BR112018007664A2 - antagonistas de ep4 - Google Patents
antagonistas de ep4Info
- Publication number
- BR112018007664A2 BR112018007664A2 BR112018007664A BR112018007664A BR112018007664A2 BR 112018007664 A2 BR112018007664 A2 BR 112018007664A2 BR 112018007664 A BR112018007664 A BR 112018007664A BR 112018007664 A BR112018007664 A BR 112018007664A BR 112018007664 A2 BR112018007664 A2 BR 112018007664A2
- Authority
- BR
- Brazil
- Prior art keywords
- formulations
- antagonists
- formula
- methods
- pharmaceutically acceptable
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
fornecemos compostos dados pela fórmula i, que é mostrado na fig. 3, ou sais farmaceuticamente aceitáveis destes, assim como formulações destes e métodos de uso daqueles compostos e formulações para o tratamento de câncer.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562242748P | 2015-10-16 | 2015-10-16 | |
US201562242734P | 2015-10-16 | 2015-10-16 | |
US62/242,734 | 2015-10-16 | ||
US62/242,748 | 2015-10-16 | ||
BD252/2016 | 2016-10-13 | ||
BD2522016 | 2016-10-13 | ||
PCT/US2016/057135 WO2017066633A1 (en) | 2015-10-16 | 2016-10-14 | Ep4 antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112018007664A2 true BR112018007664A2 (pt) | 2018-11-06 |
BR112018007664B1 BR112018007664B1 (pt) | 2023-12-19 |
Family
ID=58518017
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018007664-3A BR112018007664B1 (pt) | 2015-10-16 | 2016-10-14 | Compostos antagonistas de ep4, composição compreendendo o composto e uso dos mesmos para tratar câncer |
Country Status (10)
Country | Link |
---|---|
US (3) | US10316040B2 (pt) |
EP (1) | EP3362454B1 (pt) |
JP (2) | JP6860559B2 (pt) |
CN (1) | CN108473497B (pt) |
AU (1) | AU2016338679B2 (pt) |
BR (1) | BR112018007664B1 (pt) |
CA (1) | CA3002144C (pt) |
IL (1) | IL258737A (pt) |
MX (1) | MX2018004664A (pt) |
WO (1) | WO2017066633A1 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
HUE056080T2 (hu) | 2017-05-18 | 2022-01-28 | Idorsia Pharmaceuticals Ltd | Fenilszármazékok mint PGE2 receptor modulátorok |
TW201900178A (zh) | 2017-05-18 | 2019-01-01 | 瑞士商愛杜西亞製藥有限公司 | 作為pge2受體調節劑之嘧啶衍生物 |
SI3625224T1 (sl) | 2017-05-18 | 2021-11-30 | Idorsia Pharmaceuticals Ltd | N-substituirani indolni derivati |
CN110621671A (zh) | 2017-05-18 | 2019-12-27 | 爱杜西亚药品有限公司 | 作为pge2受体调节剂的苯并呋喃及苯并噻吩衍生物 |
ES2896476T3 (es) | 2017-05-18 | 2022-02-24 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina |
KR20200118037A (ko) * | 2018-02-05 | 2020-10-14 | 셴젠 이오노바 라이프 사이언스 시오., 엘티디. | 암 또는 염증성 질환들을 치료하기 위한 헤테로비시클릭 카르복시산들 |
EP3759114A4 (en) * | 2018-03-02 | 2021-12-15 | Shenzhen Ionova Life Science Co., Ltd. | HETEROBICYCLIC CARBOXYLIC ACIDS AND THEIR SALTS |
US20220064113A1 (en) | 2019-01-22 | 2022-03-03 | Keythera (Suzhou) Pharmaceuticals Co. Ltd. | Compound for inhibiting pge2/ep4 signaling transduction inhibiting, preparation method therefor, and medical uses thereof |
TW202228674A (zh) | 2020-11-13 | 2022-08-01 | 日商小野藥品工業股份有限公司 | 藉由併用ep4拮抗藥與免疫檢查點抑制物質而進行之癌症治療 |
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-
2016
- 2016-10-14 WO PCT/US2016/057135 patent/WO2017066633A1/en active Application Filing
- 2016-10-14 MX MX2018004664A patent/MX2018004664A/es unknown
- 2016-10-14 JP JP2018519749A patent/JP6860559B2/ja active Active
- 2016-10-14 CN CN201680073562.6A patent/CN108473497B/zh active Active
- 2016-10-14 CA CA3002144A patent/CA3002144C/en active Active
- 2016-10-14 BR BR112018007664-3A patent/BR112018007664B1/pt active IP Right Grant
- 2016-10-14 EP EP16790486.1A patent/EP3362454B1/en active Active
- 2016-10-14 US US15/768,668 patent/US10316040B2/en active Active
- 2016-10-14 AU AU2016338679A patent/AU2016338679B2/en active Active
-
2018
- 2018-04-16 IL IL258737A patent/IL258737A/en unknown
-
2019
- 2019-04-23 US US16/391,882 patent/US10941148B2/en active Active
-
2021
- 2021-01-05 US US17/141,557 patent/US11434246B2/en active Active
- 2021-03-26 JP JP2021053182A patent/JP7090770B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
US10316040B2 (en) | 2019-06-11 |
BR112018007664B1 (pt) | 2023-12-19 |
US20190315754A1 (en) | 2019-10-17 |
WO2017066633A1 (en) | 2017-04-20 |
MX2018004664A (es) | 2018-08-24 |
AU2016338679A1 (en) | 2018-06-07 |
JP7090770B2 (ja) | 2022-06-24 |
CN108473497A (zh) | 2018-08-31 |
US10941148B2 (en) | 2021-03-09 |
US11434246B2 (en) | 2022-09-06 |
CA3002144C (en) | 2024-01-23 |
CN108473497B (zh) | 2021-09-10 |
US20180305362A1 (en) | 2018-10-25 |
US20210347779A1 (en) | 2021-11-11 |
EP3362454B1 (en) | 2021-12-08 |
CA3002144A1 (en) | 2017-04-20 |
EP3362454A1 (en) | 2018-08-22 |
AU2016338679B2 (en) | 2021-05-06 |
KR20180083863A (ko) | 2018-07-23 |
JP6860559B2 (ja) | 2021-04-14 |
JP2018530595A (ja) | 2018-10-18 |
JP2021100969A (ja) | 2021-07-08 |
IL258737A (en) | 2018-06-28 |
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