JP7069177B2 - シグレック－１５に対する抗体及びその使用方法 - Google Patents

シグレック－１５に対する抗体及びその使用方法 Download PDF

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JP7069177B2
JP7069177B2 JP2019537042A JP2019537042A JP7069177B2 JP 7069177 B2 JP7069177 B2 JP 7069177B2 JP 2019537042 A JP2019537042 A JP 2019537042A JP 2019537042 A JP2019537042 A JP 2019537042A JP 7069177 B2 JP7069177 B2 JP 7069177B2
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antibody
siglec
heavy chain
light chain
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JP2019536470A5 (enExample
JP2019536470A6 (ja
JP2019536470A (ja
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リンダ リュー
ダラス ベンジャミン フライズ
ソーローモン ランゲルマン
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ネクストキュア インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Food Science & Technology (AREA)
JP2019537042A 2016-09-21 2017-09-21 シグレック－１５に対する抗体及びその使用方法 Active JP7069177B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022075712A JP7382444B2 (ja) 2016-09-21 2022-05-02 シグレック－１５に対する抗体及びその使用方法
JP2023189126A JP7720375B2 (ja) 2016-09-21 2023-11-06 シグレック－１５に対する抗体及びその使用方法

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201662397794P 2016-09-21 2016-09-21
US62/397,794 2016-09-21
US201762451271P 2017-01-27 2017-01-27
US62/451,271 2017-01-27
US62/451,272 2017-01-27
US201762500578P 2017-05-03 2017-05-03
US62/500,578 2017-05-03
PCT/US2017/052714 WO2018057735A1 (en) 2016-09-21 2017-09-21 Antibodies for siglec-15 and methods of use thereof

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JP2019536470A JP2019536470A (ja) 2019-12-19
JP2019536470A5 JP2019536470A5 (enExample) 2020-02-13
JP2019536470A6 JP2019536470A6 (ja) 2020-02-27
JP7069177B2 true JP7069177B2 (ja) 2022-05-17

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JP2022075712A Active JP7382444B2 (ja) 2016-09-21 2022-05-02 シグレック－１５に対する抗体及びその使用方法
JP2023189126A Active JP7720375B2 (ja) 2016-09-21 2023-11-06 シグレック－１５に対する抗体及びその使用方法

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JP2023189126A Active JP7720375B2 (ja) 2016-09-21 2023-11-06 シグレック－１５に対する抗体及びその使用方法

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US (1) US11390675B2 (enExample)
EP (1) EP3515478B1 (enExample)
JP (3) JP7069177B2 (enExample)
KR (2) KR102644544B1 (enExample)
CN (1) CN110035769A (enExample)
AU (3) AU2017330346C1 (enExample)
BR (1) BR112019005292A2 (enExample)
CA (1) CA3033571A1 (enExample)
DK (1) DK3515478T3 (enExample)
ES (1) ES2982558T3 (enExample)
RU (1) RU2759334C2 (enExample)
WO (1) WO2018057735A1 (enExample)

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JP7069177B2 (ja) 2016-09-21 2022-05-17 ネクストキュア インコーポレイテッド シグレック－１５に対する抗体及びその使用方法
CN110386982A (zh) * 2019-04-09 2019-10-29 广东三九脑科医院 鼠抗人Siglec-15蛋白单克隆抗体制备及其用途
US11104732B2 (en) * 2019-04-24 2021-08-31 Innovative Cellular Therapeutics Holdings, Ltd. Reducing immune inhibition induced by SIGLEC-15
MX2022010217A (es) * 2020-02-21 2022-09-19 Jiangsu Hengrui Pharmaceuticals Co Ltd Composicion farmaceutica que contiene anticuerpo anti-il-4r y uso de la misma.
CN115348970B (zh) * 2020-03-27 2023-11-14 博奥信生物技术（南京）有限公司 结合siglec15的抗体及其用途
WO2021211963A1 (en) * 2020-04-17 2021-10-21 Washington University Anti-sars-cov-2 monoclonal antibodies
TW202208428A (zh) 2020-05-06 2022-03-01 美商蜻蜓醫療公司 結合ｎｋｇ２ｄ、ｃｄ１６及ｃｌｅｃ１２ａ之蛋白質
BR112022022418A2 (pt) * 2020-05-06 2022-12-13 Dragonfly Therapeutics Inc Anticorpos de alvejamento de clec12a e uso dos mesmos
CN113817057B (zh) * 2020-06-19 2024-02-20 盛禾(中国)生物制药有限公司 一种抗siglec15抗体及其应用
EP4222173A4 (en) * 2020-09-30 2024-10-30 NA Biotech Corp ANTI-ADENOSINE RECEPTOR (A2AR) ANTIBODIES
US20240092897A1 (en) * 2020-11-05 2024-03-21 Shanghai Jmt-Bio Technology Co., Ltd. Anti-siglec-15 antibody and application thereof in preparing drug
WO2022123394A1 (en) 2020-12-08 2022-06-16 Guizhou Sinorda Biotechnology Co. Ltd. Modified t cells for adoptive immunotherapy
CN114657132A (zh) * 2020-12-22 2022-06-24 未来智人再生医学研究院(广州)有限公司 一种表达Siglec-15靶向抑制因子的多能干细胞及其衍生物与应用
CN112625132B (zh) * 2021-01-15 2022-08-02 沈阳荣欣生物制药科技有限公司 纳米抗体及其编码基因、表达载体、宿主细胞和应用
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WO2022179483A1 (zh) * 2021-02-23 2022-09-01 上海济煜医药科技有限公司 Siglec-15结合蛋白的制备及其用途
CN114957468A (zh) 2021-02-25 2022-08-30 石药集团巨石生物制药有限公司 一种抗Siglec15抗体及其用途
EP4308609A4 (en) * 2021-03-19 2025-06-04 Elpis Biopharmaceuticals Antibodies specific to sialic acid-binding ig-like lectin 15 and uses thereof
CN112961214B (zh) * 2021-03-19 2022-08-02 江苏元本生物科技有限公司 一种靶向Siglec-15的噬菌体多肽
CN112979761B (zh) * 2021-03-19 2021-12-10 江苏元本生物科技有限公司 一种靶向Siglec-15的噬菌体多肽
WO2022228183A1 (zh) * 2021-04-30 2022-11-03 杭州邦顺制药有限公司 抗siglec15抗体及其制备方法和用途
WO2022237819A1 (zh) * 2021-05-13 2022-11-17 信达生物制药(苏州)有限公司 抗Siglec-15抗体及其用途
WO2023030311A1 (zh) * 2021-08-31 2023-03-09 上海医药集团股份有限公司 靶向Siglec15的抗原结合蛋白及其用途
CN118159286A (zh) 2021-11-25 2024-06-07 正大天晴药业集团股份有限公司 抗Siglec-15抗体及其应用
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CN117430707B (zh) * 2023-10-25 2024-04-19 重庆天科雅生物科技有限公司 一种cik细胞的制备方法及其在治疗癌症中的用途
CN117645665B (zh) * 2024-01-29 2024-05-07 北京热景生物技术股份有限公司 一种针对α-突触核蛋白的抗体及其制备方法和应用
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