MX370138B - Liberación de protones de nitrobenzaldehído para la manipulación de la acidosis celular. - Google Patents

Liberación de protones de nitrobenzaldehído para la manipulación de la acidosis celular.

Info

Publication number
MX370138B
MX370138B MX2016011182A MX2016011182A MX370138B MX 370138 B MX370138 B MX 370138B MX 2016011182 A MX2016011182 A MX 2016011182A MX 2016011182 A MX2016011182 A MX 2016011182A MX 370138 B MX370138 B MX 370138B
Authority
MX
Mexico
Prior art keywords
nitrobenzaldehyde
manipulation
proton release
photo
cellular acidosis
Prior art date
Application number
MX2016011182A
Other languages
English (en)
Other versions
MX2016011182A (es
Inventor
GDOVIN Matthew
O´GRADY Brian
FRIAS Elma
HAZLETT Haley
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of MX2016011182A publication Critical patent/MX2016011182A/es
Publication of MX370138B publication Critical patent/MX370138B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0661—Radiation therapy using light characterised by the wavelength of light used ultraviolet

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Algunas modalidades se refieren a compuestos foto-activados para la manipulación del pH en una célula. En ciertos aspectos, el compuesto foto-activado es 2-nitrobenzaldehído (NBA). Los compuestos foto-activados se pueden utilizar como una terapia dirigida para una variedad de estados y condiciones de enfermedad, tales como el cáncer.
MX2016011182A 2014-02-26 2015-02-26 Liberación de protones de nitrobenzaldehído para la manipulación de la acidosis celular. MX370138B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461944988P 2014-02-26 2014-02-26
PCT/US2015/017862 WO2015130997A1 (en) 2014-02-26 2015-02-26 Nitrobenzaldehyde proton release for manipulation of cellular acidosis

Publications (2)

Publication Number Publication Date
MX2016011182A MX2016011182A (es) 2017-01-23
MX370138B true MX370138B (es) 2019-12-03

Family

ID=54009638

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016011182A MX370138B (es) 2014-02-26 2015-02-26 Liberación de protones de nitrobenzaldehído para la manipulación de la acidosis celular.

Country Status (8)

Country Link
US (1) US10946096B2 (es)
EP (1) EP3110448B1 (es)
JP (1) JP6836399B2 (es)
CN (1) CN107073119A (es)
AU (1) AU2015222879B2 (es)
CA (1) CA2940961C (es)
MX (1) MX370138B (es)
WO (1) WO2015130997A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018094035A2 (en) * 2016-11-16 2018-05-24 Purdue Research Foundation Ligand ionophore conjugates
WO2023161862A2 (en) * 2022-02-24 2023-08-31 Robinov Shmuel Methods of use of benzaldehyde compositions
CN114931583B (zh) * 2022-05-27 2023-09-22 四川大学 一种核壳型近红外光控顺序释药水凝胶的制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1181804A (en) 1913-12-27 1916-05-02 Frank Simpson Removable bottle-valve.
JPS5569510A (en) 1978-11-16 1980-05-26 Mitsubishi Chem Ind Ltd Carcinostatic agent
JP4187277B2 (ja) 1997-04-30 2008-11-26 エンゾン ファーマシューティカルズ， インコーポレイテッド グリコシル化し得る抗原結合単鎖タンパク質、それらの生成および使用
US6180095B1 (en) 1997-12-17 2001-01-30 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
AU1825299A (en) 1997-12-17 1999-07-05 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US5965119A (en) 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US6624142B2 (en) 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
GB9818627D0 (en) 1998-08-26 1998-10-21 Glaxo Group Ltd Improvements in dva vaccination
US6464625B2 (en) 1999-06-23 2002-10-15 Robert A. Ganz Therapeutic method and apparatus for debilitating or killing microorganisms within the body
US20030114434A1 (en) 1999-08-31 2003-06-19 James Chen Extended duration light activated cancer therapy
US7122189B2 (en) 2002-08-13 2006-10-17 Enzon, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
US7087229B2 (en) 2003-05-30 2006-08-08 Enzon Pharmaceuticals, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
CA2585091C (en) * 2004-11-03 2016-07-19 University Of Kansas Novobiocin analogues as anticancer agents
JP4696259B2 (ja) 2004-11-10 2011-06-08 独立行政法人産業技術総合研究所 新規光感受性薬剤及びその製造方法
US7795380B2 (en) * 2006-06-02 2010-09-14 University Of Iowa Research Foundation Compositions and methods for nucleic acid delivery
CZ2008523A3 (cs) 2008-08-29 2009-10-14 Fyzikální ústav AV CR, v.v.i. Zpusob prípravy hybridních nanocástic z aglomerátu nanocástic komplexních vícesložkových oxidu kovu
TWI402501B (zh) 2009-12-09 2013-07-21 Nat Univ Tsing Hua 免疫檢測探針及利用免疫檢測方法

Also Published As

Publication number Publication date
EP3110448A4 (en) 2017-09-13
CA2940961A1 (en) 2015-09-03
US10946096B2 (en) 2021-03-16
EP3110448A1 (en) 2017-01-04
EP3110448B1 (en) 2020-09-09
AU2015222879A1 (en) 2016-09-15
JP6836399B2 (ja) 2021-03-03
MX2016011182A (es) 2017-01-23
CN107073119A (zh) 2017-08-18
JP2017506665A (ja) 2017-03-09
CA2940961C (en) 2022-07-12
AU2015222879B2 (en) 2019-12-05
WO2015130997A1 (en) 2015-09-03
US20170202964A1 (en) 2017-07-20

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