IL258737A - Antagonists ep4 - Google Patents

Antagonists ep4

Info

Publication number
IL258737A
IL258737A IL258737A IL25873718A IL258737A IL 258737 A IL258737 A IL 258737A IL 258737 A IL258737 A IL 258737A IL 25873718 A IL25873718 A IL 25873718A IL 258737 A IL258737 A IL 258737A
Authority
IL
Israel
Prior art keywords
antagonists
Prior art date
Application number
IL258737A
Other languages
English (en)
Hebrew (he)
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of IL258737A publication Critical patent/IL258737A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL258737A 2015-10-16 2018-04-16 Antagonists ep4 IL258737A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562242748P 2015-10-16 2015-10-16
US201562242734P 2015-10-16 2015-10-16
BD2522016 2016-10-13
PCT/US2016/057135 WO2017066633A1 (en) 2015-10-16 2016-10-14 Ep4 antagonists

Publications (1)

Publication Number Publication Date
IL258737A true IL258737A (en) 2018-06-28

Family

ID=58518017

Family Applications (1)

Application Number Title Priority Date Filing Date
IL258737A IL258737A (en) 2015-10-16 2018-04-16 Antagonists ep4

Country Status (11)

Country Link
US (3) US10316040B2 (enExample)
EP (1) EP3362454B1 (enExample)
JP (2) JP6860559B2 (enExample)
KR (1) KR102684436B1 (enExample)
CN (1) CN108473497B (enExample)
AU (1) AU2016338679B2 (enExample)
BR (1) BR112018007664B1 (enExample)
CA (1) CA3002144C (enExample)
IL (1) IL258737A (enExample)
MX (1) MX390051B (enExample)
WO (1) WO2017066633A1 (enExample)

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US11839613B2 (en) 2017-05-18 2023-12-12 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives as PGE2 receptor modulators
PE20191814A1 (es) 2017-05-18 2019-12-27 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
TW201900179A (zh) 2017-05-18 2019-01-01 瑞士商愛杜西亞製藥有限公司 作為pge2受體調節劑之苯并呋喃及苯并噻吩衍生物
KR102612140B1 (ko) 2017-05-18 2023-12-08 이도르시아 파마슈티컬스 리미티드 피리미딘 유도체
CN111727044A (zh) * 2018-02-05 2020-09-29 深圳市原力生命科学有限公司 用于治疗癌症或炎性疾病的杂二环羧酸
EP3759114A4 (en) * 2018-03-02 2021-12-15 Shenzhen Ionova Life Science Co., Ltd. HETEROBICYCLIC CARBONIC ACIDS AND SALT THEREOF
US12240812B2 (en) 2019-01-22 2025-03-04 Keythera (Suzhou) Pharmaceuticals Co. Ltd. Compound for inhibiting PGE2/EP4 signaling transduction inhibiting, preparation method therefor, and medical uses thereof
US20230390303A1 (en) 2020-11-13 2023-12-07 Ono Pharmaceutical Co., Ltd. Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor

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Also Published As

Publication number Publication date
US11434246B2 (en) 2022-09-06
MX2018004664A (es) 2018-08-24
CA3002144A1 (en) 2017-04-20
BR112018007664B1 (pt) 2023-12-19
US10941148B2 (en) 2021-03-09
JP2018530595A (ja) 2018-10-18
JP2021100969A (ja) 2021-07-08
US10316040B2 (en) 2019-06-11
JP6860559B2 (ja) 2021-04-14
BR112018007664A2 (pt) 2018-11-06
US20190315754A1 (en) 2019-10-17
CN108473497A (zh) 2018-08-31
KR20180083863A (ko) 2018-07-23
CA3002144C (en) 2024-01-23
WO2017066633A1 (en) 2017-04-20
EP3362454B1 (en) 2021-12-08
EP3362454A1 (en) 2018-08-22
JP7090770B2 (ja) 2022-06-24
MX390051B (es) 2025-03-20
US20210347779A1 (en) 2021-11-11
AU2016338679A1 (en) 2018-06-07
CN108473497B (zh) 2021-09-10
US20180305362A1 (en) 2018-10-25
KR102684436B1 (ko) 2024-07-15
AU2016338679B2 (en) 2021-05-06

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