JP2019513347A - 複数のキメラ抗原受容体（ｃａｒ）分子を発現する細胞およびその使用 - Google Patents

複数のキメラ抗原受容体（ｃａｒ）分子を発現する細胞およびその使用 Download PDF

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JP2019513347A
JP2019513347A JP2018546503A JP2018546503A JP2019513347A JP 2019513347 A JP2019513347 A JP 2019513347A JP 2018546503 A JP2018546503 A JP 2018546503A JP 2018546503 A JP2018546503 A JP 2018546503A JP 2019513347 A JP2019513347 A JP 2019513347A
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cell
amino acid
car
acid sequence
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JP2019513347A5 (OSRAM
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グレン・ドラノフ
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ノバルティス アーゲー
ノバルティス アーゲー
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
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JP2018546503A 2016-03-04 2017-03-03 複数のキメラ抗原受容体（ｃａｒ）分子を発現する細胞およびその使用 Pending JP2019513347A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662303466P 2016-03-04 2016-03-04
US62/303,466 2016-03-04
PCT/IB2017/051267 WO2017149515A1 (en) 2016-03-04 2017-03-03 Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore

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JP2019513347A true JP2019513347A (ja) 2019-05-30
JP2019513347A5 JP2019513347A5 (OSRAM) 2020-04-16

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US (2) US20200281973A1 (OSRAM)
EP (1) EP3423482A1 (OSRAM)
JP (1) JP2019513347A (OSRAM)
KR (1) KR20180118175A (OSRAM)
CN (1) CN109153714A (OSRAM)
AU (1) AU2017225733A1 (OSRAM)
BR (1) BR112018067679A2 (OSRAM)
CA (1) CA3016287A1 (OSRAM)
IL (1) IL261525A (OSRAM)
MX (1) MX2018010733A (OSRAM)
RU (1) RU2018134771A (OSRAM)
SG (1) SG11201807489PA (OSRAM)
WO (1) WO2017149515A1 (OSRAM)

Cited By (4)

* Cited by examiner, † Cited by third party
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JP2018065805A (ja) * 2016-10-20 2018-04-26 ミルテニー バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｉｌｔｅｎｙｉ Ｂｉｏｔｅｃ ＧｍｂＨ 腫瘍細胞に特異的なキメラ抗原レセプター
JP2022544580A (ja) * 2019-08-16 2022-10-19 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド 骨髄性悪性腫瘍を処置するためのキメラ抗原受容体
JP2023518538A (ja) * 2020-03-20 2023-05-02 インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） ヒトｃｄ４５ｒｃに特異的なキメラ抗原受容体およびその使用
WO2024128081A1 (ja) * 2022-12-16 2024-06-20 東亞合成株式会社 合成ペプチド及び構築物

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CN111139256A (zh) 2013-02-20 2020-05-12 诺华股份有限公司 使用人源化抗EGFRvIII嵌合抗原受体治疗癌症
US9745368B2 (en) 2013-03-15 2017-08-29 The Trustees Of The University Of Pennsylvania Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
EP4420663A3 (en) 2013-12-20 2024-10-30 Novartis AG Regulatable chimeric antigen receptor
ES2963718T3 (es) 2014-01-21 2024-04-01 Novartis Ag Capacidad presentadora de antígenos de células CAR-T potenciada mediante introducción conjunta de moléculas co-estimuladoras
WO2016014553A1 (en) 2014-07-21 2016-01-28 Novartis Ag Sortase synthesized chimeric antigen receptors
JP7054622B2 (ja) 2014-07-21 2022-04-14 ノバルティス アーゲー ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置
AU2015305531B2 (en) 2014-08-19 2021-05-20 Novartis Ag Anti-CD123 chimeric antigen receptor (CAR) for use in cancer treatment
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CN107708710A (zh) 2015-03-17 2018-02-16 嵌合体生物工程公司 Smart CAR装置,DE CAR多肽,Side CAR及其使用
HRP20220893T1 (hr) 2015-04-08 2022-10-14 Novartis Ag Cd20 terapije, cd22 terapije, i kombinirane terapije sa stanicom koja eksprimira cd19 kimerni antigenski receptor
EP3283619B1 (en) 2015-04-17 2023-04-05 Novartis AG Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
AU2016297014B2 (en) 2015-07-21 2021-06-17 Novartis Ag Methods for improving the efficacy and expansion of immune cells
WO2017027392A1 (en) 2015-08-07 2017-02-16 Novartis Ag Treatment of cancer using chimeric cd3 receptor proteins
US11747346B2 (en) 2015-09-03 2023-09-05 Novartis Ag Biomarkers predictive of cytokine release syndrome
US11052111B2 (en) 2015-12-08 2021-07-06 Chimera Bioengineering, Inc. Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses
US11549099B2 (en) 2016-03-23 2023-01-10 Novartis Ag Cell secreted minibodies and uses thereof
EP3458077A4 (en) 2016-05-17 2020-04-01 Chimera Bioengineering Inc. METHODS OF MANUFACTURING NEW AREAS OF ANTIGEN BINDING
JP7114490B2 (ja) * 2016-06-24 2022-08-08 アイセル・ジーン・セラピューティクス・エルエルシー キメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法
JP7193862B2 (ja) 2016-08-03 2022-12-21 ワシントン・ユニバーシティ キメラ抗原受容体でのｔ細胞性悪性腫瘍の治療のためのｃａｒ－ｔ細胞の遺伝子編集
EP4342978A3 (en) * 2016-09-01 2024-07-03 Chimera Bioengineering Inc. Gold optimized car t-cells
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US11440958B2 (en) 2016-11-22 2022-09-13 National University Of Singapore Blockade of CD7 expression and chimeric antigen receptors for immunotherapy of T-cell malignancies
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US20200281973A1 (en) 2020-09-10
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US20240139244A1 (en) 2024-05-02
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