JP2020521740A - 変異体kras、hrasまたはnrasの調節因子としてのキナゾリン誘導体 - Google Patents

変異体kras、hrasまたはnrasの調節因子としてのキナゾリン誘導体 Download PDF

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JP2020521740A
JP2020521740A JP2019564453A JP2019564453A JP2020521740A JP 2020521740 A JP2020521740 A JP 2020521740A JP 2019564453 A JP2019564453 A JP 2019564453A JP 2019564453 A JP2019564453 A JP 2019564453A JP 2020521740 A JP2020521740 A JP 2020521740A
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cancer
compound
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JP2020521740A5 (enExample
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リアンシェン リー,
リアンシェン リー,
フェン, ジュン
ジュン フェン,
タオ ウー,
タオ ウー,
ユアン リウ,
ユアン リウ,
イー ワン,
イー ワン,
ピンダ レン,
ピンダ レン,
イー リウ,
イー リウ,
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アラクセス ファーマ エルエルシー
アラクセス ファーマ エルエルシー
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2019564453A 2017-05-25 2018-05-24 変異体kras、hrasまたはnrasの調節因子としてのキナゾリン誘導体 Pending JP2020521740A (ja)

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Application Number Priority Date Filing Date Title
US201762511152P 2017-05-25 2017-05-25
US62/511,152 2017-05-25
PCT/US2018/034470 WO2018218069A1 (en) 2017-05-25 2018-05-24 Quinazoline derivatives as modulators of mutant kras, hras or nras

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JP2020521740A true JP2020521740A (ja) 2020-07-27
JP2020521740A5 JP2020521740A5 (enExample) 2021-07-26

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US (1) US11639346B2 (enExample)
EP (1) EP3630747A1 (enExample)
JP (1) JP2020521740A (enExample)
CN (1) CN110831933A (enExample)
WO (1) WO2018218069A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020521742A (ja) * 2017-05-25 2020-07-27 アラクセス ファーマ エルエルシー Krasの共有結合性阻害剤

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