JP5578241B2 - 管内で対象成分を操作するためのデバイス及び方法 - Google Patents

管内で対象成分を操作するためのデバイス及び方法 Download PDF

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JP5578241B2
JP5578241B2 JP2012549655A JP2012549655A JP5578241B2 JP 5578241 B2 JP5578241 B2 JP 5578241B2 JP 2012549655 A JP2012549655 A JP 2012549655A JP 2012549655 A JP2012549655 A JP 2012549655A JP 5578241 B2 JP5578241 B2 JP 5578241B2
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tube
aqueous liquid
magnetic field
magnetic particles
nucleic acid
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JPWO2012086243A1 (ja
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鉄雄 大橋
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Shimadzu Corp
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Shimadzu Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/005—Pretreatment specially adapted for magnetic separation
    • B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/10—Magnetic separation acting directly on the substance being separated with cylindrical material carriers
    • B03C1/12—Magnetic separation acting directly on the substance being separated with cylindrical material carriers with magnets moving during operation; with movable pole pieces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/30—Combinations with other devices, not otherwise provided for
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00466—Beads in a slurry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00468—Beads by manipulation of individual beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2012549655A 2010-12-21 2011-07-13 管内で対象成分を操作するためのデバイス及び方法 Active JP5578241B2 (ja)

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Applications Claiming Priority (4)

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JP2010285210 2010-12-21
JP2010285210 2010-12-21
PCT/JP2011/065995 WO2012086243A1 (ja) 2010-12-21 2011-07-13 管内で対象成分を操作するためのデバイス及び方法
JP2012549655A JP5578241B2 (ja) 2010-12-21 2011-07-13 管内で対象成分を操作するためのデバイス及び方法

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JP5578241B2 true JP5578241B2 (ja) 2014-08-27

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CN (2) CN103269787B9 (enExample)
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Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8207497B2 (en) 2009-05-08 2012-06-26 Ionsense, Inc. Sampling of confined spaces
US8276762B2 (en) 2009-05-15 2012-10-02 Gen-Probe Incorporated Method and system for performing a magnetic separation procedure
US9517472B2 (en) * 2010-12-21 2016-12-13 Shimadzu Corporation Device and method for processing target component in tube
US8822949B2 (en) 2011-02-05 2014-09-02 Ionsense Inc. Apparatus and method for thermal assisted desorption ionization systems
US8901488B1 (en) * 2011-04-18 2014-12-02 Ionsense, Inc. Robust, rapid, secure sample manipulation before during and after ionization for a spectroscopy system
JP5954532B2 (ja) * 2012-04-05 2016-07-20 セイコーエプソン株式会社 核酸抽出用デバイス、核酸抽出用キット、核酸抽出用装置及び核酸抽出方法
JP2014033663A (ja) * 2012-08-10 2014-02-24 Seiko Epson Corp 核酸抽出装置及び核酸抽出方法
JP6120518B2 (ja) * 2012-10-10 2017-04-26 公益財団法人かずさＤｎａ研究所 簡易測定器具
JP2014083041A (ja) * 2012-10-26 2014-05-12 Seiko Epson Corp 核酸抽出用装置
JP2014083040A (ja) * 2012-10-26 2014-05-12 Seiko Epson Corp 核酸抽出用器具及びそれを用いた核酸抽出方法
JP2014093988A (ja) * 2012-11-12 2014-05-22 Seiko Epson Corp 固相担体の操作方法及び固相担体の操作装置
JP2014176306A (ja) * 2013-03-13 2014-09-25 Seiko Epson Corp 核酸増幅反応用カートリッジ
JP2014176302A (ja) * 2013-03-13 2014-09-25 Seiko Epson Corp 核酸増幅反応装置及び核酸増幅方法
JP2014176304A (ja) * 2013-03-13 2014-09-25 Seiko Epson Corp 核酸増幅反応用カートリッジ
JP2014176305A (ja) * 2013-03-13 2014-09-25 Seiko Epson Corp 核酸増幅反応用カートリッジ
WO2014144209A1 (en) 2013-03-15 2014-09-18 Abbott Molecular Inc. One-step procedure for the purification of nucleic acids
WO2015001629A1 (ja) * 2013-07-03 2015-01-08 株式会社島津製作所 粒子操作方法および粒子操作用デバイス
JP2015073485A (ja) * 2013-10-09 2015-04-20 セイコーエプソン株式会社 核酸増幅方法、核酸抽出用デバイス、核酸増幅反応用カートリッジ、及び核酸増幅反応用キット
JP2015073513A (ja) * 2013-10-11 2015-04-20 セイコーエプソン株式会社 核酸抽出用デバイス、核酸抽出用キット、及び核酸抽出用装置
JP2015084657A (ja) * 2013-10-28 2015-05-07 セイコーエプソン株式会社 核酸抽出用デバイス
EP3074132A2 (en) * 2013-11-25 2016-10-05 Gencell Biosystems Limited Magnetic separation
JP2015104363A (ja) * 2013-11-29 2015-06-08 セイコーエプソン株式会社 核酸増幅反応用カートリッジ、及び核酸増幅反応用カートリッジキット
JP2015104364A (ja) * 2013-11-29 2015-06-08 セイコーエプソン株式会社 核酸増幅反応用容器、核酸増幅反応用カートリッジ、及び核酸増幅反応用カートリッジキット
JP2015159754A (ja) * 2014-02-27 2015-09-07 セイコーエプソン株式会社 核酸増幅方法、核酸抽出用デバイス、核酸増幅反応用カートリッジ、及び核酸増幅反応用キット
JP2015159786A (ja) * 2014-02-28 2015-09-07 セイコーエプソン株式会社 標的物質の精製装置及び精製方法
US10533170B2 (en) 2014-03-14 2020-01-14 Shimadzu Corporation Method for manipulating magnetic particles and device for manipulating magnetic particles
WO2015141828A1 (ja) * 2014-03-20 2015-09-24 ユニバーサル・バイオ・リサーチ株式会社 導光集積検査装置およびその検査方法
JP2015188378A (ja) * 2014-03-28 2015-11-02 セイコーエプソン株式会社 核酸分析装置、及び核酸分析方法
JP6323550B2 (ja) * 2014-05-23 2018-05-16 株式会社島津製作所 磁性体粒子の操作方法
JP6350654B2 (ja) * 2014-05-23 2018-07-04 株式会社島津製作所 磁性体粒子の操作方法
EP3155421B1 (en) * 2014-06-12 2019-02-20 Sikeliup S.r.l. Container for determining of analytes and/or chemico-physical parameters, as well as determining of urinary sediment, in urine; and method of full urine analysis using this container
US9337007B2 (en) 2014-06-15 2016-05-10 Ionsense, Inc. Apparatus and method for generating chemical signatures using differential desorption
KR102323205B1 (ko) * 2014-08-22 2021-11-08 삼성전자주식회사 표적물질 분리장치 및 표적물질 분리방법
CN104297039B (zh) 2014-09-25 2017-01-11 深圳市奥特库贝科技有限公司 一种新型磁分离机构
JP2016067277A (ja) * 2014-09-30 2016-05-09 セイコーエプソン株式会社 生体関連物質抽出デバイス及び生体関連物質抽出装置
JP2016067273A (ja) * 2014-09-30 2016-05-09 セイコーエプソン株式会社 容器組立体及び容器組立体キット
JP2016067274A (ja) * 2014-09-30 2016-05-09 セイコーエプソン株式会社 物質精製デバイス及びカートリッジ
JP6378780B2 (ja) * 2014-11-17 2018-08-22 株式会社島津製作所 粒子操作方法および粒子操作用装置
JP2016101097A (ja) * 2014-11-27 2016-06-02 セイコーエプソン株式会社 核酸抽出用デバイス
JP6353155B2 (ja) * 2014-12-02 2018-07-04 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 微小流体工学システムにおける磁性粒子の分散および蓄積
CN105754988B (zh) * 2014-12-15 2019-05-03 深圳华大智造科技有限公司 用于磁珠捕获dna的纯化方法、装置及自动化移液站
JP6332012B2 (ja) * 2014-12-22 2018-05-30 株式会社島津製作所 磁性体粒子操作用装置
US10941394B2 (en) 2015-01-15 2021-03-09 Shimadzu Corporation Device for manipulating magnetic particles and method for manipulating magnetic particles
WO2016121102A1 (ja) * 2015-01-30 2016-08-04 株式会社島津製作所 磁性体粒子操作用デバイスおよび磁性体粒子の操作方法
JP2016158557A (ja) * 2015-03-02 2016-09-05 セイコーエプソン株式会社 容器、生体関連物質精製カートリッジ及び生体関連物質精製カートリッジ組立体キット
CN105176972B (zh) * 2015-08-26 2019-05-21 复旦大学附属华山医院 一种快速提取全血基因组dna的装置及其方法
US9656267B2 (en) * 2015-09-17 2017-05-23 Nvigen, Inc. Magnetic rack
US9899196B1 (en) 2016-01-12 2018-02-20 Jeol Usa, Inc. Dopant-assisted direct analysis in real time mass spectrometry
JP2017127224A (ja) * 2016-01-19 2017-07-27 株式会社島津製作所 核酸前処理キット、および塩基配列解析方法
CN119056579A (zh) * 2016-03-18 2024-12-03 安德鲁联合有限公司 液体处理器的尖端中的珠子操作方法及装置
JP7035316B2 (ja) * 2017-02-09 2022-03-15 株式会社島津製作所 磁性体粒子操作用デバイス
KR101895597B1 (ko) * 2017-02-20 2018-09-07 강릉원주대학교산학협력단 정지 액체상 랩온어튜빙
WO2018185908A1 (ja) 2017-04-06 2018-10-11 株式会社島津製作所 磁性体粒子操作用デバイス
US10636640B2 (en) 2017-07-06 2020-04-28 Ionsense, Inc. Apparatus and method for chemical phase sampling analysis
US20190015833A1 (en) * 2017-07-14 2019-01-17 Dexter Magnetic Technologies, Inc. Illumination device for microtiter well trays, tubes and tube strips
JP2018161649A (ja) * 2018-04-10 2018-10-18 株式会社島津製作所 磁性体粒子の操作方法および磁性体粒子操作用デバイス
US10825673B2 (en) 2018-06-01 2020-11-03 Ionsense Inc. Apparatus and method for reducing matrix effects
CN108796038B (zh) * 2018-06-26 2019-10-18 杭州优思达生物技术有限公司 一种核酸一体化检测方法及检测试剂管
JP7091891B2 (ja) * 2018-07-06 2022-06-28 株式会社島津製作所 磁性体粒子操作用容器
JP3220518U (ja) 2018-11-14 2019-03-14 株式会社島津製作所 磁性体粒子操作用装置
WO2020105159A1 (ja) * 2018-11-22 2020-05-28 株式会社島津製作所 磁性体粒子の操作方法及び装置
WO2020129365A1 (ja) * 2018-12-19 2020-06-25 株式会社島津製作所 磁性体粒子操作デバイス
JP7305988B2 (ja) * 2019-03-09 2023-07-11 株式会社島津製作所 粒子操作用デバイス
JP7705845B2 (ja) 2019-10-28 2025-07-10 イオンセンス インコーポレイテッド 大気リアルタイムイオン化
CN115362372A (zh) 2020-04-03 2022-11-18 安德鲁联合有限公司 耗材中的微珠操控
US11913861B2 (en) 2020-05-26 2024-02-27 Bruker Scientific Llc Electrostatic loading of powder samples for ionization
JP7138677B2 (ja) * 2020-07-14 2022-09-16 株式会社島津製作所 核酸前処理キット、および塩基配列解析方法
EP4334469A4 (en) * 2021-05-06 2025-01-29 Abbott Molecular Inc. COMPOSITIONS AND METHODS OF COLLECTION OF SINGLE SAMPLES
CN113528333B (zh) * 2021-07-20 2022-03-08 北京擎科生物科技有限公司 核酸合成反应装置及核酸合成方法
CN116727104A (zh) * 2022-03-04 2023-09-12 宁德时代新能源科技股份有限公司 分离方法及分离装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59154362A (ja) * 1983-02-18 1984-09-03 テクニコン，インストルメンツ，コーポレーシヨン 凝固防止血液からリンパ球を分離する方法および装置
JPH02502405A (ja) * 1987-12-01 1990-08-02 ベーリンガー　マンヘイム　コーポレイション アッセイを実施するための方法及び装置
US20080160630A1 (en) * 2006-12-29 2008-07-03 Intel Corporation Enzymatic signal generation and detection of binding complexes in stationary fluidic chip

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3313358A (en) 1964-04-01 1967-04-11 Chevron Res Conductor casing for offshore drilling and well completion
US4786600A (en) 1984-05-25 1988-11-22 The Trustees Of Columbia University In The City Of New York Autocatalytic replication of recombinant RNA
FI850481A0 (fi) * 1985-02-06 1985-02-06 Labsystems Oy Foerfarande foer bestaemning av motmedel eller antigener.
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
NL8900725A (nl) 1989-03-23 1990-10-16 Az Univ Amsterdam Werkwijze en combinatie van middelen voor het isoleren van nucleinezuur.
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5354688A (en) 1990-05-11 1994-10-11 Associated Universities, Inc. Anaerobic microbial remobilization of coprecipitated metals
JP2643586B2 (ja) 1990-11-09 1997-08-20 日本電気株式会社 光学式情報記録再生装置
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US6951722B2 (en) 1999-03-19 2005-10-04 Takara Bio Inc. Method for amplifying nucleic acid sequence
EA004327B1 (ru) 1999-03-19 2004-04-29 Такара Био. Инк. Способ амплификации последовательности нуклеиновой кислоты
WO2000058877A2 (en) 1999-03-26 2000-10-05 Basil Products A/S Electronic resource system
CA2592204C (en) * 2004-12-23 2013-03-12 I-Stat Corporation Nucleic acid diagnostics system and methods
US7998708B2 (en) * 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
WO2008063135A1 (en) * 2006-11-24 2008-05-29 Agency For Science, Technology And Research Apparatus for processing a sample in a liquid droplet and method of using the same
EP2060637A1 (en) * 2007-11-14 2009-05-20 Koninklijke Philips Electronics N.V. Means and methods for detection of nucleic acids
CN101430334A (zh) * 2008-11-05 2009-05-13 中国科学院上海应用物理研究所 基于核酸适体的靶物质的检测方法及其固相生物感应器
CN101838702A (zh) * 2010-06-02 2010-09-22 何农跃 高通量单核苷酸多态性检测方法
US9517472B2 (en) * 2010-12-21 2016-12-13 Shimadzu Corporation Device and method for processing target component in tube

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59154362A (ja) * 1983-02-18 1984-09-03 テクニコン，インストルメンツ，コーポレーシヨン 凝固防止血液からリンパ球を分離する方法および装置
JPH02502405A (ja) * 1987-12-01 1990-08-02 ベーリンガー　マンヘイム　コーポレイション アッセイを実施するための方法及び装置
US20080160630A1 (en) * 2006-12-29 2008-07-03 Intel Corporation Enzymatic signal generation and detection of binding complexes in stationary fluidic chip

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