KR102497443B1 - Cd38 및 cd3에 결합하는 이중특이적 항체 - Google Patents
Cd38 및 cd3에 결합하는 이중특이적 항체 Download PDFInfo
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- KR102497443B1 KR102497443B1 KR1020217023950A KR20217023950A KR102497443B1 KR 102497443 B1 KR102497443 B1 KR 102497443B1 KR 1020217023950 A KR1020217023950 A KR 1020217023950A KR 20217023950 A KR20217023950 A KR 20217023950A KR 102497443 B1 KR102497443 B1 KR 102497443B1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020237004018A KR20230022270A (ko) | 2014-03-28 | 2015-03-30 | Cd38 및 cd3에 결합하는 이중특이적 항체 |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461972172P | 2014-03-28 | 2014-03-28 | |
| US61/972,172 | 2014-03-28 | ||
| US201462025974P | 2014-07-17 | 2014-07-17 | |
| US201462025931P | 2014-07-17 | 2014-07-17 | |
| US62/025,974 | 2014-07-17 | ||
| US62/025,931 | 2014-07-17 | ||
| PCT/US2015/023411 WO2015149077A1 (en) | 2014-03-28 | 2015-03-30 | Bispecific antibodies that bind to cd38 and cd3 |
| KR1020167029551A KR102327996B1 (ko) | 2014-03-28 | 2015-03-30 | Cd38 및 cd3에 결합하는 이중특이적 항체 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167029551A Division KR102327996B1 (ko) | 2014-03-28 | 2015-03-30 | Cd38 및 cd3에 결합하는 이중특이적 항체 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237004018A Division KR20230022270A (ko) | 2014-03-28 | 2015-03-30 | Cd38 및 cd3에 결합하는 이중특이적 항체 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20210097222A KR20210097222A (ko) | 2021-08-06 |
| KR102497443B1 true KR102497443B1 (ko) | 2023-02-08 |
Family
ID=53053074
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167029551A Active KR102327996B1 (ko) | 2014-03-28 | 2015-03-30 | Cd38 및 cd3에 결합하는 이중특이적 항체 |
| KR1020217023950A Active KR102497443B1 (ko) | 2014-03-28 | 2015-03-30 | Cd38 및 cd3에 결합하는 이중특이적 항체 |
| KR1020237004018A Ceased KR20230022270A (ko) | 2014-03-28 | 2015-03-30 | Cd38 및 cd3에 결합하는 이중특이적 항체 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167029551A Active KR102327996B1 (ko) | 2014-03-28 | 2015-03-30 | Cd38 및 cd3에 결합하는 이중특이적 항체 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237004018A Ceased KR20230022270A (ko) | 2014-03-28 | 2015-03-30 | Cd38 및 cd3에 결합하는 이중특이적 항체 |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US9822186B2 (OSRAM) |
| EP (3) | EP3122781B1 (OSRAM) |
| JP (3) | JP6775422B2 (OSRAM) |
| KR (3) | KR102327996B1 (OSRAM) |
| CN (2) | CN111410691B (OSRAM) |
| AP (1) | AP2016009475A0 (OSRAM) |
| AU (2) | AU2015237184B2 (OSRAM) |
| BR (1) | BR112016022385A2 (OSRAM) |
| CA (1) | CA2943621A1 (OSRAM) |
| CL (1) | CL2016002460A1 (OSRAM) |
| CR (1) | CR20160506A (OSRAM) |
| CY (1) | CY1123236T1 (OSRAM) |
| DK (1) | DK3122781T3 (OSRAM) |
| EA (1) | EA201691925A1 (OSRAM) |
| ES (1) | ES2775431T3 (OSRAM) |
| HR (1) | HRP20200164T1 (OSRAM) |
| HU (1) | HUE048734T2 (OSRAM) |
| IL (1) | IL248007B (OSRAM) |
| LT (1) | LT3122781T (OSRAM) |
| ME (1) | ME03666B (OSRAM) |
| MX (2) | MX385936B (OSRAM) |
| PE (1) | PE20161431A1 (OSRAM) |
| PH (1) | PH12016501908A1 (OSRAM) |
| PL (1) | PL3122781T3 (OSRAM) |
| PT (1) | PT3122781T (OSRAM) |
| RS (1) | RS59907B1 (OSRAM) |
| SG (2) | SG11201607983YA (OSRAM) |
| SI (1) | SI3122781T1 (OSRAM) |
| SM (1) | SMT202000141T1 (OSRAM) |
| TN (1) | TN2017000532A1 (OSRAM) |
| UA (1) | UA119167C2 (OSRAM) |
| WO (1) | WO2015149077A1 (OSRAM) |
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| US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
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| BR112016026299A2 (pt) * | 2014-05-13 | 2018-02-20 | Chugai Seiyaku Kabushiki Kaisha | molécula de ligação ao antígeno redirecionado à célula t para células tendo função de imunossupressão |
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| US20130209355A1 (en) | 2010-06-09 | 2013-08-15 | Genmab A/S | Antibodies against human cd38 |
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