KR102684436B1 - Ep4 길항제 - Google Patents

Ep4 길항제 Download PDF

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Publication number
KR102684436B1
KR102684436B1 KR1020187013843A KR20187013843A KR102684436B1 KR 102684436 B1 KR102684436 B1 KR 102684436B1 KR 1020187013843 A KR1020187013843 A KR 1020187013843A KR 20187013843 A KR20187013843 A KR 20187013843A KR 102684436 B1 KR102684436 B1 KR 102684436B1
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trifluoromethyl
imidazo
pyrazole
ethyl
dihydro
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Korean (ko)
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KR20180083863A (ko
Inventor
완준 쟁
샤오지에 주
홍 두
마아르텐 포스테마
위민 장
징 리
로버트 유
형-욱 최
재문 이
프랑크 팽
다니엘 쿠스타
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에자이 알앤드디 매니지먼트 가부시키가이샤
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Publication of KR20180083863A publication Critical patent/KR20180083863A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020187013843A 2015-10-16 2016-10-14 Ep4 길항제 Active KR102684436B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562242734P 2015-10-16 2015-10-16
US201562242748P 2015-10-16 2015-10-16
US62/242,748 2015-10-16
US62/242,734 2015-10-16
BD252/2016 2016-10-13
BD2522016 2016-10-13
PCT/US2016/057135 WO2017066633A1 (en) 2015-10-16 2016-10-14 Ep4 antagonists

Publications (2)

Publication Number Publication Date
KR20180083863A KR20180083863A (ko) 2018-07-23
KR102684436B1 true KR102684436B1 (ko) 2024-07-15

Family

ID=58518017

Family Applications (1)

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KR1020187013843A Active KR102684436B1 (ko) 2015-10-16 2016-10-14 Ep4 길항제

Country Status (11)

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US (3) US10316040B2 (enExample)
EP (1) EP3362454B1 (enExample)
JP (2) JP6860559B2 (enExample)
KR (1) KR102684436B1 (enExample)
CN (1) CN108473497B (enExample)
AU (1) AU2016338679B2 (enExample)
BR (1) BR112018007664B1 (enExample)
CA (1) CA3002144C (enExample)
IL (1) IL258737A (enExample)
MX (1) MX390051B (enExample)
WO (1) WO2017066633A1 (enExample)

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* Cited by examiner, † Cited by third party
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CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
CN110621671A (zh) 2017-05-18 2019-12-27 爱杜西亚药品有限公司 作为pge2受体调节剂的苯并呋喃及苯并噻吩衍生物
PE20191811A1 (es) 2017-05-18 2019-12-26 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
PE20191814A1 (es) 2017-05-18 2019-12-27 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
JP7065117B2 (ja) 2017-05-18 2022-05-11 イドーシア ファーマシューティカルズ リミテッド Ｎ－置換インドール誘導体
EP3625223B1 (en) 2017-05-18 2021-08-11 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives
CN117643587A (zh) * 2018-02-05 2024-03-05 深圳市原力生命科学有限公司 用于治疗癌症的杂二环羧酸
KR20200129102A (ko) * 2018-03-02 2020-11-17 셴젠 이오노바 라이프 사이언스 시오., 엘티디. 헤테로비시클릭 카르복시산들 및 그의 염들
JP7488269B2 (ja) 2019-01-22 2024-05-21 キーセラ・（スーチョウ）・ファーマシューティカルズ・カンパニー・リミテッド Ｐｇｅ２／ｅｐ４シグナル伝達を阻害する化合物、その製造方法及びその医薬における応用
US20230390303A1 (en) 2020-11-13 2023-12-07 Ono Pharmaceutical Co., Ltd. Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor

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JP7090770B2 (ja) 2022-06-24
JP2021100969A (ja) 2021-07-08
CN108473497A (zh) 2018-08-31
CA3002144A1 (en) 2017-04-20
US10941148B2 (en) 2021-03-09
US20180305362A1 (en) 2018-10-25
US10316040B2 (en) 2019-06-11
CA3002144C (en) 2024-01-23
AU2016338679A1 (en) 2018-06-07
CN108473497B (zh) 2021-09-10
US20210347779A1 (en) 2021-11-11
EP3362454B1 (en) 2021-12-08
US11434246B2 (en) 2022-09-06
EP3362454A1 (en) 2018-08-22
IL258737A (en) 2018-06-28
WO2017066633A1 (en) 2017-04-20
MX2018004664A (es) 2018-08-24
US20190315754A1 (en) 2019-10-17
JP6860559B2 (ja) 2021-04-14
BR112018007664A2 (pt) 2018-11-06
MX390051B (es) 2025-03-20
BR112018007664B1 (pt) 2023-12-19
JP2018530595A (ja) 2018-10-18
KR20180083863A (ko) 2018-07-23
AU2016338679B2 (en) 2021-05-06

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