JP2019513764A5 - - Google Patents

Info

Publication number

JP2019513764A5

JP2019513764A5 JP2018553142A JP2018553142A JP2019513764A5 JP 2019513764 A5 JP2019513764 A5 JP 2019513764A5 JP 2018553142 A JP2018553142 A JP 2018553142A JP 2018553142 A JP2018553142 A JP 2018553142A JP 2019513764 A5 JP2019513764 A5 JP 2019513764A5

Authority

JP

Japan

Prior art keywords

ligand

car

complex

targeting moiety

cell

Prior art date

2017-04-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000003446 ligand Substances 0.000 claims 25
• 230000008685 targeting Effects 0.000 claims 13
• 210000001744 T-lymphocyte Anatomy 0.000 claims 12
• 229940000425 combination drug Drugs 0.000 claims 7
• 239000000203 mixture Substances 0.000 claims 7
• 150000003839 salts Chemical class 0.000 claims 7
• 150000003384 small molecules Chemical class 0.000 claims 7
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 5
• SOAPXKSPJAZNGO-WDSKDSINSA-N (2s)-2-[[(1s)-1,3-dicarboxypropyl]carbamoylamino]pentanedioic acid Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)N[C@H](C(O)=O)CCC(O)=O SOAPXKSPJAZNGO-WDSKDSINSA-N 0.000 claims 3
• 108700012439 CA9 Proteins 0.000 claims 3
• 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims 3
• OVBPIULPVIDEAO-LBPRGKRZSA-N Folic acid Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 3
• 101710107035 Gamma-glutamyltranspeptidase Proteins 0.000 claims 3
• 101710173228 Glutathione hydrolase proenzyme Proteins 0.000 claims 3
• OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 3
• 102100037346 Substance-P receptor Human genes 0.000 claims 3
• 101710097909 Substance-P receptor Proteins 0.000 claims 3
• 150000001875 compounds Chemical class 0.000 claims 3
• 229960000304 folic acid Drugs 0.000 claims 3
• 235000019152 folic acid Nutrition 0.000 claims 3
• 239000011724 folic acid Substances 0.000 claims 3
• 125000003929 folic acid group Chemical group 0.000 claims 3
• 102000006640 gamma-Glutamyltransferase Human genes 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 150000007523 nucleic acids Chemical class 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 2
• 229920001184 polypeptide Polymers 0.000 claims 2
• 102000004196 processed proteins & peptides Human genes 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 108091007741 Chimeric antigen receptor T cells Proteins 0.000 claims 1
• 241000713666 Lentivirus Species 0.000 claims 1
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical group O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 claims 1