MX390051B - Antagonistas de ep4. - Google Patents
Antagonistas de ep4.Info
- Publication number
- MX390051B MX390051B MX2018004664A MX2018004664A MX390051B MX 390051 B MX390051 B MX 390051B MX 2018004664 A MX2018004664 A MX 2018004664A MX 2018004664 A MX2018004664 A MX 2018004664A MX 390051 B MX390051 B MX 390051B
- Authority
- MX
- Mexico
- Prior art keywords
- formulations
- antagonists
- cancer
- formula
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562242734P | 2015-10-16 | 2015-10-16 | |
| US201562242748P | 2015-10-16 | 2015-10-16 | |
| BD2522016 | 2016-10-13 | ||
| PCT/US2016/057135 WO2017066633A1 (en) | 2015-10-16 | 2016-10-14 | Ep4 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018004664A MX2018004664A (es) | 2018-08-24 |
| MX390051B true MX390051B (es) | 2025-03-20 |
Family
ID=58518017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018004664A MX390051B (es) | 2015-10-16 | 2016-10-14 | Antagonistas de ep4. |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10316040B2 (enExample) |
| EP (1) | EP3362454B1 (enExample) |
| JP (2) | JP6860559B2 (enExample) |
| KR (1) | KR102684436B1 (enExample) |
| CN (1) | CN108473497B (enExample) |
| AU (1) | AU2016338679B2 (enExample) |
| BR (1) | BR112018007664B1 (enExample) |
| CA (1) | CA3002144C (enExample) |
| IL (1) | IL258737A (enExample) |
| MX (1) | MX390051B (enExample) |
| WO (1) | WO2017066633A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| WO2018210992A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives |
| AU2018268311B2 (en) | 2017-05-18 | 2022-02-10 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives as PGE2 receptor modulators |
| EP3625224B1 (en) | 2017-05-18 | 2021-08-04 | Idorsia Pharmaceuticals Ltd | N-substituted indole derivatives |
| US11325899B2 (en) | 2017-05-18 | 2022-05-10 | Idorsia Pharmaceuticals Ltd | Benzofurane and benzothiophene derivatives as PGE2 receptor modulators |
| WO2018210994A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Phenyl derivatives as pge2 receptor modulators |
| WO2019149286A1 (en) * | 2018-02-05 | 2019-08-08 | Shenzhen Ionova Life Science Co., Ltd. | Heterobicyclic carboxylic acids for treating cancer or inflammatory diseases |
| EP3759114A4 (en) * | 2018-03-02 | 2021-12-15 | Shenzhen Ionova Life Science Co., Ltd. | HETEROBICYCLIC CARBOXYLIC ACIDS AND THEIR SALTS |
| JP7488269B2 (ja) | 2019-01-22 | 2024-05-21 | キーセラ・（スーチョウ）・ファーマシューティカルズ・カンパニー・リミテッド | Ｐｇｅ２／ｅｐ４シグナル伝達を阻害する化合物、その製造方法及びその医薬における応用 |
| WO2022102731A1 (ja) | 2020-11-13 | 2022-05-19 | 小野薬品工業株式会社 | Ｅｐ４拮抗薬と免疫チェックポイント阻害物質との併用によるがん治療 |
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| US4847256A (en) | 1986-10-16 | 1989-07-11 | American Cyanamid Company | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo(1,5-A)-pyrimidines |
| US4963553A (en) | 1986-10-16 | 1990-10-16 | American Cyanamid Co. | 4-[(substituted) alkylcarbonyl]-4,5-dihydro- and -4,5,6,7-tetrahydro-7-[(substituted)phenyl]pyrazolo[1,5-a]pyrimidines |
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| DD294943A5 (de) | 1990-06-05 | 1991-10-17 | Wilhelm-Pieck-Uni. Rostock Direktorat Fuer Forschung,De | Verfahren zur herstellung von kondensierten n-heterocyclen |
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| SMT201700160T1 (it) | 2013-04-25 | 2017-05-08 | Beigene Ltd | Composti eterociclici fusi come inibitori di protein chinasi |
| CA2913035C (en) | 2013-05-20 | 2017-08-01 | University Of Washington Through Its Center For Commercialization | 5-aminopyrazole-4-carboxamide inhibitors of cdpk1 |
| JP5954278B2 (ja) | 2013-08-09 | 2016-07-20 | コニカミノルタ株式会社 | 静電荷像現像用トナー、その製造方法および画像形成方法 |
| FR3014687B1 (fr) | 2013-12-13 | 2016-11-25 | Oreal | Procede de coloration des matieres keratiniques a partir d'oligomeres et/ou de polymeres colores issus de coupleurs, composition et agent de coloration |
| CN110354266A (zh) | 2014-05-23 | 2019-10-22 | 卫材 R&D 管理有限公司 | 用于治疗癌症的组合疗法 |
| WO2016088903A1 (en) | 2014-12-05 | 2016-06-09 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds |
-
2016
- 2016-10-14 CA CA3002144A patent/CA3002144C/en active Active
- 2016-10-14 WO PCT/US2016/057135 patent/WO2017066633A1/en not_active Ceased
- 2016-10-14 US US15/768,668 patent/US10316040B2/en active Active
- 2016-10-14 CN CN201680073562.6A patent/CN108473497B/zh active Active
- 2016-10-14 MX MX2018004664A patent/MX390051B/es unknown
- 2016-10-14 KR KR1020187013843A patent/KR102684436B1/ko active Active
- 2016-10-14 JP JP2018519749A patent/JP6860559B2/ja active Active
- 2016-10-14 AU AU2016338679A patent/AU2016338679B2/en active Active
- 2016-10-14 BR BR112018007664-3A patent/BR112018007664B1/pt active IP Right Grant
- 2016-10-14 EP EP16790486.1A patent/EP3362454B1/en active Active
-
2018
- 2018-04-16 IL IL258737A patent/IL258737A/en unknown
-
2019
- 2019-04-23 US US16/391,882 patent/US10941148B2/en active Active
-
2021
- 2021-01-05 US US17/141,557 patent/US11434246B2/en active Active
- 2021-03-26 JP JP2021053182A patent/JP7090770B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180083863A (ko) | 2018-07-23 |
| AU2016338679B2 (en) | 2021-05-06 |
| CN108473497A (zh) | 2018-08-31 |
| KR102684436B1 (ko) | 2024-07-15 |
| AU2016338679A1 (en) | 2018-06-07 |
| CN108473497B (zh) | 2021-09-10 |
| IL258737A (en) | 2018-06-28 |
| JP2018530595A (ja) | 2018-10-18 |
| BR112018007664A2 (pt) | 2018-11-06 |
| WO2017066633A1 (en) | 2017-04-20 |
| EP3362454A1 (en) | 2018-08-22 |
| MX2018004664A (es) | 2018-08-24 |
| US20210347779A1 (en) | 2021-11-11 |
| US20190315754A1 (en) | 2019-10-17 |
| JP7090770B2 (ja) | 2022-06-24 |
| CA3002144A1 (en) | 2017-04-20 |
| BR112018007664B1 (pt) | 2023-12-19 |
| CA3002144C (en) | 2024-01-23 |
| US11434246B2 (en) | 2022-09-06 |
| JP6860559B2 (ja) | 2021-04-14 |
| EP3362454B1 (en) | 2021-12-08 |
| US10316040B2 (en) | 2019-06-11 |
| JP2021100969A (ja) | 2021-07-08 |
| US10941148B2 (en) | 2021-03-09 |
| US20180305362A1 (en) | 2018-10-25 |
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