US6867195B1
(en)
|
1989-03-21 |
2005-03-15 |
Vical Incorporated |
Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected
|
EP0465529B1
(en)
|
1989-03-21 |
1998-04-29 |
Vical, Inc. |
Expression of exogenous polynucleotide sequences in a vertebrate
|
FR2676072B1
(fr)
|
1991-05-03 |
1994-11-18 |
Transgene Sa |
Vecteur de delivrance d'arn.
|
US5795587A
(en)
|
1995-01-23 |
1998-08-18 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
EP0855184A1
(en)
|
1997-01-23 |
1998-07-29 |
Grayson B. Dr. Lipford |
Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination
|
US6251665B1
(en)
|
1997-02-07 |
2001-06-26 |
Cem Cezayirli |
Directed maturation of stem cells and production of programmable antigen presenting dentritic cells therefrom
|
US6261281B1
(en)
|
1997-04-03 |
2001-07-17 |
Electrofect As |
Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
|
CA2305785A1
(en)
|
1997-10-07 |
1999-04-15 |
University Of Maryland Biotechnology Institute |
Method for introducing and expressing rna in animal cells
|
US6432925B1
(en)
|
1998-04-16 |
2002-08-13 |
John Wayne Cancer Institute |
RNA cancer vaccine and methods for its use
|
US8206749B1
(en)
|
1999-02-26 |
2012-06-26 |
Novartis Vaccines And Diagnostics, Inc. |
Microemulsions with adsorbed macromolecules and microparticles
|
US6514948B1
(en)
|
1999-07-02 |
2003-02-04 |
The Regents Of The University Of California |
Method for enhancing an immune response
|
ATE289630T1
(de)
|
1999-09-09 |
2005-03-15 |
Curevac Gmbh |
Transfer von mrnas unter verwendung von polykationischen verbindungen
|
AU7398200A
(en)
|
1999-09-17 |
2001-04-24 |
Aventis Pasteur Limited |
Chlamydia antigens and corresponding dna fragments and uses thereof
|
US7060291B1
(en)
|
1999-11-24 |
2006-06-13 |
Transave, Inc. |
Modular targeted liposomal delivery system
|
DE60124918T2
(de)
|
2000-07-21 |
2007-08-02 |
Glaxo Group Ltd., Greenford |
Kodon-optimierte papillomavirussequenzen
|
US6998115B2
(en)
|
2000-10-10 |
2006-02-14 |
Massachusetts Institute Of Technology |
Biodegradable poly(β-amino esters) and uses thereof
|
US7708915B2
(en)
|
2004-05-06 |
2010-05-04 |
Castor Trevor P |
Polymer microspheres/nanospheres and encapsulating therapeutic proteins therein
|
ATE376434T1
(de)
|
2001-04-21 |
2007-11-15 |
Curevac Gmbh |
Injektionsgerät für mrna applikation
|
EP1604688B1
(de)
|
2001-06-05 |
2010-02-03 |
CureVac GmbH |
Stabilisierte Tumorantigen-mRNA mit erhöhtem G/C-Gehalt
|
EP1412065A2
(en)
|
2001-07-27 |
2004-04-28 |
President And Fellows Of Harvard College |
Laminar mixing apparatus and methods
|
CA2462593A1
(en)
|
2001-10-03 |
2003-04-10 |
Kam W. Leong |
Compositions for oral gene therapy and methods of using same
|
DE10162480A1
(de)
|
2001-12-19 |
2003-08-07 |
Ingmar Hoerr |
Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen
|
AU2003230806B2
(en)
|
2002-04-04 |
2009-05-07 |
Zoetis Belgium S.A. |
Immunostimulatory G,U-containing oligoribonucleotides
|
WO2003092665A2
(en)
|
2002-05-02 |
2003-11-13 |
Massachusetts Eye And Ear Infirmary |
Ocular drug delivery systems and use thereof
|
DE10229872A1
(de)
|
2002-07-03 |
2004-01-29 |
Curevac Gmbh |
Immunstimulation durch chemisch modifizierte RNA
|
ES2429338T3
(es)
|
2002-12-23 |
2013-11-14 |
Vical Incorporated |
Vacuna basada en polinucleótidos optimizados por codones contra infección por citomegalovirus humano
|
WO2005007689A1
(en)
|
2003-07-11 |
2005-01-27 |
Alphavax, Inc. |
Alphavirus-based cytomegalovirus vaccines
|
DE10347710B4
(de)
|
2003-10-14 |
2006-03-30 |
Johannes-Gutenberg-Universität Mainz |
Rekombinante Impfstoffe und deren Verwendung
|
US8957034B2
(en)
|
2004-01-28 |
2015-02-17 |
Johns Hopkins University |
Drugs and gene carrier particles that rapidly move through mucous barriers
|
CN101084016A
(zh)
|
2004-04-15 |
2007-12-05 |
克艾思马有限公司 |
能够容易穿透生物学障碍的组合物
|
US8354476B2
(en)
|
2004-12-10 |
2013-01-15 |
Kala Pharmaceuticals, Inc. |
Functionalized poly(ether-anhydride) block copolymers
|
GB0504436D0
(en)
*
|
2005-03-03 |
2005-04-06 |
Glaxosmithkline Biolog Sa |
Vaccine
|
KR101288729B1
(ko)
|
2005-04-01 |
2013-07-23 |
인터자인 테크놀로지스, 인코포레이티드 |
약물 전달용 중합체성 마이셀
|
US8273339B2
(en)
|
2005-04-12 |
2012-09-25 |
Nektar Therapeutics |
Polymer-based compositions and conjugates of antimicrobial agents
|
EP2279758B1
(en)
|
2005-06-16 |
2015-02-25 |
Nektar Therapeutics |
Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
|
ES2735531T3
(es)
|
2005-08-23 |
2019-12-19 |
Univ Pennsylvania |
ARN que contiene nucleósidos modificados y métodos de uso del mismo
|
DE102006007433A1
(de)
|
2006-02-17 |
2007-08-23 |
Curevac Gmbh |
Adjuvanz in Form einer Lipid-modifizierten Nukleinsäure
|
CN103030801B
(zh)
|
2006-02-21 |
2015-07-22 |
尼克塔治疗公司 |
嵌段可降解聚合物及由其制备的轭合物
|
CN101573141B
(zh)
|
2006-05-15 |
2016-05-04 |
麻省理工学院 |
用于功能性颗粒的聚合物
|
AU2007280690C1
(en)
|
2006-07-31 |
2012-08-23 |
Curevac Gmbh |
Nucleic acid of formula (I): GIXmGn, or (II): CIXmCn, in particular as an immune-stimulating agent/adjuvant
|
US20100215580A1
(en)
|
2006-09-08 |
2010-08-26 |
The Johns Hopkins University |
Compositions and methods for enhancing transport through mucus
|
DE102006051516A1
(de)
|
2006-10-31 |
2008-05-08 |
Curevac Gmbh |
(Basen-)modifizierte RNA zur Expressionssteigerung eines Proteins
|
EP2120859B1
(en)
|
2006-12-21 |
2013-11-20 |
Stryker Corporation |
Sustained-release formulations comprising bmp-7 crystals
|
DE102007001370A1
(de)
|
2007-01-09 |
2008-07-10 |
Curevac Gmbh |
RNA-kodierte Antikörper
|
KR20100063030A
(ko)
*
|
2007-07-19 |
2010-06-10 |
노바백스, 인코포레이티드 |
바리셀라 조스터 바이러스-바이러스 유사 입자(VLPs) 및 항원
|
WO2009030254A1
(en)
|
2007-09-04 |
2009-03-12 |
Curevac Gmbh |
Complexes of rna and cationic peptides for transfection and for immunostimulation
|
HUE034775T2
(hu)
|
2007-09-28 |
2018-02-28 |
Pfizer |
Rákos sejt célzása nanorészecskék alkalmazásával
|
EP2620157A3
(en)
|
2007-10-12 |
2013-10-16 |
Massachusetts Institute of Technology |
Vaccine nanotechnology
|
DK2279254T3
(en)
|
2008-04-15 |
2017-09-18 |
Protiva Biotherapeutics Inc |
PRESENT UNKNOWN LIPID FORMS FOR NUCLEIC ACID ADMINISTRATION
|
US8613951B2
(en)
|
2008-06-16 |
2013-12-24 |
Bind Therapeutics, Inc. |
Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
|
WO2010005740A2
(en)
|
2008-06-16 |
2010-01-14 |
Bind Biosciences, Inc. |
Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles
|
JP2012501965A
(ja)
|
2008-06-16 |
2012-01-26 |
バインド バイオサイエンシズ インコーポレイテッド |
薬剤を装填したポリマーナノ粒子及びその製造方法と使用方法
|
EA020753B1
(ru)
|
2008-06-16 |
2015-01-30 |
Бинд Терапьютикс, Инк. |
Терапевтические полимерные наночастицы, содержащие алкалоиды vinca, и их применение
|
WO2010030763A2
(en)
|
2008-09-10 |
2010-03-18 |
Bind Biosciences, Inc. |
High throughput fabrication of nanoparticles
|
WO2010037408A1
(en)
|
2008-09-30 |
2010-04-08 |
Curevac Gmbh |
Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
|
CA2984026C
(en)
|
2008-10-09 |
2020-02-11 |
Arbutus Biopharma Corporation |
Improved amino lipids and methods for the delivery of nucleic acids
|
MX359674B
(es)
|
2008-11-10 |
2018-10-05 |
Alnylam Pharmaceuticals Inc |
Lipidos y composiciones novedosas para el suministro de terapeuticos.
|
US8734853B2
(en)
|
2008-11-17 |
2014-05-27 |
University Of North Texas Health Science Center At Fort Worth |
HDL particles for delivery of nucleic acids
|
JP2012512175A
(ja)
|
2008-12-15 |
2012-05-31 |
バインド バイオサイエンシズ インコーポレイテッド |
治療薬を徐放するための長時間循環性ナノ粒子
|
WO2010088927A1
(en)
|
2009-02-09 |
2010-08-12 |
Curevac Gmbh |
Use of pei for the improvement of endosomal release and expression of transfected nucleic acids, complexed with cationic or polycationic compounds
|
JP5622254B2
(ja)
|
2009-03-31 |
2014-11-12 |
国立大学法人東京大学 |
二本鎖リボ核酸ポリイオンコンプレックス
|
JP5661735B2
(ja)
|
2009-04-01 |
2015-01-28 |
ユニバーシティ オブ マイアミ |
ワクチン組成物及びその使用方法
|
WO2010127159A2
(en)
|
2009-04-30 |
2010-11-04 |
Intezyne Technologies, Incorporated |
Polymeric micelles for polynucleotide encapsulation
|
WO2011000106A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Improved cationic lipids and methods for the delivery of therapeutic agents
|
CA2766907A1
(en)
|
2009-07-06 |
2011-01-13 |
Novartis Ag |
Self replicating rna molecules and uses thereof
|
RU2573409C2
(ru)
|
2009-11-04 |
2016-01-20 |
Дзе Юниверсити Оф Бритиш Коламбиа |
Содержащие нуклеиновые кислоты липидные частицы и относящиеся к ним способы
|
WO2011069529A1
(en)
|
2009-12-09 |
2011-06-16 |
Curevac Gmbh |
Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids
|
WO2011084518A2
(en)
|
2009-12-15 |
2011-07-14 |
Bind Biosciences, Inc. |
Therapeutic polymeric nanoparticles comprising corticosteroids and methods of making and using same
|
EA201290499A1
(ru)
|
2009-12-15 |
2013-01-30 |
Байнд Байосайенсиз, Инк. |
Композиции терапевтических полимерных наночастиц с высокой температурой стеклования и высокомолекулярными сополимерами
|
JP5898627B2
(ja)
|
2009-12-15 |
2016-04-06 |
バインド セラピューティックス インコーポレイテッド |
エポチロンを含む治療用ポリマーナノ粒子ならびにそれを製造および使用する方法
|
WO2012082165A1
(en)
|
2010-01-24 |
2012-06-21 |
Novartis Ag |
Irradiated biodegradable polymer microparticles
|
US8207290B2
(en)
|
2010-03-26 |
2012-06-26 |
Cerulean Pharma Inc. |
Methods and systems for generating nanoparticles
|
US20110262491A1
(en)
|
2010-04-12 |
2011-10-27 |
Selecta Biosciences, Inc. |
Emulsions and methods of making nanocarriers
|
EP2387999A1
(en)
|
2010-05-21 |
2011-11-23 |
CureVac GmbH |
Histidine-containing solution for transfection and/or injection of nucleic acids and uses thereof
|
WO2011149733A2
(en)
|
2010-05-24 |
2011-12-01 |
Merck Sharp & Dohme Corp. |
Novel amino alcohol cationic lipids for oligonucleotide delivery
|
WO2011163483A2
(en)
|
2010-06-25 |
2011-12-29 |
Massachusetts Institute Of Technology |
Polymers for biomaterials and therapeutics
|
US10487332B2
(en)
|
2010-07-06 |
2019-11-26 |
Glaxosmithkline Biologicals Sa |
Immunisation of large mammals with low doses of RNA
|
US9192661B2
(en)
|
2010-07-06 |
2015-11-24 |
Novartis Ag |
Delivery of self-replicating RNA using biodegradable polymer particles
|
MX2013000164A
(es)
|
2010-07-06 |
2013-03-05 |
Novartis Ag |
Liposomas con lipidos que tienen valor de pka ventajoso para suministro de arn.
|
BR112013000391B8
(pt)
|
2010-07-06 |
2022-10-04 |
Novartis Ag |
Composição de emulsão catiônica de óleo em água e seu uso
|
CN103052400B
(zh)
|
2010-07-06 |
2016-11-16 |
诺华股份有限公司 |
自我复制rna分子的病毒样递送颗粒
|
EP2955230A1
(en)
|
2010-07-30 |
2015-12-16 |
CureVac AG |
Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation
|
WO2012019168A2
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
WO2012019630A1
(en)
|
2010-08-13 |
2012-02-16 |
Curevac Gmbh |
Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein
|
AU2011291522A1
(en)
*
|
2010-08-20 |
2013-01-24 |
Selecta Biosciences, Inc. |
Synthetic nanocarrier vaccines comprising peptides obtained or derived from human influenza A virus M2E
|
ES2727583T3
(es)
|
2010-08-31 |
2019-10-17 |
Glaxosmithkline Biologicals Sa |
Lípidos adecuados para la administración liposómica de ARN que codifica proteínas
|
DK3981427T3
(da)
|
2010-08-31 |
2022-07-11 |
Glaxosmithkline Biologicals Sa |
Pegylerede liposomer til afgivelse af immunogen-kodende RNA
|
FI4043040T3
(fi)
|
2010-08-31 |
2023-04-04 |
Glaxosmithkline Biologicals Sa |
Pieniä liposomeja immunogeeniä koodaavan rna:n toimittamiseksi
|
WO2012039979A2
(en)
|
2010-09-10 |
2012-03-29 |
The Johns Hopkins University |
Rapid diffusion of large polymeric nanoparticles in the mammalian brain
|
DE19177059T1
(de)
|
2010-10-01 |
2021-10-07 |
Modernatx, Inc. |
N1-methyl-pseudouracile enthältendes ribonucleinsäuren sowie ihre verwendungen
|
EP4098325A1
(en)
*
|
2010-10-11 |
2022-12-07 |
GlaxoSmithKline Biologicals S.A. |
Antigen delivery platforms
|
US20150056300A1
(en)
|
2010-10-22 |
2015-02-26 |
Bind Therapeutics, Inc. |
Therapeutic nanoparticles with high molecular weight copolymers
|
AU2011323250B2
(en)
|
2010-11-05 |
2015-11-19 |
The Johns Hopkins University |
Compositions and methods relating to reduced mucoadhesion
|
WO2012075040A2
(en)
|
2010-11-30 |
2012-06-07 |
Shire Human Genetic Therapies, Inc. |
mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES
|
WO2012089225A1
(en)
|
2010-12-29 |
2012-07-05 |
Curevac Gmbh |
Combination of vaccination and inhibition of mhc class i restricted antigen presentation
|
US20120189700A1
(en)
|
2011-01-19 |
2012-07-26 |
Zoraida Aguilar |
Nanoparticle Based Immunological Stimulation
|
US9243041B2
(en)
*
|
2011-01-31 |
2016-01-26 |
The Trustees Of The University Of Pennsylvania |
Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof
|
US20140066363A1
(en)
|
2011-02-07 |
2014-03-06 |
Arun K. Bhunia |
Carbohydrate nanoparticles for prolonged efficacy of antimicrobial peptide
|
WO2012116715A1
(en)
|
2011-03-02 |
2012-09-07 |
Curevac Gmbh |
Vaccination in newborns and infants
|
WO2012113413A1
(en)
|
2011-02-21 |
2012-08-30 |
Curevac Gmbh |
Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates
|
WO2012116714A1
(en)
|
2011-03-02 |
2012-09-07 |
Curevac Gmbh |
Vaccination in elderly patients
|
EP2691078A1
(en)
|
2011-03-31 |
2014-02-05 |
Ingell Technologies Holding B.V. |
Biodegradable compositions suitable for controlled release
|
DE12722942T1
(de)
|
2011-03-31 |
2021-09-30 |
Modernatx, Inc. |
Freisetzung und formulierung von manipulierten nukleinsäuren
|
AU2012237260A1
(en)
|
2011-03-31 |
2013-11-14 |
Ingell Technologies Holding B.V. |
Biodegradable compositions suitable for controlled release
|
US8691750B2
(en)
|
2011-05-17 |
2014-04-08 |
Axolabs Gmbh |
Lipids and compositions for intracellular delivery of biologically active compounds
|
AU2012255913A1
(en)
|
2011-05-17 |
2013-11-21 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof for non-human vertebrates
|
WO2012166923A2
(en)
|
2011-05-31 |
2012-12-06 |
Bind Biosciences |
Drug loaded polymeric nanoparticles and methods of making and using same
|
ES2685333T3
(es)
|
2011-06-02 |
2018-10-08 |
The Regents Of The University Of California |
Nanopartículas encapsuladas en membrana y método de utilización
|
ES2656050T3
(es)
|
2011-07-06 |
2018-02-22 |
Glaxosmithkline Biologicals Sa |
Composiciones de combinación inmunogénica y usos de las mismas
|
RU2649133C2
(ru)
*
|
2011-07-06 |
2018-03-29 |
Новартис Аг |
Катионные эмульсии масло-в-воде
|
CA2841047A1
(en)
|
2011-07-06 |
2013-01-10 |
Novartis Ag |
Immunogenic compositions and uses thereof
|
SG10201605537XA
(en)
*
|
2011-07-06 |
2016-09-29 |
Novartis Ag |
Liposomes having useful n:p ratio for delivery of rna molecules
|
JP6018197B2
(ja)
|
2011-07-21 |
2016-11-02 |
クローダ インターナショナル パブリック リミティド カンパニー |
分枝状ポリエーテル−ポリアミドブロックコポリマー並びにそれらの製造方法及び使用方法
|
CA2842039A1
(en)
|
2011-08-26 |
2013-03-07 |
Arrowhead Research Corporation |
Poly(vinyl ester) polymers for in vivo nucleic acid delivery
|
JP2014527071A
(ja)
|
2011-08-31 |
2014-10-09 |
マリンクロッド エルエルシー |
H−ホスホネートによるナノ粒子pegの改変
|
KR20140057374A
(ko)
|
2011-09-02 |
2014-05-12 |
노파르티스 아게 |
Hsf1-관련 질환을 치료하기 위한 유기 조성물
|
WO2013039861A2
(en)
|
2011-09-12 |
2013-03-21 |
modeRNA Therapeutics |
Engineered nucleic acids and methods of use thereof
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
JP2014531456A
(ja)
|
2011-09-22 |
2014-11-27 |
バインド セラピューティックス インコーポレイテッド |
治療用ナノ粒子と癌を治療する方法
|
WO2013072929A2
(en)
|
2011-09-23 |
2013-05-23 |
Indian Institute Of Technology |
Nanop article based cosmetic composition
|
WO2013055905A1
(en)
*
|
2011-10-11 |
2013-04-18 |
Novartis Ag |
Recombinant self-replicating polycistronic rna molecules
|
MX2014004415A
(es)
|
2011-10-14 |
2015-06-05 |
Stc Unm |
Bicapas lipidicas soportadas por nanoparticulas porosas (protecelulas) para suministro dirigido, incluido el suministro transdermico de carga, y los metodos relacionados.
|
ES2745373T3
(es)
|
2011-10-18 |
2020-03-02 |
Dicerna Pharmaceuticals Inc |
Lípidos catiónicos de amina y uso de los mismos
|
CA3119789A1
(en)
|
2011-10-27 |
2013-05-02 |
Massachusetts Institute Of Technology |
Amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
|
WO2013078199A2
(en)
|
2011-11-23 |
2013-05-30 |
Children's Medical Center Corporation |
Methods for enhanced in vivo delivery of synthetic, modified rnas
|
WO2013086373A1
(en)
|
2011-12-07 |
2013-06-13 |
Alnylam Pharmaceuticals, Inc. |
Lipids for the delivery of active agents
|
US20140378538A1
(en)
|
2011-12-14 |
2014-12-25 |
Moderma Therapeutics, Inc. |
Methods of responding to a biothreat
|
MX2014007233A
(es)
*
|
2011-12-16 |
2015-02-04 |
Moderna Therapeutics Inc |
Composiciones de nucleosidos, nucleotidos y acidos nucleicos modificados.
|
CN104968354A
(zh)
|
2011-12-21 |
2015-10-07 |
现代治疗公司 |
增加器官或器官外植体的活力或寿命的方法
|
CN104936620B
(zh)
|
2012-01-19 |
2019-08-09 |
约翰霍普金斯大学 |
增强粘膜渗透的纳米粒子调配物
|
WO2013113325A1
(en)
|
2012-01-31 |
2013-08-08 |
Curevac Gmbh |
Negatively charged nucleic acid comprising complexes for immunostimulation
|
EP3312155B1
(en)
|
2012-02-03 |
2020-08-05 |
Rutgers, The State University of New Jersey |
Polymeric biomaterials derived from phenolic monomers and their medical uses
|
US20150337068A1
(en)
|
2012-02-10 |
2015-11-26 |
Karl K Berggren |
Preparation, purification and use of high-x diblock copolymers
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
EP2834259A4
(en)
|
2012-04-02 |
2016-08-24 |
Moderna Therapeutics Inc |
MODIFIED POLYNUCLEOTIDES
|
US10501512B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides
|
US10501513B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides for the production of oncology-related proteins and peptides
|
EP3498267A1
(en)
|
2012-05-25 |
2019-06-19 |
CureVac AG |
Reversible immobilization and/or controlled release of nucleic acid containing nanoparticles by (biodegradable) polymer coatings
|
EP2858679B1
(en)
*
|
2012-06-08 |
2021-02-24 |
Translate Bio, Inc. |
Pulmonary delivery of mrna to non-lung target cells
|
WO2014028429A2
(en)
|
2012-08-14 |
2014-02-20 |
Moderna Therapeutics, Inc. |
Enzymes and polymerases for the synthesis of rna
|
WO2014071963A1
(en)
|
2012-11-09 |
2014-05-15 |
Biontech Ag |
Method for cellular rna expression
|
CA2890529C
(en)
|
2012-11-09 |
2020-07-28 |
Biontech Ag |
Method for modification of cellular rna expression comprising interferon (ifn) receptors and signalling
|
CA2892529C
(en)
|
2012-11-26 |
2023-04-25 |
Moderna Therapeutics, Inc. |
Terminally modified rna
|
CA2891911C
(en)
|
2012-12-07 |
2023-03-07 |
Alnylam Pharmaceuticals, Inc. |
Improved nucleic acid lipid particle formulations
|
US20150366997A1
(en)
*
|
2012-12-07 |
2015-12-24 |
Shire Human Genetics Therapies, Inc. |
COMPOSITIONS AND METHODS FOR mRNA DELIVERY
|
WO2014093574A1
(en)
|
2012-12-13 |
2014-06-19 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for altering cell phenotype
|
EP2931319B1
(en)
*
|
2012-12-13 |
2019-08-21 |
ModernaTX, Inc. |
Modified nucleic acid molecules and uses thereof
|
MX2015010880A
(es)
|
2013-02-22 |
2015-12-03 |
Curevac Gmbh |
Combinacion de vacunacion e inhibicion de la trayectoria pd-1.
|
MX2015011955A
(es)
*
|
2013-03-08 |
2016-04-07 |
Novartis Ag |
Lipidos y composiciones de lipidos para el suministro de agentes activos.
|
US20160032316A1
(en)
|
2013-03-14 |
2016-02-04 |
The Trustees Of The University Of Pennsylvania |
Purification and Purity Assessment of RNA Molecules Synthesized with Modified Nucleosides
|
SI2970456T1
(sl)
|
2013-03-14 |
2022-01-31 |
Translate Bio, Inc. |
Postopki in sestavki za dostavo MRNA-kodiranih protiteles
|
US10258698B2
(en)
|
2013-03-14 |
2019-04-16 |
Modernatx, Inc. |
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
|
EP3578663A1
(en)
|
2013-03-15 |
2019-12-11 |
ModernaTX, Inc. |
Manufacturing methods for production of rna transcripts
|
EP2983804A4
(en)
|
2013-03-15 |
2017-03-01 |
Moderna Therapeutics, Inc. |
Ion exchange purification of mrna
|
US10077439B2
(en)
|
2013-03-15 |
2018-09-18 |
Modernatx, Inc. |
Removal of DNA fragments in mRNA production process
|
WO2014144039A1
(en)
|
2013-03-15 |
2014-09-18 |
Moderna Therapeutics, Inc. |
Characterization of mrna molecules
|
WO2014152031A1
(en)
|
2013-03-15 |
2014-09-25 |
Moderna Therapeutics, Inc. |
Ribonucleic acid purification
|
ES2670529T3
(es)
*
|
2013-03-15 |
2018-05-30 |
Translate Bio, Inc. |
Mejora sinergística de la entrega de ácidos nucleicos a través de formulaciones mezcladas
|
WO2014144711A1
(en)
|
2013-03-15 |
2014-09-18 |
Moderna Therapeutics, Inc. |
Analysis of mrna heterogeneity and stability
|
TW201534578A
(zh)
|
2013-07-08 |
2015-09-16 |
Daiichi Sankyo Co Ltd |
新穎脂質
|
JP6685903B2
(ja)
|
2013-07-25 |
2020-04-22 |
アバター・メディカル・エルエルシー |
立体構造的に安定化されたrsv融合前fタンパク質
|
AU2014310934B2
(en)
|
2013-08-21 |
2019-09-12 |
CureVac SE |
Respiratory syncytial virus (RSV) vaccine
|
SG10201801428RA
(en)
|
2013-08-21 |
2018-03-28 |
Curevac Ag |
Method for increasing expression of rna-encoded proteins
|
EP3052511A4
(en)
|
2013-10-02 |
2017-05-31 |
Moderna Therapeutics, Inc. |
Polynucleotide molecules and uses thereof
|
AU2014337156A1
(en)
|
2013-10-18 |
2016-05-12 |
Modernatx, Inc. |
Compositions and methods for tolerizing cellular systems
|
WO2015130584A2
(en)
*
|
2014-02-25 |
2015-09-03 |
Merck Sharp & Dohme Corp. |
Lipid nanoparticle vaccine adjuvants and antigen delivery systems
|
RU2746406C2
(ru)
|
2014-04-23 |
2021-04-13 |
МОДЕРНАТиЭкс, ИНК. |
Вакцины на основе нуклеиновых кислот
|
CA2951430A1
(en)
|
2014-06-13 |
2015-12-17 |
Glaxosmithkline Biologicals Sa |
Immunogenic combinations
|
US10286086B2
(en)
|
2014-06-19 |
2019-05-14 |
Modernatx, Inc. |
Alternative nucleic acid molecules and uses thereof
|
WO2016011306A2
(en)
|
2014-07-17 |
2016-01-21 |
Moderna Therapeutics, Inc. |
Terminal modifications of polynucleotides
|
CA2970840A1
(en)
*
|
2014-12-18 |
2016-06-23 |
Glaxosmithkline Biologicals S.A. |
Vaccine composition comprising truncated varicella zoster virus glycoprotein e antigen
|
WO2016118724A1
(en)
|
2015-01-21 |
2016-07-28 |
Moderna Therapeutics, Inc. |
Lipid nanoparticle compositions
|
WO2016164762A1
(en)
|
2015-04-08 |
2016-10-13 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding low density lipoprotein receptor egf-a and intracellular domain mutants and methods of using the same
|
AU2016253972B2
(en)
|
2015-04-27 |
2020-01-02 |
Acuitas Therapeutics Inc. |
Nucleoside-modified RNA for inducing an adaptive immune response
|
EP3307305A4
(en)
|
2015-06-10 |
2019-05-22 |
Modernatx, Inc. |
TARGETED ADAPTIVE VACCINES
|
EP3310384A1
(en)
|
2015-06-17 |
2018-04-25 |
CureVac AG |
Vaccine composition
|
WO2017015457A1
(en)
|
2015-07-21 |
2017-01-26 |
Modernatx, Inc. |
Ebola vaccine
|
MA42502A
(fr)
|
2015-07-21 |
2018-05-30 |
Modernatx Inc |
Vaccins contre une maladie infectieuse
|
US20190008938A1
(en)
|
2015-07-30 |
2019-01-10 |
Modernatx, Inc. |
Concatemeric peptide epitope rnas
|
WO2017019935A1
(en)
|
2015-07-30 |
2017-02-02 |
Modernatx, Inc. |
Multimeric mrna
|
US20180237849A1
(en)
|
2015-08-17 |
2018-08-23 |
Modernatx, Inc. |
Rna mapping/fingerprinting
|
US11564893B2
(en)
|
2015-08-17 |
2023-01-31 |
Modernatx, Inc. |
Methods for preparing particles and related compositions
|
RS63030B1
(sr)
|
2015-09-17 |
2022-04-29 |
Modernatx Inc |
Jedinjenja i kompozicije za intracelularno isporučivanje terapeutskih sredstava
|
AU2016336344A1
(en)
|
2015-10-05 |
2018-04-19 |
Modernatx, Inc. |
Methods for therapeutic administration of messenger ribonucleic acid drugs
|
WO2017066789A1
(en)
|
2015-10-16 |
2017-04-20 |
Modernatx, Inc. |
Mrna cap analogs with modified sugar
|
CA3003090A1
(en)
|
2015-10-22 |
2017-04-27 |
Modernatx, Inc. |
Cancer vaccines
|
AU2016342376A1
(en)
|
2015-10-22 |
2018-06-07 |
Modernatx, Inc. |
Sexually transmitted disease vaccines
|
PE20181529A1
(es)
|
2015-10-22 |
2018-09-26 |
Modernatx Inc |
Vacunas de acido nucleico para el virus varicela-zoster (vzv)
|
EP3364950A4
(en)
|
2015-10-22 |
2019-10-23 |
ModernaTX, Inc. |
VACCINES AGAINST TROPICAL DISEASES
|
WO2017070613A1
(en)
|
2015-10-22 |
2017-04-27 |
Modernatx, Inc. |
Human cytomegalovirus vaccine
|
WO2017070620A2
(en)
|
2015-10-22 |
2017-04-27 |
Modernatx, Inc. |
Broad spectrum influenza virus vaccine
|
BR112018008102A2
(pt)
|
2015-10-22 |
2018-11-06 |
Modernatx Inc |
vacina de vírus sincicial respiratório
|
US20180303929A1
(en)
|
2015-10-22 |
2018-10-25 |
Moderna TX, Inc. |
Herpes simplex virus vaccine
|
HRP20220872T1
(hr)
|
2015-10-22 |
2022-12-23 |
Modernatx, Inc. |
Cjepiva protiv respiratornih virusa
|
MD3386484T2
(ro)
|
2015-12-10 |
2022-11-30 |
Modernatx Inc |
Compoziții și metode de livrare a unor agenți terapeutici
|
EP3390630A1
(en)
|
2015-12-17 |
2018-10-24 |
Modernatx, Inc. |
POLYNUCLEOTIDES ENCODING METHYLMALONYL-CoA MUTASE
|
US10465190B1
(en)
|
2015-12-23 |
2019-11-05 |
Modernatx, Inc. |
In vitro transcription methods and constructs
|
WO2017127750A1
(en)
|
2016-01-22 |
2017-07-27 |
Modernatx, Inc. |
Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof
|
WO2017201332A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Polynucleotides encoding acyl-coa dehydrogenase, very long-chain for the treatment of very long-chain acyl-coa dehydrogenase deficiency
|
EP3458108A4
(en)
|
2016-05-18 |
2020-04-22 |
ModernaTX, Inc. |
POLYNUCLEOTIDES FOR CODING THE TRANSMEMBRANE CONDUCTIVE REGULATOR OF CYSTIC FIBROSE FOR TREATING CYSTIC FIBROSE
|
CA3024507A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Polynucleotides encoding .alpha.-galactosidase a for the treatment of fabry disease
|
US11001861B2
(en)
|
2016-05-18 |
2021-05-11 |
Modernatx, Inc. |
Polynucleotides encoding galactose-1-phosphate uridylyltransferase for the treatment of galactosemia type 1
|
CA3024509A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Mrna combination therapy for the treatment of cancer
|
US20190390181A1
(en)
|
2016-05-18 |
2019-12-26 |
Modernatx, Inc. |
Polynucleotides Encoding Lipoprotein Lipase for the Treatment of Hyperlipidemia
|
BR112018073683A2
(pt)
|
2016-05-18 |
2019-02-26 |
Modernatx, Inc. |
polinucleotídeos codificadores de relaxina
|
US20200085916A1
(en)
|
2016-05-18 |
2020-03-19 |
Modernatx, Inc. |
Polynucleotides encoding porphobilinogen deaminase for the treatment of acute intermittent porphyria
|
WO2017201317A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Polyribonucleotides containing reduced uracil content and uses thereof
|
AU2017268396B2
(en)
|
2016-05-18 |
2023-05-18 |
Modernatx, Inc. |
Polynucleotides encoding citrin for the treatment of citrullinemia type 2
|
EP3458107B1
(en)
|
2016-05-18 |
2024-03-13 |
ModernaTX, Inc. |
Polynucleotides encoding jagged1 for the treatment of alagille syndrome
|
EP3468537A1
(en)
|
2016-06-14 |
2019-04-17 |
Modernatx, Inc. |
Stabilized formulations of lipid nanoparticles
|
MX2019002904A
(es)
|
2016-09-14 |
2019-09-26 |
Modernatx Inc |
Composiciones de arn de alta pureza y métodos para su preparación.
|
WO2018075980A1
(en)
|
2016-10-21 |
2018-04-26 |
Modernatx, Inc. |
Human cytomegalovirus vaccine
|
JP2019532657A
(ja)
|
2016-10-26 |
2019-11-14 |
モデルナティーエックス, インコーポレイテッド |
免疫応答を増強するためのメッセンジャーリボ核酸及びその使用方法
|
JP7289265B2
(ja)
|
2016-10-26 |
2023-06-09 |
キュアバック エスイー |
脂質ナノ粒子mRNAワクチン
|
MA46643A
(fr)
|
2016-10-26 |
2019-09-04 |
Modernatx Inc |
Méthodes et compositions pour le mappage d'arn
|
CN110167587A
(zh)
|
2016-11-11 |
2019-08-23 |
摩登纳特斯有限公司 |
流感疫苗
|
EP3551193A4
(en)
|
2016-12-08 |
2020-08-19 |
Modernatx, Inc. |
NUCLEIC ACID VACCINES AGAINST RESPIRATORY VIRUSES
|
WO2018111967A1
(en)
|
2016-12-13 |
2018-06-21 |
Modernatx, Inc. |
Rna affinity purification
|
US20180243225A1
(en)
|
2017-01-25 |
2018-08-30 |
Modernatx, Inc. |
Ebola/marburg vaccines
|
EP3577221A4
(en)
|
2017-02-01 |
2020-12-23 |
ModernaTX, Inc. |
SECONDARY POLYNUCLEOTIDE STRUCTURE
|
NZ755780A
(en)
|
2017-02-01 |
2023-10-27 |
Modernatx Inc |
Rna cancer vaccines
|
BR112019015797A2
(pt)
|
2017-02-01 |
2020-03-17 |
Modernatx, Inc. |
Composições de mrna terapêuticas imunomoduladoras que codificam peptídeos de mutação de oncogene de ativação
|
EP3582790A4
(en)
|
2017-02-16 |
2020-11-25 |
ModernaTX, Inc. |
VERY POWERFUL IMMUNOGENIC COMPOSITIONS
|
WO2018157009A1
(en)
|
2017-02-24 |
2018-08-30 |
Modernatx, Inc. |
Nucleic acid-based therapy of muscular dystrophies
|
US11752206B2
(en)
|
2017-03-15 |
2023-09-12 |
Modernatx, Inc. |
Herpes simplex virus vaccine
|
WO2018170245A1
(en)
|
2017-03-15 |
2018-09-20 |
Modernatx, Inc. |
Broad spectrum influenza virus vaccine
|
US11045540B2
(en)
|
2017-03-15 |
2021-06-29 |
Modernatx, Inc. |
Varicella zoster virus (VZV) vaccine
|
WO2018170260A1
(en)
|
2017-03-15 |
2018-09-20 |
Modernatx, Inc. |
Respiratory syncytial virus vaccine
|
SG11201907916TA
(en)
|
2017-03-15 |
2019-09-27 |
Modernatx Inc |
Compounds and compositions for intracellular delivery of therapeutic agents
|
WO2018170347A1
(en)
|
2017-03-17 |
2018-09-20 |
Modernatx, Inc. |
Zoonotic disease rna vaccines
|
WO2018175783A1
(en)
|
2017-03-22 |
2018-09-27 |
Modernatx, Inc. |
Rna bacterial vaccines
|
WO2018187590A1
(en)
|
2017-04-05 |
2018-10-11 |
Modernatx, Inc. |
Reduction or elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins
|
WO2018200737A1
(en)
|
2017-04-26 |
2018-11-01 |
Modernatx, Inc. |
Herpes simplex virus vaccine
|
WO2018232357A1
(en)
|
2017-06-15 |
2018-12-20 |
Modernatx, Inc. |
Rna formulations
|
WO2018232355A1
(en)
|
2017-06-15 |
2018-12-20 |
Modernatx, Inc. |
Rna antibodies
|
JP7408098B2
(ja)
|
2017-08-18 |
2024-01-05 |
モデルナティエックス インコーポレイテッド |
Rnaポリメラーゼバリアント
|
WO2019036685A1
(en)
|
2017-08-18 |
2019-02-21 |
Modernatx, Inc. |
METHODS FOR HPLC ANALYSIS
|
US20200254086A1
(en)
|
2017-08-18 |
2020-08-13 |
Moderna TX, Inc. |
Efficacious mrna vaccines
|
EP3668977A4
(en)
|
2017-08-18 |
2021-04-21 |
Modernatx, Inc. |
HPLC ANALYTICAL PROCESSES
|
WO2019055807A1
(en)
|
2017-09-14 |
2019-03-21 |
Modernatx, Inc. |
RNA VACCINES AGAINST ZIKA VIRUS
|
US20190192646A1
(en)
|
2017-11-03 |
2019-06-27 |
Modernatx, Inc. |
Salmonella vaccines
|
AU2018372922A1
(en)
|
2017-11-21 |
2020-06-11 |
Modernatx, Inc. |
Epstein-Barr virus vaccines
|
US11911453B2
(en)
|
2018-01-29 |
2024-02-27 |
Modernatx, Inc. |
RSV RNA vaccines
|
US20210268086A1
(en)
|
2018-06-27 |
2021-09-02 |
Modernatx, Inc. |
Personalized cancer vaccine epitope selection
|
AU2019338557A1
(en)
|
2018-09-13 |
2021-03-25 |
Modernatx, Inc. |
Modified mRNA for the treatment of progressive familial intrahepatic cholestasis disorders
|
WO2020061367A1
(en)
|
2018-09-19 |
2020-03-26 |
Modernatx, Inc. |
Compounds and compositions for intracellular delivery of therapeutic agents
|
AU2019345067A1
(en)
|
2018-09-19 |
2021-04-08 |
Modernatx, Inc. |
High-purity peg lipids and uses thereof
|
JP2022501359A
(ja)
|
2018-09-19 |
2022-01-06 |
モデルナティーエックス, インコーポレイテッド |
Peg脂質及びそれらの使用
|
JP2022506839A
(ja)
|
2018-11-07 |
2022-01-17 |
モデルナティエックス インコーポレイテッド |
Rnaがんワクチン
|
CA3130888A1
(en)
|
2019-02-20 |
2020-08-27 |
Modernatx, Inc. |
Rna polymerase variants for co-transcriptional capping
|
CA3132975A1
(en)
|
2019-03-11 |
2020-09-17 |
Modernatx, Inc. |
Fed-batch in vitro transcription process
|
WO2020190750A1
(en)
|
2019-03-15 |
2020-09-24 |
Modernatx, Inc. |
Hiv rna vaccines
|
US20220236253A1
(en)
|
2019-05-31 |
2022-07-28 |
Modernatx, Inc. |
Expanded t cell assay
|
US20220348900A1
(en)
|
2019-08-14 |
2022-11-03 |
Modernatx, Inc. |
Processes for purifying downstream products of in vitro transcription
|
JP2022547313A
(ja)
|
2019-09-11 |
2022-11-11 |
モデルナティエックス インコーポレイテッド |
ヒトサイトメガロウイルスワクチン
|
EP4031666A4
(en)
|
2019-09-19 |
2023-11-15 |
ModernaTX, Inc. |
CAP GUIDES AND METHODS OF USE FOR RNA MAPPING
|