JP2016527286A5 - - Google Patents

Download PDF

Info

Publication number
JP2016527286A5
JP2016527286A5 JP2016532266A JP2016532266A JP2016527286A5 JP 2016527286 A5 JP2016527286 A5 JP 2016527286A5 JP 2016532266 A JP2016532266 A JP 2016532266A JP 2016532266 A JP2016532266 A JP 2016532266A JP 2016527286 A5 JP2016527286 A5 JP 2016527286A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
antibody
amino acid
interleukin
combined
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016532266A
Other languages
English (en)
Japanese (ja)
Other versions
JP6794255B2 (ja
JP2016527286A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2014/002182 external-priority patent/WO2015018529A1/en
Publication of JP2016527286A publication Critical patent/JP2016527286A/ja
Publication of JP2016527286A5 publication Critical patent/JP2016527286A5/ja
Priority to JP2019123809A priority Critical patent/JP7565678B2/ja
Application granted granted Critical
Publication of JP6794255B2 publication Critical patent/JP6794255B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016532266A 2013-08-08 2014-08-08 組合せ医薬組成物 Active JP6794255B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019123809A JP7565678B2 (ja) 2013-08-08 2019-07-02 組合せ医薬組成物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13003964.7 2013-08-08
EP13003964 2013-08-08
PCT/EP2014/002182 WO2015018529A1 (en) 2013-08-08 2014-08-08 Combined pharmaceutical composition

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019123809A Division JP7565678B2 (ja) 2013-08-08 2019-07-02 組合せ医薬組成物

Publications (3)

Publication Number Publication Date
JP2016527286A JP2016527286A (ja) 2016-09-08
JP2016527286A5 true JP2016527286A5 (cg-RX-API-DMAC7.html) 2017-08-24
JP6794255B2 JP6794255B2 (ja) 2020-12-02

Family

ID=48951300

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016532266A Active JP6794255B2 (ja) 2013-08-08 2014-08-08 組合せ医薬組成物
JP2019123809A Active JP7565678B2 (ja) 2013-08-08 2019-07-02 組合せ医薬組成物
JP2022063995A Pending JP2022091985A (ja) 2013-08-08 2022-04-07 組合せ医薬組成物
JP2024092095A Withdrawn JP2024116254A (ja) 2013-08-08 2024-06-06 組合せ医薬組成物

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2019123809A Active JP7565678B2 (ja) 2013-08-08 2019-07-02 組合せ医薬組成物
JP2022063995A Pending JP2022091985A (ja) 2013-08-08 2022-04-07 組合せ医薬組成物
JP2024092095A Withdrawn JP2024116254A (ja) 2013-08-08 2024-06-06 組合せ医薬組成物

Country Status (18)

Country Link
US (3) US20160184399A1 (cg-RX-API-DMAC7.html)
EP (2) EP3030262B1 (cg-RX-API-DMAC7.html)
JP (4) JP6794255B2 (cg-RX-API-DMAC7.html)
KR (3) KR20220148304A (cg-RX-API-DMAC7.html)
CN (1) CN105579062A (cg-RX-API-DMAC7.html)
CA (1) CA2920539C (cg-RX-API-DMAC7.html)
CY (1) CY1122465T1 (cg-RX-API-DMAC7.html)
DK (1) DK3030262T3 (cg-RX-API-DMAC7.html)
ES (1) ES2760249T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20192174T1 (cg-RX-API-DMAC7.html)
HU (1) HUE046964T2 (cg-RX-API-DMAC7.html)
LT (1) LT3030262T (cg-RX-API-DMAC7.html)
PL (1) PL3030262T3 (cg-RX-API-DMAC7.html)
PT (1) PT3030262T (cg-RX-API-DMAC7.html)
RS (1) RS59756B1 (cg-RX-API-DMAC7.html)
SI (1) SI3030262T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201900684T1 (cg-RX-API-DMAC7.html)
WO (1) WO2015018529A1 (cg-RX-API-DMAC7.html)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA016217B1 (ru) 2005-12-02 2012-03-30 Маунт Синай Скул Оф Медсин Химерные вирусы, представляющие неприродные поверхностные белки, и их применение
CA2905272A1 (en) 2013-03-14 2014-10-02 Icahn School Of Medicine At Mount Sinai Newcastle disease viruses and uses thereof
HUE046964T2 (hu) * 2013-08-08 2020-04-28 Cytune Pharma Kombinált gyógyászati készítmény
WO2015109124A2 (en) * 2014-01-15 2015-07-23 Kadmon Corporation, Llc Immunomodulatory agents
EP3110443A4 (en) 2014-02-27 2017-11-15 Viralytics Limited Combination method for treatment of cancer
EP2915569A1 (en) 2014-03-03 2015-09-09 Cytune Pharma IL-15/IL-15Ralpha based conjugates purification method
US11173179B2 (en) 2015-06-25 2021-11-16 Icell Gene Therapeutics Llc Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof
TW202444897A (zh) 2015-06-25 2024-11-16 美商生物細胞基因治療有限公司 嵌合抗原受體(car)、組合物及其使用方法
EP3350205A1 (en) * 2015-09-16 2018-07-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Specific interleukin-15 (il-15) antagonist polypeptide and uses thereof for the treatment of inflammatory and auto-immune diseases
WO2017123643A1 (en) * 2016-01-11 2017-07-20 Flagship Pioneering, Inc. Methods and compositions for modulating thymic function
EP3443001B1 (en) 2016-04-11 2025-04-30 Obsidian Therapeutics, Inc. REGULATED BIOCIRCUIT SYSTEMS
JP2019519516A (ja) 2016-05-18 2019-07-11 モデルナティーエックス， インコーポレイテッド がんの治療のためのｍＲＮＡ併用療法
US11472856B2 (en) 2016-06-13 2022-10-18 Torque Therapeutics, Inc. Methods and compositions for promoting immune cell function
US20200283534A1 (en) * 2016-06-24 2020-09-10 iCell Gene Therapeuticics LLC CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS THEREOF
US12162919B2 (en) 2016-08-01 2024-12-10 Virogin Biotech Canada Ltd Oncolytic herpes simplex virus vectors expressing immune system-stimulatory molecules
MA46534A (fr) 2016-10-14 2019-08-21 Xencor Inc Protéines de fusion fc hétérodimères il15/il15r
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
JOP20190256A1 (ar) 2017-05-12 2019-10-28 Icahn School Med Mount Sinai فيروسات داء نيوكاسل واستخداماتها
US12275787B2 (en) 2017-06-21 2025-04-15 Icell Gene Therapeutics Llc Chimeric antigen receptors (CARs), compositions and methods thereof
WO2019006472A1 (en) 2017-06-30 2019-01-03 Xencor, Inc. TARGETED HETETRODIMERIC FUSION PROTEINS CONTAINING IL-15 / IL-15RA AND ANTIGEN-BINDING DOMAINS
KR20210032924A (ko) 2017-09-05 2021-03-25 토크 테라퓨틱스, 인코포레이티드 치료용 단백질 조성물 및 그의 제조 및 사용 방법
JP7386161B2 (ja) * 2017-12-19 2023-11-24 ブレイズ バイオサイエンス， インコーポレイテッド 腫瘍ホーミング及び細胞透過性ペプチド免疫抗がん剤複合体、ならびにそれらの使用方法
EP3759129A1 (en) 2018-02-28 2021-01-06 Pfizer Inc Il-15 variants and uses thereof
EP3781598A1 (en) 2018-04-18 2021-02-24 Xencor, Inc. Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains
KR20210010862A (ko) 2018-04-18 2021-01-28 젠코어 인코포레이티드 IL-15/IL-15Rα Fc-융합 단백질 및 PD-1 항원 결합 도메인을 함유하는 PD-1 표적화 이종이량체 융합 단백질 및 이의 용도
MA52289A (fr) 2018-04-18 2021-02-24 Xencor Inc Protéines de fusion fc hétérodimères il-15/il-15ra et leurs utilisations
WO2020037215A1 (en) 2018-08-17 2020-02-20 Icahn School Of Medicine At Mount Sinai Recombinant newcastle disease viruses and uses thereof for the prevention of rsv disease or human metapneumovirus disease
CR20210239A (es) 2018-10-12 2021-12-15 Xencor Inc Proteínas de fusión de il-15/il-15ralfa-fc dirigidas a pd-1 y usos de las mismas en terapias combinadas
WO2020132646A1 (en) 2018-12-20 2020-06-25 Xencor, Inc. Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and nkg2d antigen binding domains
CA3136241A1 (en) * 2019-05-20 2020-11-26 Ulrich Moebius Il-2/il-15r.beta.y agonist dosing regimens for treating cancer or infectious diseases
TW202128757A (zh) 2019-10-11 2021-08-01 美商建南德克公司 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白
US20230034677A1 (en) * 2019-11-21 2023-02-02 INSERM (Institut National de la Santé et la Recherche (Médicale) Novel immunotherapies targeting pd-1 with anti-pd-1/il-15 immunocytokines
WO2022090202A1 (en) * 2020-10-26 2022-05-05 Cytune Pharma IL-2/IL-15RBβү AGONIST FOR TREATING NON-MELANOMA SKIN CANCER
MX2023011310A (es) 2021-03-26 2023-10-05 Innate Pharma Anclajes de citocina para proteinas de celulas nk de union a nkp46.
WO2022258678A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a
BR112023025331A2 (pt) 2021-06-09 2024-02-27 Innate Pharma Proteína multiespecífica, composição farmacêutica, célula recombinante, ácido nucleico ou conjunto de ácidos nucleicos, uso de uma proteína ou composição, métodos ou uso
WO2022258691A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a
EP4362957A1 (en) 2021-07-01 2024-05-08 Indapta Therapeutics, Inc. Engineered natural killer (nk) cells and related methods
WO2023086772A1 (en) 2021-11-12 2023-05-19 Xencor, Inc. Bispecific antibodies that bind to b7h3 and nkg2d
CN120051297A (zh) 2022-06-30 2025-05-27 因达普塔治疗公司 工程化自然杀伤(nk)细胞与抗体疗法的组合及相关方法
WO2024102636A1 (en) 2022-11-07 2024-05-16 Xencor, Inc. Bispecific antibodies that bind to b7h3 and mica/b
TW202502372A (zh) * 2023-03-07 2025-01-16 南韓商韓美藥品股份有限公司 包含ｉｌ－２類似物或其接合物之用於預防或治療癌症之醫藥組成物
IL322698A (en) * 2023-03-07 2025-10-01 Hanmi Pharmaceutical Co Ltd Combination therapy containing interleukin 2 analogs or conjugates and immune checkpoint inhibitors for the prevention or treatment of cancer
WO2025085672A1 (en) 2023-10-17 2025-04-24 Xencor, Inc. Bispecific antibodies that bind to nkp46 and mica/b

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5997856A (en) 1988-10-05 1999-12-07 Chiron Corporation Method and compositions for solubilization and stabilization of polypeptides, especially proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5108910A (en) 1989-08-22 1992-04-28 Immunex Corporation DNA sequences encoding fusion proteins comprising GM-CSF and IL-3
US5073627A (en) 1989-08-22 1991-12-17 Immunex Corporation Fusion proteins comprising GM-CSF and IL-3
US5851795A (en) 1991-06-27 1998-12-22 Bristol-Myers Squibb Company Soluble CTLA4 molecules and uses thereof
US5811097A (en) 1995-07-25 1998-09-22 The Regents Of The University Of California Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US6051227A (en) 1995-07-25 2000-04-18 The Regents Of The University Of California, Office Of Technology Transfer Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US5855887A (en) 1995-07-25 1999-01-05 The Regents Of The University Of California Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
WO1998042752A1 (en) 1997-03-21 1998-10-01 Brigham And Women's Hospital Inc. Immunotherapeutic ctla-4 binding peptides
EE05627B1 (et) 1998-12-23 2013-02-15 Pfizer Inc. CTLA-4 vastased inimese monoklonaalsed antikehad
ES2706547T3 (es) 1998-12-23 2019-03-29 Pfizer Anticuerpos monoclonales humanos para CTLA-4
US7109003B2 (en) 1998-12-23 2006-09-19 Abgenix, Inc. Methods for expressing and recovering human monoclonal antibodies to CTLA-4
WO2001014424A2 (en) 1999-08-24 2001-03-01 Medarex, Inc. Human ctla-4 antibodies and their uses
US7740845B2 (en) 2000-10-18 2010-06-22 Sloan-Kettering Institute For Cancer Research Uses of monoclonal antibody 8H9
IL149701A0 (en) 2001-05-23 2002-11-10 Pfizer Prod Inc Use of anti-ctla-4 antibodies
PT1558648E (pt) 2002-10-17 2012-04-23 Genmab As Anticorpos monoclonais humanos contra cd20
ES2367430T3 (es) 2002-12-23 2011-11-03 Wyeth Llc Anticuerpos contra pd-1 y sus usos.
ES2367027T3 (es) 2004-02-27 2011-10-27 Inserm (Institut National De La Santé Et De La Recherche Medicale) Sitio de unión de la il-15 para il-15ralfa y mutantes específicos de il-15 que tienen actividad agonista/antagonista.
SI2287195T1 (sl) 2004-07-01 2019-08-30 Novo Nordisk A/S Pan-kir2dl nk-receptor protitelesa in njihova uporaba pri diagnostiki in terapiji
WO2006056875A1 (en) 2004-11-29 2006-06-01 Pharmacia & Upjohn Company Llc Thiazepine oxazolidinones as antibacterial agents
EP1896582A4 (en) 2005-05-09 2009-04-08 Ono Pharmaceutical Co HUMAN MONOCLONAL ANTIBODIES AGAINST PROGRAMMED CELL DEATH 1 (PD-1) AND METHOD FOR CREATING TREATMENT WITH ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTICS
NZ581779A (en) 2005-05-17 2011-09-30 Univ Connecticut Composition and methods for immunomodulation in an organism comprising interleukin-15 polypeptide and interleukin-15 receptor subunit A polypeptide complex
CN104356236B (zh) 2005-07-01 2020-07-03 E.R.施贵宝&圣斯有限责任公司 抗程序性死亡配体1(pd-l1)的人单克隆抗体
EP1777294A1 (en) * 2005-10-20 2007-04-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
NZ577085A (en) 2006-11-15 2012-06-29 Medarex Inc Human monoclonal antibodies to btla and methods of use
EP2133365B1 (en) 2006-12-27 2017-05-17 Emory University Compositions and methods for the treatment of infections and tumors
WO2008116219A2 (en) 2007-03-22 2008-09-25 Sloan-Kettering Institute For Cancer Research Uses of monoclonal antibody 8h9
WO2008156712A1 (en) 2007-06-18 2008-12-24 N. V. Organon Antibodies to human programmed death receptor pd-1
NZ616254A (en) * 2007-06-27 2015-04-24 Us Sec Dep Of Health And Human Services Complexes of il-15 and il-15ralpha and uses thereof
AR069747A1 (es) 2007-11-30 2010-02-17 Medarex Inc Conjugado anticuerpo monoclonal anti-b7h4- farmaco y metodos de utilizacion
BRPI0907718A2 (pt) 2008-02-11 2017-06-13 Curetech Ltd método para tratar um tumor, método para melhorar a tolerabilidade a pelo menos um agente quimiterápico, método para aumentar a sobrevida de um indivíduo que tem um tumor, método para reduzir ou prevenir recidiva tumoral, uso de um anticorpo monoclonal humanizado ou seu fragmento e anticorpo monoclonal humanizado ou seu fragmento
WO2009114335A2 (en) 2008-03-12 2009-09-17 Merck & Co., Inc. Pd-1 binding proteins
WO2009135031A1 (en) 2008-04-30 2009-11-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Substituted il-15
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
EP2350129B1 (en) 2008-08-25 2015-06-10 Amplimmune, Inc. Compositions of pd-1 antagonists and methods of use
EP2328919A2 (en) 2008-08-25 2011-06-08 Amplimmune, Inc. Pd-i antagonists and methods for treating infectious disease
WO2010029435A1 (en) 2008-09-12 2010-03-18 Isis Innovation Limited Pd-1 specific antibodies and uses thereof
EP2342228B1 (en) 2008-09-12 2017-09-06 Oxford University Innovation Limited Pd-1 specific antibodies and uses thereof
US8552154B2 (en) 2008-09-26 2013-10-08 Emory University Anti-PD-L1 antibodies and uses therefor
TW202442680A (zh) 2008-12-09 2024-11-01 美商建南德克公司 抗pd-l1抗體及其於增進t細胞功能之用途
WO2010089411A2 (en) 2009-02-09 2010-08-12 Universite De La Mediterranee Pd-1 antibodies and pd-l1 antibodies and uses thereof
WO2010106051A1 (en) 2009-03-17 2010-09-23 Universite De La Mediterranee Btla antibodies and uses thereof
MX2012001417A (es) 2009-07-31 2012-07-03 Organon Nv Anticuerpos completamente humanos para atenuante de linfocitos b y t (btla).
EP2982380B1 (en) 2010-03-04 2021-09-01 MacroGenics, Inc. Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
WO2011110604A1 (en) 2010-03-11 2011-09-15 Ucb Pharma, S.A. Pd-1 antibody
ES2651170T3 (es) * 2010-09-21 2018-01-24 Altor Bioscience Corporation Moléculas de fusión solubles multímeras de IL-15 y métodos para elaborar y usar las mismas
GB201103955D0 (en) 2011-03-09 2011-04-20 Antitope Ltd Antibodies
DK2691112T3 (en) 2011-03-31 2018-07-30 Merck Sharp & Dohme STABLE FORMULATIONS OF ANTIBODIES AGAINST HUMAN PD (PROGRAMMED DEATH) 1- RECEPTOR AND RELATED TREATMENTS
PT2699264T (pt) 2011-04-20 2018-05-23 Medimmune Llc Anticorpos e outras moléculas que ligam b7-h1 e pd-1
EP2537933A1 (en) * 2011-06-24 2012-12-26 Institut National de la Santé et de la Recherche Médicale (INSERM) An IL-15 and IL-15Ralpha sushi domain based immunocytokines
US8841418B2 (en) 2011-07-01 2014-09-23 Cellerant Therapeutics, Inc. Antibodies that specifically bind to TIM3
CA2888896A1 (en) * 2012-10-24 2014-05-01 Admune Therapeutics Llc Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes
HUE046964T2 (hu) 2013-08-08 2020-04-28 Cytune Pharma Kombinált gyógyászati készítmény

Similar Documents

Publication Publication Date Title
JP2016527286A5 (cg-RX-API-DMAC7.html)
JP7617839B2 (ja) 融合構築物およびその使用法
ES3006183T3 (en) Antibody molecules that bind pd-l1 and cd137
JP7397055B2 (ja) Ｃｄ１３７及びｏｘ４０に結合する抗体分子
HRP20192174T1 (hr) Kombinirani farmaceutski pripravak
JP7474235B2 (ja) ＯＸ４０抗原結合部位を含むＦｃ結合断片
JP2018501197A5 (cg-RX-API-DMAC7.html)
JP2016537340A5 (cg-RX-API-DMAC7.html)
JP2016539096A5 (cg-RX-API-DMAC7.html)
JP2016532693A5 (cg-RX-API-DMAC7.html)
WO2015037000A1 (en) Vstm5 polypeptides and uses thereof as a drug for treatment of cancer, infectious diseases and immune related diseases
HRP20212023T1 (hr) Modulokini temeljeni na il-15 i il-15ralpha sushi domeni
WO2014089169A4 (en) Immunotherapy with binding agents
RU2016122957A (ru) Способы применения интерлейкина-10 для лечения заболеваний и расстройств
FI3421486T3 (fi) Uusia vista-ig-rakenteita ja vista-ig:n käyttö autoimmuuni-, allergia- ja tulehdushäiriöiden hoitamiseksi
JP2017534633A5 (cg-RX-API-DMAC7.html)
JP2023165946A (ja) Ｅｐ４阻害剤およびその使用
JP2020521478A5 (cg-RX-API-DMAC7.html)
AU2021202634B2 (en) Hla-b57 open conformers
JP2019526528A5 (cg-RX-API-DMAC7.html)
JP2020517658A5 (cg-RX-API-DMAC7.html)
ES3040993T3 (en) Monospecific and bispecific proteins with immune checkpoint regulation for cancer therapy
CN113543809A (zh) 用于治疗癌症的免疫疗法
JP2019517508A5 (cg-RX-API-DMAC7.html)
CN114599398A (zh) 用gm-csf拮抗剂治疗癌症