JP2018035138A5 - - Google Patents
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- JP2018035138A5 JP2018035138A5 JP2017138861A JP2017138861A JP2018035138A5 JP 2018035138 A5 JP2018035138 A5 JP 2018035138A5 JP 2017138861 A JP2017138861 A JP 2017138861A JP 2017138861 A JP2017138861 A JP 2017138861A JP 2018035138 A5 JP2018035138 A5 JP 2018035138A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- seq
- binding fragment
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000427 antigen Substances 0.000 claims 17
- 102000036639 antigens Human genes 0.000 claims 17
- 108091007433 antigens Proteins 0.000 claims 17
- 239000012634 fragment Substances 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 2
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 230000005867 T cell response Effects 0.000 claims 1
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000000779 depleting effect Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 102000049823 human TIGIT Human genes 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462096267P | 2014-12-23 | 2014-12-23 | |
| US62/096,267 | 2014-12-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016564332A Division JP6180663B2 (ja) | 2014-12-23 | 2015-12-22 | Ｔｉｇｉｔに対する抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019223659A Division JP2020062026A (ja) | 2014-12-23 | 2019-12-11 | Ｔｉｇｉｔに対する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018035138A JP2018035138A (ja) | 2018-03-08 |
| JP2018035138A5 true JP2018035138A5 (OSRAM) | 2019-02-14 |
| JP6633032B2 JP6633032B2 (ja) | 2020-01-22 |
Family
ID=55168435
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016564332A Active JP6180663B2 (ja) | 2014-12-23 | 2015-12-22 | Ｔｉｇｉｔに対する抗体 |
| JP2017138861A Active JP6633032B2 (ja) | 2014-12-23 | 2017-07-18 | Ｔｉｇｉｔに対する抗体 |
| JP2019223659A Pending JP2020062026A (ja) | 2014-12-23 | 2019-12-11 | Ｔｉｇｉｔに対する抗体 |
| JP2021102155A Pending JP2021177759A (ja) | 2014-12-23 | 2021-06-21 | Ｔｉｇｉｔに対する抗体 |
| JP2023111614A Pending JP2023139046A (ja) | 2014-12-23 | 2023-07-06 | Ｔｉｇｉｔに対する抗体 |
| JP2025087824A Pending JP2025128184A (ja) | 2014-12-23 | 2025-05-27 | Ｔｉｇｉｔに対する抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016564332A Active JP6180663B2 (ja) | 2014-12-23 | 2015-12-22 | Ｔｉｇｉｔに対する抗体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019223659A Pending JP2020062026A (ja) | 2014-12-23 | 2019-12-11 | Ｔｉｇｉｔに対する抗体 |
| JP2021102155A Pending JP2021177759A (ja) | 2014-12-23 | 2021-06-21 | Ｔｉｇｉｔに対する抗体 |
| JP2023111614A Pending JP2023139046A (ja) | 2014-12-23 | 2023-07-06 | Ｔｉｇｉｔに対する抗体 |
| JP2025087824A Pending JP2025128184A (ja) | 2014-12-23 | 2025-05-27 | Ｔｉｇｉｔに対する抗体 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10189902B2 (OSRAM) |
| EP (2) | EP4249066A3 (OSRAM) |
| JP (6) | JP6180663B2 (OSRAM) |
| KR (1) | KR102644115B1 (OSRAM) |
| CN (3) | CN110256558B (OSRAM) |
| AR (1) | AR103268A1 (OSRAM) |
| AU (2) | AU2015369683C1 (OSRAM) |
| BR (1) | BR112017013385A2 (OSRAM) |
| CA (1) | CA2971732A1 (OSRAM) |
| CL (1) | CL2017001660A1 (OSRAM) |
| CO (1) | CO2017006989A2 (OSRAM) |
| EA (1) | EA039219B1 (OSRAM) |
| IL (2) | IL253013B (OSRAM) |
| MA (1) | MA40662B1 (OSRAM) |
| MX (2) | MX389267B (OSRAM) |
| MY (1) | MY187045A (OSRAM) |
| PE (1) | PE20171244A1 (OSRAM) |
| PH (2) | PH12022550771A1 (OSRAM) |
| SG (2) | SG10202006538TA (OSRAM) |
| TN (1) | TN2017000267A1 (OSRAM) |
| TW (1) | TWI708786B (OSRAM) |
| UY (1) | UY36471A (OSRAM) |
| WO (1) | WO2016106302A1 (OSRAM) |
| ZA (2) | ZA201704981B (OSRAM) |
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