ATE437657T1 - Phospholipid-analoga für die behandlung von krebs - Google Patents
Phospholipid-analoga für die behandlung von krebsInfo
- Publication number
- ATE437657T1 ATE437657T1 AT05729873T AT05729873T ATE437657T1 AT E437657 T1 ATE437657 T1 AT E437657T1 AT 05729873 T AT05729873 T AT 05729873T AT 05729873 T AT05729873 T AT 05729873T AT E437657 T1 ATE437657 T1 AT E437657T1
- Authority
- AT
- Austria
- Prior art keywords
- phospholipide
- analogues
- cancer
- treatment
- diagnostic
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- -1 phospholipid ether analogs Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0408—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52116604P | 2004-03-02 | 2004-03-02 | |
| PCT/US2005/006681 WO2005084716A2 (en) | 2004-03-02 | 2005-03-02 | Phospholipid analogs for diagnosis and treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE437657T1 true ATE437657T1 (de) | 2009-08-15 |
Family
ID=34919310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05729873T ATE437657T1 (de) | 2004-03-02 | 2005-03-02 | Phospholipid-analoga für die behandlung von krebs |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US8535641B2 (de) |
| EP (3) | EP2044961B1 (de) |
| JP (7) | JP2007528374A (de) |
| KR (1) | KR20070015518A (de) |
| CN (1) | CN1929869B (de) |
| AT (1) | ATE437657T1 (de) |
| AU (1) | AU2005219412A1 (de) |
| BR (1) | BRPI0508425A (de) |
| CA (1) | CA2557698A1 (de) |
| DE (1) | DE602005015687D1 (de) |
| DK (1) | DK1729824T3 (de) |
| ES (3) | ES2430065T3 (de) |
| HK (1) | HK1130186A1 (de) |
| IL (1) | IL177645A0 (de) |
| MX (1) | MXPA06009681A (de) |
| WO (1) | WO2005084716A2 (de) |
| ZA (1) | ZA200607042B (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070015518A (ko) | 2004-03-02 | 2007-02-05 | 셀렉타, 엘엘씨 | 암의 진단 및 치료를 위한 포스포리피드 유사체 |
| US8540968B2 (en) | 2004-03-02 | 2013-09-24 | Cellectar, Inc. | Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof |
| CN101001647A (zh) * | 2004-07-08 | 2007-07-18 | 塞勒克塔有限公司 | 使用放射性标记的磷脂醚类似物的虚拟结肠镜检查 |
| CA2591907A1 (en) * | 2004-12-20 | 2007-02-01 | Cellectar, Llc | Phospholipid ether analogs for detecting and treating cancer |
| WO2009005509A1 (en) * | 2006-08-15 | 2009-01-08 | Cellectar, Inc. | Near infrared-fluorescence using phospholipid ether analog dyes in endoscopic applications |
| US8022235B2 (en) | 2007-06-01 | 2011-09-20 | Cellectar, Inc. | Compositions of phospholipid ether boronic acids and esters and methods for their synthesis and use |
| US7893286B2 (en) | 2007-06-01 | 2011-02-22 | Cellectar, Inc. | Method for the synthesis of phospholipid ethers |
| WO2010011844A1 (en) * | 2008-07-25 | 2010-01-28 | Tufts Medical Center | A system and method of clinical treatment planning of complex, monte carlo-based brachytherapy dose distributions |
| US8871181B2 (en) | 2009-05-11 | 2014-10-28 | Cellectar, Inc. | Fluorescent phospholipid ether compounds, compositions, and methods of use |
| ES2549459T3 (es) * | 2009-05-11 | 2015-10-28 | Cellectar, Inc. | Compuestos de éter de fosfolípido fluorescentes, composiciones y procedimientos de uso |
| US7811548B1 (en) | 2009-05-11 | 2010-10-12 | Cellectar, Inc. | Fluorescent phospholipid ether compounds and compositions |
| US20100316567A1 (en) * | 2009-06-12 | 2010-12-16 | Weichert Jamey P | Ether and alkyl phospholipid compounds for treating cancer and imaging and detection of cancer stem cells |
| US10007961B2 (en) * | 2009-09-09 | 2018-06-26 | Wisconsin Alumni Research Foundation | Treatment planning system for radiopharmaceuticals |
| JP2013504590A (ja) * | 2009-09-11 | 2013-02-07 | セレクター，インコーポレイティド | 非放射性リン脂質化合物、組成物、及び使用方法 |
| ES2811367T3 (es) | 2014-11-17 | 2021-03-11 | Cellectar Biosciences Inc | Análogos de éteres fosfolipídicos como vehículos de fármacos que seleccionan como objetivo el cáncer |
| AU2016349577B2 (en) | 2015-11-06 | 2023-10-26 | Wisconsin Alumni Research Foundation | Long-lived gadolinium based tumor targeted imaging and therapy agents |
| MX2018015710A (es) * | 2016-06-14 | 2019-06-10 | Cellectar Biosciences Inc | Análogos fosfolipídicos de éter para la identificación y el aislamiento de células tumorales circulantes. |
| US11147823B2 (en) * | 2016-07-13 | 2021-10-19 | Wisconsin Alumni Research Foundation | Phospholipid ether analogs for imaging and targeted treatment of pediatric solid tumors |
| US11633506B2 (en) * | 2016-07-18 | 2023-04-25 | Wisconsin Alumni Research Foundation | Using targeted radiotherapy (TRT) to drive anti-tumor immune response to immunotherapies |
| US10736949B2 (en) * | 2016-07-18 | 2020-08-11 | Wisconsin Alumni Research Foundation | Radiohalogenated agents for in situ immune modulated cancer vaccination |
| CN109789227B (zh) * | 2016-07-25 | 2022-10-11 | 威斯康星校友研究基金会 | 用于癌症成像和疗法的放射性磷脂金属螯合物 |
| CN109789207B (zh) * | 2016-07-25 | 2022-11-18 | 威斯康星校友研究基金会 | 用于原位免疫调节的癌症疫苗接种的靶向放射治疗螯合物 |
| AU2018219226A1 (en) | 2017-02-07 | 2019-08-15 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
| CN110582288A (zh) | 2017-02-28 | 2019-12-17 | 恩多塞特公司 | 用于car t细胞疗法的组合物和方法 |
| CN111565762A (zh) * | 2017-11-10 | 2020-08-21 | 威斯康星校友研究基金会 | 使用靶向放射治疗(trt)来驱动对免疫疗法的抗肿瘤免疫反应 |
| US20190184040A1 (en) * | 2017-12-15 | 2019-06-20 | Wisconsin Alumni Research Foundation | Targeted Macrocyclic Agents for Dual Modality PET and MRI Imaging of Cancer |
| US11779602B2 (en) | 2018-01-22 | 2023-10-10 | Endocyte, Inc. | Methods of use for CAR T cells |
| SG11202007426XA (en) * | 2018-02-06 | 2020-09-29 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors |
| BR112022006739B1 (pt) * | 2019-10-10 | 2024-01-23 | Cellectar Biosciences, Inc | Conjugados fosfolipídio-flavagina e métodos de uso do mesmo para terapia direcionada a câncer |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5851526A (en) * | 1985-04-19 | 1998-12-22 | Ludwig Institute For Cancer Research | Methods of treating colon cancer utilizing tumor-specific antibodies |
| US4873075A (en) * | 1985-09-10 | 1989-10-10 | The University Of Michigan | Polyiodinated triglyceride analogs as radiologic agents |
| US5093042A (en) * | 1985-09-10 | 1992-03-03 | The University Of Michigan | Polyiodinated triglyceride analogs as radiologic agents |
| US4957729A (en) * | 1985-09-10 | 1990-09-18 | The University Of Michigan | Polyiodinated triglyceride analogs as radiologic agents |
| US4925649A (en) * | 1987-06-12 | 1990-05-15 | The University Of Michigan | Radioiodinated diacylglycerol analogues and methods of use |
| US5347030A (en) * | 1987-10-23 | 1994-09-13 | The Board Of Regents Of The University Of Michigan | Radioiodinated phospholipid ether analogues and methods of using same |
| US5087721A (en) | 1987-10-23 | 1992-02-11 | The University Of Michigan | Radioiodinated phosphate esters |
| US4965391A (en) | 1987-10-23 | 1990-10-23 | The University Of Michigan | Radioiodinated phospholipid ether analogues |
| US5041859A (en) * | 1988-10-04 | 1991-08-20 | Nikon Corporation | Automatic focusing detection device for cameras |
| US5274113A (en) | 1991-11-01 | 1993-12-28 | Molecular Probes, Inc. | Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates |
| US5369097A (en) * | 1991-04-25 | 1994-11-29 | The University Of British Columbia | Phosphonates as anti-cancer agents |
| US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
| US5626654A (en) * | 1995-12-05 | 1997-05-06 | Xerox Corporation | Ink compositions containing liposomes |
| WO1998024480A1 (en) | 1996-12-04 | 1998-06-11 | The Regents Of The University Of Michigan | Radioiodinated phospholipid ether analogs and methods of using the same |
| US6255519B1 (en) * | 1996-12-04 | 2001-07-03 | Regents Of The University Of Michigan | Radioiodinated phospholipid ether analogs and methods of using the same |
| US6503478B2 (en) * | 1999-01-13 | 2003-01-07 | Lightouch Medical, Inc. | Chemically specific imaging of tissue |
| CA2370081C (en) * | 1999-06-24 | 2014-06-03 | The University Of British Columbia | Lpl variant therapeutics |
| US20020133001A1 (en) * | 2000-11-27 | 2002-09-19 | Praecis Pharmaceuticals Inc. | Therapeutic agents and methods of use thereof for treating an amyloidogenic disease |
| GB2393123B (en) * | 2001-06-06 | 2005-01-12 | Brookhaven Science Ass Llc | Halogenated tetraphenylporphyrins and their uses as radiosensitizers for radiation therapy |
| US7220539B1 (en) * | 2002-06-12 | 2007-05-22 | The Salk Institute For Biological Studies | Protein kinase B/Akt modulators and methods for the use thereof |
| JP5110768B2 (ja) * | 2002-06-14 | 2012-12-26 | イミューノメディクス、インコーポレイテッド | モノクローナル抗体ｐａｍ４ならびに膵臓癌の診断および治療のためのその使用 |
| US20070037825A1 (en) * | 2002-07-19 | 2007-02-15 | Janina Baranowska-Kortylewicz | Enhancing the effect of radioimmunotherapy in the treatment of tumors |
| WO2005028681A1 (en) | 2003-09-19 | 2005-03-31 | Arcturus Bioscience, Inc. | Predicting breast cancer treatment outcome |
| US7829742B2 (en) | 2003-12-22 | 2010-11-09 | Johns Hopkins University | Boronic acid aryl analogs |
| US7632644B2 (en) * | 2004-03-02 | 2009-12-15 | Cellectar, Inc. | Imaging and selective retention of phospholipid ether analogs |
| US8540968B2 (en) | 2004-03-02 | 2013-09-24 | Cellectar, Inc. | Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof |
| KR20070015518A (ko) * | 2004-03-02 | 2007-02-05 | 셀렉타, 엘엘씨 | 암의 진단 및 치료를 위한 포스포리피드 유사체 |
| JP2007530697A (ja) * | 2004-03-29 | 2007-11-01 | ジ・アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・ザ・ユニバーシティー・オブ・アリゾナ | 両親媒性グリコペプチド |
| CN101001647A (zh) * | 2004-07-08 | 2007-07-18 | 塞勒克塔有限公司 | 使用放射性标记的磷脂醚类似物的虚拟结肠镜检查 |
| US20060115426A1 (en) * | 2004-08-11 | 2006-06-01 | Weichert Jamey P | Methods of detecting breast cancer, brain cancer, and pancreatic cancer |
| US7041859B1 (en) | 2004-09-09 | 2006-05-09 | University Of Tennessee Research Foundation | Method for halogenating or radiohalogenating a chemical compound |
| CA2591907A1 (en) * | 2004-12-20 | 2007-02-01 | Cellectar, Llc | Phospholipid ether analogs for detecting and treating cancer |
| WO2009005509A1 (en) * | 2006-08-15 | 2009-01-08 | Cellectar, Inc. | Near infrared-fluorescence using phospholipid ether analog dyes in endoscopic applications |
| US8022235B2 (en) * | 2007-06-01 | 2011-09-20 | Cellectar, Inc. | Compositions of phospholipid ether boronic acids and esters and methods for their synthesis and use |
| US7893286B2 (en) * | 2007-06-01 | 2011-02-22 | Cellectar, Inc. | Method for the synthesis of phospholipid ethers |
| GB0819280D0 (en) | 2008-10-21 | 2008-11-26 | Gen Electric | Imgaing and radiotherapy methods |
| US20100316567A1 (en) | 2009-06-12 | 2010-12-16 | Weichert Jamey P | Ether and alkyl phospholipid compounds for treating cancer and imaging and detection of cancer stem cells |
| JP2013504590A (ja) * | 2009-09-11 | 2013-02-07 | セレクター，インコーポレイティド | 非放射性リン脂質化合物、組成物、及び使用方法 |
| US20110064660A1 (en) * | 2009-09-11 | 2011-03-17 | Pinchuk Anatoly | Deuterated alkyl phospholipid compounds, compositions, and methods of use |
-
2005
- 2005-03-02 KR KR1020067018488A patent/KR20070015518A/ko not_active Application Discontinuation
- 2005-03-02 DK DK05729873T patent/DK1729824T3/da active
- 2005-03-02 ES ES08020805T patent/ES2430065T3/es active Active
- 2005-03-02 DE DE602005015687T patent/DE602005015687D1/de active Active
- 2005-03-02 EP EP08020805.1A patent/EP2044961B1/de active Active
- 2005-03-02 ES ES05729873T patent/ES2330951T3/es active Active
- 2005-03-02 EP EP08010321.1A patent/EP2044960B1/de active Active
- 2005-03-02 BR BRPI0508425-3A patent/BRPI0508425A/pt not_active Application Discontinuation
- 2005-03-02 US US10/906,687 patent/US8535641B2/en active Active
- 2005-03-02 AT AT05729873T patent/ATE437657T1/de not_active IP Right Cessation
- 2005-03-02 CN CN2005800070569A patent/CN1929869B/zh active Active
- 2005-03-02 JP JP2007501917A patent/JP2007528374A/ja not_active Withdrawn
- 2005-03-02 EP EP05729873A patent/EP1729824B1/de active Active
- 2005-03-02 ES ES08010321.1T patent/ES2440257T3/es active Active
- 2005-03-02 CA CA002557698A patent/CA2557698A1/en not_active Abandoned
- 2005-03-02 AU AU2005219412A patent/AU2005219412A1/en not_active Abandoned
- 2005-03-02 MX MXPA06009681A patent/MXPA06009681A/es active IP Right Grant
- 2005-03-02 WO PCT/US2005/006681 patent/WO2005084716A2/en active Application Filing
-
2006
- 2006-08-22 IL IL177645A patent/IL177645A0/en unknown
- 2006-08-23 ZA ZA200607042A patent/ZA200607042B/en unknown
-
2009
- 2009-09-30 HK HK09109089.4A patent/HK1130186A1/xx unknown
-
2012
- 2012-01-13 JP JP2012005213A patent/JP2012097113A/ja not_active Withdrawn
- 2012-10-24 JP JP2012234608A patent/JP2013040201A/ja active Pending
-
2013
- 2013-08-12 US US13/964,315 patent/US8877159B2/en active Active
-
2014
- 2014-07-18 JP JP2014147869A patent/JP6228080B2/ja active Active
- 2014-09-30 US US14/501,373 patent/US9550002B2/en active Active
-
2015
- 2015-01-05 JP JP2015000135A patent/JP6342818B2/ja active Active
-
2016
- 2016-07-08 JP JP2016135920A patent/JP6453818B2/ja active Active
-
2017
- 2017-05-31 JP JP2017108141A patent/JP2017173339A/ja active Pending
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