MD663G2 - Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente - Google Patents

Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente

Info

Publication number
MD663G2
MD663G2 MD95-0431A MD950431A MD663G2 MD 663 G2 MD663 G2 MD 663G2 MD 950431 A MD950431 A MD 950431A MD 663 G2 MD663 G2 MD 663G2
Authority
MD
Moldova
Prior art keywords
compounds
heteroatoms
formula
saturated
possibly
Prior art date
Application number
MD95-0431A
Other languages
English (en)
Romanian (ro)
Russian (ru)
Other versions
MD663F1 (ro
Inventor
Constantin Agouridas
Yannick Benedetti
Jean-Francois Chantot
Alexis Denis
Odile Le Martret
Original Assignee
Roussel Uclaf, Societe Anonyme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf, Societe Anonyme filed Critical Roussel Uclaf, Societe Anonyme
Publication of MD663F1 publication Critical patent/MD663F1/xx
Publication of MD663G2 publication Critical patent/MD663G2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MD95-0431A 1994-04-08 1995-04-06 Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente MD663G2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
PCT/FR1995/000441 WO1995027720A1 (fr) 1994-04-08 1995-04-06 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
MD663F1 MD663F1 (ro) 1997-01-31
MD663G2 true MD663G2 (ro) 1997-07-31

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0431A MD663G2 (ro) 1994-04-08 1995-04-06 Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente

Country Status (49)

Country Link
US (2) US5656607A (enrdf_load_stackoverflow)
EP (1) EP0676409B1 (enrdf_load_stackoverflow)
JP (1) JP3000023B2 (enrdf_load_stackoverflow)
KR (1) KR100317148B1 (enrdf_load_stackoverflow)
CN (1) CN1059445C (enrdf_load_stackoverflow)
AP (1) AP587A (enrdf_load_stackoverflow)
AT (1) ATE234853T1 (enrdf_load_stackoverflow)
AU (1) AU684939B2 (enrdf_load_stackoverflow)
BG (1) BG61916B1 (enrdf_load_stackoverflow)
BR (1) BR9506147A (enrdf_load_stackoverflow)
CA (1) CA2164638C (enrdf_load_stackoverflow)
CO (1) CO4370097A1 (enrdf_load_stackoverflow)
CZ (1) CZ296005B6 (enrdf_load_stackoverflow)
DE (1) DE69529934T2 (enrdf_load_stackoverflow)
DK (1) DK0676409T3 (enrdf_load_stackoverflow)
DZ (1) DZ1869A1 (enrdf_load_stackoverflow)
EE (1) EE04498B1 (enrdf_load_stackoverflow)
ES (1) ES2189820T3 (enrdf_load_stackoverflow)
FI (1) FI111264B (enrdf_load_stackoverflow)
FR (1) FR2718450B1 (enrdf_load_stackoverflow)
GB (1) GB2288174A (enrdf_load_stackoverflow)
GE (1) GEP19991836B (enrdf_load_stackoverflow)
HR (1) HRP950217B1 (enrdf_load_stackoverflow)
HU (1) HU215396B (enrdf_load_stackoverflow)
IL (1) IL112954A (enrdf_load_stackoverflow)
IS (1) IS1865B (enrdf_load_stackoverflow)
JO (1) JO1850B1 (enrdf_load_stackoverflow)
LV (1) LV11182B (enrdf_load_stackoverflow)
MA (1) MA23501A1 (enrdf_load_stackoverflow)
MD (1) MD663G2 (enrdf_load_stackoverflow)
MY (1) MY114672A (enrdf_load_stackoverflow)
NO (1) NO308361B1 (enrdf_load_stackoverflow)
NZ (1) NZ284498A (enrdf_load_stackoverflow)
OA (1) OA10200A (enrdf_load_stackoverflow)
PE (1) PE2896A1 (enrdf_load_stackoverflow)
PL (1) PL180837B1 (enrdf_load_stackoverflow)
PT (1) PT676409E (enrdf_load_stackoverflow)
RO (1) RO115634B1 (enrdf_load_stackoverflow)
RU (1) RU2141965C1 (enrdf_load_stackoverflow)
SA (1) SA97170757A (enrdf_load_stackoverflow)
SI (1) SI0676409T1 (enrdf_load_stackoverflow)
SK (1) SK284079B6 (enrdf_load_stackoverflow)
SV (1) SV1995000018A (enrdf_load_stackoverflow)
TN (1) TNSN95026A1 (enrdf_load_stackoverflow)
TW (1) TW316908B (enrdf_load_stackoverflow)
UA (1) UA44705C2 (enrdf_load_stackoverflow)
WO (1) WO1995027720A1 (enrdf_load_stackoverflow)
YU (1) YU49221B (enrdf_load_stackoverflow)
ZA (1) ZA952059B (enrdf_load_stackoverflow)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
JP2002502366A (ja) * 1996-05-07 2002-01-22 アボット・ラボラトリーズ ３―デスクラジノース―２，３―無水エリスロマイシン誘導体
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
WO1998009978A1 (en) * 1996-09-04 1998-03-12 Abbott Laboratories 6-o-substituted ketolides having antibacterial activity
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US6165986A (en) * 1997-03-10 2000-12-26 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
US6140479A (en) * 1997-03-24 2000-10-31 Taisho Pharmaceuticals Co., Ltd. Erythromycin a derivatives
US6162794A (en) * 1997-05-09 2000-12-19 Pfizer Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
CA2293335A1 (en) * 1997-06-11 1998-12-17 Pfizer Products Inc., 9-oxime erythromycin derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
ES2243066T3 (es) * 1998-09-22 2005-11-16 Pfizer Products Inc. Antibioticos de carbamato y carbazato cetolida.
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
AU6484199A (en) 1998-12-10 2000-06-26 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
JP2002542197A (ja) 1999-04-16 2002-12-10 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ケトライド抗菌剤
CN1241931C (zh) * 1999-04-16 2006-02-15 高山生物科学股份有限公司 大环内酯抗感染药物
PL352720A1 (en) * 1999-05-24 2003-09-08 Pfizer Products Inc. 13-methyl-erythromycin derivatives
US6756359B2 (en) 2001-07-03 2004-06-29 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
KR101035043B1 (ko) 2002-07-01 2011-05-19 아르키온 라이프 사이언씨즈 엘엘씨 글루코사민 및 ｎ-아세틸글루코사민의 제조를 위한 물질및 공정
CA2801100A1 (en) * 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Macrolides and processes for their preparation
JP2006524702A (ja) * 2003-04-25 2006-11-02 カイロン コーポレイション ピリジル置換ケトライド抗体
EP1618120A2 (en) * 2003-04-25 2006-01-25 Chiron Corporation Novel ketolide derivatives
CN105732745A (zh) * 2007-10-25 2016-07-06 森普拉制药公司 大环内酯类抗菌剂的制备方法
DK2358379T3 (en) 2008-10-24 2016-03-07 Cempra Pharmaceuticals Inc BIOFORSVAR USING TRIAZOLHOLDIGE macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
CN108570083A (zh) 2010-03-22 2018-09-25 森普拉制药公司 大环内脂的结晶形式及其用途
EP2571506B1 (en) 2010-05-20 2017-05-10 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
KR20180110181A (ko) 2010-09-10 2018-10-08 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
SG11201405895UA (en) 2012-03-27 2014-10-30 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
CA2905975A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CA2907085A1 (en) 2013-03-15 2014-09-18 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CA2908575C (en) 2013-04-04 2021-11-16 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
US10633407B2 (en) * 2014-10-08 2020-04-28 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
CN107530365A (zh) 2015-03-25 2018-01-02 哈佛大学的校长及成员们 具有修饰的脱氧糖胺糖的大环内酯及其用途
MD1222Z (ro) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868414A (en) * 1973-01-22 1975-02-25 Merck & Co Inc Tetrahydrofluorene carboxylic acids and related compounds
AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
DE2842759A1 (de) * 1978-09-30 1980-04-10 Merck Patent Gmbh Basische aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

Also Published As

Publication number Publication date
BG61916B1 (bg) 1998-09-30
YU49221B (sh) 2004-11-25
PL311871A1 (en) 1996-03-18
PT676409E (pt) 2003-08-29
JO1850B1 (en) 1995-12-27
HRP950217B1 (en) 2004-06-30
FI955913A7 (fi) 1995-12-08
CO4370097A1 (es) 1996-10-07
SA97170757A (ar) 2005-12-03
SI0676409T1 (en) 2003-06-30
EP0676409A1 (fr) 1995-10-11
SK284079B6 (sk) 2004-09-08
AU684939B2 (en) 1998-01-08
YU21695A (sh) 1997-12-05
US5760233A (en) 1998-06-02
US5656607A (en) 1997-08-12
DE69529934D1 (de) 2003-04-24
MA23501A1 (fr) 1995-12-31
GEP19991836B (en) 1999-11-05
HUT73772A (en) 1996-09-30
DE69529934T2 (de) 2003-09-04
RO115634B1 (ro) 2000-04-28
CA2164638C (fr) 2003-12-30
FI955913A0 (fi) 1995-12-08
MD663F1 (ro) 1997-01-31
EE9500080A (et) 1996-12-16
SK154695A3 (en) 1996-10-02
SV1995000018A (es) 1997-10-24
HU9503505D0 (en) 1996-02-28
IL112954A (en) 2000-07-16
AP9500743A0 (en) 1995-07-31
EP0676409B1 (fr) 2003-03-19
KR100317148B1 (ko) 2002-06-22
RU2141965C1 (ru) 1999-11-27
NO308361B1 (no) 2000-09-04
FR2718450A1 (fr) 1995-10-13
JPH07278177A (ja) 1995-10-24
FI111264B (fi) 2003-06-30
JP3000023B2 (ja) 2000-01-17
NZ284498A (en) 1997-07-27
CN1059445C (zh) 2000-12-13
IS1865B (is) 2003-05-02
FR2718450B1 (fr) 1997-01-10
ES2189820T3 (es) 2003-07-16
LV11182B (en) 1997-04-20
AP587A (en) 1997-04-29
CA2164638A1 (fr) 1995-10-19
AU2310795A (en) 1995-10-30
NO954942D0 (no) 1995-12-06
MY114672A (en) 2002-12-31
LV11182A (lv) 1996-04-20
IS4309A (is) 1995-11-17
OA10200A (fr) 1996-12-18
TW316908B (enrdf_load_stackoverflow) 1997-10-01
ZA952059B (en) 1996-03-13
HRP950217A2 (en) 1997-08-31
WO1995027720A1 (fr) 1995-10-19
CZ296005B6 (cs) 2005-12-14
DZ1869A1 (fr) 2002-02-17
CZ322395A3 (en) 1996-08-14
DK0676409T3 (da) 2003-06-23
UA44705C2 (uk) 2002-03-15
PL180837B1 (pl) 2001-04-30
GB9506856D0 (en) 1995-05-24
PE2896A1 (es) 1996-02-12
ATE234853T1 (de) 2003-04-15
BR9506147A (pt) 1996-04-16
NO954942L (no) 1996-02-07
HU215396B (hu) 1998-12-28
CN1126997A (zh) 1996-07-17
IL112954A0 (en) 1995-06-29
TNSN95026A1 (fr) 1996-02-06
GB2288174A (en) 1995-10-11
EE04498B1 (et) 2005-06-15
BG100150A (bg) 1996-06-28

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Legal Events

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FG3A Granted patent for invention
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20150406

MM4A Patent for invention definitely lapsed due to non-payment of fees