|
US3030025A
(en)
|
|
1962-04-17 |
|
Thermostatic gas valve |
|
DE3381783D1
(de)
|
1982-03-03 |
1990-09-13 |
Genentech Inc |
Menschliches antithrombin iii, dns sequenzen dafuer, expressions- und klonierungsvektoren die solche sequenzen enthalten und damit transformierte zellkulturen, verfahren zur expression von menschlichem antithrombin iii und diese enthaltende pharmazeutische zusammensetzungen.
|
|
US6582959B2
(en)
|
1991-03-29 |
2003-06-24 |
Genentech, Inc. |
Antibodies to vascular endothelial cell growth factor
|
|
US20030206899A1
(en)
|
1991-03-29 |
2003-11-06 |
Genentech, Inc. |
Vascular endothelial cell growth factor antagonists
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
US7067637B1
(en)
|
1992-02-12 |
2006-06-27 |
Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh |
Antibody or antibody fragments specific for a protein of the TGF-β family
|
|
US5861499A
(en)
|
1994-02-10 |
1999-01-19 |
Imclone Systems Incorporated |
Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain
|
|
US6448077B1
(en)
|
1994-02-10 |
2002-09-10 |
Imclone Systems, Inc. |
Chimeric and humanized monoclonal antibodies specific to VEGF receptors
|
|
US6054287A
(en)
|
1994-05-27 |
2000-04-25 |
Methodist Hospital Of Indiana, Inc. |
Cell-type-specific methods and devices for the low temperature preservation of the cells of an animal species
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US6410690B1
(en)
*
|
1995-06-07 |
2002-06-25 |
Medarex, Inc. |
Therapeutic compounds comprised of anti-Fc receptor antibodies
|
|
US5922845A
(en)
|
1996-07-11 |
1999-07-13 |
Medarex, Inc. |
Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
|
|
DE69738749D1
(de)
|
1996-08-16 |
2008-07-17 |
Schering Corp |
Zelloberflächen-antigen aus säugetieren und verwandte reagenzien
|
|
US6111090A
(en)
|
1996-08-16 |
2000-08-29 |
Schering Corporation |
Mammalian cell surface antigens; related reagents
|
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
|
US20020032315A1
(en)
|
1997-08-06 |
2002-03-14 |
Manuel Baca |
Anti-vegf antibodies
|
|
US20070059302A1
(en)
|
1997-04-07 |
2007-03-15 |
Genentech, Inc. |
Anti-vegf antibodies
|
|
IL132240A0
(en)
|
1997-04-07 |
2001-03-19 |
Genentech Inc |
Anti-vegf antibodies
|
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
WO1999020758A1
(en)
|
1997-10-21 |
1999-04-29 |
Human Genome Sciences, Inc. |
Human tumor necrosis factor receptor-like proteins tr11, tr11sv1, and tr11sv2
|
|
CN1322126C
(zh)
|
1998-02-04 |
2007-06-20 |
思罗姆-X股份有限公司 |
免疫原性降低和/或清除率降低的葡激酶衍生物的鉴定、生产和应用
|
|
JP2002502607A
(ja)
|
1998-02-09 |
2002-01-29 |
ジェネンテク・インコーポレイテッド |
新規な腫瘍壊死因子レセプター相同体及びそれをコードする核酸
|
|
US6376653B1
(en)
|
1998-09-28 |
2002-04-23 |
Smithkline Beecham Plc |
Tie2 antagonist antibodies
|
|
US6703020B1
(en)
|
1999-04-28 |
2004-03-09 |
Board Of Regents, The University Of Texas System |
Antibody conjugate methods for selectively inhibiting VEGF
|
|
PT1196186E
(pt)
|
1999-07-12 |
2008-02-14 |
Genentech Inc |
Promoção ou inibição da angiogénese e da cardiovascularização com homólogos de ligandos/receptores do factor de necrose tumoral.
|
|
JP2001206899A
(ja)
|
1999-11-18 |
2001-07-31 |
Japan Tobacco Inc |
TGF−βII型受容体に対するヒトモノクローナル抗体及びその医薬用途
|
|
US6528959B2
(en)
|
2000-07-19 |
2003-03-04 |
Honda Giken Kogyo Kabushiki Kaisha |
Driving force control system for front-and-rear wheel drive vehicles
|
|
US20030161809A1
(en)
|
2000-10-02 |
2003-08-28 |
Houston L. L. |
Compositions and methods for the transport of biologically active agents across cellular barriers
|
|
US7138370B2
(en)
|
2001-10-11 |
2006-11-21 |
Amgen Inc. |
Specific binding agents of human angiopoietin-2
|
|
US7658924B2
(en)
|
2001-10-11 |
2010-02-09 |
Amgen Inc. |
Angiopoietin-2 specific binding agents
|
|
US7521053B2
(en)
|
2001-10-11 |
2009-04-21 |
Amgen Inc. |
Angiopoietin-2 specific binding agents
|
|
US6874679B2
(en)
|
2001-10-12 |
2005-04-05 |
Innovative Packaging Designs, L.P. |
Container having sliding corner support
|
|
AR039067A1
(es)
|
2001-11-09 |
2005-02-09 |
Pfizer Prod Inc |
Anticuerpos para cd40
|
|
US7498414B2
(en)
|
2002-03-04 |
2009-03-03 |
Imclone Systems Incorporated |
Human antibodies specific to KDR and uses thereof
|
|
CA2384922C
(en)
|
2002-05-03 |
2008-09-02 |
Purepharm Inc. |
Topical glycopyrrolate product for the reduction of sweating
|
|
US7025982B2
(en)
|
2002-09-19 |
2006-04-11 |
Medtronic, Inc. |
Medical assembly suitable for long-term implantation and method for fabricating the same
|
|
CA2513113A1
(en)
|
2003-01-23 |
2004-08-05 |
Genentech, Inc. |
Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
|
|
AU2004244626A1
(en)
|
2003-05-23 |
2004-12-09 |
The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
GITR ligand and GITR ligand-related molecules and antibodies and uses thereof
|
|
NZ621449A
(en)
|
2003-05-30 |
2015-07-31 |
Genentech Inc |
Treatment with anti-vegf antibodies
|
|
US20050048054A1
(en)
|
2003-07-11 |
2005-03-03 |
Shino Hanabuchi |
Lymphocytes; methods
|
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
|
US7758859B2
(en)
|
2003-08-01 |
2010-07-20 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
US7182135B2
(en)
|
2003-11-14 |
2007-02-27 |
Halliburton Energy Services, Inc. |
Plug systems and methods for using plugs in subterranean formations
|
|
WO2005055808A2
(en)
|
2003-12-02 |
2005-06-23 |
Genzyme Corporation |
Compositions and methods to diagnose and treat lung cancer
|
|
CA2561686C
(en)
|
2004-03-31 |
2014-12-02 |
Genentech, Inc. |
Humanized anti-tgf-beta antibodies
|
|
GB0409799D0
(en)
|
2004-04-30 |
2004-06-09 |
Isis Innovation |
Method of generating improved immune response
|
|
US20060002932A1
(en)
|
2004-06-04 |
2006-01-05 |
Duke University |
Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity
|
|
US20060009360A1
(en)
|
2004-06-25 |
2006-01-12 |
Robert Pifer |
New adjuvant composition
|
|
CA2572765C
(en)
*
|
2004-07-08 |
2013-05-21 |
Amgen Inc. |
Compound having improved bioefficiency when administered in a multidose regimen
|
|
BRPI0517837A
(pt)
|
2004-11-12 |
2008-10-21 |
Xencor Inc |
variantes fc com ligação alterada a fcrn
|
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
EP3312196B1
(en)
|
2005-03-23 |
2019-07-17 |
Genmab A/S |
Antibodies against cd38 for treatment of multiple myeloma
|
|
AU2006230099B2
(en)
|
2005-03-25 |
2012-04-19 |
Gitr, Inc. |
GITR binding molecules and uses therefor
|
|
CA2607448C
(en)
|
2005-04-22 |
2014-11-18 |
Eli Lilly And Company |
Tgf beta 1 specific antibodies
|
|
WO2006117910A1
(ja)
*
|
2005-04-28 |
2006-11-09 |
Mochida Pharmaceutical Co., Ltd. |
抗血小板膜糖蛋白質ⅵモノクローナル抗体
|
|
ITBS20050066A1
(it)
|
2005-06-01 |
2006-12-02 |
Sys Tec S R L |
Metodo e macchina per allineare lastre di stampa flessografica su cilindri di stampa
|
|
WO2006138627A2
(en)
|
2005-06-16 |
2006-12-28 |
Inhibitex, Inc. |
Monoclonal antibodies recognizing a coagulase-negative staphylococcal protein
|
|
ES2379194T3
(es)
|
2005-12-23 |
2012-04-23 |
Eli Lilly And Company |
Anticuerpos de unión a TGF-beta
|
|
WO2007133822A1
(en)
|
2006-01-19 |
2007-11-22 |
Genzyme Corporation |
Gitr antibodies for the treatment of cancer
|
|
CN101801413A
(zh)
|
2007-07-12 |
2010-08-11 |
托勒克斯股份有限公司 |
采用gitr结合分子的联合疗法
|
|
US8574577B2
(en)
|
2008-01-03 |
2013-11-05 |
The Scripps Research Institute |
VEGF antibodies comprising modular recognition domains
|
|
JO2913B1
(en)
|
2008-02-20 |
2015-09-15 |
امجين إنك, |
Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
|
|
KR20110044992A
(ko)
|
2008-07-02 |
2011-05-03 |
이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 |
TGF-β 길항제 다중-표적 결합 단백질
|
|
WO2010019263A2
(en)
*
|
2008-08-15 |
2010-02-18 |
Genzyme Corporation |
Soluble flt constructs for treating cancers
|
|
CN102149820B
(zh)
|
2008-09-12 |
2014-07-23 |
国立大学法人三重大学 |
能够表达外源gitr配体的细胞
|
|
US8268314B2
(en)
*
|
2008-10-08 |
2012-09-18 |
Hoffmann-La Roche Inc. |
Bispecific anti-VEGF/anti-ANG-2 antibodies
|
|
PT2417156E
(pt)
|
2009-04-07 |
2015-04-29 |
Roche Glycart Ag |
Anticorpos trivalentes, biespecíficos
|
|
PT3023438T
(pt)
|
2009-09-03 |
2020-05-08 |
Merck Sharp & Dohme |
Anticorpos anti-gitr
|
|
GB0919074D0
(en)
|
2009-10-30 |
2009-12-16 |
Cambridge Reactor Design Ltd |
Crystallisation process and apparatus
|
|
GB0919054D0
(en)
|
2009-10-30 |
2009-12-16 |
Isis Innovation |
Treatment of obesity
|
|
SI2519543T1
(sl)
|
2009-12-29 |
2016-08-31 |
Emergent Product Development Seattle, Llc |
Beljakovine, ki se vežejo s heterodimeri in njihova uporaba
|
|
PT2542590T
(pt)
*
|
2010-03-05 |
2017-08-31 |
Univ Johns Hopkins |
Composições e métodos para anticorpos e proteínas de fusão imunomoduladores direcionados
|
|
US9527925B2
(en)
|
2011-04-01 |
2016-12-27 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules binding to VEGF and ANG2
|
|
ES2694411T3
(es)
|
2011-08-19 |
2018-12-20 |
Regeneron Pharmaceuticals, Inc. |
Anticuerpos anti-Tie2 y usos de los mismos
|
|
WO2013039954A1
(en)
|
2011-09-14 |
2013-03-21 |
Sanofi |
Anti-gitr antibodies
|
|
US8581886B2
(en)
|
2011-10-28 |
2013-11-12 |
Atmel Corporation |
Tuning algorithm for noise reduction in an active stylus
|
|
AU2012356894B2
(en)
|
2011-12-23 |
2018-01-18 |
Araris Biotech Ltd. |
Enzymatic conjugation of polypeptides
|
|
CA2865464C
(en)
|
2012-03-30 |
2022-07-12 |
Boehringer Ingelheim International Gmbh |
Ang2-binding molecules
|
|
MY177331A
(en)
|
2012-06-15 |
2020-09-12 |
Pfizer |
Improved antagonist antibodies against gdf-8 and uses therefor
|
|
EP2906295A4
(en)
*
|
2012-10-15 |
2016-06-01 |
Oncomed Pharm Inc |
METHOD FOR THE TREATMENT OF EYE DISEASES
|
|
WO2014079000A1
(en)
|
2012-11-21 |
2014-05-30 |
Wuhan Yzy Biopharma Co., Ltd. |
Bispecific antibody
|
|
US20140308285A1
(en)
|
2013-03-15 |
2014-10-16 |
Amgen Inc. |
Heterodimeric bispecific antibodies
|
|
US20160137717A1
(en)
*
|
2013-06-20 |
2016-05-19 |
Gabriela Burian |
Use of a vegf antagonist in treating choroidal neovascularisation
|
|
TWI888366B
(zh)
|
2013-07-16 |
2025-07-01 |
美商建南德克公司 |
利用pd-1軸結合拮抗劑及tigit抑制劑治療癌症之方法
|
|
TWI681969B
(zh)
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
針對pd-1的人類抗體
|
|
EP3105246B1
(en)
|
2014-02-10 |
2021-03-31 |
Merck Patent GmbH |
Targeted tgf beta inhibition
|
|
EP3593812A3
(en)
*
|
2014-03-15 |
2020-05-27 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor
|
|
US9994632B2
(en)
*
|
2014-05-26 |
2018-06-12 |
Samsung Electronics Co., Ltd. |
Humanized or affinity-matured anti Ang-2 antibody and uses thereof
|
|
CR20170060A
(es)
|
2014-08-19 |
2017-04-18 |
Merck Sharp & Dohme |
Anticuerpos anti tigit
|
|
KR20170072343A
(ko)
*
|
2014-11-06 |
2017-06-26 |
제넨테크, 인크. |
Ox40 결합 효능제 및 tigit 억제제를 포함하는 병용 요법
|
|
MY187045A
(en)
*
|
2014-12-23 |
2021-08-27 |
Bristol Myers Squibb Co |
Antibodies to tigit
|
|
CN107466446B
(zh)
|
2015-04-10 |
2021-02-12 |
Lg 电子株式会社 |
在无线通信系统中报告信道状态信息的方法及其设备
|
|
MX383614B
(es)
|
2015-05-21 |
2025-03-14 |
Harpoon Therapeutics Inc |
Proteinas de union triespecificas y metodos de uso.
|
|
TWI715587B
(zh)
|
2015-05-28 |
2021-01-11 |
美商安可美德藥物股份有限公司 |
Tigit結合劑和彼之用途
|
|
TWI773646B
(zh)
*
|
2015-06-08 |
2022-08-11 |
美商宏觀基因股份有限公司 |
結合lag-3的分子和其使用方法
|
|
CN105111314B
(zh)
*
|
2015-08-13 |
2019-01-08 |
成都百世博生物技术有限公司 |
一种新型融合蛋白、药物组合物及其制备方法和用途
|
|
CA2996996A1
(en)
*
|
2015-08-31 |
2017-03-09 |
National Research Council Of Canada |
Tgf-.beta.-receptor ectodomain fusion molecules and uses thereof
|
|
CA3007135A1
(en)
|
2016-03-23 |
2017-09-28 |
Mabspace Biosciences (Suzhou) Co., Ltd |
Novel anti-pd-l1 antibodies
|
|
CN109069638B
(zh)
*
|
2016-03-24 |
2022-03-29 |
璟尚生物制药公司 |
用于癌症治疗的三特异性抑制剂
|
|
MA45255A
(fr)
*
|
2016-06-14 |
2019-04-17 |
Xencor Inc |
Anticorps inhibiteurs de points de contrôle bispécifiques
|
|
JP7461741B2
(ja)
*
|
2016-06-20 |
2024-04-04 |
カイマブ・リミテッド |
抗pd-l1およびil-2サイトカイン
|
|
CN109071656B
(zh)
*
|
2017-01-05 |
2021-05-18 |
璟尚生物制药公司 |
检查点调节物拮抗剂
|
|
WO2020006516A1
(en)
*
|
2018-06-29 |
2020-01-02 |
Gensun Biopharma, Inc. |
Antitumor immune checkpoint regulator antagonists
|
|
EP3990116A1
(en)
*
|
2019-06-28 |
2022-05-04 |
Gensun Biopharma Inc. |
ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD
|
|
WO2022063114A1
(zh)
*
|
2020-09-23 |
2022-03-31 |
海正生物制药有限公司 |
Tgfbr2-ecd突变体及包含其的融合蛋白与应用
|
|
WO2022256820A1
(en)
*
|
2021-06-03 |
2022-12-08 |
Gensun Biopharma Inc. |
Multispecific antagonists
|