JP2016507523A - ＣＤ３εおよびＢＣＭＡに対する二重特異的抗体 - Google Patents

ＣＤ３εおよびＢＣＭＡに対する二重特異的抗体 Download PDF

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JP2016507523A
JP2016507523A JP2015555752A JP2015555752A JP2016507523A JP 2016507523 A JP2016507523 A JP 2016507523A JP 2015555752 A JP2015555752 A JP 2015555752A JP 2015555752 A JP2015555752 A JP 2015555752A JP 2016507523 A JP2016507523 A JP 2016507523A
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antibody
bcma
cells
april
human
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JP2016507523A5 (enExample
Inventor
ミン ディエム ヴー，
ミン ディエム ヴー，
クラウス シュトライン，
クラウス シュトライン，
エッケハルト メスナー，
エッケハルト メスナー，
ラルフ ホッセ，
ラルフ ホッセ，
オリヴァー アスト，
オリヴァー アスト，
アンネ フライモーザー−グルントショーバー，
アンネ フライモーザー−グルントショーバー，
マリーナ バツァツ，
マリーナ バツァツ，
ターニャ ファウティ，
ターニャ ファウティ，
クリスティアン クライン，
クリスティアン クライン，
パブロ ウマーナ，
パブロ ウマーナ，
サミュエル モーザー，
サミュエル モーザー，
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エンクマフ アーゲー
エンクマフ アーゲー
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Priority claimed from EP13000571.3A external-priority patent/EP2762497A1/en
Priority claimed from EP13000570.5A external-priority patent/EP2762496A1/en
Application filed by エンクマフ アーゲー, エンクマフ アーゲー filed Critical エンクマフ アーゲー
Publication of JP2016507523A publication Critical patent/JP2016507523A/ja
Publication of JP2016507523A5 publication Critical patent/JP2016507523A5/ja
Priority to JP2020126460A priority Critical patent/JP6944573B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/71—Decreased effector function due to an Fc-modification
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JP2015555752A 2013-02-05 2014-02-05 ＣＤ３εおよびＢＣＭＡに対する二重特異的抗体 Withdrawn JP2016507523A (ja)

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JP2020126460A JP6944573B2 (ja) 2013-02-05 2020-07-27 ＣＤ３εおよびＢＣＭＡに対する二重特異的抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP13000570.5 2013-02-05
EP13000571.3A EP2762497A1 (en) 2013-02-05 2013-02-05 Bispecific antibodies against CD3epsilon and BCMA
EP13000571.3 2013-02-05
EP13000570.5A EP2762496A1 (en) 2013-02-05 2013-02-05 Method for the selection of antibodies against BCMA
PCT/EP2014/052190 WO2014122144A1 (en) 2013-02-05 2014-02-05 BISPECIFIC ANTIBODIES AGAINST CD3ε AND BCMA

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JP2015555752A Withdrawn JP2016507523A (ja) 2013-02-05 2014-02-05 ＣＤ３εおよびＢＣＭＡに対する二重特異的抗体
JP2015555751A Expired - Fee Related JP6636803B2 (ja) 2013-02-05 2014-02-05 Ｂｃｍａに対する抗体の選択のための方法
JP2019183002A Expired - Fee Related JP6918065B2 (ja) 2013-02-05 2019-10-03 Ｂｃｍａに対する抗体の選択のための方法
JP2020126460A Active JP6944573B2 (ja) 2013-02-05 2020-07-27 ＣＤ３εおよびＢＣＭＡに対する二重特異的抗体

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JP2015555751A Expired - Fee Related JP6636803B2 (ja) 2013-02-05 2014-02-05 Ｂｃｍａに対する抗体の選択のための方法
JP2019183002A Expired - Fee Related JP6918065B2 (ja) 2013-02-05 2019-10-03 Ｂｃｍａに対する抗体の選択のための方法
JP2020126460A Active JP6944573B2 (ja) 2013-02-05 2020-07-27 ＣＤ３εおよびＢＣＭＡに対する二重特異的抗体

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US (4) US9963513B2 (enExample)
EP (3) EP2953972B1 (enExample)
JP (4) JP2016507523A (enExample)
CN (3) CN104968682A (enExample)
DK (1) DK2953972T3 (enExample)
ES (2) ES2667420T3 (enExample)
PL (1) PL2953972T3 (enExample)
WO (2) WO2014122144A1 (enExample)

Cited By (4)

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JP2019515661A (ja) * 2016-04-01 2019-06-13 カイト ファーマ インコーポレイテッドＫｉｔｅ Ｐｈａｒｍａ， Ｉｎｃ Ｂｃｍａ結合分子及びその使用方法
KR20190121294A (ko) * 2016-12-22 2019-10-25 다이이찌 산쿄 가부시키가이샤 항-cd3 항체, 및 항-cd3 항체를 포함하는 분자
JP2020023523A (ja) * 2013-02-05 2020-02-13 エンクマフ エスアーエールエル Ｂｃｍａに対する抗体の選択のための方法
JP2021525715A (ja) * 2018-06-01 2021-09-27 ノバルティス アーゲー Ｂｃｍａに対する結合分子及びその使用

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RU2605390C2 (ru) 2011-08-23 2016-12-20 Рош Гликарт Аг Биспецифические антитела, специфичные к антигенам, активирующим т-клетки, и опухолевому антигену, и способы их применения
TWI679212B (zh) 2011-11-15 2019-12-11 美商安進股份有限公司 針對ｂｃｍａ之e3以及ｃｄ３的結合分子
MX2015003616A (es) 2012-10-08 2015-06-05 Roche Glycart Ag Anticuerpos sin fc que comprenden dos fragmentos fab y metodos de uso.
MX375359B (es) 2013-02-26 2025-03-06 Roche Glycart Ag Moléculas biespecíficas de unión a antígeno activadoras de células t.
TWI755763B (zh) 2013-06-04 2022-02-21 美商再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
TWI682781B (zh) 2013-07-11 2020-01-21 美商再生元醫藥公司 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法
GB201317928D0 (en) * 2013-10-10 2013-11-27 Ucl Business Plc Molecule
AU2015213437B2 (en) * 2014-02-07 2018-04-05 Mcmaster University Trifunctional T cell-antigen coupler and methods and uses thereof
US10370449B2 (en) 2014-02-28 2019-08-06 Regeneron Pharmaceuticals, Inc. Methods for treating skin infection by administering an IL-4R antagonist
JP6464255B2 (ja) 2014-08-04 2019-02-06 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 二重特異性ｔ細胞活性化抗原結合分子
CA2963692A1 (en) 2014-10-09 2016-04-14 Engmab Ag Bispecific antibodies against cd3epsilon and ror1
EP3023437A1 (en) * 2014-11-20 2016-05-25 EngMab AG Bispecific antibodies against CD3epsilon and BCMA
HRP20201156T1 (hr) 2014-11-20 2020-11-13 F. Hoffmann - La Roche Ag Zajednički laki lanci i postupci primjene
CA2960929A1 (en) 2014-11-20 2016-05-26 F. Hoffmann-La Roche Ag T cell activating bispecific antigen binding molecules against folr1 and cd3
SG11201704056XA (en) 2014-11-20 2017-06-29 Hoffmann La Roche Combination therapy of t cell activating bispecific antigen binding molecules cd3 abd folate receptor 1 (folr1) and pd-1 axis binding antagonists
EP3029068A1 (en) * 2014-12-03 2016-06-08 EngMab AG Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases
TWI703159B (zh) 2015-04-13 2020-09-01 美商輝瑞股份有限公司 Bcma特異性治療性抗體及其用途
ES3039918T3 (en) 2015-04-13 2025-10-27 Pfizer Chimeric antigen receptors targeting b-cell maturation antigen
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