DE602005015687D1 - Phospholipid-analoga für die behandlung von krebs - Google Patents

Phospholipid-analoga für die behandlung von krebs

Info

Publication number
DE602005015687D1
DE602005015687D1 DE602005015687T DE602005015687T DE602005015687D1 DE 602005015687 D1 DE602005015687 D1 DE 602005015687D1 DE 602005015687 T DE602005015687 T DE 602005015687T DE 602005015687 T DE602005015687 T DE 602005015687T DE 602005015687 D1 DE602005015687 D1 DE 602005015687D1
Authority
DE
Germany
Prior art keywords
phospholipide
analogue
cancer
treatment
diagnostic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005015687T
Other languages
English (en)
Inventor
Jamey Weichert
Marc Longino
Anatoly Pinchuk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cellectar Inc
Original Assignee
Cellectar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellectar Inc filed Critical Cellectar Inc
Publication of DE602005015687D1 publication Critical patent/DE602005015687D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0408—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE602005015687T 2004-03-02 2005-03-02 Phospholipid-analoga für die behandlung von krebs Active DE602005015687D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52116604P 2004-03-02 2004-03-02
PCT/US2005/006681 WO2005084716A2 (en) 2004-03-02 2005-03-02 Phospholipid analogs for diagnosis and treatment of cancer

Publications (1)

Publication Number Publication Date
DE602005015687D1 true DE602005015687D1 (de) 2009-09-10

Family

ID=34919310

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005015687T Active DE602005015687D1 (de) 2004-03-02 2005-03-02 Phospholipid-analoga für die behandlung von krebs

Country Status (17)

Country Link
US (3) US8535641B2 (de)
EP (3) EP2044960B1 (de)
JP (7) JP2007528374A (de)
KR (1) KR20070015518A (de)
CN (1) CN1929869B (de)
AT (1) ATE437657T1 (de)
AU (1) AU2005219412A1 (de)
BR (1) BRPI0508425A (de)
CA (1) CA2557698A1 (de)
DE (1) DE602005015687D1 (de)
DK (1) DK1729824T3 (de)
ES (3) ES2440257T3 (de)
HK (1) HK1130186A1 (de)
IL (1) IL177645A0 (de)
MX (1) MXPA06009681A (de)
WO (1) WO2005084716A2 (de)
ZA (1) ZA200607042B (de)

Families Citing this family (29)

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US8540968B2 (en) 2004-03-02 2013-09-24 Cellectar, Inc. Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof
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KR20080005178A (ko) * 2004-12-20 2008-01-10 셀렉타, 엘엘씨 암 검출 및 치료용 인지질 에테르 동족체
US20080075660A1 (en) * 2006-08-15 2008-03-27 Cellectar, Llc Near infrared-fluorescence using phospholipid ether analog dyes in endoscopic applications
US7893286B2 (en) 2007-06-01 2011-02-22 Cellectar, Inc. Method for the synthesis of phospholipid ethers
WO2008150439A1 (en) 2007-06-01 2008-12-11 Cellectar, Inc. Compositions of phospholipid ether boronic acids and esters and methods for their synthesis and use
WO2010011844A1 (en) * 2008-07-25 2010-01-28 Tufts Medical Center A system and method of clinical treatment planning of complex, monte carlo-based brachytherapy dose distributions
US7811548B1 (en) 2009-05-11 2010-10-12 Cellectar, Inc. Fluorescent phospholipid ether compounds and compositions
US8871181B2 (en) 2009-05-11 2014-10-28 Cellectar, Inc. Fluorescent phospholipid ether compounds, compositions, and methods of use
EP2429591B1 (de) * 2009-05-11 2015-08-26 Cellectar, Inc. Fluoreszierende phospholipidetherverbindungen und -zusammensetzungen sowie verfahren zu ihrer verwendung
SI3708192T1 (sl) 2009-06-12 2023-12-29 Cellectar, Inc. Eter fosfolipidne spojine za zdravljenje raka in slikanje in detekcijo rakavih izvornih celic
US10007961B2 (en) * 2009-09-09 2018-06-26 Wisconsin Alumni Research Foundation Treatment planning system for radiopharmaceuticals
EP2475400A2 (de) * 2009-09-11 2012-07-18 Cellectar, Inc. Nicht radioaktive phospholipidverbindungen, zusammensetzungen und verwendungsverfahren
US9925269B2 (en) 2014-11-17 2018-03-27 Cellectar Biosciences, Inc. Phospholipid ether analogs as cancer-targeting drug vehicles
US10265398B2 (en) 2015-11-06 2019-04-23 Wisconsin Alumni Research Foundation Long-lived gadolinium based tumor targeted imaging and therapy agents
BR112018077197A2 (pt) * 2016-06-14 2019-08-20 Pinchuk Anatoly análogos de éter de fosfolipídio para identificação e isolamento de células tumorais circulantes
US11147823B2 (en) * 2016-07-13 2021-10-19 Wisconsin Alumni Research Foundation Phospholipid ether analogs for imaging and targeted treatment of pediatric solid tumors
US10751430B2 (en) * 2016-07-25 2020-08-25 Wisconsin Alumni Research Foundation Targeted radiotherapy chelates for in situ immune modulated cancer vaccination
CN109689100A (zh) * 2016-07-18 2019-04-26 威斯康星校友研究基金会 用于原位免疫调节的癌症疫苗接种的放射性卤化剂
US11633506B2 (en) 2016-07-18 2023-04-25 Wisconsin Alumni Research Foundation Using targeted radiotherapy (TRT) to drive anti-tumor immune response to immunotherapies
EP3487543A1 (de) * 2016-07-25 2019-05-29 Wisconsin Alumni Research Foundation Radioaktive phospholipid-metallchelate für die krebsbildgebung und -therapie
US11649288B2 (en) 2017-02-07 2023-05-16 Seattle Children's Hospital Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
WO2018160622A1 (en) 2017-02-28 2018-09-07 Endocyte, Inc. Compositions and methods for car t cell therapy
JP2021502368A (ja) * 2017-11-10 2021-01-28 ウイスコンシン アラムナイ リサーチ ファウンデーシヨンＷｉｓｃｏｎｓｉｎ Ａｌｕｍｎｉ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 免疫療法に対する抗腫瘍免疫応答を促進するための標的化放射線療法（ｔｒｔ）の使用
US20190184040A1 (en) * 2017-12-15 2019-06-20 Wisconsin Alumni Research Foundation Targeted Macrocyclic Agents for Dual Modality PET and MRI Imaging of Cancer
CN112292138A (zh) 2018-01-22 2021-01-29 西雅图儿童医院（Dba西雅图儿童研究所） Car t细胞的使用方法
SG11202007426XA (en) * 2018-02-06 2020-09-29 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors
CA3154192A1 (en) * 2019-10-10 2021-04-15 Cellectar Biosciences, Inc. Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy

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NZ552914A (en) * 2004-07-08 2009-12-24 Cellectar Inc Virtual colonoscopy with radiolabeled 18-(4-iodophenyl)-octadecylphosphocholine (NM404)
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US20080075660A1 (en) 2006-08-15 2008-03-27 Cellectar, Llc Near infrared-fluorescence using phospholipid ether analog dyes in endoscopic applications
US7893286B2 (en) 2007-06-01 2011-02-22 Cellectar, Inc. Method for the synthesis of phospholipid ethers
WO2008150439A1 (en) * 2007-06-01 2008-12-11 Cellectar, Inc. Compositions of phospholipid ether boronic acids and esters and methods for their synthesis and use
GB0819280D0 (en) 2008-10-21 2008-11-26 Gen Electric Imgaing and radiotherapy methods
SI3708192T1 (sl) 2009-06-12 2023-12-29 Cellectar, Inc. Eter fosfolipidne spojine za zdravljenje raka in slikanje in detekcijo rakavih izvornih celic
EP2475400A2 (de) 2009-09-11 2012-07-18 Cellectar, Inc. Nicht radioaktive phospholipidverbindungen, zusammensetzungen und verwendungsverfahren
US20110064660A1 (en) 2009-09-11 2011-03-17 Pinchuk Anatoly Deuterated alkyl phospholipid compounds, compositions, and methods of use

Also Published As

Publication number Publication date
AU2005219412A1 (en) 2005-09-15
JP2007528374A (ja) 2007-10-11
EP2044961A2 (de) 2009-04-08
EP1729824B1 (de) 2009-07-29
JP6453818B2 (ja) 2019-01-16
JP2017002060A (ja) 2017-01-05
BRPI0508425A (pt) 2007-07-24
CN1929869A (zh) 2007-03-14
JP2017173339A (ja) 2017-09-28
WO2005084716A2 (en) 2005-09-15
US20050196339A1 (en) 2005-09-08
KR20070015518A (ko) 2007-02-05
CN1929869B (zh) 2010-11-24
ATE437657T1 (de) 2009-08-15
ZA200607042B (en) 2007-12-27
US9550002B2 (en) 2017-01-24
EP2044960A2 (de) 2009-04-08
IL177645A0 (en) 2006-12-31
CA2557698A1 (en) 2005-09-15
US20140023587A1 (en) 2014-01-23
ES2440257T3 (es) 2014-01-28
WO2005084716A3 (en) 2006-06-01
US20150093330A1 (en) 2015-04-02
US8535641B2 (en) 2013-09-17
JP2015071642A (ja) 2015-04-16
DK1729824T3 (da) 2009-11-02
EP2044960A3 (de) 2009-11-04
JP6228080B2 (ja) 2017-11-08
JP2014210803A (ja) 2014-11-13
HK1130186A1 (en) 2009-12-24
ES2330951T3 (es) 2009-12-17
MXPA06009681A (es) 2007-03-15
JP2012097113A (ja) 2012-05-24
JP6342818B2 (ja) 2018-06-13
US8877159B2 (en) 2014-11-04
EP1729824A2 (de) 2006-12-13
EP2044961A3 (de) 2009-08-12
EP2044961B1 (de) 2013-07-17
JP2013040201A (ja) 2013-02-28
EP2044960B1 (de) 2013-11-20
ES2430065T3 (es) 2013-11-18

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