JP2019534260A - Ｒａｓの阻害剤としての複素環式化合物およびその使用方法 - Google Patents

Ｒａｓの阻害剤としての複素環式化合物およびその使用方法 Download PDF

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JP2019534260A
JP2019534260A JP2019518391A JP2019518391A JP2019534260A JP 2019534260 A JP2019534260 A JP 2019534260A JP 2019518391 A JP2019518391 A JP 2019518391A JP 2019518391 A JP2019518391 A JP 2019518391A JP 2019534260 A JP2019534260 A JP 2019534260A
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cancer
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JP2019534260A5 (enExample
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タオ ウー，
タオ ウー，
イー ワン，
イー ワン，
リアンシェン リー，
リアンシェン リー，
フェン，　ジュン
ジュン フェン，
ユアン リウ，
ユアン リウ，
ピンダ レン，
ピンダ レン，
イー リウ，
イー リウ，
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アラクセス ファーマ エルエルシー
アラクセス ファーマ エルエルシー
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    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2019518391A 2016-10-07 2017-10-06 Ｒａｓの阻害剤としての複素環式化合物およびその使用方法 Pending JP2019534260A (ja)

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US201662405701P 2016-10-07 2016-10-07
US62/405,701 2016-10-07
US201762450966P 2017-01-26 2017-01-26
US62/450,966 2017-01-26
PCT/US2017/055656 WO2018068017A1 (en) 2016-10-07 2017-10-06 Heterocyclic compounds as inhibitors of ras and methods of use thereof

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