CL2017001660A1 - Anticuerpos contra el inmunorreceptor de células t con dominios de inmunoglobulina y de motivo inhibidor de inmunorreceptor basado en tirosina (tigit) - Google Patents
Anticuerpos contra el inmunorreceptor de células t con dominios de inmunoglobulina y de motivo inhibidor de inmunorreceptor basado en tirosina (tigit)Info
- Publication number
- CL2017001660A1 CL2017001660A1 CL2017001660A CL2017001660A CL2017001660A1 CL 2017001660 A1 CL2017001660 A1 CL 2017001660A1 CL 2017001660 A CL2017001660 A CL 2017001660A CL 2017001660 A CL2017001660 A CL 2017001660A CL 2017001660 A1 CL2017001660 A1 CL 2017001660A1
- Authority
- CL
- Chile
- Prior art keywords
- immunoreceptor
- tigit
- tyrosine
- antibodies
- antibodies against
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 title 1
- 101100369641 Mus musculus Tigit gene Proteins 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 230000002584 immunomodulator Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
<p>LA PRESENTE INVENCIÓN PROPORCIONA ANTICUERPOS, O FRAGMENTOS DE LOS MISMOS DE UNIÓN AL ANTÍGENO, QUE SE UNEN A TIGIT HUMANO (INMUNORRECEPTOR DE CÉLULAS T CON DOMINIOS IG E ITIM), Y A LOS USOS DE LOS MISMOS ANTICUERPOS O FRAGMENTOS EN APLICACIONES TERAPÉUTICAS, TALES COMO EN EL TRATAMIENTO DE CÁNCER O INFECCIÓN VIRAL CRÓNICA. TAL MÉTODO DE TRATAMIENTO INCLUYE LA TERAPIA DE COMBINACIÓN CON INHIBIDORES DE OTRAS INTERACCIONES DEL RECEPTOR INMUNOMODULADOR, TALES COMO LA INTERACCIÓN PD-I/PD-LI. LA INVENCIÓN TAMBIÉN PROPORCIONA POLINUCLEÓTIDOS QUE CODIFICAN LA REGIÓN VARIABLE DE LAS CADENAS LIGERA Y/O DAT PESADA DE LOS ANTICUERPOS, VECTORES DE EXPRESIÓN QUE COMPRENDEN LOS POLINUCLEÓTIDOS QUE CODIFICAN LA REGIÓN VARIABLE DE LAS CADENAS LIGERA Y/O PESADA DE LOS ANTICUERPOS, CÉLULAS QUE COMPRENDEN LOS VECTORES Y MÉTODOS PARA ELABORAR ANTICUERPOS O FRAGMENTOS EXPRESÁNDOLOS DE LAS CÉLULAS.</p>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462096267P | 2014-12-23 | 2014-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2017001660A1 true CL2017001660A1 (es) | 2018-03-23 |
Family
ID=55168435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017001660A CL2017001660A1 (es) | 2014-12-23 | 2017-06-22 | Anticuerpos contra el inmunorreceptor de células t con dominios de inmunoglobulina y de motivo inhibidor de inmunorreceptor basado en tirosina (tigit) |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10189902B2 (es) |
| EP (2) | EP3237448A1 (es) |
| JP (5) | JP6180663B2 (es) |
| KR (1) | KR102644115B1 (es) |
| CN (3) | CN116731176A (es) |
| AR (1) | AR103268A1 (es) |
| AU (2) | AU2015369683C1 (es) |
| BR (1) | BR112017013385A2 (es) |
| CA (1) | CA2971732A1 (es) |
| CL (1) | CL2017001660A1 (es) |
| CO (1) | CO2017006989A2 (es) |
| EA (1) | EA039219B1 (es) |
| IL (2) | IL253013B (es) |
| MA (1) | MA40662B1 (es) |
| MX (2) | MX2017007744A (es) |
| MY (1) | MY187045A (es) |
| PE (1) | PE20171244A1 (es) |
| PH (1) | PH12017501166A1 (es) |
| SG (2) | SG10202006538TA (es) |
| TN (1) | TN2017000267A1 (es) |
| TW (1) | TWI708786B (es) |
| UY (1) | UY36471A (es) |
| WO (1) | WO2016106302A1 (es) |
| ZA (2) | ZA201704981B (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11390678B2 (en) | 2008-04-09 | 2022-07-19 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
Families Citing this family (154)
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| US10053513B2 (en) | 2009-11-30 | 2018-08-21 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
| SI2506871T1 (sl) | 2009-11-30 | 2016-12-30 | Janssen Biotech, Inc. | Mutanti Fc protitelesa z odstranjenimi efektorskimi funkcijami |
| HRP20230078T1 (hr) | 2011-09-23 | 2023-05-12 | Mereo Biopharma 5, Inc. | Sredstva za vezivanje vegf/dll4 i njihova uporaba |
| PE20160953A1 (es) | 2013-12-12 | 2016-09-26 | Shanghai hengrui pharmaceutical co ltd | Anticuerpo pd-1, fragmento de union al antigeno de este y uso medico de este |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
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| US10550173B2 (en) | 2015-02-19 | 2020-02-04 | Compugen, Ltd. | PVRIG polypeptides and methods of treatment |
| KR102669294B1 (ko) | 2015-02-19 | 2024-05-23 | 컴퓨젠 엘티디. | 항-pvrig 항체 및 사용 방법 |
| TWI715587B (zh) * | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Ｔｉｇｉｔ結合劑和彼之用途 |
| US10766957B2 (en) | 2015-08-14 | 2020-09-08 | Merck Sharp & Dohme Corp | Anti-TIGIT antibodies |
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| WO2017053705A1 (en) | 2015-09-23 | 2017-03-30 | Oncomed Pharmaceuticals, Inc. | Methods and compositions for treatment of cancer |
| DK3356413T3 (da) * | 2015-10-01 | 2022-04-11 | Potenza Therapeutics Inc | Anti-tigit-antigenbindingsproteiner og fremgangsmåder til anvendelse deraf |
| MY191649A (en) | 2016-03-04 | 2022-07-05 | Jn Biosciences Llc | Antibodies to tigit |
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| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
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| CN107698684B (zh) * | 2016-08-03 | 2021-09-28 | 广东东阳光药业有限公司 | 包含突变的免疫球蛋白Fc部分的GLP-1融合蛋白 |
| RU2764548C2 (ru) | 2016-08-09 | 2022-01-18 | Кимаб Лимитед | Анти-icos антитела |
| CA3032331A1 (en) | 2016-08-17 | 2018-02-22 | Compugen Ltd. | Anti-tigit antibodies, anti-pvrig antibodies and combinations thereof |
| CN107815467B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| WO2018041120A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric tigit |
| TWI773694B (zh) | 2016-10-11 | 2022-08-11 | 美商艾吉納斯公司 | 抗ｌａｇ－３抗體及其使用方法 |
| US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
| RU2765410C2 (ru) | 2016-11-30 | 2022-01-28 | Онкомед Фармасьютикалс, Инк. | Способы лечения рака, включающие связывающие tigit агенты |
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| KR102603681B1 (ko) | 2016-12-07 | 2023-11-17 | 아게누스 인코포레이티드 | 항체 및 이의 사용방법 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11390678B2 (en) | 2008-04-09 | 2022-07-19 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
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