JP6385825B2 - 置換されたヌクレオシド、ヌクレオチドおよびそのアナログ - Google Patents

置換されたヌクレオシド、ヌクレオチドおよびそのアナログ Download PDF

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JP6385825B2
JP6385825B2 JP2014548912A JP2014548912A JP6385825B2 JP 6385825 B2 JP6385825 B2 JP 6385825B2 JP 2014548912 A JP2014548912 A JP 2014548912A JP 2014548912 A JP2014548912 A JP 2014548912A JP 6385825 B2 JP6385825 B2 JP 6385825B2
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JP2015503506A (ja
JP2015503506A5 (pt
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ベイゲルマン、レオニード
ワン、グァンイー
スミス、デイビッド、バーナード
デュバル、ジェローム
プルハブク、マーリッジャー
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アリオス バイオファーマ インク．
アリオス バイオファーマ インク．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
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    • C07D473/32—Nitrogen atom
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/127—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07048—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase

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  • Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)
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JP2014548912A 2011-12-22 2012-12-20 置換されたヌクレオシド、ヌクレオチドおよびそのアナログ Expired - Fee Related JP6385825B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161579560P 2011-12-22 2011-12-22
US61/579,560 2011-12-22
US201261613836P 2012-03-21 2012-03-21
US61/613,836 2012-03-21
PCT/US2012/071063 WO2013096679A1 (en) 2011-12-22 2012-12-20 Substituted nucleosides, nucleotides and analogs thereof

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JP2018149017A Division JP6718487B2 (ja) 2011-12-22 2018-08-08 置換されたヌクレオシド、ヌクレオチドおよびそのアナログ

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JP2015503506A JP2015503506A (ja) 2015-02-02
JP2015503506A5 JP2015503506A5 (pt) 2016-02-12
JP6385825B2 true JP6385825B2 (ja) 2018-09-05

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JP2018149017A Expired - Fee Related JP6718487B2 (ja) 2011-12-22 2018-08-08 置換されたヌクレオシド、ヌクレオチドおよびそのアナログ

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US (4) US9073960B2 (pt)
EP (2) EP3466959A1 (pt)
JP (2) JP6385825B2 (pt)
KR (1) KR102072041B1 (pt)
CN (2) CN107459544B (pt)
AP (1) AP2014007796A0 (pt)
AR (1) AR089408A1 (pt)
AU (2) AU2012358803C1 (pt)
BR (1) BR112014014740B1 (pt)
CA (2) CA2860289C (pt)
CL (1) CL2014001641A1 (pt)
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DK (1) DK2794627T3 (pt)
EA (1) EA035493B1 (pt)
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GE (1) GEP20166496B (pt)
HK (3) HK1203076A1 (pt)
HR (1) HRP20182096T1 (pt)
HU (1) HUE041509T2 (pt)
IL (2) IL233152B (pt)
LT (1) LT2794627T (pt)
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PH (2) PH12014501436B1 (pt)
PL (1) PL2794627T3 (pt)
PT (1) PT2794627T (pt)
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SG (3) SG10201610936RA (pt)
SI (1) SI2794627T1 (pt)
TW (1) TWI659963B (pt)
UA (1) UA117095C2 (pt)
UY (1) UY34536A (pt)
WO (1) WO2013096679A1 (pt)
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SG10201610936RA (en) 2017-02-27
AR089408A1 (es) 2014-08-20
AU2018203423B2 (en) 2020-04-30
EP2794627A1 (en) 2014-10-29
PH12015502273A1 (en) 2017-12-11
AU2012358803B2 (en) 2018-02-15
US20150315228A1 (en) 2015-11-05
HK1248239A1 (zh) 2018-10-12
ECSP14010277A (es) 2015-08-31
PL2794627T3 (pl) 2019-04-30
CL2014001641A1 (es) 2014-12-12
HK1203204A1 (en) 2015-10-23
CN104114568B (zh) 2017-09-01
IL272953B (en) 2021-10-31
SG11201402826YA (en) 2014-12-30
MX356509B (es) 2018-05-30
SG10201913554YA (en) 2020-03-30
NZ627179A (en) 2016-07-29
US11021509B2 (en) 2021-06-01
US20200024297A1 (en) 2020-01-23
AU2012358803C1 (en) 2019-12-19
DK2794627T3 (en) 2019-01-14
HUE041509T2 (hu) 2019-05-28
CN107459544A (zh) 2017-12-12
TWI659963B (zh) 2019-05-21
US20210179656A1 (en) 2021-06-17
CY1121416T1 (el) 2020-05-29
UA117095C2 (uk) 2018-06-25
EP3466959A1 (en) 2019-04-10
JP6718487B2 (ja) 2020-07-08
US20130165400A1 (en) 2013-06-27
PH12014501436B1 (en) 2014-10-08
ES2702060T3 (es) 2019-02-27
EA201491040A1 (ru) 2015-01-30
CA3107640A1 (en) 2013-06-27

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