JPH0581600B1 - - Google Patents

Info

Publication number
JPH0581600B1
JPH0581600B1 JP1500565A JP50056589A JPH0581600B1 JP H0581600 B1 JPH0581600 B1 JP H0581600B1 JP 1500565 A JP1500565 A JP 1500565A JP 50056589 A JP50056589 A JP 50056589A JP H0581600 B1 JPH0581600 B1 JP H0581600B1
Authority
JP
Japan
Prior art keywords
hcv
cdna
sequence
clone
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP1500565A
Other languages
English (en)
Japanese (ja)
Other versions
JPH02500880A (ja
Inventor
Michael Houghton
Qui-Lim Choo
George Kuo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27557988&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPH0581600(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of JPH02500880A publication Critical patent/JPH02500880A/ja
Publication of JPH0581600B1 publication Critical patent/JPH0581600B1/ja
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/706Specific hybridization probes for hepatitis
    • C12Q1/707Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24211Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
JP89500565A 1987-11-18 1988-11-18 Nanbvの診断用薬およびワクチン Expired - Lifetime JPH02500880A (ja)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US12271487A 1987-11-18 1987-11-18
US122,714 1987-11-18
US13988687A 1987-12-30 1987-12-30
US139,886 1987-12-30
US16107288A 1988-02-26 1988-02-26
US19126388A 1988-05-06 1988-05-06
US26358488A 1988-10-26 1988-10-26
US263,584 1988-10-26
US27145088A 1988-11-14 1988-11-14
US161072 1988-11-14
US271,450 1988-11-14
US191263 1988-11-14

Related Child Applications (5)

Application Number Title Priority Date Filing Date
JP4361785A Division JP2662350B2 (ja) 1987-11-18 1992-12-16 Nanbvの診断用薬
JP4361786A Division JP2532805B2 (ja) 1987-11-18 1992-12-16 Nanbvの診断用薬およびワクチン
JP4361787A Division JP2662351B2 (ja) 1987-11-18 1992-12-16 Nanbvの診断用薬およびワクチン
JP4361784A Division JP2809956B2 (ja) 1987-11-18 1992-12-16 Nanbvの診断用薬
JP5178446A Division JP2662358B2 (ja) 1987-11-18 1993-06-11 Nanbvの診断用薬

Publications (2)

Publication Number Publication Date
JPH02500880A JPH02500880A (ja) 1990-03-29
JPH0581600B1 true JPH0581600B1 (fr) 1993-11-15

Family

ID=27557988

Family Applications (16)

Application Number Title Priority Date Filing Date
JP89500565A Expired - Lifetime JPH02500880A (ja) 1987-11-18 1988-11-18 Nanbvの診断用薬およびワクチン
JP4361785A Expired - Lifetime JP2662350B2 (ja) 1987-11-18 1992-12-16 Nanbvの診断用薬
JP4361784A Expired - Lifetime JP2809956B2 (ja) 1987-11-18 1992-12-16 Nanbvの診断用薬
JP4361787A Expired - Lifetime JP2662351B2 (ja) 1987-11-18 1992-12-16 Nanbvの診断用薬およびワクチン
JP4361786A Expired - Lifetime JP2532805B2 (ja) 1987-11-18 1992-12-16 Nanbvの診断用薬およびワクチン
JP5178446A Expired - Lifetime JP2662358B2 (ja) 1987-11-18 1993-06-11 Nanbvの診断用薬
JP8239921A Expired - Lifetime JP2810022B2 (ja) 1987-11-18 1996-08-21 Nanbvの診断用薬
JP24145196A Expired - Lifetime JP3171793B2 (ja) 1987-11-18 1996-08-22 Nanbvの診断用薬
JP9099651A Expired - Lifetime JP2810032B2 (ja) 1987-11-18 1997-04-01 Nanbvの診断用薬
JP10111631A Pending JPH10290696A (ja) 1987-11-18 1998-04-06 Nanbvの診断用薬およびワクチン
JP10111632A Pending JPH10290697A (ja) 1987-11-18 1998-04-06 Nanbvの培養法
JP11157193A Pending JP2000023683A (ja) 1987-11-18 1999-06-03 Nanbvの診断用薬
JP2005325483A Withdrawn JP2006104207A (ja) 1987-11-18 2005-11-09 Nanbvの診断用薬
JP2005325486A Withdrawn JP2006117681A (ja) 1987-11-18 2005-11-09 Nanbvの診断用薬およびワクチン
JP2007095590A Pending JP2007197456A (ja) 1987-11-18 2007-03-30 Nanbvの診断用薬
JP2007179093A Pending JP2008007508A (ja) 1987-11-18 2007-07-06 Nanbvの診断用薬およびワクチン

Family Applications After (15)

Application Number Title Priority Date Filing Date
JP4361785A Expired - Lifetime JP2662350B2 (ja) 1987-11-18 1992-12-16 Nanbvの診断用薬
JP4361784A Expired - Lifetime JP2809956B2 (ja) 1987-11-18 1992-12-16 Nanbvの診断用薬
JP4361787A Expired - Lifetime JP2662351B2 (ja) 1987-11-18 1992-12-16 Nanbvの診断用薬およびワクチン
JP4361786A Expired - Lifetime JP2532805B2 (ja) 1987-11-18 1992-12-16 Nanbvの診断用薬およびワクチン
JP5178446A Expired - Lifetime JP2662358B2 (ja) 1987-11-18 1993-06-11 Nanbvの診断用薬
JP8239921A Expired - Lifetime JP2810022B2 (ja) 1987-11-18 1996-08-21 Nanbvの診断用薬
JP24145196A Expired - Lifetime JP3171793B2 (ja) 1987-11-18 1996-08-22 Nanbvの診断用薬
JP9099651A Expired - Lifetime JP2810032B2 (ja) 1987-11-18 1997-04-01 Nanbvの診断用薬
JP10111631A Pending JPH10290696A (ja) 1987-11-18 1998-04-06 Nanbvの診断用薬およびワクチン
JP10111632A Pending JPH10290697A (ja) 1987-11-18 1998-04-06 Nanbvの培養法
JP11157193A Pending JP2000023683A (ja) 1987-11-18 1999-06-03 Nanbvの診断用薬
JP2005325483A Withdrawn JP2006104207A (ja) 1987-11-18 2005-11-09 Nanbvの診断用薬
JP2005325486A Withdrawn JP2006117681A (ja) 1987-11-18 2005-11-09 Nanbvの診断用薬およびワクチン
JP2007095590A Pending JP2007197456A (ja) 1987-11-18 2007-03-30 Nanbvの診断用薬
JP2007179093A Pending JP2008007508A (ja) 1987-11-18 2007-07-06 Nanbvの診断用薬およびワクチン

Country Status (18)

Country Link
EP (1) EP0318216B2 (fr)
JP (16) JPH02500880A (fr)
KR (2) KR0138776B1 (fr)
CN (5) CN1049686C (fr)
BR (1) BR8807310A (fr)
CA (1) CA1341629C (fr)
DE (2) DE3886363T3 (fr)
ES (1) ES2012739T5 (fr)
FI (3) FI105652B (fr)
GR (1) GR900300069T1 (fr)
HK (3) HK38293A (fr)
HU (3) HU216017B (fr)
IE (1) IE62868B1 (fr)
LV (1) LV10726B (fr)
NO (1) NO304990B1 (fr)
NZ (1) NZ227011A (fr)
UA (1) UA42668C2 (fr)
WO (1) WO1989004669A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004506018A (ja) * 2000-08-17 2004-02-26 トリペップ アクチ ボラゲット リバビリンを含むワクチンおよびその使用方法

Families Citing this family (256)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3886363T3 (de) * 1987-11-18 2004-09-09 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville NANBV-Diagnostika
US5714596A (en) * 1987-11-18 1998-02-03 Chiron Corporation NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus
US5698390A (en) * 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US5712088A (en) * 1987-11-18 1998-01-27 Chiron Corporation Methods for detecting Hepatitis C virus using polynucleotides specific for same
US6171782B1 (en) 1987-11-18 2001-01-09 Chiron Corporation Antibody compositions to HCV and uses thereof
US5683864A (en) * 1987-11-18 1997-11-04 Chiron Corporation Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US6861212B1 (en) 1987-11-18 2005-03-01 Chiron Corporation NANBV diagnostics and vaccines
JP2696116B2 (ja) * 1988-09-30 1998-01-14 財団法人阪大微生物病研究会 非a非b肝炎患者の血清と抗原抗体反応するペプチド、及び該ペプチドをコードするdna
US5191064A (en) * 1988-09-30 1993-03-02 The Research Foundation For Microbial Diseases (Osaka University) Non-a, non-b hepatitis virus antigen peptide
JPH02167081A (ja) * 1988-12-21 1990-06-27 Tetsuo Nakamura 非A非B型肝炎ウイルスゲノムRNA、cDNAおよびウイルス抗原蛋白質
KR0185373B1 (ko) * 1989-03-17 1999-05-01 로버트 피. 블랙버언 Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용
US6027729A (en) * 1989-04-20 2000-02-22 Chiron Corporation NANBV Diagnostics and vaccines
WO1990014436A1 (fr) * 1989-05-18 1990-11-29 Chiron Corporation Diagnostic du nanbv (virus de l'hepatite non-a et non-b): polynucleotides utiles pour depister le virus de l'hepatite c
JPH0330676A (ja) * 1989-06-28 1991-02-08 Sanwa Kagaku Kenkyusho Co Ltd 非a非b型肝炎ウイルスのdna、そのクローン及びこれらの調製法
EP0416725A3 (en) * 1989-07-14 1991-03-20 Chugai Seiyaku Kabushiki Kaisha Blood-borne non-a, non-b hepatitis specific protein, dna encoding it, and process for its production
ATE161041T1 (de) * 1989-08-25 1997-12-15 Chiron Corp Verfahren zur hcv-züchtung in zell-linien aus b- oder t-lymphozyten
JP3156200B2 (ja) * 1989-09-15 2001-04-16 国立予防衛生研究所長 新規のhcv分離株
US5372928A (en) * 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
FR2654113A1 (fr) * 1989-11-09 1991-05-10 Pasteur Institut Procede de diagnostic de virus appartenant a la famille des flaviviridae.
ES2029171A6 (es) * 1989-12-18 1992-07-16 Wellcome Found Un procedimiento para preparar un polipeptido virico de hepatitis no a y no b post-transfusional (pt-nanbh)
US7166287B1 (en) 1989-12-18 2007-01-23 Glaxo Wellcome Inc. Viral agent
US5308750A (en) * 1989-12-22 1994-05-03 Abbott Laboratories Monoclonal antibodies to putative HCV E2/NS1 proteins and methods for using same
CA2032907C (fr) * 1989-12-22 2002-05-14 Richard R. Lesniewski Test pour la recherche du virus de l'hepatite c
EP0435229A1 (fr) * 1989-12-27 1991-07-03 Sanwa Kagaku Kenkyusho Co., Ltd. ADN d'un gène du virus de l'hépatite non-A non-B, son clonage et utilisation
DE69121933T2 (de) * 1990-02-09 1997-04-30 Japan Immuno Inc Nukleinsäuren, Antigene und Antikörper betreffend Non-A, Non-B Hepatitis und deren Nachweisreagenzien
US5747239A (en) * 1990-02-16 1998-05-05 United Biomedical, Inc. Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and preventions thereof as vaccines
KR940000755B1 (ko) * 1990-02-16 1994-01-29 유나이티드 바이오메디칼 인코오포레이티드 Hcv에 대한 항체 검출, hcv 감염의 진단 및 백신으로서의 그 예방에 특히 적합한 합성 펩티드
US5106726A (en) * 1990-02-16 1992-04-21 United Biomedical, Inc. Synthetic peptides specific for the detection of antibodies to HCV
US5582968A (en) * 1990-02-16 1996-12-10 United Biomedical, Inc. Branched hybrid and cluster peptides effective in diagnosing and detecting non-A, non-B hepatitis
US5639594A (en) * 1990-02-16 1997-06-17 United Biomedical, Inc. Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis
EP0445801A3 (en) * 1990-03-08 1992-07-01 Kuraray Co., Ltd. Peptide and its use
EP0447984A1 (fr) * 1990-03-20 1991-09-25 Abbott Laboratories Globuline hyperimmune contre le virus de l'hépatite C et son procédé de préparation
WO1991014779A1 (fr) * 1990-03-28 1991-10-03 Mitsui Toatsu Chemicals, Incorporated Diagnostic du virus de l'hepatite
JPH0436185A (ja) * 1990-03-28 1992-02-06 Kyowa Hakko Kogyo Co Ltd 融合抗原ポリペプチド
AU7675491A (en) * 1990-04-04 1991-10-30 Chiron Corporation Hepatitis c virus protease
US6194140B1 (en) * 1990-04-04 2001-02-27 Chiron Corporation HCV NS3 protein fragments having helicase activity and improved solubility
US5712087A (en) * 1990-04-04 1998-01-27 Chiron Corporation Immunoassays for anti-HCV antibodies employing combinations of hepatitis C virus (HCV) antigens
WO1991015771A1 (fr) 1990-04-04 1991-10-17 Chiron Corporation Combinaisons d'antigenes du virus de l'hepatite c (vhc) utilisees dans des immunoanalyses visant a detecter la presence d'anticorps anti-vhc
CA2079912C (fr) * 1990-04-06 2000-07-11 Gregory Reyes Epitopes du virus de l'hepatite c
JP3050395B2 (ja) * 1990-06-12 2000-06-12 国立感染症研究所長 C型肝炎ウイルス抗原ポリペプチド、その産生方法および抗体の検出方法
EP0461863A1 (fr) * 1990-06-12 1991-12-18 Immuno Japan Inc. Amorces oligonucléotidiques et leur utilisation pour la détection de non-A, non-B virus d'hépatite à haute fidélité
US5747339A (en) 1990-06-25 1998-05-05 Research Foundation For Microbial Diseases Of Osaka Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptide
FI913068A (fi) * 1990-06-25 1991-12-26 Univ Osaka Res Found Non-a-, non-b-hepatitisviruspartiklar.
EP0933426A1 (fr) * 1990-06-25 1999-08-04 The Research Foundation for Microbial Diseases of Osaka University CADN génomique du virus de l'hépatite non-A non-B et antigènes polypeptidiques
AU7967191A (en) * 1990-06-30 1992-01-23 Akzo N.V. Non-a non-b sequences
KR0181517B1 (ko) * 1990-07-09 1999-04-01 나까하라 노부유끼 비-에이 비-비형 간염-특이 항원 및 간염 진단에서 그의 용도
DE69125066T2 (de) * 1990-07-11 1997-09-25 Shionogi Seiyaku K K Trading U cDNS-Sequenz und Detektion des Hepatitis C-Virus
WO1992001714A1 (fr) * 1990-07-24 1992-02-06 Yamanouchi Pharmaceutical Co., Ltd. Antigene du virus de l'hepatite non a, non b
CA2047792C (fr) * 1990-07-26 2002-07-02 Chang Y. Wang Peptides synthetiques specifiques pour la detection des anticorps diriges contre le vhc, diagnostic de l'infection a vhc et sa prevention grace a des vaccins
US6172189B1 (en) * 1990-08-24 2001-01-09 Abbott Laboratories Hepatitis C assay utilizing recombinant antigens
KR920004577A (ko) * 1990-08-24 1992-03-27 원본미기재 단백질 합성의 cks 방법
CA2049679C (fr) * 1990-08-24 2005-06-21 Sushil G. Devare Recherche des anticorps de l'hepatite c a l'aide d'antigenes recombinants
DK1227323T4 (da) * 1990-08-25 2011-04-26 Bioprocess Pty Ltd Ikke-A, ikke-B hepatitisvirusantigen, diagnostiske fremgangsmåder og vacciner
US7863008B2 (en) 1990-08-25 2011-01-04 Bioprocess Pty Ltd. Method for detecting NANBV associated seroconversion
CA2093919A1 (fr) * 1990-10-12 1992-04-13 Mahlon F. Miller Anticorps dirige contre le virus de l'hepatite c
JP3549201B2 (ja) * 1990-10-24 2004-08-04 中外製薬株式会社 非a非b型肝炎特異的遺伝子の検出方法及び検出用試薬組成物
DK0484787T3 (da) * 1990-11-03 2002-02-04 Dade Behring Marburg Gmbh HCV-specifikke peptider, fremgangsmåde til opnåelse deraf og anvendelse deraf
DE4121431A1 (de) * 1991-06-28 1993-01-07 Behringwerke Ag Synthetische core-peptide zur bestimmung von hcv-antikoerpern und hcv-antigenen, mittel dazu und ihre verwendung in diesen nachweis-verfahren
DE4120281C2 (de) * 1991-06-19 1999-11-25 Dade Behring Marburg Gmbh Immunchemisches Verfahren zum gleichzeitigen Nachweis von mehreren verschiedenen Antikörperspezifitäten, Peptidmischungen und Test dazu
DE4112743C2 (de) * 1991-04-19 2000-01-13 Dade Behring Marburg Gmbh Synthetische Core-Peptide zur Bestimmung von HCV-Antikörpern und HCV-Antigenen, Mittel dazu und ihre Verwendung in diesen Nachweis-Verfahren
DE4034982C2 (de) * 1990-11-03 1999-12-23 Dade Behring Marburg Gmbh Synthetische Polypeptide zur Bestimmung von HCV-Antikörpern und HCV-Antigenen, Mittel dazu und ihre Verwendung in diesen Nachweis-Verfahren
ES2132115T3 (es) * 1990-11-07 1999-08-16 Abbott Lab Anticuerpos monoclonales contra el virus de la hepatitis c y su procedimiento de utilizacion.
US5753430A (en) * 1990-11-07 1998-05-19 Abbott Laboratories Monoclonal antibodies to hepatitis C virus and method for using same
EP0485209A1 (fr) * 1990-11-08 1992-05-13 Immuno Japan Inc. Antigène relatif au virus de l'hépatite non-A non-B, systèmes de détection d'anticorps, polynucléotides et polypeptides
US6274148B1 (en) * 1990-11-08 2001-08-14 Chiron Corporation Hepatitis C virus asialoglycoproteins
ES2139591T5 (es) * 1990-11-08 2007-08-01 Novartis Vaccines And Diagnostics, Inc. Asialoglicoproteinas del virus de la hepatitis c.
WO1992009634A1 (fr) * 1990-11-29 1992-06-11 Toray Industries, Incorporated Proteine anti-genique du virus de l'hepatite non a et non b
DK0488812T3 (da) * 1990-11-30 1999-12-13 Japan Immuno Inc Non-A, non-B hepatitis-relaterede nucleinsyrer, antigener og antistoffer samt reagenser til deres påvisning
DK0644202T3 (da) * 1990-12-14 1997-09-15 Innogenetics Nv Syntetiske antigener til påvisning af antistoffer imod hepatitis C virus
US6007982A (en) * 1990-12-14 1999-12-28 Innogenetics N.V. Synthetic antigens for the detection of antibodies to hepatitis C virus
US5910404A (en) 1990-12-14 1999-06-08 Innogenetics N.V. Synthetic antigens for the detection of antibodies to hepatitis C virus
CA2101056A1 (fr) * 1991-01-25 1992-07-26 Adrienne L. Gilbert Utilisation de la superoxyde-dismutase dans des diluants d'echantillons
AU662517B2 (en) * 1991-01-31 1995-09-07 Abbott Laboratories Monoclonal antibodies to putative HCV envelope region and methods for using same
JP2655205B2 (ja) * 1991-03-26 1997-09-17 デイド、インターナショナル、インコーポレイテッド 非a非b肝炎のアッセイ
US5574132A (en) * 1991-04-05 1996-11-12 Biochem Immunosystems Inc. Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV)
EP0516270A3 (en) * 1991-04-10 1993-06-23 Immuno Japan Inc. Non-a, non-b hepatitis virus related antigen, antibody, detection systems, polynucleotides and polypeptides
WO1992018532A1 (fr) * 1991-04-17 1992-10-29 Eisai Co., Ltd. Arn, adn et proteine antigenique virale du virus de l'hepatite non-a, non-b
EP0510952A1 (fr) * 1991-04-26 1992-10-28 Immuno Japan Inc. Primaires d'oligonucleotides et leur application de détection à haut détail de non-A, non-B hepatitis
JPH06508026A (ja) * 1991-05-08 1994-09-14 カイロン コーポレイション 診断と治療に用いるhcvゲノム配列
ES2040615B1 (es) * 1991-05-27 1994-05-16 Nebrda Fernando Javi Bartolome Procedimiento para el aislamiento y clonaje de cdnas derivados del virus c de la hepatitis.
FR2677372B1 (fr) * 1991-06-06 1994-11-10 Pasteur Institut Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques.
WO1992022655A1 (fr) * 1991-06-10 1992-12-23 Lucky Limited Diagnostics de l'hepatite c et vaccin anti-hepatite c
CA2070952A1 (fr) * 1991-06-11 1992-12-12 Makoto Seki Gene du virus de l'hepatite c ou fragment dudit gene, polypeptide code par le gene
DE69232871T2 (de) * 1991-06-24 2003-05-08 Chiron Corp Polypeptide des hepatitis c-virus (hiv)
DE4209215A1 (de) 1991-07-04 1993-01-07 Boehringer Mannheim Gmbh Hcv peptidantigene und verfahren zur bestimmung von hcv
JPH06510188A (ja) * 1991-08-21 1994-11-17 アボツト・ラボラトリーズ 推定hcv ns5タンパクに対するモノクローナル抗体およびそれを使用する方法
WO1993004089A1 (fr) * 1991-08-21 1993-03-04 Abbott Laboratories Analyse de detection de l'hepatite c utilisant des antigenes de recombinaison venant de la region ns5
EP0600009A4 (fr) * 1991-08-21 1995-03-01 Abbott Lab Depistage de l'hepatite c a l'aide d'antigenes recombines diriges contre la region ns1.
DE69233083T2 (de) * 1991-08-27 2003-12-18 Hoffmann La Roche Primers und Sondern zum Nachweis von Hepatitis C
CA2116764C (fr) * 1991-09-13 1999-12-07 Amy J. Weiner Compositions de polypeptides du virus de l'hepatite c immunoreactives
ZA927837B (en) * 1991-10-15 1994-03-11 Akzo Nv Monoclonal antibodiesto hepatitis C virus
JPH05130874A (ja) * 1991-11-07 1993-05-28 Sanwa Kagaku Kenkyusho Co Ltd ヒトC型肝炎ウイルスのcDNA、そのクローン及びこれらの利用法
CA2099883A1 (fr) * 1991-11-07 1993-05-08 John A. Kink Cartographie de l'epitope de la region c33c du vhc
US5763159A (en) * 1991-11-21 1998-06-09 Common Services Agency Hepatitis-C virus testing
JP3439209B2 (ja) * 1992-01-31 2003-08-25 アボツト・ラボラトリーズ Hcv蛋白のための哺乳動物発現システム
US6667387B1 (en) 1996-09-30 2003-12-23 N.V. Innogenetics S.A. HCV core peptides
US6709828B1 (en) 1992-03-06 2004-03-23 N.V. Innogenetics S.A. Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them
MA22842A1 (fr) * 1992-03-27 1993-10-01 Smithkline Beecham Biolog Procede de preparation de compositions de vaccin.
US6620414B2 (en) 1992-03-27 2003-09-16 Smithkline Beecham Biologicals (S.A.) Hepatitis vaccines containing 3-0-deacylated monophoshoryl lipid A
US5866139A (en) * 1992-06-04 1999-02-02 Institut Pasteur Nucleotide and peptide sequences of a hepatitis C virus isolate, diagnostic and therapeutic applications
US5980899A (en) * 1992-06-10 1999-11-09 The United States Of America As Represented By The Department Of Health And Human Services Identification of peptides that stimulate hepatitis C virus specific cytotoxic T cells
UA39944C2 (uk) 1992-07-07 2001-07-16 Чірон Корпорейшн Спосіб визначення ранньої сероконверсії у ссавця-хазяїна до вірусу гепатиту с і набір для використання в способі
US5859230A (en) * 1992-07-30 1999-01-12 Genelabs Technologies, Inc. Non-A/non-B/non-C/non-D/non-E hepatitis agents and molecular cloning thereof
DE4240980A1 (de) * 1992-08-07 1994-02-10 Boehringer Mannheim Gmbh HCV Peptidantigene und Verfahren zur Bestimmung von HCV
US6433159B1 (en) 1992-09-10 2002-08-13 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of Hepatitis C virus associated diseases
US6995146B2 (en) 1992-09-10 2006-02-07 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of hepatitis C virus-associated diseases
US6391542B1 (en) 1992-09-10 2002-05-21 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of Hepatitis C virus-associated diseases
US6174868B1 (en) 1992-09-10 2001-01-16 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of hepatitis C virus-associated diseases
NZ286209A (en) 1992-09-10 2000-09-29 Isis Pharmaceuticals Inc Use of HCV RNA anti-sense nucleotide sequences for treating Hepatitis C virus related disease
US6057093A (en) 1992-09-28 2000-05-02 Chiron Corporation Methods and compositions for controlling translation of HCV proteins
CN1059928C (zh) * 1992-09-29 2000-12-27 天津普生生物科技有限公司 利用大肠杆菌制备可用来检验c型肝炎之抗原蛋白的方法
JP2778886B2 (ja) * 1992-10-16 1998-07-23 エバーニュー バイオテック インコーポレイティド C型肝炎ウィルスのコア抗原タンパク質及びそれを用いての診断方法及びキット
EP0593291A3 (fr) * 1992-10-16 1995-03-15 Evernew Biotech Inc Protéine nonstructurale du virus de l'hépatite C, et méthode diagnostique et nécessaire.
JPH06153959A (ja) * 1992-10-16 1994-06-03 Evernew Biotec Inc C型肝炎ウィルスの非構造タンパク質及びそれを用いての診断方法及びキット
US6153378A (en) * 1992-10-16 2000-11-28 Bionova Corporation Diagnosis of, and vaccination against, a positive stranded RNA virus using an isolated, unprocessed polypeptide encoded by a substantially complete genome of such virus
EP0672065A1 (fr) * 1992-12-07 1995-09-20 Akzo Nobel N.V. Virus de l'hepatite c (hcv), peptides non structurels-3, anticorps associes et procedes de detection du hcv
EP0672066A1 (fr) * 1992-12-07 1995-09-20 Akzo Nobel N.V. Peptides provenant de la region c33 du vhc, anticorps diriges contre ces peptides et procedes de detection du vhc
WO1994024565A1 (fr) * 1993-04-22 1994-10-27 Genelabs Technologies, Inc. Antigenes et anticorps utiles dans l'immunodiagnostic du virus de l'hepatite c
ATE551423T1 (de) * 1993-04-27 2012-04-15 Innogenetics Nv Sequenzen von hepatitis c virus-genotypen sowie ihre verwendungen als therapeutika und diagnostika
ATE281526T1 (de) 1993-05-05 2004-11-15 Common Services Agency Hepatitis-c virus typ 4,5 und 6
DK0698216T4 (da) 1993-05-10 2009-06-15 Novartis Vaccines & Diagnostic Fremgangsmåder til typebestemmelse af hepatitis-C-virus og anvendte reagenser heri
CA2162557C (fr) 1993-05-12 2004-09-28 Amy J. Weiner Motif conserve de la region e2/ns1 du virus de l'hepatite c
AU8003894A (en) * 1993-10-29 1995-05-22 Srl Inc. Antigen peptide compound and immunoassay method
US5610009A (en) * 1994-01-28 1997-03-11 Abbott Laboratories Mammalian expression systems for hepatitis C virus envelope genes
US5843450A (en) * 1994-02-14 1998-12-01 Abbott Laboratories Hepatitis GB Virus synthetic peptides and uses thereof
US6156495A (en) * 1994-02-14 2000-12-05 Abbott Laboratories Hepatitis GB virus recombinant proteins and uses thereof
US6720166B2 (en) 1994-02-14 2004-04-13 Abbott Laboratories Non-a, non-b, non-c, non-c, non-d, non-e hepatitis reagents and methods for their use
US6051374A (en) * 1994-02-14 2000-04-18 Abbott Laboratories Non-A, non-B, non-C, non-D, non-E hepatitis reagents and methods for their use
US6558898B1 (en) 1994-02-14 2003-05-06 Abbott Laboratories Non-A, non-B, non-C, non-D, non-E hepatitis reagents and methods for their use
US5981172A (en) * 1994-02-14 1999-11-09 Abbott Laboratories Non-A, non-B, non-C, non-D, non-E Hepatitis reagents and methods for their use
US6451578B1 (en) 1994-02-14 2002-09-17 Abbott Laboratories Non-A, non-B, non-C, non-D, non-E hepatitis reagents and methods for their use
US5874563A (en) * 1994-05-20 1999-02-23 Genelabs Technologies, Inc. Hepatitis G virus and molecular cloning thereof
US5824507A (en) * 1994-05-20 1998-10-20 Genelabs Technologies, Inc. Hepatitis G virus and molecular cloning thereof
JP3217600B2 (ja) 1994-07-12 2001-10-09 株式会社先端生命科学研究所 非a非b型肝炎ウイルス関連抗原のイムノアッセイ、それに使用するモノクローナル抗体、およびこの抗体を産生するハイブリドーマ
ES2244965T3 (es) 1994-07-29 2005-12-16 Chiron Corporation Complejos e1/e2 secretados de virus de la hepatitis c obtenidos de polipeptidos e1 y e2 truncados en c-terminal.
WO1996004301A2 (fr) * 1994-07-29 1996-02-15 Chiron Corporation Nouveaux polypeptides a troncature e1 et e2 de l'hepatite c et procede d'obtention de ces derniers
DE4428705A1 (de) 1994-08-12 1996-02-15 Boehringer Mannheim Gmbh Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus
US5807670A (en) * 1995-08-14 1998-09-15 Abbott Laboratories Detection of hepatitis GB virus genotypes
US5709997A (en) * 1995-08-14 1998-01-20 Abbott Laboratories Nucleic acid detection of hepatitis GB virus
US5955318A (en) * 1995-08-14 1999-09-21 Abbott Laboratories Reagents and methods useful for controlling the translation of hepatitis GBV proteins
US6127116A (en) 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
GB9517926D0 (en) 1995-09-01 1995-11-01 Biocine Spa Binding protein
US5851758A (en) * 1995-10-25 1998-12-22 Childrens Research Institute Cytopathic replication of hepatitis C virus in a new cell line
US5837442A (en) 1995-11-29 1998-11-17 Roche Molecular Systems, Inc. Oligonucleotide primers for amplifying HCV nucleic acid
US5851759A (en) * 1996-04-19 1998-12-22 Chiron Corporation Heteroduplex tracking assay (HTA) for genotyping HCV
JP3715027B2 (ja) 1996-05-07 2005-11-09 シスメックス株式会社 C型肝炎ウイルス感染症診断薬
CU22642A1 (es) * 1996-12-12 2000-12-22 Ct Ingenieria Genetica Biotech Secuencia de adnc derivadas del genoma del virus de la hepatitis c y su uso
US7049428B1 (en) 1998-03-04 2006-05-23 Washington University HCV variants
US7338759B1 (en) 1997-03-04 2008-03-04 Washington University HCV variants
AU7471698A (en) 1997-05-06 1998-11-27 Chiron Corporation Intracellular production of hepatitis c e1 and e2 truncated polypeptides
US6010848A (en) * 1997-07-02 2000-01-04 Smithkline Beecham Corporation Screening methods using an atpase protein from hepatitis C virus
US6153392A (en) * 1997-07-30 2000-11-28 Bionova Corporation Devices and methods comprising an HBcAg from hepatitis B virus
EP1021534B1 (fr) 1997-10-06 2009-11-25 Novartis Vaccines and Diagnostics S.r.l. Proteine receptrice cd81 de l'hepatite c
EP2278006A3 (fr) 1997-11-06 2011-03-02 Novartis Vaccines and Diagnostics S.r.l. Antigènes de Neisseria
JP2001526028A (ja) 1997-12-11 2001-12-18 スミスクライン・ビーチャム・コーポレイション C型肝炎ウイルスns5b末端切断タンパク質およびその抗ウイルス化合物同定方法
JP4399112B2 (ja) 1998-01-14 2010-01-13 カイロン ソチエタ ア レスポンサビリタ リミタータ NeisseriaMeningitidis抗原
GB9808932D0 (en) 1998-04-27 1998-06-24 Chiron Spa Polyepitope carrier protein
EP2261351A3 (fr) 1998-05-01 2012-01-11 Novartis Vaccines and Diagnostics, Inc. Antigènes de Neisseria meningitidis et compositions
EP2286792A1 (fr) 1999-02-26 2011-02-23 Novartis Vaccines and Diagnostics, Inc. Microemulsions avec une surface adsorbante, comprenant une émulsion de microgouttes
DE69942774D1 (de) 1999-02-26 2010-10-28 Novartis Vaccines & Diagnostic Verwendung von bioadhaesiven und adjuvantien für die mukosale anwendung von antigenen
EP2290083B1 (fr) 1999-04-30 2014-08-20 Novartis Vaccines and Diagnostics S.r.l. Antigènes conservés de Neisseria
GB9911683D0 (en) 1999-05-19 1999-07-21 Chiron Spa Antigenic peptides
GB9916529D0 (en) 1999-07-14 1999-09-15 Chiron Spa Antigenic peptides
EP1200109A4 (fr) * 1999-07-19 2005-06-15 Epimmune Inc Induction de reponses immunitaires cellulaires au virus de l'hepatite c mettant en oeuvre des compositions de peptides et d'acide nucleique
BR0015137A (pt) 1999-10-29 2003-03-25 Chiron Spa Peptìdeos antigênicos de neisseria
US7196066B1 (en) 1999-11-03 2007-03-27 Powderject Vaccines, Inc. DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
ATE413190T1 (de) * 1999-12-01 2008-11-15 Novartis Vaccines & Diagnostic Hervorrufen von antikörpern spezifisch für hepatitis c virus (hcv)
DK2289545T3 (en) 2000-01-17 2016-09-05 Glaxosmithkline Biologicals Sa Supplemented OMV vaccine against meningococcus
CN1441806A (zh) 2000-04-05 2003-09-10 先灵公司 包含n-环p2部分的丙型肝炎病毒的大环ns3-丝氨酸蛋白酶抑制剂
AU2001253621A1 (en) 2000-04-19 2001-11-07 Schering Corporation Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties
EP1829891B1 (fr) * 2000-06-15 2012-12-26 Novartis Vaccines and Diagnostics, Inc. Immunoessais pour anticorps anti-VHC
BRPI0111682B8 (pt) * 2000-06-15 2021-07-27 Chiron Corp suporte sólido de imunoensaio, kit de teste de imunodiagnóstico, métodos de produção de um suporte sólido de imunoensaio, e de detecção de infecção pelo vírus da hepatite c (hcv) em uma amostra biológica, e, uso de um suporte sólido de imunoensaio
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
CZ303213B6 (cs) 2000-07-21 2012-05-23 Schering Corporation Peptidové inhibitory serinové proteázy NS3 a farmaceutický prostredek
AR029851A1 (es) 2000-07-21 2003-07-16 Dendreon Corp Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
CA2410682A1 (fr) 2000-07-21 2002-01-31 Schering Corporation Nouveaux peptides utilises comme inhibiteurs de la serine protease ns3 du virus de l'hepatite c
US6680059B2 (en) 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
RU2286172C2 (ru) 2000-08-17 2006-10-27 Трипеп Аб Вакцины, содержащие рибавирин, и способы их использования
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
AU2002214127B2 (en) 2000-10-27 2007-06-07 J. Craig Venter Institute, Inc. Nucleic acids and proteins from streptococcus groups A and B
IL155842A0 (en) 2000-12-12 2003-12-23 Schering Corp Diaryl peptides as ns3-serine protease inhibitors of hepatitis c virus
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
GB0107658D0 (en) 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
WO2002099035A2 (fr) 2001-05-31 2002-12-12 Chiron Corporation Particules de replicon d'alphavirus chimerique
US7196183B2 (en) 2001-08-31 2007-03-27 Innogenetics N.V. Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
CA2469620A1 (fr) 2001-12-12 2003-06-19 Chiron Srl. Immunisation contre chlamydia trachomatis
ATE443703T1 (de) 2002-01-23 2009-10-15 Schering Corp Prolinderivate als ns3-serine protease hemmer, zur verwendung bei der bekämpfung von hepatitis c virusinfektion
EP1531796B1 (fr) 2002-02-20 2016-09-28 GlaxoSmithKline Biologicals SA Microparticules comprenant des molecules adsorbees qui contiennent polypeptides
WO2003077729A2 (fr) 2002-03-11 2003-09-25 Carol Holland-Staley Methodes et compositions permettant d'identifier et de caracteriser l'hepatite c
US7598421B2 (en) 2002-05-08 2009-10-06 Ucl Biomedica Plc Materials for the delivery of biologically-active material to cells
AU2003239894A1 (en) 2002-05-24 2003-12-12 Restoragen Inc. Methods and constructs for high yield expression of clostripain
BR0314166B8 (pt) 2002-09-09 2021-07-27 Chiron Corp teste de hcv
US7927840B2 (en) 2006-09-11 2011-04-19 Gen Probe Incorporated Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region
CA2957200C (fr) 2002-10-16 2020-05-26 Gen-Probe Incorporated Compositions et methodes de detection du virus du nil occidental
CA2511512C (fr) 2002-12-27 2013-10-29 Chiron Corporation Immunogenes contenant des compositions de phospholipide
US7695725B2 (en) 2003-02-06 2010-04-13 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
AU2004246999B2 (en) 2003-02-06 2010-06-10 Aduro Biotech, Inc., Listeria attenuated for entry into non-phagocytic cells, vaccines comprising the listeria, and methods of use thereof
CA2515298C (fr) 2003-02-06 2014-04-08 Cerus Corporation Microbes modifies vivant en milieu naturel, compositions de vaccins, et procedes d'utilisation correspondants
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
EP1664090A2 (fr) 2003-08-26 2006-06-07 Schering Corporation Nouveaux inhibiteurs peptidomimetiques de la serine protease ns3 du virus de l'hepatite c
US8124747B2 (en) 2003-08-29 2012-02-28 Innogenetics HCV clade and prototype sequences thereof
KR20060087574A (ko) 2003-09-22 2006-08-02 가부시키가이샤 그린 펩티드 C형 간염 바이러스 유래 펩티드
TWI280964B (en) 2003-09-26 2007-05-11 Schering Corp Macrocyclic inhibitors of hepatitis C virus NS3 serine protease
WO2005037214A2 (fr) * 2003-10-14 2005-04-28 Intermune, Inc. Acylsulfonamides et acides carboxyliques macrocycliques utilises en tant qu'inhibiteurs de la replication du virus de l'hepatite c
CN1902216A (zh) 2003-11-20 2007-01-24 先灵公司 丙肝病毒ns3蛋白酶的去肽化抑制剂
US7842289B2 (en) 2003-12-24 2010-11-30 Aduro Biotech Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
US7205330B2 (en) 2004-02-27 2007-04-17 Schering Corporation Inhibitors of hepatitis C virus NS3 protease
JP2007525510A (ja) 2004-02-27 2007-09-06 シェーリング コーポレイション C型肝炎ウイルスns3セリンプロテアーゼのインヒビターとしての化合物
DE602005015093D1 (de) 2004-02-27 2009-08-06 Schering Corp Neue verbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus
ATE438622T1 (de) 2004-02-27 2009-08-15 Schering Corp 3,4-(cyclopentyl)kondensierte prolinverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus
WO2005113581A1 (fr) 2004-05-20 2005-12-01 Schering Corporation Prolines substituées en tant qu’inhibiteurs de la sérine protéase du virus ns3 de l’hépatite c
WO2006078318A2 (fr) 2004-07-29 2006-07-27 Novartis Vaccines And Diagnostics Inc. Compositions immunogenes pour bacteries a gram positif telles que streptococcus agalactiae
EP1802778B1 (fr) 2004-08-27 2011-10-05 Novartis Vaccines and Diagnostics, Inc. Antigenes de fusion a epitopes multiples hcv presentant des sites de clivage proteolytiques modifies et utilisations associees
CN101068828A (zh) 2004-08-27 2007-11-07 先灵公司 用作丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的酰基磺酰胺化合物
BRPI0516385B1 (pt) 2004-12-22 2021-07-20 Ambrx, Inc. Composto ou sal do mesmo contendo aminoácidos não naturais e polipeptídeos, métodos para produção e derivatização de um polipeptídeo
KR101205064B1 (ko) 2005-04-26 2012-11-27 에자이 알앤드디 매니지먼트 가부시키가이샤 암 면역요법을 위한 조성물과 방법
EP1888751A2 (fr) 2005-05-25 2008-02-20 Tripep Ab Gene de fusion ns3/4a non structurel de l'hepatite c
JP5160415B2 (ja) 2005-06-02 2013-03-13 メルク・シャープ・アンド・ドーム・コーポレーション 医薬処方物およびそれを用いる治療方法
US8119602B2 (en) 2005-06-02 2012-02-21 Schering Corporation Administration of HCV protease inhibitors in combination with food to improve bioavailability
ES2886923T3 (es) 2005-09-20 2021-12-21 Menarini Silicon Biosystems Spa Métodos y composición para generar sondas de ADN de secuencia única, marcaje de sondas de ADN y el uso de estas sondas
US9502624B2 (en) 2006-05-18 2016-11-22 Nichia Corporation Resin molding, surface mounted light emitting apparatus and methods for manufacturing the same
ATE522541T1 (de) 2006-06-09 2011-09-15 Novartis Ag Bakterielle adhäsine konformere
US8071561B2 (en) 2007-08-16 2011-12-06 Chrontech Pharma Ab Immunogen platform
US20090214593A1 (en) 2007-08-16 2009-08-27 Tripep Ab Immunogen platform
WO2009061996A2 (fr) 2007-11-07 2009-05-14 Celldex Therapeutics Inc. Anticorps qui se lient à la cellule dendritique et épithéliale 205 (dec-205) humaine
WO2009076158A1 (fr) 2007-12-07 2009-06-18 Novartis Ag Compositions utilisées pour induire des réponses immunitaires
NZ602170A (en) 2008-02-08 2014-03-28 Ambrx Inc Modified leptin polypeptides and their uses
EP2283112B1 (fr) 2008-05-19 2016-10-12 Aduro Biotech Compositions comportant un mutant prfa de listeria, et leurs procédés d'utilisation
AU2009296397B2 (en) 2008-09-26 2012-11-08 Ambrx Inc. Modified animal erythropoietin polypeptides and their uses
US20110286969A1 (en) 2008-12-12 2011-11-24 Schering Corporation Deuterated compounds as hepatitis c virus (hcv) inhibitors
CN102427828A (zh) 2009-03-09 2012-04-25 威廉·亨利 含具有信号肽的细菌毒素作为载体的半抗原-载体缀合物和它们在免疫原性组合物中的用途
US8980920B2 (en) 2009-05-29 2015-03-17 Merck Sharp & Dohme Corp. Antiviral compounds of three linked aryl moieties to treat diseases such as hepatitis C
US20110300205A1 (en) 2009-07-06 2011-12-08 Novartis Ag Self replicating rna molecules and uses thereof
US20120276047A1 (en) 2009-11-25 2012-11-01 Rosenblum Stuart B Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases
EP2333074A1 (fr) 2009-12-14 2011-06-15 Robert Steinfeld Substances et procédés pour le traitement de maladies liées au stockage lysosomal
JP2013515068A (ja) 2009-12-22 2013-05-02 メルク・シャープ・アンド・ドーム・コーポレーション ウイルス性疾患の治療のための縮合三環式化合物およびその使用方法
CN102140100B (zh) 2010-01-27 2014-06-11 爱博新药研发(上海)有限公司 高效抑制丙型肝炎病毒的多环化合物及其制备方法和用途
MX2012010392A (es) 2010-03-09 2012-10-03 Merck Sharp & Dohme Compuesto de sililo triciclicos fusionados y metodos de uso de los mismos para el tratamiento de enfermedades virales.
US9169325B2 (en) 2010-04-13 2015-10-27 Celldex Therapeutics, Inc. Antibodies that bind human CD27 and uses thereof
RU2625546C2 (ru) 2010-07-06 2017-07-14 Новартис Аг Катионные эмульсии "масло-в-воде"
US20140377223A1 (en) 2010-07-26 2014-12-25 Joseph A. Kozlowski Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases
AU2011314168A1 (en) 2010-09-29 2013-04-04 Merck Sharp & Dohme Corp. Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases
CN103582420B (zh) 2011-04-13 2016-10-19 默沙东公司 2’-取代的核苷衍生物和使用其治疗病毒病的方法
US9156872B2 (en) 2011-04-13 2015-10-13 Merck Sharp & Dohme Corp. 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
CA2857705A1 (fr) 2011-06-16 2012-12-20 AB Pharma Ltd. Compose heterocyclique macrocyclique pour l'inhibition du virus de l'hepatite c, sa preparation et ses applications
WO2013006834A1 (fr) 2011-07-06 2013-01-10 Novartis Ag Émulsions aqueuses contenant des acides nucléiques
JP6120839B2 (ja) 2011-07-06 2017-04-26 ノバルティス アーゲー カチオン性水中油型エマルジョン
EP2755981A4 (fr) 2011-09-14 2015-03-25 Merck Sharp & Dohme Composés hétérocycliques contenant un silyle et méthodes d'utilisation desdits composés pour traiter les maladies virales
US20140271829A1 (en) 2011-10-11 2014-09-18 Anders Lilja Recombinant self-replicating polycistronic rna molecules
US20180044429A1 (en) 2015-03-09 2018-02-15 Celldex Therapeutics, Inc. Cd27 agonists
DK3274478T3 (da) 2015-03-27 2020-11-23 Ortho Clinical Diagnostics K K Hcv-ns4a/modificerede ns3-polypeptider og anvendelser deraf
US10550379B2 (en) 2015-06-29 2020-02-04 The Board Of Trustees Of The Leland Stanford Junior University Degron fusion constructs and methods for controlling protein production
MX2018012757A (es) 2016-04-18 2019-06-24 Celldex Therapeutics Inc Anticuerpos agonistas que se unen a cd40 humana y usos de los mismos.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464474A (en) * 1980-07-09 1984-08-07 Connaught Laboratories Limited Non-A, non-B hepatitis assay and vaccine
CA1168579A (fr) * 1981-02-11 1984-06-05 Philippe Maupas (Deceased) Virus de l'hepatite nona - nonb
US4702909A (en) * 1982-05-05 1987-10-27 Louisiana State University A & M Non-A, non-B hepatitis antigen, antigen compositions, vaccine and diagnostic reagent
US4673634A (en) * 1985-03-08 1987-06-16 The United States Of America As Represented By The Department Of Health And Human Services Purified antigen from non-A, non-B hepatitis causing factor
EP0261233A4 (fr) * 1986-04-01 1988-08-29 Genelabs Inc Cellules tissulaires immortalisees a specificite virale.
JPS6391328A (ja) * 1986-10-07 1988-04-22 Mitsubishi Kasei Corp 非a非b型肝炎抗原
NZ222465A (en) * 1986-11-07 1992-11-25 Pasteur Institut Nanb (non a, non b hepatitis viral) antigen
DE3744242A1 (de) * 1987-02-20 1989-07-06 Seelig Renate Virusantigen, verfahren zu seiner gewinnung und anwendung in diagnose und therapie (impfstoff)
DE3886363T3 (de) * 1987-11-18 2004-09-09 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville NANBV-Diagnostika

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004506018A (ja) * 2000-08-17 2004-02-26 トリペップ アクチ ボラゲット リバビリンを含むワクチンおよびその使用方法

Also Published As

Publication number Publication date
FI893447A (fi) 1989-07-17
JPH06128292A (ja) 1994-05-10
HU220204B (hu) 2001-11-28
HK38293A (en) 1993-04-30
JP2662350B2 (ja) 1997-10-08
NO304990B1 (no) 1999-03-15
JP2008007508A (ja) 2008-01-17
EP0318216B2 (fr) 2001-08-29
HK1026023A1 (en) 2000-12-01
BR8807310A (pt) 1990-03-13
ES2012739T3 (es) 1994-12-01
JPH10290697A (ja) 1998-11-04
CN1074422C (zh) 2001-11-07
CA1341629C (fr) 2012-05-08
JPH06128293A (ja) 1994-05-10
JP2810022B2 (ja) 1998-10-15
JP2000023683A (ja) 2000-01-25
ES2012739T5 (es) 2001-12-01
DE3886363T3 (de) 2004-09-09
HU216017B (hu) 1999-04-28
NZ227011A (en) 1992-03-26
JP2532805B2 (ja) 1996-09-11
JPH06128290A (ja) 1994-05-10
GR900300069T1 (en) 1991-07-31
UA42668C2 (uk) 2001-11-15
CN1299973A (zh) 2001-06-20
ES2012739A4 (es) 1990-04-16
FI105652B (fi) 2000-09-29
NO892931D0 (no) 1989-07-17
JP2006117681A (ja) 2006-05-11
FI106564B (fi) 2001-02-28
HK1033773A1 (en) 2001-09-21
JP2006104207A (ja) 2006-04-20
CN100397082C (zh) 2008-06-25
LV10726B (en) 1995-12-20
CN1159584C (zh) 2004-07-28
JPH06128291A (ja) 1994-05-10
FI981380A0 (fi) 1988-11-18
WO1989004669A1 (fr) 1989-06-01
KR19980701583A (ko) 1998-05-15
LV10726A (lv) 1995-06-20
FI981380A (fi) 1998-06-15
DE3886363T2 (de) 1994-05-19
JPH10290696A (ja) 1998-11-04
JPH09184844A (ja) 1997-07-15
HUT53148A (en) 1990-09-28
AU2796789A (en) 1989-06-14
CN1249433A (zh) 2000-04-05
EP0318216B1 (fr) 1993-12-15
CN1129796C (zh) 2003-12-03
FI20001390A (fi) 2000-06-12
IE883472L (en) 1989-05-18
EP0318216A1 (fr) 1989-05-31
KR0138776B1 (ko) 1998-05-15
DE3886363D1 (de) 1994-01-27
JP2662351B2 (ja) 1997-10-08
JP3171793B2 (ja) 2001-06-04
JP2810032B2 (ja) 1998-10-15
HU9502949D0 (en) 1995-12-28
JPH06225797A (ja) 1994-08-16
JP2007197456A (ja) 2007-08-09
JPH02500880A (ja) 1990-03-29
HU211905A9 (en) 1996-01-29
CN1073719A (zh) 1993-06-30
FI893447A0 (fi) 1989-07-17
CN1035679A (zh) 1989-09-20
KR100216013B1 (ko) 1999-08-16
JP2662358B2 (ja) 1997-10-08
KR890701126A (ko) 1989-12-19
JP2809956B2 (ja) 1998-10-15
JPH09173079A (ja) 1997-07-08
JPH10108674A (ja) 1998-04-28
FI107620B (fi) 2001-09-14
CN1049686C (zh) 2000-02-23
CN1285514A (zh) 2001-02-28
NO892931L (no) 1989-09-13
IE62868B1 (en) 1995-03-08
DE318216T1 (de) 1990-06-13

Similar Documents

Publication Publication Date Title
JP2662358B2 (ja) Nanbvの診断用薬
JP3514751B2 (ja) C型肝炎ウイルス(hcv)ポリペプチド
JP2809987B2 (ja) Nanbvの診断用薬
DK175975B1 (da) NANBV-diagnostika og -vacciner
DK176280B1 (da) NANBV-diagnostika og -vacciner
HRP940493A2 (en) Nanbv diagnostics and vaccines

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20071115

Year of fee payment: 14

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20081115

Year of fee payment: 15

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20091115

Year of fee payment: 16

EXPY Cancellation because of completion of term
FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20091115

Year of fee payment: 16

S533 Written request for registration of change of name

Free format text: JAPANESE INTERMEDIATE CODE: R313533

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20091115

Year of fee payment: 16

R370 Written measure of declining of transfer procedure

Free format text: JAPANESE INTERMEDIATE CODE: R370

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20091115

Year of fee payment: 16