ATE382053T1 - System zur antikörperexpression und- synthese - Google Patents
System zur antikörperexpression und- syntheseInfo
- Publication number
- ATE382053T1 ATE382053T1 AT02763536T AT02763536T ATE382053T1 AT E382053 T1 ATE382053 T1 AT E382053T1 AT 02763536 T AT02763536 T AT 02763536T AT 02763536 T AT02763536 T AT 02763536T AT E382053 T1 ATE382053 T1 AT E382053T1
- Authority
- AT
- Austria
- Prior art keywords
- expression
- antibodies
- synthesis
- systems
- recombinant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31520901P | 2001-08-27 | 2001-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE382053T1 true ATE382053T1 (de) | 2008-01-15 |
Family
ID=23223369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02763536T ATE382053T1 (de) | 2001-08-27 | 2002-08-26 | System zur antikörperexpression und- synthese |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US20030077739A1 (de) |
| EP (1) | EP1427744B1 (de) |
| JP (1) | JP4461210B2 (de) |
| KR (1) | KR100968664B1 (de) |
| CN (1) | CN100513414C (de) |
| AT (1) | ATE382053T1 (de) |
| CA (1) | CA2454731C (de) |
| DE (1) | DE60224291T2 (de) |
| MX (1) | MXPA04001566A (de) |
| NZ (1) | NZ530852A (de) |
| WO (1) | WO2003018771A2 (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6979556B2 (en) * | 2000-12-14 | 2005-12-27 | Genentech, Inc. | Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes |
| EP1427744B1 (de) * | 2001-08-27 | 2007-12-26 | Genentech, Inc. | System zur antikörperexpression und- synthese |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| PT2314629E (pt) | 2002-07-18 | 2014-01-22 | Merus B V | Produção recombinante de misturas de anticorpos |
| US7575893B2 (en) | 2003-01-23 | 2009-08-18 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| US9708410B2 (en) | 2003-05-30 | 2017-07-18 | Janssen Biotech, Inc. | Anti-tissue factor antibodies and compositions |
| EP2395016A3 (de) | 2003-05-30 | 2012-12-19 | Merus B.V. | Entwurf und Verwendung von gepaarten unterschiedlichen Regionen von spezifisch bindenden Molekülen |
| US7605235B2 (en) * | 2003-05-30 | 2009-10-20 | Centocor, Inc. | Anti-tissue factor antibodies and compositions |
| KR100570422B1 (ko) * | 2003-10-16 | 2006-04-11 | 한미약품 주식회사 | 대장균 분비서열을 이용하여 항체 단편을 분비·생산하는 발현벡터 및 이를 이용하여 항체 단편을 대량 생산하는 방법 |
| CN100475965C (zh) * | 2005-07-22 | 2009-04-08 | 上海高科联合生物技术研发有限公司 | 一种大肠杆菌高效外分泌表达溶葡萄球菌酶的方法 |
| WO2009021548A1 (en) * | 2007-08-10 | 2009-02-19 | Wacker Chemie Ag | Expression of full length igg and secretion into the culture medium of prokaryotic cells |
| WO2009107129A1 (en) * | 2008-02-29 | 2009-09-03 | Ramot At Tel Aviv University Ltd. | Immunoglobulin compositions and methods of producing same |
| JP5463528B2 (ja) * | 2009-02-25 | 2014-04-09 | 味の素株式会社 | L−システイン生産菌及びl−システインの製造法 |
| IN2012DN02401A (de) | 2009-09-24 | 2015-08-21 | Ucb Pharma Sa | |
| CN105274170A (zh) * | 2009-11-05 | 2016-01-27 | 弗·哈夫曼-拉罗切有限公司 | 分泌异源多肽的方法和组合物 |
| GB201000587D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| GB201000588D0 (en) * | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
| GB201000590D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
| GB201000591D0 (en) * | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| GB201012599D0 (en) | 2010-07-27 | 2010-09-08 | Ucb Pharma Sa | Process for purifying proteins |
| US8722044B2 (en) | 2011-03-15 | 2014-05-13 | Janssen Biotech, Inc. | Human tissue factor antibody and uses thereof |
| JP5972866B2 (ja) | 2011-03-31 | 2016-08-17 | クニミネ工業株式会社 | タンパク質結晶化条件探索剤及びタンパク質結晶化条件探索方法 |
| PL2731973T3 (pl) | 2011-07-13 | 2018-04-30 | Ucb Biopharma Sprl | Bakteryjny szczep gospodarz wykazujący ekspresję dsbc |
| WO2013124474A2 (en) | 2012-02-23 | 2013-08-29 | Stage Cell Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| DK2838917T3 (da) | 2012-04-20 | 2019-08-26 | Merus Nv | Fremgangsmåder og midler til frembringelse af heterodimere ig-lignende molekyler |
| GB201208367D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Biological product |
| SI2870247T1 (sl) * | 2012-07-05 | 2019-10-30 | Hoffmann La Roche | Ekspresijski in sekrecijski sistem |
| US20150353940A1 (en) * | 2013-08-05 | 2015-12-10 | Absci, Llc | Vectors for use in an inducible coexpression system |
| ES2750005T3 (es) * | 2012-08-05 | 2020-03-24 | Absci Llc | Sistema de coexpresión inducible |
| CN103468735B (zh) * | 2013-09-18 | 2016-01-20 | 山西大学 | 重组华溪蟹金属硫蛋白(rcMT)及其单克隆抗体的制备 |
| BR112016020822A2 (pt) | 2014-03-14 | 2017-10-03 | Genentech Inc | Métodos e composições para secreção de polipeptídeos heterólogos |
| BR112016021383A2 (pt) | 2014-03-24 | 2017-10-03 | Genentech Inc | Método para identificar um paciente com câncer que é susceptível ou menos susceptível a responder ao tratamento com um antagonista de cmet, método para identificar um paciente apresentando câncer previamente tratado, método para determinar a expressão do biomarcador hgf, antagonista anti-c-met e seu uso, kit de diagnóstico e seu método de preparo |
| MX368664B (es) | 2014-04-29 | 2019-10-10 | Novartis Ag | Células novedosas de vertebrados y métodos para la expresión recombinante de un polipéptido de interés. |
| SI3164492T1 (sl) * | 2014-07-03 | 2020-02-28 | F. Hoffmann-La Roche Ag | Sistem polipeptidne ekspresije |
| PT3167065T (pt) * | 2014-07-09 | 2020-07-01 | Lupin Ltd | Sistema de expressão bacteriana dual cistrónica |
| AU2015342964B2 (en) | 2014-11-05 | 2021-06-24 | Genentech, Inc. | Methods of producing two chain proteins in bacteria |
| CA2966558C (en) | 2014-11-05 | 2024-03-12 | Genentech, Inc. | Methods of producing two chain proteins in bacteria |
| EP3365678A1 (de) | 2015-10-22 | 2018-08-29 | Juno Therapeutics GmbH | Verfahren zur kultivierung von zellen sowie kits und vorrichtung dafür |
| EP3365453A2 (de) | 2015-10-22 | 2018-08-29 | Juno Therapeutics GmbH | Verfahren, kits, mittel und vorrichtungen zur transduktion |
| CN105505884B (zh) * | 2016-01-26 | 2017-10-03 | 郑州师范学院 | 进行抗体表达和组装的重组系统及应用 |
| EP4647493A3 (de) | 2017-04-27 | 2026-01-14 | Juno Therapeutics, Inc. | Oligomere partikelreagenzien und verfahren zur verwendung davon |
| JP7278261B2 (ja) | 2017-08-23 | 2023-05-19 | ノバルティス アーゲー | マルチコピー遺伝子タンパク質発現系 |
| EP3727470B1 (de) | 2017-12-18 | 2024-11-20 | Ventana Medical Systems, Inc. | Peptid-nukleinsäure-konjugate |
| AU2019221642A1 (en) * | 2018-02-14 | 2020-07-09 | Generation Bio Co. | Non-viral DNA vectors and uses thereof for antibody and fusion protein production |
| EP3774926A1 (de) | 2018-04-05 | 2021-02-17 | Bio-Rad ABD Serotec GmbH | Anzeigesysteme für proteine von interesse |
| US12522660B2 (en) | 2018-10-31 | 2026-01-13 | C3S2 Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| EP3877407B1 (de) * | 2018-11-05 | 2026-03-11 | F. Hoffmann-La Roche AG | Verfahren zur herstellung von zwei kettenproteinen in prokaryotischen wirtszellen |
| US11352445B2 (en) * | 2018-12-31 | 2022-06-07 | Jecho Laboratories Inc. | Method for preparing recombinant protein from bacterium and composition containing the same |
| CN120248098A (zh) * | 2019-01-23 | 2025-07-04 | 豪夫迈·罗氏有限公司 | 在真核宿主细胞中产生多聚体蛋白质的方法 |
| WO2020188350A1 (en) | 2019-03-18 | 2020-09-24 | Bio-Rad Abd Serotec Gmbh | Protection of spytag-containing periplasmic fusion proteins from protease tsp and ompt degradation |
| SE544000C2 (en) * | 2020-03-17 | 2021-10-26 | Xbrane Biopharma Ab | Novel combination of tis sequence, signal peptide sequence and nucleic acid sequence encoding a recombinant protein |
| SE544001C2 (en) * | 2020-03-17 | 2021-10-26 | Xbrane Biopharma Ab | Novel combination of tis sequences, signal peptide sequences and nucleic acid sequences encoding heavy and light chains of an antibody |
| WO2022051167A1 (en) * | 2020-09-03 | 2022-03-10 | Acumed Llc | Drill having radiographically visible depth indications |
| KR20250099224A (ko) | 2022-11-01 | 2025-07-01 | 하이델베르크 파마 리서치 게엠베하 | 항-gucy2c 항체 및 이의 용도 |
| EP4566631A1 (de) | 2023-12-06 | 2025-06-11 | Heidelberg Pharma Research GmbH | Neues antikörper-wirkstoff-konjugat sowie verfahren zur herstellung und verwendungen davon |
Family Cites Families (56)
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|---|---|---|---|---|
| USRE30985E (en) * | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| US4560655A (en) * | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) * | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
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| US4767704A (en) * | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
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| US5508192A (en) * | 1990-11-09 | 1996-04-16 | Board Of Regents, The University Of Texas System | Bacterial host strains for producing proteolytically sensitive polypeptides |
| US5264365A (en) * | 1990-11-09 | 1993-11-23 | Board Of Regents, The University Of Texas System | Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides |
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| WO1993008300A1 (en) | 1991-10-18 | 1993-04-29 | The University Of Calgary | Expression-secretion vectors for the production of biologically active fv fragments |
| US20020037558A1 (en) | 1991-10-23 | 2002-03-28 | Kin-Ming Lo | E.coli produced immunoglobulin constructs |
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| EP0627940B1 (de) | 1992-03-05 | 2003-05-07 | Board of Regents, The University of Texas System | Verwendung von Immunokonjugate zur Diagnose und/oder Therapie der vaskularisierten Tumoren |
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| FR2715664B1 (fr) * | 1994-01-31 | 1996-04-12 | Proteine Performance Sa | Baculovirus recombinant et son utilisation pour la production d'anticorps monoclonaux. |
| FR2724182B1 (fr) * | 1994-09-02 | 1996-12-13 | Pasteur Institut | Obtention d'un anticorps monoclonal recombinant a partir d'un anticorps monoclonal humain anti-rhesus d, sa production en cellules d'insecte, et ses utilisations |
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| DK0999853T3 (da) | 1997-06-13 | 2003-04-22 | Genentech Inc | Stabiliseret antostofformulering |
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| CA2305631A1 (en) * | 1997-10-23 | 1999-05-06 | Andreas Pluckthun | Methods for identifying nucleic acid sequences and (poly)peptides which increase the expression yields of functional periplasmic proteins |
| DE69937291T2 (de) | 1998-04-02 | 2008-07-10 | Genentech, Inc., South San Francisco | Antikörpervarianten und fragmente davon |
| PT1124941E (pt) * | 1998-10-28 | 2004-02-27 | Genentech Inc | Processo para recuperar polipeptidos heterologos a partir de celulas bacterianas |
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| EP1077263A1 (de) * | 1999-07-29 | 2001-02-21 | F.Hoffmann-La Roche Ag | Verfahren zur Herstellung von natürlich gefalteten und sekretierten Proteinen durch Co-Sekretion von Chaperonen |
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| AU2001270118A1 (en) * | 2000-08-24 | 2002-03-04 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| US6979556B2 (en) * | 2000-12-14 | 2005-12-27 | Genentech, Inc. | Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes |
| MXPA03005273A (es) * | 2000-12-14 | 2003-09-25 | Genentech Inc | Anticuerpos producidos procarioticamente y sus usos. |
| CA2430249A1 (en) * | 2000-12-14 | 2002-06-20 | Genentech, Inc. | Bacterial host strains |
| EP1427744B1 (de) | 2001-08-27 | 2007-12-26 | Genentech, Inc. | System zur antikörperexpression und- synthese |
-
2002
- 2002-08-26 EP EP02763536A patent/EP1427744B1/de not_active Expired - Lifetime
- 2002-08-26 CA CA2454731A patent/CA2454731C/en not_active Expired - Lifetime
- 2002-08-26 DE DE60224291T patent/DE60224291T2/de not_active Expired - Lifetime
- 2002-08-26 AT AT02763536T patent/ATE382053T1/de active
- 2002-08-26 MX MXPA04001566A patent/MXPA04001566A/es active IP Right Grant
- 2002-08-26 JP JP2003523622A patent/JP4461210B2/ja not_active Expired - Lifetime
- 2002-08-26 CN CNB028168879A patent/CN100513414C/zh not_active Expired - Lifetime
- 2002-08-26 KR KR1020047002856A patent/KR100968664B1/ko not_active Expired - Lifetime
- 2002-08-26 WO PCT/US2002/027220 patent/WO2003018771A2/en not_active Ceased
- 2002-08-26 NZ NZ530852A patent/NZ530852A/en not_active IP Right Cessation
- 2002-08-26 US US10/227,694 patent/US20030077739A1/en not_active Abandoned
-
2006
- 2006-02-09 US US11/351,886 patent/US20060246542A1/en not_active Abandoned
- 2006-05-22 US US11/438,484 patent/US20070015244A1/en not_active Abandoned
-
2007
- 2007-01-25 US US11/627,071 patent/US20070224664A1/en not_active Abandoned
-
2011
- 2011-02-23 US US13/033,521 patent/US20110244517A1/en not_active Abandoned
-
2013
- 2013-09-05 US US14/019,399 patent/US9688775B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60224291D1 (de) | 2008-02-07 |
| US20030077739A1 (en) | 2003-04-24 |
| US20060246542A1 (en) | 2006-11-02 |
| CN100513414C (zh) | 2009-07-15 |
| EP1427744A4 (de) | 2005-12-07 |
| EP1427744A2 (de) | 2004-06-16 |
| NZ530852A (en) | 2006-11-30 |
| JP2005517385A (ja) | 2005-06-16 |
| US20110244517A1 (en) | 2011-10-06 |
| JP4461210B2 (ja) | 2010-05-12 |
| KR100968664B1 (ko) | 2010-07-06 |
| US20140120580A1 (en) | 2014-05-01 |
| MXPA04001566A (es) | 2004-05-17 |
| US20070015244A1 (en) | 2007-01-18 |
| CA2454731A1 (en) | 2003-03-06 |
| CA2454731C (en) | 2010-11-02 |
| EP1427744B1 (de) | 2007-12-26 |
| CN1549821A (zh) | 2004-11-24 |
| DE60224291T2 (de) | 2008-12-11 |
| US20070224664A1 (en) | 2007-09-27 |
| WO2003018771A3 (en) | 2004-03-11 |
| WO2003018771A2 (en) | 2003-03-06 |
| KR20040031011A (ko) | 2004-04-09 |
| US9688775B2 (en) | 2017-06-27 |
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