AU2016338679B2 - EP4 antagonists - Google Patents

EP4 antagonists Download PDF

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Publication number
AU2016338679B2
AU2016338679B2 AU2016338679A AU2016338679A AU2016338679B2 AU 2016338679 B2 AU2016338679 B2 AU 2016338679B2 AU 2016338679 A AU2016338679 A AU 2016338679A AU 2016338679 A AU2016338679 A AU 2016338679A AU 2016338679 B2 AU2016338679 B2 AU 2016338679B2
Authority
AU
Australia
Prior art keywords
trifluoromethyl
imidazo
dihydro
ethyl
pyrazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2016338679A
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English (en)
Other versions
AU2016338679A1 (en
Inventor
Hyeong-Wook Choi
Daniel CUSTAR
Hong Du
Frank Fang
Yimin Jiang
Jaemoon Lee
Jing Li
Maarten POSTEMA
Robert Yu
Wanjun Zheng
Xiaojie Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai R&D Management Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd
Publication of AU2016338679A1 publication Critical patent/AU2016338679A1/en
Application granted granted Critical
Publication of AU2016338679B2 publication Critical patent/AU2016338679B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2016338679A 2015-10-16 2016-10-14 EP4 antagonists Ceased AU2016338679B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562242734P 2015-10-16 2015-10-16
US201562242748P 2015-10-16 2015-10-16
US62/242,734 2015-10-16
US62/242,748 2015-10-16
BD2522016 2016-10-13
BD252/2016 2016-10-13
PCT/US2016/057135 WO2017066633A1 (en) 2015-10-16 2016-10-14 Ep4 antagonists

Publications (2)

Publication Number Publication Date
AU2016338679A1 AU2016338679A1 (en) 2018-06-07
AU2016338679B2 true AU2016338679B2 (en) 2021-05-06

Family

ID=58518017

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016338679A Ceased AU2016338679B2 (en) 2015-10-16 2016-10-14 EP4 antagonists

Country Status (11)

Country Link
US (3) US10316040B2 (enExample)
EP (1) EP3362454B1 (enExample)
JP (2) JP6860559B2 (enExample)
KR (1) KR102684436B1 (enExample)
CN (1) CN108473497B (enExample)
AU (1) AU2016338679B2 (enExample)
BR (1) BR112018007664B1 (enExample)
CA (1) CA3002144C (enExample)
IL (1) IL258737A (enExample)
MX (1) MX390051B (enExample)
WO (1) WO2017066633A1 (enExample)

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CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
PE20191787A1 (es) 2017-05-18 2019-12-24 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituidos
KR102612140B1 (ko) 2017-05-18 2023-12-08 이도르시아 파마슈티컬스 리미티드 피리미딘 유도체
AR111808A1 (es) 2017-05-18 2019-08-21 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
EA201992676A1 (ru) 2017-05-18 2020-05-06 Идорсия Фармасьютиклз Лтд Фенильные производные в качестве модуляторов pge2 рецепторов
US11325899B2 (en) 2017-05-18 2022-05-10 Idorsia Pharmaceuticals Ltd Benzofurane and benzothiophene derivatives as PGE2 receptor modulators
US20200352906A1 (en) * 2018-02-05 2020-11-12 Shenzhen Ionova Life Science Co., Ltd. Heterobicyclic Carboxylic Acids for Treating Cancer or Inflammatory Diseases
WO2019166022A1 (en) * 2018-03-02 2019-09-06 Shenzhen Ionova Life Science Co., Ltd. Heterobicyclic carboxylic acids and salts thereof
KR102861190B1 (ko) 2019-01-22 2025-09-17 키테라 (쑤저우) 바이오-파마슈티컬스 컴퍼니 리미티드 Pge2/ep4 신호 전달을 억제하기 위한 화합물, 이의 제조 방법, 및 이의 의약적 용도
IL296007B2 (en) 2020-03-04 2026-03-01 Wuhan Humanwell Innovative Drug Res And Development Center Limited Company Synthesis of a novel EP4 antibody and use for cancer and inflammation
JP7816164B2 (ja) 2020-11-13 2026-02-18 小野薬品工業株式会社 Ｅｐ４拮抗薬と免疫チェックポイント阻害物質との併用によるがん治療

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2010019796A1 (en) * 2008-08-14 2010-02-18 Chemietek, Llc Heterocyclic amide derivatives as ep4 receptor antagonists

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Patent Citations (1)

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Also Published As

Publication number Publication date
BR112018007664B1 (pt) 2023-12-19
EP3362454A1 (en) 2018-08-22
US10941148B2 (en) 2021-03-09
CA3002144C (en) 2024-01-23
US11434246B2 (en) 2022-09-06
WO2017066633A1 (en) 2017-04-20
JP2018530595A (ja) 2018-10-18
CN108473497A (zh) 2018-08-31
MX2018004664A (es) 2018-08-24
KR102684436B1 (ko) 2024-07-15
IL258737A (en) 2018-06-28
US10316040B2 (en) 2019-06-11
EP3362454B1 (en) 2021-12-08
JP7090770B2 (ja) 2022-06-24
AU2016338679A1 (en) 2018-06-07
CN108473497B (zh) 2021-09-10
US20210347779A1 (en) 2021-11-11
JP6860559B2 (ja) 2021-04-14
KR20180083863A (ko) 2018-07-23
BR112018007664A2 (pt) 2018-11-06
US20180305362A1 (en) 2018-10-25
JP2021100969A (ja) 2021-07-08
US20190315754A1 (en) 2019-10-17
CA3002144A1 (en) 2017-04-20
MX390051B (es) 2025-03-20

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