JP6982362B2 - オリゴ核酸変異体ライブラリーとその合成 - Google Patents
オリゴ核酸変異体ライブラリーとその合成 Download PDFInfo
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- JP6982362B2 JP6982362B2 JP2018512262A JP2018512262A JP6982362B2 JP 6982362 B2 JP6982362 B2 JP 6982362B2 JP 2018512262 A JP2018512262 A JP 2018512262A JP 2018512262 A JP2018512262 A JP 2018512262A JP 6982362 B2 JP6982362 B2 JP 6982362B2
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- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5029—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell motility
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- G—PHYSICS
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
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- C12Q2600/00—Oligonucleotides characterized by their use
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562220879P | 2015-09-18 | 2015-09-18 | |
| US62/220,879 | 2015-09-18 | ||
| US201562263548P | 2015-12-04 | 2015-12-04 | |
| US62/263,548 | 2015-12-04 | ||
| US201662354034P | 2016-06-23 | 2016-06-23 | |
| US62/354,034 | 2016-06-23 | ||
| PCT/US2016/052336 WO2017049231A1 (en) | 2015-09-18 | 2016-09-16 | Oligonucleic acid variant libraries and synthesis thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018532705A JP2018532705A (ja) | 2018-11-08 |
| JP2018532705A5 JP2018532705A5 (enExample) | 2019-10-24 |
| JP6982362B2 true JP6982362B2 (ja) | 2021-12-17 |
Family
ID=58276736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018512262A Active JP6982362B2 (ja) | 2015-09-18 | 2016-09-16 | オリゴ核酸変異体ライブラリーとその合成 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10844373B2 (enExample) |
| EP (1) | EP3350314A4 (enExample) |
| JP (1) | JP6982362B2 (enExample) |
| KR (1) | KR20180050411A (enExample) |
| CN (1) | CN108368482A (enExample) |
| AU (2) | AU2016324296A1 (enExample) |
| CA (1) | CA2998169A1 (enExample) |
| EA (1) | EA201890763A1 (enExample) |
| GB (1) | GB2557529A (enExample) |
| HK (1) | HK1258869A1 (enExample) |
| IL (1) | IL258164B (enExample) |
| WO (1) | WO2017049231A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI695067B (zh) | 2013-08-05 | 2020-06-01 | 美商扭轉生物科技有限公司 | 重新合成之基因庫 |
| WO2016126882A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| WO2016172377A1 (en) | 2015-04-21 | 2016-10-27 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| CN108368482A (zh) | 2015-09-18 | 2018-08-03 | 特韦斯特生物科学公司 | 寡核酸变体文库及其合成 |
| US11512347B2 (en) | 2015-09-22 | 2022-11-29 | Twist Bioscience Corporation | Flexible substrates for nucleic acid synthesis |
| WO2017095958A1 (en) | 2015-12-01 | 2017-06-08 | Twist Bioscience Corporation | Functionalized surfaces and preparation thereof |
| GB2568444A (en) * | 2016-08-22 | 2019-05-15 | Twist Bioscience Corp | De novo synthesized nucleic acid libraries |
| EP3516528B1 (en) | 2016-09-21 | 2025-10-15 | Atlas Data Storage, Inc. | Nucleic acid based data storage |
| CA3047128A1 (en) | 2016-12-16 | 2018-06-21 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| JP2020508661A (ja) | 2017-02-22 | 2020-03-26 | ツイスト バイオサイエンス コーポレーション | 核酸ベースのデータ保存 |
| CN110914486B (zh) * | 2017-03-15 | 2024-01-30 | 特韦斯特生物科学公司 | 从头合成的组合核酸文库 |
| CA3056388A1 (en) | 2017-03-15 | 2018-09-20 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| WO2018231872A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| US11407837B2 (en) | 2017-09-11 | 2022-08-09 | Twist Bioscience Corporation | GPCR binding proteins and synthesis thereof |
| CA3079613A1 (en) | 2017-10-20 | 2019-04-25 | Twist Bioscience Corporation | Heated nanowells for polynucleotide synthesis |
| KR20250069684A (ko) | 2018-01-04 | 2025-05-19 | 트위스트 바이오사이언스 코포레이션 | Dna 기반 디지털 정보 저장 |
| CN118957038A (zh) | 2018-05-18 | 2024-11-15 | 特韦斯特生物科学公司 | 用于核酸杂交的多核苷酸、试剂和方法 |
| WO2020139871A1 (en) | 2018-12-26 | 2020-07-02 | Twist Bioscience Corporation | Highly accurate de novo polynucleotide synthesis |
| JP2022521551A (ja) | 2019-02-26 | 2022-04-08 | ツイスト バイオサイエンス コーポレーション | Glp1受容体の変異体核酸ライブラリ |
| US11492728B2 (en) | 2019-02-26 | 2022-11-08 | Twist Bioscience Corporation | Variant nucleic acid libraries for antibody optimization |
| WO2020257612A1 (en) | 2019-06-21 | 2020-12-24 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| CN115003697A (zh) | 2019-09-23 | 2022-09-02 | 特韦斯特生物科学公司 | Crth2的变异核酸文库 |
| US12173282B2 (en) | 2019-09-23 | 2024-12-24 | Twist Bioscience, Inc. | Antibodies that bind CD3 epsilon |
| JP2023523336A (ja) | 2020-04-27 | 2023-06-02 | ツイスト バイオサイエンス コーポレーション | コロナウイルス用の変異体核酸ライブラリー |
| EP4150080A4 (en) | 2020-05-15 | 2025-11-19 | Codex Dna Inc | On-demand synthesis of polynucleotide sequences |
| JP2023539245A (ja) | 2020-08-26 | 2023-09-13 | ツイスト バイオサイエンス コーポレーション | Glp1r変異体に関する方法および組成物 |
| EP4229210A4 (en) | 2020-10-19 | 2025-01-08 | Twist Bioscience Corporation | METHOD FOR THE SYNTHESIS OF OLIGONUCLEOTIDES USING BOUND NUCLEOTIDES |
| JP2024504384A (ja) | 2021-01-21 | 2024-01-31 | ツイスト バイオサイエンス コーポレーション | アデノシン受容体に関する方法および組成物 |
| WO2022204316A2 (en) | 2021-03-24 | 2022-09-29 | Twist Bioscience Corporation | Variant nucleic acid libraries for cd3 |
| WO2022235584A1 (en) * | 2021-05-03 | 2022-11-10 | Twist Bioscience Corporation | Variant nucleic acid libraries for glycans |
| US12201857B2 (en) | 2021-06-22 | 2025-01-21 | Twist Bioscience Corporation | Methods and compositions relating to covid antibody epitopes |
| JP2024542194A (ja) | 2021-11-18 | 2024-11-13 | ツイスト バイオサイエンス コーポレーション | Dickkopf-1バリアント抗体及び使用方法 |
| US12325739B2 (en) | 2022-01-03 | 2025-06-10 | Twist Bioscience Corporation | Bispecific SARS-CoV-2 antibodies and methods of use |
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| US10844373B2 (en) | 2020-11-24 |
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| CN108368482A (zh) | 2018-08-03 |
| JP2018532705A (ja) | 2018-11-08 |
| US11807956B2 (en) | 2023-11-07 |
| WO2017049231A1 (en) | 2017-03-23 |
| CA2998169A1 (en) | 2017-03-23 |
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| EA201890763A1 (ru) | 2018-08-31 |
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| EP3350314A4 (en) | 2019-02-06 |
| GB201804999D0 (en) | 2018-05-09 |
| US20240158955A1 (en) | 2024-05-16 |
| US20210040476A1 (en) | 2021-02-11 |
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