CN108473497B - Ep4拮抗剂 - Google Patents

Ep4拮抗剂 Download PDF

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Publication number
CN108473497B
CN108473497B CN201680073562.6A CN201680073562A CN108473497B CN 108473497 B CN108473497 B CN 108473497B CN 201680073562 A CN201680073562 A CN 201680073562A CN 108473497 B CN108473497 B CN 108473497B
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Prior art keywords
trifluoromethyl
pyrazole
imidazo
dihydro
ethyl
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CN201680073562.6A
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Chinese (zh)
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CN108473497A (zh
Inventor
郑完俊
朱潇杰
杜宏
马登·波斯特马
蒋益民
李静
罗伯特·于
崔亨旭
李在文
方家范
丹尼尔·喀斯特
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Sanitary Material R&d Management Co ltd
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Sanitary Material R&d Management Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201680073562.6A 2015-10-16 2016-10-14 Ep4拮抗剂 Active CN108473497B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562242734P 2015-10-16 2015-10-16
US201562242748P 2015-10-16 2015-10-16
US62/242,734 2015-10-16
US62/242,748 2015-10-16
BD252/2016 2016-10-13
BD2522016 2016-10-13
PCT/US2016/057135 WO2017066633A1 (en) 2015-10-16 2016-10-14 Ep4 antagonists

Publications (2)

Publication Number Publication Date
CN108473497A CN108473497A (zh) 2018-08-31
CN108473497B true CN108473497B (zh) 2021-09-10

Family

ID=58518017

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680073562.6A Active CN108473497B (zh) 2015-10-16 2016-10-14 Ep4拮抗剂

Country Status (11)

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US (3) US10316040B2 (enExample)
EP (1) EP3362454B1 (enExample)
JP (2) JP6860559B2 (enExample)
KR (1) KR102684436B1 (enExample)
CN (1) CN108473497B (enExample)
AU (1) AU2016338679B2 (enExample)
BR (1) BR112018007664B1 (enExample)
CA (1) CA3002144C (enExample)
IL (1) IL258737A (enExample)
MX (1) MX390051B (enExample)
WO (1) WO2017066633A1 (enExample)

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AU2018268311B2 (en) 2017-05-18 2022-02-10 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives as PGE2 receptor modulators
EP3625224B1 (en) 2017-05-18 2021-08-04 Idorsia Pharmaceuticals Ltd N-substituted indole derivatives
US11325899B2 (en) 2017-05-18 2022-05-10 Idorsia Pharmaceuticals Ltd Benzofurane and benzothiophene derivatives as PGE2 receptor modulators
WO2018210994A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Phenyl derivatives as pge2 receptor modulators
WO2019149286A1 (en) * 2018-02-05 2019-08-08 Shenzhen Ionova Life Science Co., Ltd. Heterobicyclic carboxylic acids for treating cancer or inflammatory diseases
EP3759114A4 (en) * 2018-03-02 2021-12-15 Shenzhen Ionova Life Science Co., Ltd. HETEROBICYCLIC CARBOXYLIC ACIDS AND THEIR SALTS
JP7488269B2 (ja) 2019-01-22 2024-05-21 キーセラ・（スーチョウ）・ファーマシューティカルズ・カンパニー・リミテッド Ｐｇｅ２／ｅｐ４シグナル伝達を阻害する化合物、その製造方法及びその医薬における応用
WO2022102731A1 (ja) 2020-11-13 2022-05-19 小野薬品工業株式会社 Ｅｐ４拮抗薬と免疫チェックポイント阻害物質との併用によるがん治療

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Also Published As

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KR20180083863A (ko) 2018-07-23
AU2016338679B2 (en) 2021-05-06
CN108473497A (zh) 2018-08-31
KR102684436B1 (ko) 2024-07-15
AU2016338679A1 (en) 2018-06-07
IL258737A (en) 2018-06-28
JP2018530595A (ja) 2018-10-18
BR112018007664A2 (pt) 2018-11-06
WO2017066633A1 (en) 2017-04-20
EP3362454A1 (en) 2018-08-22
MX2018004664A (es) 2018-08-24
US20210347779A1 (en) 2021-11-11
US20190315754A1 (en) 2019-10-17
JP7090770B2 (ja) 2022-06-24
CA3002144A1 (en) 2017-04-20
BR112018007664B1 (pt) 2023-12-19
CA3002144C (en) 2024-01-23
US11434246B2 (en) 2022-09-06
JP6860559B2 (ja) 2021-04-14
EP3362454B1 (en) 2021-12-08
US10316040B2 (en) 2019-06-11
JP2021100969A (ja) 2021-07-08
MX390051B (es) 2025-03-20
US10941148B2 (en) 2021-03-09
US20180305362A1 (en) 2018-10-25

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