JP2017501155A5 - - Google Patents
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- JP2017501155A5 JP2017501155A5 JP2016539319A JP2016539319A JP2017501155A5 JP 2017501155 A5 JP2017501155 A5 JP 2017501155A5 JP 2016539319 A JP2016539319 A JP 2016539319A JP 2016539319 A JP2016539319 A JP 2016539319A JP 2017501155 A5 JP2017501155 A5 JP 2017501155A5
- Authority
- JP
- Japan
- Prior art keywords
- medicament
- binding antagonist
- cancer
- medicament according
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 claims 80
- 239000005557 antagonist Substances 0.000 claims 57
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 44
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 44
- 201000011510 cancer Diseases 0.000 claims 25
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 24
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 24
- 206010028980 Neoplasm Diseases 0.000 claims 23
- 229940123237 Taxane Drugs 0.000 claims 19
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 19
- 239000003937 drug carrier Substances 0.000 claims 13
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 12
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 12
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 12
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical group O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 9
- 229960001592 paclitaxel Drugs 0.000 claims 8
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 5
- 102000048362 human PDCD1 Human genes 0.000 claims 5
- 108010012934 Albumin-Bound Paclitaxel Proteins 0.000 claims 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
- 229930012538 Paclitaxel Natural products 0.000 claims 4
- 229940028652 abraxane Drugs 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 201000005202 lung cancer Diseases 0.000 claims 4
- 208000020816 lung neoplasm Diseases 0.000 claims 4
- 229960003301 nivolumab Drugs 0.000 claims 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 4
- 229960002621 pembrolizumab Drugs 0.000 claims 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 4
- 230000004044 response Effects 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 229960003668 docetaxel Drugs 0.000 claims 2
- 229950009791 durvalumab Drugs 0.000 claims 2
- 150000003278 haem Chemical class 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 229910052697 platinum Inorganic materials 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 108010058566 130-nm albumin-bound paclitaxel Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 229960004562 carboplatin Drugs 0.000 claims 1
- 190000008236 carboplatin Chemical group 0.000 claims 1
- 230000001461 cytolytic effect Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000036737 immune function Effects 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000007914 intraventricular administration Methods 0.000 claims 1
- 230000037452 priming Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000002459 sustained effect Effects 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361917264P | 2013-12-17 | 2013-12-17 | |
| US61/917,264 | 2013-12-17 | ||
| PCT/US2014/070974 WO2015095404A2 (en) | 2013-12-17 | 2014-12-17 | Methods of treating cancers using pd-1 axis binding antagonists and taxanes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020034955A Division JP2020111580A (ja) | 2013-12-17 | 2020-03-02 | Ｐｄ−１軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501155A JP2017501155A (ja) | 2017-01-12 |
| JP2017501155A5 true JP2017501155A5 (esLanguage) | 2018-02-01 |
| JP6841656B2 JP6841656B2 (ja) | 2021-03-10 |
Family
ID=52293262
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016539319A Active JP6841656B2 (ja) | 2013-12-17 | 2014-12-17 | Ｐｄ−１軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
| JP2016539949A Withdrawn JP2017507900A (ja) | 2013-12-17 | 2014-12-17 | Ｐｄ−１軸結合アンタゴニスト及び抗ｈｅｒ２抗体を使用してｈｅｒ２陽性がんを治療する方法 |
| JP2019074325A Pending JP2019142900A (ja) | 2013-12-17 | 2019-04-09 | Ｐｄ−１軸結合アンタゴニスト及び抗ｈｅｒ２抗体を使用してｈｅｒ２陽性がんを治療する方法 |
| JP2020034955A Withdrawn JP2020111580A (ja) | 2013-12-17 | 2020-03-02 | Ｐｄ−１軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
| JP2022000201A Active JP7645204B2 (ja) | 2013-12-17 | 2022-01-04 | Ｐｄ－１軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
| JP2024179266A Pending JP2025020147A (ja) | 2013-12-17 | 2024-10-11 | Ｐｄ－１軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016539949A Withdrawn JP2017507900A (ja) | 2013-12-17 | 2014-12-17 | Ｐｄ−１軸結合アンタゴニスト及び抗ｈｅｒ２抗体を使用してｈｅｒ２陽性がんを治療する方法 |
| JP2019074325A Pending JP2019142900A (ja) | 2013-12-17 | 2019-04-09 | Ｐｄ−１軸結合アンタゴニスト及び抗ｈｅｒ２抗体を使用してｈｅｒ２陽性がんを治療する方法 |
| JP2020034955A Withdrawn JP2020111580A (ja) | 2013-12-17 | 2020-03-02 | Ｐｄ−１軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
| JP2022000201A Active JP7645204B2 (ja) | 2013-12-17 | 2022-01-04 | Ｐｄ－１軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
| JP2024179266A Pending JP2025020147A (ja) | 2013-12-17 | 2024-10-11 | Ｐｄ－１軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
Country Status (27)
| Country | Link |
|---|---|
| US (13) | US10570213B2 (esLanguage) |
| EP (4) | EP3083686B2 (esLanguage) |
| JP (6) | JP6841656B2 (esLanguage) |
| KR (5) | KR20240017102A (esLanguage) |
| CN (3) | CN112353943A (esLanguage) |
| AU (3) | AU2014364587C1 (esLanguage) |
| BR (1) | BR112016013896A2 (esLanguage) |
| CA (2) | CA2933883A1 (esLanguage) |
| DK (1) | DK3083686T4 (esLanguage) |
| ES (1) | ES2763429T5 (esLanguage) |
| FI (1) | FI3083686T4 (esLanguage) |
| HK (1) | HK1225634A1 (esLanguage) |
| HR (1) | HRP20192288T4 (esLanguage) |
| HU (1) | HUE047699T2 (esLanguage) |
| IL (3) | IL296657A (esLanguage) |
| LT (1) | LT3083686T (esLanguage) |
| MX (3) | MX2016007887A (esLanguage) |
| MY (1) | MY189089A (esLanguage) |
| NZ (2) | NZ720515A (esLanguage) |
| PL (1) | PL3083686T5 (esLanguage) |
| PT (1) | PT3083686T (esLanguage) |
| RS (1) | RS59659B2 (esLanguage) |
| RU (1) | RU2719487C2 (esLanguage) |
| SG (4) | SG11201604995YA (esLanguage) |
| SI (1) | SI3083686T2 (esLanguage) |
| WO (2) | WO2015095404A2 (esLanguage) |
| ZA (1) | ZA201603753B (esLanguage) |
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| BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
| BRPI0917592B1 (pt) | 2008-12-09 | 2021-08-17 | Genentech, Inc | Anticorpo anti-pd-l1, composição, artigos manufaturados e usos de uma composição |
| EP2747781B1 (en) | 2011-08-23 | 2017-11-15 | Roche Glycart AG | Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use |
| ES3023516T3 (en) | 2011-10-14 | 2025-06-02 | Hoffmann La Roche | Uses for and article of manufacture including her2 dimerization inhibitor pertuzumab |
| JP6444874B2 (ja) | 2012-10-08 | 2018-12-26 | ロシュ グリクアート アーゲー | ２つのＦａｂフラグメントを含むＦｃ不含抗体および使用方法 |
| NZ708182A (en) | 2013-02-26 | 2019-08-30 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
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2021
- 2021-03-09 US US17/196,457 patent/US20210189004A1/en not_active Abandoned
- 2021-09-23 US US17/483,281 patent/US20220002437A1/en not_active Abandoned
-
2022
- 2022-01-04 JP JP2022000201A patent/JP7645204B2/ja active Active
- 2022-04-01 US US17/711,170 patent/US20220306766A1/en not_active Abandoned
- 2022-12-16 US US18/067,407 patent/US20230203194A1/en not_active Abandoned
-
2023
- 2023-09-29 US US18/477,924 patent/US20240076404A1/en not_active Abandoned
-
2024
- 2024-05-08 US US18/657,996 patent/US20240309111A1/en not_active Abandoned
- 2024-10-11 JP JP2024179266A patent/JP2025020147A/ja active Pending
- 2024-11-22 US US18/956,269 patent/US20250084185A1/en not_active Abandoned
-
2025
- 2025-01-17 US US19/027,348 patent/US20250154282A1/en active Pending
- 2025-10-07 US US19/351,816 patent/US20260028419A1/en active Pending
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