JP4187277B2 - グリコシル化し得る抗原結合単鎖タンパク質、それらの生成および使用 - Google Patents

グリコシル化し得る抗原結合単鎖タンパク質、それらの生成および使用 Download PDF

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JP4187277B2
JP4187277B2 JP54735198A JP54735198A JP4187277B2 JP 4187277 B2 JP4187277 B2 JP 4187277B2 JP 54735198 A JP54735198 A JP 54735198A JP 54735198 A JP54735198 A JP 54735198A JP 4187277 B2 JP4187277 B2 JP 4187277B2
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polypeptide
amino acid
antigen
asn
binding
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JP2002516610A (ja
JP2002516610A5 (US07632504-20091215-C00005.png
Inventor
アール． フィルプラ，デイビッド
ワン，マオリャン
ジー．エル． ショー，ロバート
ディー． ウィトロー，マーク
エス． リー，リーシュン
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エンゾン ファーマシューティカルズ， インコーポレイテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
JP54735198A 1997-04-30 1998-04-30 グリコシル化し得る抗原結合単鎖タンパク質、それらの生成および使用 Expired - Lifetime JP4187277B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US4444997P 1997-04-30 1997-04-30
US60/044,449 1997-04-30
US5047297P 1997-06-23 1997-06-23
US60/050,472 1997-06-23
US6307497P 1997-10-27 1997-10-27
US60/063,074 1997-10-27
US6734197P 1997-12-02 1997-12-02
US60/067,341 1997-12-02
PCT/US1998/008662 WO1998049198A1 (en) 1997-04-30 1998-04-30 Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof

Publications (3)

Publication Number Publication Date
JP2002516610A JP2002516610A (ja) 2002-06-04
JP2002516610A5 JP2002516610A5 (US07632504-20091215-C00005.png) 2005-12-02
JP4187277B2 true JP4187277B2 (ja) 2008-11-26

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JP54734798A Pending JP2002505574A (ja) 1997-04-30 1998-04-30 ポリアルキレンオキシド修飾された単鎖ポリペプチド
JP54735198A Expired - Lifetime JP4187277B2 (ja) 1997-04-30 1998-04-30 グリコシル化し得る抗原結合単鎖タンパク質、それらの生成および使用
JP2008008563A Withdrawn JP2008115193A (ja) 1997-04-30 2008-01-17 ポリアルキレンオキシド修飾された単鎖ポリペプチド
JP2009281051A Withdrawn JP2010051331A (ja) 1997-04-30 2009-12-10 ポリアルキレンオキシド修飾された単鎖ポリペプチド

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JP54734798A Pending JP2002505574A (ja) 1997-04-30 1998-04-30 ポリアルキレンオキシド修飾された単鎖ポリペプチド

Family Applications After (2)

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JP2008008563A Withdrawn JP2008115193A (ja) 1997-04-30 2008-01-17 ポリアルキレンオキシド修飾された単鎖ポリペプチド
JP2009281051A Withdrawn JP2010051331A (ja) 1997-04-30 2009-12-10 ポリアルキレンオキシド修飾された単鎖ポリペプチド

Country Status (6)

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US (8) US6323322B1 (US07632504-20091215-C00005.png)
EP (2) EP0979102A4 (US07632504-20091215-C00005.png)
JP (4) JP2002505574A (US07632504-20091215-C00005.png)
AU (2) AU7266698A (US07632504-20091215-C00005.png)
CA (2) CA2288994C (US07632504-20091215-C00005.png)
WO (2) WO1998049198A1 (US07632504-20091215-C00005.png)

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