 1
- 206010067869 Reflux laryngitis Diseases 0.000 abstract 1
- 206010039424 Salivary hypersecretion Diseases 0.000 abstract 1
- 208000008630 Sialorrhea Diseases 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000010643 digestive system disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000000718 duodenal ulcer Diseases 0.000 abstract 1
- 208000006881 esophagitis Diseases 0.000 abstract 1
- 201000005917 gastric ulcer Diseases 0.000 abstract 1
- 208000029493 gastroesophageal disease Diseases 0.000 abstract 1
- 208000018685 gastrointestinal system disease Diseases 0.000 abstract 1
- 208000024798 heartburn Diseases 0.000 abstract 1
- 229940037467 helicobacter pylori Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008693 nausea Effects 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
- 208000011906 peptic ulcer disease Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
- 208000009935 visceral pain Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82644206P | 2006-09-21 | 2006-09-21 | |
| US91226407P | 2007-04-17 | 2007-04-17 | |
| PCT/IB2007/002749 WO2008035195A1 (en) | 2006-09-21 | 2007-09-17 | Benzimidazole derivatives as selective acid pump inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE512969T1 true ATE512969T1 (de) | 2011-07-15 |
Family
ID=38980958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07825160T ATE512969T1 (de) | 2006-09-21 | 2007-09-17 | Benzimidazolderivate als selektive säurepumpenhemmer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8466166B2 (de) |
| EP (1) | EP2081939B1 (de) |
| JP (1) | JP5140080B2 (de) |
| KR (1) | KR101109866B1 (de) |
| AT (1) | ATE512969T1 (de) |
| BR (1) | BRPI0717102A2 (de) |
| CA (1) | CA2657550C (de) |
| MX (1) | MX2009000080A (de) |
| RU (1) | RU2412188C2 (de) |
| WO (1) | WO2008035195A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2624179A1 (en) | 2005-10-06 | 2007-04-12 | Auspex Pharmaceuticals, Inc. | Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties |
| WO2008114123A1 (en) * | 2007-03-21 | 2008-09-25 | Raqualia Pharma Inc. | Spiro benzimidazole derivatives as acid pump inhibitors |
| MX2012000275A (es) | 2009-07-09 | 2012-02-08 | Raqualia Pharma Inc | Antagonista de bomba de acido para el tratamiento de enfermedades involucradas en la motilidad gastrointestinal anormal. |
| EA021295B1 (ru) * | 2012-02-29 | 2015-05-29 | Ооо "Фармацевтическая Компания "Славянская Аптека" | Фармацевтический состав, обладающий сосудосуживающим, антиконгестивным, противовоспалительным действием (варианты) |
| EA021265B1 (ru) * | 2012-02-29 | 2015-05-29 | Ооо "Фармацевтическая Компания "Славянская Аптека" | Фармацевтический состав, обладающий сосудосуживающим, антиконгестивным, противовоспалительным действием (варианты) |
| EA022836B1 (ru) * | 2012-03-02 | 2016-03-31 | ООО "Эн.Си. ФАРМ" | Фармацевтический состав для инъекций, обладающий нейропротекторной, антиамнестической, антиоксидантной, противогипоксической, противоишемической активностью (варианты) |
| EA020040B1 (ru) * | 2012-03-11 | 2014-08-29 | Ооо "Эн.Си.Фарм" | Твердая лекарственная форма, обладающая нейропротекторной, антиамнестической, антиоксидантной, противогипоксической, противоишемической активностью (варианты) |
| EA020033B1 (ru) * | 2012-03-11 | 2014-08-29 | Ооо "Эн.Си.Фарм" | Твердая лекарственная форма, обладающая нейропротекторной, антиамнестической, антиоксидантной, противогипоксической, противоишемической активностью (варианты) |
| EA020042B1 (ru) * | 2012-03-11 | 2014-08-29 | Ооо "Эн.Си.Фарм" | Твердая лекарственная форма, обладающая нейропротекторной, антиамнестической, антиоксидантной, противогипоксической, противоишемической активностью (варианты) |
| EA021246B1 (ru) * | 2012-03-14 | 2015-05-29 | Ооо "Фармацевтическая Компания "Славянская Аптека" | Фармацевтический состав, обладающий сосудосуживающим, антиконгестивным, противовоспалительным действием (варианты) |
| EA020058B1 (ru) * | 2012-03-14 | 2014-08-29 | Ооо "Эн.Си.Фарм" | Твердая лекарственная форма, обладающая нейропротекторной, антиамнестической, антиоксидантной, противогипоксической, противоишемической активностью (варианты) |
| KR102254957B1 (ko) | 2013-11-22 | 2021-05-25 | 씨엘 바이오사이언시즈 엘엘씨 | 골다공증 치료 및 예방을 위한 가스트린 길항제(ｅｇ ｙｆ476, 네타제피드) |
| KR102708701B1 (ko) * | 2021-12-27 | 2024-09-24 | 에이치케이이노엔 주식회사 | 벤즈이미다졸 유도체의 제조방법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0699439B2 (ja) * | 1988-02-03 | 1994-12-07 | 日産化学工業株式会社 | ピラノベンゾオキサジアゾール誘導体 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| TW334423B (en) * | 1993-10-22 | 1998-06-21 | Hoffmann La Roche | Tricyclic 1-aminoethylpyrrole-derivatives |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| AR043063A1 (es) | 2002-12-13 | 2005-07-13 | Altana Pharma Ag | Bencimidazoles 6-sustituidos y su uso como inhibidores de secreciones gastricas |
| BRPI0408893A (pt) * | 2003-04-04 | 2006-04-11 | Altana Pharma Ag | benzimidazóis cìclicos |
| AR051041A1 (es) | 2004-10-04 | 2006-12-13 | Altana Pharma Ag | Bencimidazoles triciclicos condensados |
| US7449262B2 (en) * | 2004-12-09 | 2008-11-11 | Praxair Technology, Inc. | Current collector to conduct an electrical current to or from an electrode layer |
| JP2008534476A (ja) | 2005-03-24 | 2008-08-28 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 胃腸疾病の治療のために有用なチオアミド置換された三環式のベンゾイミダゾール |
| JP2008546736A (ja) | 2005-06-22 | 2008-12-25 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 三環式ベンゾイミダゾールの製造のための中間体の製造方法 |
-
2007
- 2007-09-17 JP JP2009528807A patent/JP5140080B2/ja not_active Expired - Fee Related
- 2007-09-17 EP EP07825160A patent/EP2081939B1/de not_active Not-in-force
- 2007-09-17 MX MX2009000080A patent/MX2009000080A/es active IP Right Grant
- 2007-09-17 BR BRPI0717102-1A patent/BRPI0717102A2/pt not_active IP Right Cessation
- 2007-09-17 KR KR1020097008041A patent/KR101109866B1/ko active Active
- 2007-09-17 AT AT07825160T patent/ATE512969T1/de not_active IP Right Cessation
- 2007-09-17 RU RU2009114859/04A patent/RU2412188C2/ru not_active IP Right Cessation
- 2007-09-17 US US12/442,277 patent/US8466166B2/en active Active
- 2007-09-17 WO PCT/IB2007/002749 patent/WO2008035195A1/en not_active Ceased
- 2007-09-17 CA CA2657550A patent/CA2657550C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2657550A1 (en) | 2008-03-27 |
| BRPI0717102A2 (pt) | 2013-10-29 |
| US20100048532A1 (en) | 2010-02-25 |
| EP2081939B1 (de) | 2011-06-15 |
| KR20090054476A (ko) | 2009-05-29 |
| WO2008035195A1 (en) | 2008-03-27 |
| JP5140080B2 (ja) | 2013-02-06 |
| HK1132507A1 (en) | 2010-02-26 |
| MX2009000080A (es) | 2009-01-23 |
| US8466166B2 (en) | 2013-06-18 |
| RU2412188C2 (ru) | 2011-02-20 |
| EP2081939A1 (de) | 2009-07-29 |
| JP2010504317A (ja) | 2010-02-12 |
| CA2657550C (en) | 2011-11-01 |
| KR101109866B1 (ko) | 2012-04-12 |
| RU2009114859A (ru) | 2010-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |