|
GB939516A
(en)
|
1961-05-29 |
1963-10-16 |
British Drug Houses Ltd |
Sulphonyl ureas
|
|
US3702849A
(en)
|
1967-10-26 |
1972-11-14 |
Pfizer |
4-(isoquinolin-1-yl) piperazine-1-carboxylic acid esters
|
|
US3752660A
(en)
|
1971-03-15 |
1973-08-14 |
Allied Chem |
Chlorophenoxyacetyloxazolidone herbicides and preparation thereof
|
|
US4436748A
(en)
|
1980-10-20 |
1984-03-13 |
Hoechst-Roussel Pharmaceuticals Inc. |
Benzo[b]thiophenes
|
|
US4439606A
(en)
|
1982-05-06 |
1984-03-27 |
American Cyanamid Company |
Antiatherosclerotic 1-piperazinecarbonyl compounds
|
|
EP0094498A3
(en)
|
1982-05-06 |
1985-04-03 |
American Cyanamid Company |
Antiatherosclerotic 1-piperazine derivatives
|
|
US4656181A
(en)
|
1982-11-24 |
1987-04-07 |
Cermol S.A. |
Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
|
|
JPS59163372A
(ja)
|
1983-03-09 |
1984-09-14 |
Showa Denko Kk |
ピラゾ−ル誘導体とその製造法及び除草剤
|
|
JPS60193955A
(ja)
|
1984-03-13 |
1985-10-02 |
Mitsui Toatsu Chem Inc |
環式不飽和アミド置換エ−テル化合物及びその製造方法
|
|
JPS6143190A
(ja)
|
1984-08-06 |
1986-03-01 |
Mitsui Petrochem Ind Ltd |
ピリドピリミジン誘導体およびその製法
|
|
US4911920A
(en)
|
1986-07-30 |
1990-03-27 |
Alcon Laboratories, Inc. |
Sustained release, comfort formulation for glaucoma therapy
|
|
FR2588189B1
(fr)
|
1985-10-03 |
1988-12-02 |
Merck Sharp & Dohme |
Composition pharmaceutique de type a transition de phase liquide-gel
|
|
US5052558A
(en)
|
1987-12-23 |
1991-10-01 |
Entravision, Inc. |
Packaged pharmaceutical product
|
|
US5033252A
(en)
|
1987-12-23 |
1991-07-23 |
Entravision, Inc. |
Method of packaging and sterilizing a pharmaceutical product
|
|
US5010175A
(en)
|
1988-05-02 |
1991-04-23 |
The Regents Of The University Of California |
General method for producing and selecting peptides with specific properties
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
US5925525A
(en)
|
1989-06-07 |
1999-07-20 |
Affymetrix, Inc. |
Method of identifying nucleotide differences
|
|
IE66205B1
(en)
|
1990-06-14 |
1995-12-13 |
Paul A Bartlett |
Polypeptide analogs
|
|
US5650489A
(en)
|
1990-07-02 |
1997-07-22 |
The Arizona Board Of Regents |
Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
|
|
DK0495421T3
(da)
|
1991-01-15 |
1996-12-09 |
Alcon Lab Inc |
Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
|
|
US5212162A
(en)
|
1991-03-27 |
1993-05-18 |
Alcon Laboratories, Inc. |
Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
|
|
US6017696A
(en)
|
1993-11-01 |
2000-01-25 |
Nanogen, Inc. |
Methods for electronic stringency control for molecular biological analysis and diagnostics
|
|
US6051380A
(en)
|
1993-11-01 |
2000-04-18 |
Nanogen, Inc. |
Methods and procedures for molecular biological analysis and diagnostics
|
|
US5573905A
(en)
|
1992-03-30 |
1996-11-12 |
The Scripps Research Institute |
Encoded combinatorial chemical libraries
|
|
US5323907A
(en)
|
1992-06-23 |
1994-06-28 |
Multi-Comp, Inc. |
Child resistant package assembly for dispensing pharmaceutical medications
|
|
US5288514A
(en)
|
1992-09-14 |
1994-02-22 |
The Regents Of The University Of California |
Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
US5605798A
(en)
|
1993-01-07 |
1997-02-25 |
Sequenom, Inc. |
DNA diagnostic based on mass spectrometry
|
|
US5858659A
(en)
|
1995-11-29 |
1999-01-12 |
Affymetrix, Inc. |
Polymorphism detection
|
|
US6045996A
(en)
|
1993-10-26 |
2000-04-04 |
Affymetrix, Inc. |
Hybridization assays on oligonucleotide arrays
|
|
US6068818A
(en)
|
1993-11-01 |
2000-05-30 |
Nanogen, Inc. |
Multicomponent devices for molecular biological analysis and diagnostics
|
|
US5538848A
(en)
|
1994-11-16 |
1996-07-23 |
Applied Biosystems Division, Perkin-Elmer Corp. |
Method for detecting nucleic acid amplification using self-quenching fluorescence probe
|
|
IL111730A
(en)
|
1993-11-29 |
1998-12-06 |
Fujisawa Pharmaceutical Co |
Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
|
|
DE69531542T2
(de)
|
1994-02-07 |
2004-06-24 |
Beckman Coulter, Inc., Fullerton |
Ligase/polymerase-vermittelte analyse genetischer elemente von einzelnukleotid-polymorphismen und ihre verwendung in der genetischen analyse
|
|
US5593853A
(en)
|
1994-02-09 |
1997-01-14 |
Martek Corporation |
Generation and screening of synthetic drug libraries
|
|
US5539083A
(en)
|
1994-02-23 |
1996-07-23 |
Isis Pharmaceuticals, Inc. |
Peptide nucleic acid combinatorial libraries and improved methods of synthesis
|
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
|
EP0786997A4
(en)
|
1994-10-27 |
1998-03-11 |
Merck & Co Inc |
MUSCARINE ANTAGONISTS
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
JP3053222B2
(ja)
|
1995-04-20 |
2000-06-19 |
ファイザー・インコーポレーテッド |
Ｍｍｐおよびｔｎｆ抑制剤としてのアリールスルホニルヒドロキサム酸誘導体
|
|
FR2734816B1
(fr)
|
1995-05-31 |
1997-07-04 |
Adir |
Nouveaux aryl (alkyl) propylamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
DE69638269D1
(de)
|
1995-06-14 |
2010-11-18 |
Univ California |
Hochaffine humane antikörper gegen tumorantigene
|
|
ATE225343T1
(de)
|
1995-12-20 |
2002-10-15 |
Hoffmann La Roche |
Matrix-metalloprotease inhibitoren
|
|
US6011029A
(en)
|
1996-02-26 |
2000-01-04 |
Bristol-Myers Squibb Company |
Inhibitors of farnesyl protein transferase
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
CA2260898C
(en)
|
1996-07-18 |
2002-05-14 |
Pfizer Limited |
Phosphinate based inhibitors of matrix metalloproteases
|
|
PL331895A1
(en)
|
1996-08-23 |
1999-08-16 |
Pfizer |
Arylosulphonylamino derivatives of hydroxamic acid
|
|
US5777324A
(en)
|
1996-09-19 |
1998-07-07 |
Sequenom, Inc. |
Method and apparatus for maldi analysis
|
|
DE69730151T2
(de)
|
1997-01-06 |
2005-08-04 |
Pfizer Inc. |
Cyclische sulfonderivate
|
|
AU721748B2
(en)
|
1997-02-03 |
2000-07-13 |
Pfizer Products Inc. |
Arylsulfonylamino hydroxamic acid derivatives
|
|
GB9702194D0
(en)
|
1997-02-04 |
1997-03-26 |
Lilly Co Eli |
Sulphonide derivatives
|
|
CA2279863A1
(en)
|
1997-02-07 |
1998-08-13 |
Pfizer Inc. |
N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
|
|
WO1998034918A1
(en)
|
1997-02-11 |
1998-08-13 |
Pfizer Inc. |
Arylsulfonyl hydroxamic acid derivatives
|
|
US6291464B1
(en)
|
1997-02-17 |
2001-09-18 |
Fujisawa Pharmaceutical Co., Ltd. |
Aminopiperazine derivatives
|
|
UA73073C2
(uk)
|
1997-04-03 |
2005-06-15 |
Уайт Холдінгз Корпорейшн |
Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
|
|
US6002008A
(en)
|
1997-04-03 |
1999-12-14 |
American Cyanamid Company |
Substituted 3-cyano quinolines
|
|
US5919626A
(en)
|
1997-06-06 |
1999-07-06 |
Orchid Bio Computer, Inc. |
Attachment of unmodified nucleic acids to silanized solid phase surfaces
|
|
AU8253598A
(en)
|
1997-06-17 |
1999-01-04 |
Schering Corporation |
Novel n-substituted urea inhibitors of farnesyl-protein transferase
|
|
ID23668A
(id)
|
1997-08-08 |
2000-05-11 |
Pfizer Prod Inc |
Turunan asam ariloksiarilsulfonilamino hidroksamat
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
US6903118B1
(en)
|
1997-12-17 |
2005-06-07 |
Klinge Pharma Gmbh |
Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
|
|
DE19756236A1
(de)
|
1997-12-17 |
1999-07-01 |
Klinge Co Chem Pharm Fab |
Neue piperazinylsubstituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
|
|
CA2314401A1
(en)
|
1997-12-22 |
1999-07-01 |
Du Pont Pharmaceuticals Company |
Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
US7060431B2
(en)
|
1998-06-24 |
2006-06-13 |
Illumina, Inc. |
Method of making and decoding of array sensors with microspheres
|
|
DK1004578T3
(da)
|
1998-11-05 |
2004-06-28 |
Pfizer Prod Inc |
5-oxo-pyrrolidin-2-carboxylsyrehydroxamidderivater
|
|
US6429027B1
(en)
|
1998-12-28 |
2002-08-06 |
Illumina, Inc. |
Composite arrays utilizing microspheres
|
|
US6586447B1
(en)
|
1999-04-01 |
2003-07-01 |
Pfizer Inc |
3,3-disubstituted-oxindole derivatives useful as anticancer agents
|
|
US6511993B1
(en)
|
1999-06-03 |
2003-01-28 |
Kevin Neil Dack |
Metalloprotease inhibitors
|
|
GB9912961D0
(en)
|
1999-06-03 |
1999-08-04 |
Pfizer Ltd |
Metalloprotease inhibitors
|
|
EP1081137A1
(en)
|
1999-08-12 |
2001-03-07 |
Pfizer Products Inc. |
Selective inhibitors of aggrecanase in osteoarthritis treatment
|
|
CA2384838C
(en)
|
1999-09-13 |
2006-07-18 |
Nugen Technologies, Inc. |
Methods and compositions for linear isothermal amplification of polynucleotide sequences
|
|
TWI271406B
(en)
|
1999-12-13 |
2007-01-21 |
Eisai Co Ltd |
Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same
|
|
US6849639B2
(en)
|
1999-12-14 |
2005-02-01 |
Amgen Inc. |
Integrin inhibitors and their methods of use
|
|
IL151249A0
(en)
|
2000-03-13 |
2003-04-10 |
American Cyanamid Co |
Use of cyanoquinolines for treating or inhibiting colonic polyps
|
|
SK13352002A3
(sk)
|
2000-03-21 |
2003-05-02 |
The Procter & Gamble Company |
Metaloproteázové inhibítory s vedľajším heterocyklickým reťazcom
|
|
BR0111280A
(pt)
|
2000-06-05 |
2003-06-10 |
Dong A Pharm Co Ltd |
Novos derivados de oxazolidinona e um processo para a preparação dos mesmos
|
|
TWI227231B
(en)
|
2000-07-12 |
2005-02-01 |
Novartis Ag |
4-benzoyl-piperidine derivatives for treating conditions mediated by CCR-3
|
|
EP1964839A3
(en)
|
2000-08-18 |
2008-11-05 |
Millennium Pharmaceuticals, Inc. |
Quinazoline derivatives as kinase inhibitors
|
|
US6890747B2
(en)
|
2000-10-23 |
2005-05-10 |
Warner-Lambert Company |
Phosphoinositide 3-kinases
|
|
US7429599B2
(en)
|
2000-12-06 |
2008-09-30 |
Signal Pharmaceuticals, Llc |
Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
|
|
US20020169300A1
(en)
|
2001-01-30 |
2002-11-14 |
Waterman Marian L. |
Method of detection and treatment of colon cancer by analysis of beta-catenin-sensitive isoforms of lymphoid enhancer factor-1
|
|
US7259157B2
(en)
|
2001-04-03 |
2007-08-21 |
Merck & Co., Inc. |
N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
|
|
JP4310109B2
(ja)
|
2001-04-26 |
2009-08-05 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
ピラゾリル基を置換基として有する含窒素縮合環化合物およびその医薬組成物
|
|
JP2002371078A
(ja)
|
2001-06-12 |
2002-12-26 |
Sankyo Co Ltd |
キノリン誘導体及びキノロン誘導体
|
|
ATE449090T1
(de)
|
2001-07-02 |
2009-12-15 |
High Point Pharmaceuticals Llc |
Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren
|
|
WO2003053958A1
(en)
|
2001-12-20 |
2003-07-03 |
Celltech R & D Limited |
Quinazolinedione derivatives
|
|
EP1348434A1
(en)
|
2002-03-27 |
2003-10-01 |
Fujisawa Deutschland GmbH |
Use of pyridyl amides as inhibitors of angiogenesis
|
|
KR20050051691A
(ko)
|
2002-10-11 |
2005-06-01 |
아스트라제네카 아베 |
1,4-이치환 피페리딘 유도체 및 11-베타ｈｓｄ1억제제로서의 이들의 용도
|
|
JP4608852B2
(ja)
|
2002-10-15 |
2011-01-12 |
チッソ株式会社 |
液晶性ビニルケトン誘導体およびその重合体
|
|
JP2004250329A
(ja)
|
2002-12-26 |
2004-09-09 |
Dainippon Pharmaceut Co Ltd |
イサチン誘導体
|
|
CA2516234A1
(en)
|
2003-02-21 |
2004-09-02 |
Pfizer Inc. |
N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors
|
|
AU2004220321B2
(en)
|
2003-03-12 |
2010-02-25 |
Kudos Pharmaceuticals Ltd |
Phthalazinone derivatives
|
|
US20050119266A1
(en)
|
2003-10-01 |
2005-06-02 |
Yan Shi |
Pyrrolidine and piperidine derivatives as factor Xa inhibitors
|
|
SE0302811D0
(sv)
|
2003-10-23 |
2003-10-23 |
Astrazeneca Ab |
Novel compounds
|
|
JP4923380B2
(ja)
|
2003-12-22 |
2012-04-25 |
Ｊｎｃ株式会社 |
低屈折率異方性化合物、組成物およびそれらの重合体または重合体組成物
|
|
JP4932495B2
(ja)
|
2004-01-23 |
2012-05-16 |
アムゲン インコーポレイテッド |
化合物及び使用方法
|
|
WO2005082892A2
(en)
|
2004-02-17 |
2005-09-09 |
Dr. Reddy's Laboratories Ltd. |
Triazole compounds as antibacterial agents and pharmaceutical compositions containing them
|
|
EP1723146A1
(en)
|
2004-03-01 |
2006-11-22 |
Eli Lilly And Company |
Fused pyrazole derivatives as tgf-beta signal transduction inhibitors for the treatment of fibrosis and neoplasms
|
|
GB0405628D0
(en)
|
2004-03-12 |
2004-04-21 |
Glaxo Group Ltd |
Novel compounds
|
|
WO2005095327A1
(ja)
|
2004-03-31 |
2005-10-13 |
Ajinomoto Co., Inc. |
アニリン誘導体
|
|
US20060167044A1
(en)
|
2004-12-20 |
2006-07-27 |
Arnaiz Damian O |
Piperidine derivatives and their use as anti-inflammatory agents
|
|
US20090264415A2
(en)
|
2004-12-30 |
2009-10-22 |
Steven De Jonghe |
Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for medical treatment
|
|
GB0428475D0
(en)
|
2004-12-30 |
2005-02-02 |
4 Aza Bioscience Nv |
Pyrido(3,2-D)pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders
|
|
TW200643015A
(en)
|
2005-03-11 |
2006-12-16 |
Akzo Nobel Nv |
2-(4-oxo-4H-quinazolin-3-yl)acetamide derivatives
|
|
JP4955646B2
(ja)
|
2005-03-16 |
2012-06-20 |
エフ．ホフマン−ラ ロシュ アーゲー |
シス−２，４，５−トリアリール−イミダゾリン及びそれらの抗癌薬としての使用
|
|
JP2007016011A
(ja)
|
2005-06-10 |
2007-01-25 |
Nippon Soda Co Ltd |
抗酸化活性を有する新規な含窒素ヘテロ環化合物、及び該化合物を含有する抗酸化薬
|
|
JP2008543888A
(ja)
|
2005-06-24 |
2008-12-04 |
ギリアード サイエンシーズ， インコーポレイテッド |
ピリド（３，２−ｄ）ピリミジン、およびＣ型肝炎を治療するのに有用な医薬組成物
|
|
CN102304075A
(zh)
|
2005-10-11 |
2012-01-04 |
因特蒙公司 |
病毒复制抑制剂
|
|
TW200800201A
(en)
|
2005-11-18 |
2008-01-01 |
Lilly Co Eli |
Pyrimidinyl benzothiophene compounds
|
|
EP1966132A2
(en)
|
2005-12-15 |
2008-09-10 |
Boehringer Ingelheim International Gmbh |
Compounds which modulate the cb2 receptor
|
|
US7632838B2
(en)
|
2006-02-07 |
2009-12-15 |
Wyeth |
11-beta HSD1 inhibitors
|
|
PE20070978A1
(es)
|
2006-02-14 |
2007-11-15 |
Novartis Ag |
COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
|
|
MX2008012617A
(es)
|
2006-03-31 |
2008-10-10 |
Novartis Ag |
Compuestos organicos.
|
|
US20090124636A1
(en)
|
2006-04-12 |
2009-05-14 |
Pfizer Inc. |
Chemical compounds
|
|
JP2009539937A
(ja)
|
2006-06-16 |
2009-11-19 |
ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー |
置換型ピペリジンカルボキサミドの医薬的使用
|
|
US20080039450A1
(en)
|
2006-06-22 |
2008-02-14 |
Jensen Annika J |
Compounds
|
|
FR2903101B1
(fr)
|
2006-06-30 |
2008-09-26 |
Servier Lab |
Nouveaux derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
CA2658764A1
(en)
|
2006-07-20 |
2008-01-24 |
Mehmet Kahraman |
Benzothiophene inhibitors of rho kinase
|
|
WO2008009078A2
(en)
|
2006-07-20 |
2008-01-24 |
Gilead Sciences, Inc. |
4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
|
|
EP1903038A1
(de)
|
2006-09-07 |
2008-03-26 |
Bayer Schering Pharma Aktiengesellschaft |
N-(1-Hetaryl-piperidin-4-yl)-(het)arylamide als EP2-Rezeptor Modulatoren
|
|
JP2010503676A
(ja)
|
2006-09-15 |
2010-02-04 |
シェーリング コーポレイション |
疼痛、糖尿病および脂質代謝の障害の治療
|
|
CN101679261A
(zh)
|
2007-03-09 |
2010-03-24 |
阿斯利康(瑞典)有限公司 |
哌嗪和哌啶mGluR5增效剂
|
|
ES2705599T3
(es)
|
2007-04-16 |
2019-03-26 |
Abbvie Inc |
Indoles sustituidos en la posición 7 como inhibidores de mcl-1
|
|
EP3269824A1
(en)
|
2008-03-28 |
2018-01-17 |
Pacific Biosciences Of California, Inc. |
Compositions and methods for nucleic acid sequencing
|
|
EP2133334A1
(en)
|
2008-06-09 |
2009-12-16 |
DAC S.r.l. |
Heterocyclic derivatives as HDAC inhibitors
|
|
CA2733533C
(en)
|
2008-08-25 |
2013-12-17 |
Irm Llc |
Hedgehog pathway modulators
|
|
JP5702293B2
(ja)
|
2008-11-10 |
2015-04-15 |
バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ |
Ａｔｒキナーゼの阻害剤として有用な化合物
|
|
WO2010087399A1
(ja)
|
2009-01-30 |
2010-08-05 |
第一三共株式会社 |
ウロテンシンｉｉ受容体拮抗薬
|
|
AU2010239188B2
(en)
|
2009-04-22 |
2016-03-31 |
Janssen Pharmaceutica Nv |
Azetidinyl diamides as monoacylglycerol lipase inhibitors
|
|
US20120083476A1
(en)
|
2009-06-05 |
2012-04-05 |
Janssen Pharmaceutica Nv |
Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase
|
|
EP2270002A1
(en)
|
2009-06-18 |
2011-01-05 |
Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patiëntenzorg |
Quinazoline derivatives as histamine H4-receptor inhibitors for use in the treatment of inflammatory disorders
|
|
EP2448581B1
(en)
|
2009-06-29 |
2016-12-07 |
Agios Pharmaceuticals, Inc. |
Therapeutic compositions and related methods of use
|
|
WO2011016559A1
(ja)
|
2009-08-07 |
2011-02-10 |
武田薬品工業株式会社 |
複素環化合物およびその用途
|
|
KR101256018B1
(ko)
|
2009-08-20 |
2013-04-18 |
한국과학기술연구원 |
단백질 키나아제 저해활성을 갖는 1,3,6-치환된 인돌 화합물
|
|
RU2595718C2
(ru)
|
2009-09-09 |
2016-08-27 |
Селджен Авиломикс Рисерч,Инк. |
Ингибиторы pi3-киназы и их применение
|
|
EP3309152B1
(en)
|
2009-12-22 |
2020-09-09 |
Vertex Pharmaceuticals Incorporated |
Isoindolinone inhibitors of phosphatidylinositol 3-kinase
|
|
AU2010339456A1
(en)
|
2009-12-30 |
2012-07-05 |
Celgene Avilomics Research, Inc. |
Ligand-directed covalent modification of protein
|
|
CN102791690B
(zh)
|
2010-01-29 |
2015-12-02 |
大塚制药株式会社 |
作为抗癌药的二取代吡啶衍生物
|
|
EP2542893A2
(en)
|
2010-03-03 |
2013-01-09 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
GB201004200D0
(en)
|
2010-03-15 |
2010-04-28 |
Univ Basel |
Spirocyclic compounds and their use as therapeutic agents and diagnostic probes
|
|
MX2012010557A
(es)
|
2010-03-16 |
2012-10-05 |
Merck Patent Gmbh |
Morfolinilquinazolinas.
|
|
CA2791020A1
(en)
|
2010-04-28 |
2011-11-03 |
Daiichi Sankyo Company, Limited |
[5,6] heterocyclic compound
|
|
TW201202230A
(en)
|
2010-05-24 |
2012-01-16 |
Mitsubishi Tanabe Pharma Corp |
Novel quinazoline compound
|
|
WO2011153553A2
(en)
|
2010-06-04 |
2011-12-08 |
The Regents Of The University Of California |
Methods and compositions for kinase inhibition
|
|
CN103119439A
(zh)
|
2010-06-08 |
2013-05-22 |
纽亘技术公司 |
用于多重测序的方法和组合物
|
|
US8658131B2
(en)
|
2010-06-21 |
2014-02-25 |
Washington University |
Compounds comprising 4-benzoylpiperidine as a sigma-1-selective ligand
|
|
WO2012016082A1
(en)
|
2010-07-30 |
2012-02-02 |
Oncotherapy Science, Inc. |
Quinoline derivatives and melk inhibitors containing the same
|
|
CN103068798A
(zh)
|
2010-09-03 |
2013-04-24 |
詹森药业有限公司 |
作为单酰甘油脂肪酶抑制剂的二-氮杂环丁烷二酰胺
|
|
BR112013006953A2
(pt)
|
2010-09-29 |
2016-07-26 |
Intervet Int Bv |
composto, composições farmacêutica e anti-helmíntica, uso de um composto, kit, e, método de tratamento de uma doença
|
|
CN103260703A
(zh)
|
2010-10-22 |
2013-08-21 |
詹森药业有限公司 |
作为单酰甘油脂肪酶抑制剂的哌啶-4-基-氮杂环丁烷二酰胺
|
|
US20130225524A1
(en)
|
2010-11-05 |
2013-08-29 |
Deping Chai |
Chemical Compounds
|
|
WO2012174489A2
(en)
|
2011-06-15 |
2012-12-20 |
The Ohio State University |
Small molecule composite surfaces as inhibitors of protein-protein interactions
|
|
EA201490177A1
(ru)
|
2011-06-29 |
2014-08-29 |
Оцука Фармасьютикал Ко., Лтд. |
Хиназолины как терапевтические соединения и связанные с ними способы их применения
|
|
CN103087077B
(zh)
|
2011-11-03 |
2016-05-18 |
上海希迈医药科技有限公司 |
噻吩并嘧啶和呋喃并嘧啶类衍生物、其制备方法及其在医药上的应用
|
|
JP2013107855A
(ja)
|
2011-11-22 |
2013-06-06 |
Mitsubishi Tanabe Pharma Corp |
医薬組成物
|
|
US9745631B2
(en)
|
2011-12-20 |
2017-08-29 |
Dana-Farber Cancer Institute, Inc. |
Methods for diagnosing and treating oncogenic kras-associated cancer
|
|
WO2013096151A1
(en)
|
2011-12-22 |
2013-06-27 |
Glaxosmithkline Llc |
Chemical compounds
|
|
ES2575604T3
(es)
|
2012-01-13 |
2016-06-29 |
Bristol-Myers Squibb Company |
Compuestos de piridilo sustituidos con tiazolilo o tiadiazolilo útiles como inhibidores cinasa
|
|
EP2828250B1
(en)
|
2012-03-19 |
2021-03-10 |
Imperial College Innovations Limited |
Quinazoline compounds and their use in therapy
|
|
WO2013155077A1
(en)
|
2012-04-09 |
2013-10-17 |
Board Of Regents,The University Of Texas System |
Response markers for src inhibitor therapies
|
|
CN104379563B
(zh)
|
2012-04-10 |
2018-12-21 |
加利福尼亚大学董事会 |
用于治疗癌症的组合物和方法
|
|
CN104685055A
(zh)
|
2012-05-09 |
2015-06-03 |
格兰达利斯有限公司 |
对单核苷酸KRAS突变特异的双功能短发夹RNA(bi-shRNA)
|
|
JO3300B1
(ar)
|
2012-06-06 |
2018-09-16 |
Novartis Ag |
مركبات وتركيبات لتعديل نشاط egfr
|
|
NZ703495A
(en)
|
2012-07-11 |
2018-02-23 |
Blueprint Medicines Corp |
Inhibitors of the fibroblast growth factor receptor
|
|
TW201414737A
(zh)
|
2012-07-13 |
2014-04-16 |
必治妥美雅史谷比公司 |
作爲激酶抑制劑之咪唑并三□甲腈
|
|
US20150299188A1
(en)
|
2012-08-24 |
2015-10-22 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound
|
|
US20150283142A1
(en)
|
2013-03-15 |
2015-10-08 |
Infinity Pharmaceuticals, Inc. |
Treatment of cancers using pi3 kinase isoform modulators
|
|
EP3181564B1
(en)
|
2012-11-20 |
2019-09-18 |
H. Hoffnabb-La Roche Ag |
Aminopyrimidine compounds as inhibitors of t790m containing egfr mutants
|
|
WO2014159837A1
(en)
|
2013-03-14 |
2014-10-02 |
Convergene Llc |
Methods and compositions for inhibition of bromodomain-containing proteins
|
|
US9227978B2
(en)
|
2013-03-15 |
2016-01-05 |
Araxes Pharma Llc |
Covalent inhibitors of Kras G12C
|
|
US9745319B2
(en)
|
2013-03-15 |
2017-08-29 |
Araxes Pharma Llc |
Irreversible covalent inhibitors of the GTPase K-Ras G12C
|
|
US9738651B2
(en)
|
2013-03-15 |
2017-08-22 |
Epizyme, Inc. |
CARM1 inhibitors and uses thereof
|
|
JP6518656B2
(ja)
|
2013-06-13 |
2019-05-22 |
バイオデシー， インコーポレイテッド |
標的生体実体を標的にする生化学実体候補をスクリーニングする方法
|
|
EP3483167A1
(en)
|
2013-06-26 |
2019-05-15 |
AbbVie Inc. |
Primary carboxamides as btk inhibitors
|
|
US20150005277A1
(en)
|
2013-06-28 |
2015-01-01 |
Beigene, Ltd. |
Protein Kinase Inhibitors and Uses Thereof
|
|
CN108440515B
(zh)
|
2013-07-03 |
2022-05-03 |
卡尔约药物治疗公司 |
取代的苯并呋喃基和苯并噁唑基化合物及其用途
|
|
MX367085B
(es)
|
2013-07-31 |
2019-08-05 |
Merck Patent Gmbh |
Piridinas, pirimidinas y pirazinas como inhibidores de tirosina cinasa de bruton e inhibidores y usos de las mismas.
|
|
CN104418860B
(zh)
|
2013-08-20 |
2016-09-07 |
中国科学院广州生物医药与健康研究院 |
嘧啶并杂环类化合物及其药用组合物和应用
|
|
DK3035936T3
(da)
|
2013-08-23 |
2019-06-11 |
Neupharma Inc |
Visse kemiske enheder, sammensætninger og fremgangsmåder
|
|
JO3805B1
(ar)
|
2013-10-10 |
2021-01-31 |
Araxes Pharma Llc |
مثبطات كراس جي12سي
|
|
US9376559B2
(en)
|
2013-11-22 |
2016-06-28 |
Exxonmobil Chemical Patents Inc. |
Reverse staged impact copolymers
|
|
WO2015108992A1
(en)
|
2014-01-15 |
2015-07-23 |
Blueprint Medicines Corporation |
Heterobicyclic compounds and their use as fgfr4 receptor inhibitors
|
|
CN105916859A
(zh)
|
2014-02-03 |
2016-08-31 |
卡迪拉保健有限公司 |
杂环化合物
|
|
CA3175724C
(en)
|
2014-03-20 |
2024-01-09 |
Capella Therapeutics, Inc. |
Benzimidazole derivatives, and pharmaceutical compositions and methods of use thereof
|
|
PE20170331A1
(es)
|
2014-03-24 |
2017-04-28 |
Guangdong Zhongsheng Pharmaceutical Co Ltd |
Derivados quinolina como inhibidores smo
|
|
MA40074A
(fr)
|
2014-05-30 |
2015-12-03 |
Univ Columbia |
Composés liant ras multivalents
|
|
EP3160486B1
(en)
|
2014-06-27 |
2020-11-18 |
Celgene Corporation |
Compositions and methods for inducing conformational changes in cereblon other e3 ubiquitin ligases
|
|
US20170305922A1
(en)
|
2014-09-17 |
2017-10-26 |
Epizyme, Inc. |
Carm1 inhibitors and uses thereof
|
|
JP2017528498A
(ja)
|
2014-09-25 |
2017-09-28 |
アラクセス ファーマ エルエルシー |
Ｋｒａｓ ｇ１２ｃ変異体タンパク質のインヒビター
|
|
WO2016049565A1
(en)
|
2014-09-25 |
2016-03-31 |
Araxes Pharma Llc |
Compositions and methods for inhibition of ras
|
|
WO2016049568A1
(en)
|
2014-09-25 |
2016-03-31 |
Araxes Pharma Llc |
Methods and compositions for inhibition of ras
|
|
PE20171057A1
(es)
|
2014-10-08 |
2017-07-21 |
Hoffmann La Roche |
Derivados espirodiamina como inhibidores de la aldosterona sintasa
|
|
CN105837576B
(zh)
|
2015-01-14 |
2019-03-26 |
湖北生物医药产业技术研究院有限公司 |
Btk抑制剂
|
|
HK1245677A1
(zh)
|
2015-01-23 |
2018-08-31 |
Aclaris Therapeutics, Inc. |
用於治疗炎症和癌症的杂环itk抑制剂
|
|
EP3270694A4
(en)
|
2015-02-17 |
2018-09-05 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
CA2981677A1
(en)
|
2015-04-03 |
2016-10-06 |
Nantbioscience, Inc. |
Compositions and methods of targeting mutant k-ras
|
|
EP3283462B1
(en)
|
2015-04-15 |
2020-12-02 |
Araxes Pharma LLC |
Fused-tricyclic inhibitors of kras and methods of use thereof
|
|
ES2928757T3
(es)
|
2015-05-01 |
2022-11-22 |
Pfizer |
Acrilamidas de pirrolo[2,3-b]pirazinilo y epóxidos de las mismas como inhibidores de la Janus Quinasa
|
|
US10144724B2
(en)
|
2015-07-22 |
2018-12-04 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use thereof
|
|
EP3356347A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
EP3356349A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
EP3356354A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058792A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
EP3356351A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
US10689356B2
(en)
|
2015-09-28 |
2020-06-23 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
WO2017058728A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
WO2017070256A2
(en)
|
2015-10-19 |
2017-04-27 |
Araxes Pharma Llc |
Method for screening inhibitors of ras
|
|
US10457669B2
(en)
|
2015-10-21 |
2019-10-29 |
Otsuka Pharmaceutical Co., Ltd. |
Benzolactam compounds as protein kinase inhibitors
|
|
WO2017100546A1
(en)
|
2015-12-09 |
2017-06-15 |
Araxes Pharma Llc |
Methods for preparation of quinazoline derivatives
|
|
CN105348271A
(zh)
|
2015-12-23 |
2016-02-24 |
常州润诺生物科技有限公司 |
喹唑啉类衍生物药用用途及其制备方法
|
|
CN105399734A
(zh)
|
2015-12-23 |
2016-03-16 |
吉林省长源药业有限公司 |
新型egfr抑制剂及其制备方法
|
|
US10822312B2
(en)
|
2016-03-30 |
2020-11-03 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use
|
|
CN105924840A
(zh)
|
2016-06-01 |
2016-09-07 |
扬州兰都塑料科技有限公司 |
一种阻燃电力电缆
|
|
CN106084164A
(zh)
|
2016-06-12 |
2016-11-09 |
四川大学 |
一种结构抗菌型聚氨酯用扩链剂的制备方法
|
|
EP3519402A1
(en)
|
2016-09-29 |
2019-08-07 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
US10377743B2
(en)
|
2016-10-07 |
2019-08-13 |
Araxes Pharma Llc |
Inhibitors of RAS and methods of use thereof
|
|
KR102540515B1
(ko)
|
2016-11-03 |
2023-06-05 |
코버스 파마슈티칼스, 인크. |
인터류킨-2-유도성 t-세포 키나제를 조절하기 위한 화합물 및 방법
|
|
US11136308B2
(en)
|
2017-01-26 |
2021-10-05 |
Araxes Pharma Llc |
Substituted quinazoline and quinazolinone compounds and methods of use thereof
|
|
EP3573954A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
|
|
CN110382482A
(zh)
|
2017-01-26 |
2019-10-25 |
亚瑞克西斯制药公司 |
稠合的杂-杂二环化合物及其使用方法
|
|
EP3573966A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
Fused n-heterocyclic compounds and methods of use thereof
|
|
US11358959B2
(en)
|
2017-01-26 |
2022-06-14 |
Araxes Pharma Llc |
Benzothiophene and benzothiazole compounds and methods of use thereof
|
|
WO2018140513A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
|
|
JOP20190186A1
(ar)
|
2017-02-02 |
2019-08-01 |
Astellas Pharma Inc |
مركب كينازولين
|
|
CN110831933A
(zh)
|
2017-05-25 |
2020-02-21 |
亚瑞克西斯制药公司 |
喹唑啉衍生物作为突变kras、hras或nras的调节剂
|
|
MX2020010836A
(es)
|
2018-05-04 |
2021-01-08 |
Amgen Inc |
Inhibidores de kras g12c y métodos para su uso.
|
|
BR112021001709A2
(pt)
|
2018-08-01 |
2021-05-04 |
Araxes Pharma Llc |
compostos espiro heterocíclicos e métodos de uso dos mesmos para o tratamento de câncer
|
|
WO2020086739A1
(en)
|
2018-10-24 |
2020-04-30 |
Araxes Pharma Llc |
2-(2-acryloyl-2,6-diazaspiro[3.4]octan-6-yl)-6-(1h-indazol-4-yl)-benzonitrile derivatives and related compounds as inhibitors of g12c mutant kras protein for inhibiting tumor metastasis
|
|
KR20210097715A
(ko)
|
2018-11-29 |
2021-08-09 |
아락세스 파마 엘엘씨 |
암 치료용 화합물 및 이의 사용 방법
|