JP6417419B2 - 免疫調節剤として有用な化合物 - Google Patents
免疫調節剤として有用な化合物 Download PDFInfo
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- JP6417419B2 JP6417419B2 JP2016540311A JP2016540311A JP6417419B2 JP 6417419 B2 JP6417419 B2 JP 6417419B2 JP 2016540311 A JP2016540311 A JP 2016540311A JP 2016540311 A JP2016540311 A JP 2016540311A JP 6417419 B2 JP6417419 B2 JP 6417419B2
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- methyl
- methoxy
- phenylphenyl
- phenyl
- amino
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- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A61K31/396—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having three-membered rings, e.g. aziridine
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- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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| AU2013355054B2 (en) | 2012-12-07 | 2017-08-24 | Chemocentryx, Inc. | Diazole lactams |
| ES2904252T3 (es) | 2015-05-21 | 2022-04-04 | Chemocentryx Inc | Moduladores de CCR2 |
| KR20180011843A (ko) | 2015-06-11 | 2018-02-02 | 바실리어 파마슈티카 인터내셔널 리미티드 | 유출-펌프 억제제 및 이의 치료적 용도 |
| US10745382B2 (en) * | 2015-10-15 | 2020-08-18 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| EP3365340B1 (en) | 2015-10-19 | 2022-08-10 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| US20170145025A1 (en) | 2015-11-19 | 2017-05-25 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| ES2916874T3 (es) | 2015-12-17 | 2022-07-06 | Incyte Corp | Derivados de N-fenil-piridina-2-carboxamida y su uso como moduladores de la interacción proteína/proteína PD-1/PD-L1 |
| AU2016379372A1 (en) * | 2015-12-22 | 2018-08-02 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| EP3190103A1 (en) * | 2016-01-08 | 2017-07-12 | Rijksuniversiteit Groningen | Inhibitors of the pd-1/pd-l1 protein/protein interaction |
| CN109310677A (zh) | 2016-04-07 | 2019-02-05 | 凯莫森特里克斯股份有限公司 | 通过联合施用ccr1拮抗剂与pd-1抑制剂或pd-l1拮抗剂降低肿瘤负荷 |
| ES2906460T3 (es) | 2016-05-06 | 2022-04-18 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
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- 2014-09-02 BR BR112016004194A patent/BR112016004194A8/pt not_active Application Discontinuation
- 2014-09-02 WO PCT/US2014/053695 patent/WO2015034820A1/en not_active Ceased
- 2014-09-02 EA EA201690316A patent/EA029901B1/ru not_active IP Right Cessation
- 2014-09-02 EP EP14766086.4A patent/EP3041822B1/en not_active Not-in-force
- 2014-09-02 PE PE2016000338A patent/PE20160432A1/es not_active Application Discontinuation
- 2014-09-02 ES ES14766086.4T patent/ES2642074T3/es active Active
- 2014-09-02 US US14/915,782 patent/US9872852B2/en active Active
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2016
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017518961A (ja) * | 2014-04-14 | 2017-07-13 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 免疫調節剤として有用な化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015034820A1 (en) | 2015-03-12 |
| EA201690316A1 (ru) | 2016-07-29 |
| JP2016536333A (ja) | 2016-11-24 |
| CN105705489A (zh) | 2016-06-22 |
| KR102276644B1 (ko) | 2021-07-13 |
| SG11201601225RA (en) | 2016-03-30 |
| US20160194307A1 (en) | 2016-07-07 |
| CA2923184A1 (en) | 2015-03-12 |
| KR20160048946A (ko) | 2016-05-04 |
| CN105705489B (zh) | 2019-04-26 |
| AU2014315457A1 (en) | 2016-04-28 |
| PE20160432A1 (es) | 2016-05-11 |
| IL244346A0 (en) | 2016-04-21 |
| CL2018000150A1 (es) | 2018-05-11 |
| EA029901B1 (ru) | 2018-05-31 |
| EP3041822A1 (en) | 2016-07-13 |
| MX2016002544A (es) | 2016-06-17 |
| EP3041822B1 (en) | 2017-08-09 |
| AU2014315457B2 (en) | 2018-05-10 |
| ES2642074T3 (es) | 2017-11-15 |
| CL2016000508A1 (es) | 2016-11-04 |
| BR112016004194A8 (pt) | 2020-02-11 |
| HK1223366A1 (en) | 2017-07-28 |
| IL244346B (en) | 2019-10-31 |
| US9872852B2 (en) | 2018-01-23 |
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