|
WO2008027558A2
(en)
|
2006-08-31 |
2008-03-06 |
Codon Devices, Inc. |
Iterative nucleic acid assembly using activation of vector-encoded traits
|
|
CN103502448B
(zh)
|
2010-11-12 |
2017-03-29 |
Gen9股份有限公司 |
核酸合成的方法和设备
|
|
EP2637780B1
(en)
|
2010-11-12 |
2022-02-09 |
Gen9, Inc. |
Protein arrays and methods of using and making the same
|
|
MX2013010911A
(es)
|
2011-03-23 |
2015-03-03 |
Pioneer Hi Bred Int |
Metodos para producir un locus de rasgo transgenico complejo.
|
|
JP6261500B2
(ja)
|
2011-07-22 |
2018-01-17 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ヌクレアーゼ切断特異性の評価および改善
|
|
LT2944693T
(lt)
|
2011-08-26 |
2019-08-26 |
Gen9, Inc. |
Kompozicijos ir būdai, skirti nukleorūgščių didelio tikslumo sąrankai
|
|
WO2013055995A2
(en)
|
2011-10-14 |
2013-04-18 |
President And Fellows Of Harvard College |
Sequencing by structure assembly
|
|
ES2991004T3
(es)
|
2011-12-22 |
2024-12-02 |
Harvard College |
Métodos para la detección de analitos
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
US9150853B2
(en)
|
2012-03-21 |
2015-10-06 |
Gen9, Inc. |
Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
|
|
CN111876409A
(zh)
|
2012-04-24 |
2020-11-03 |
Gen9股份有限公司 |
在体外克隆中分选核酸和多重制备物的方法
|
|
IN2014DN09261A
(https=)
|
2012-04-25 |
2015-07-10 |
Regeneron Pharma |
|
|
EP3597741A1
(en)
|
2012-04-27 |
2020-01-22 |
Duke University |
Genetic correction of mutated genes
|
|
EP3241902B1
(en)
|
2012-05-25 |
2018-02-28 |
The Regents of The University of California |
Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
|
|
EP2861737B1
(en)
|
2012-06-19 |
2019-04-17 |
Regents Of The University Of Minnesota |
Gene targeting in plants using dna viruses
|
|
AU2013280661A1
(en)
|
2012-06-25 |
2015-01-22 |
Gen9, Inc. |
Methods for nucleic acid assembly and high throughput sequencing
|
|
KR102530118B1
(ko)
*
|
2012-07-25 |
2023-05-08 |
더 브로드 인스티튜트, 인코퍼레이티드 |
유도 ｄｎａ 결합 단백질 및 게놈 교란 도구 및 이의 적용
|
|
EP4357457B1
(en)
*
|
2012-10-23 |
2024-10-16 |
Toolgen Incorporated |
Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof
|
|
ES2778033T3
(es)
|
2012-11-16 |
2020-08-07 |
Poseida Therapeutics Inc |
Enzimas específicas de sitio y métodos de uso
|
|
EP3363902B1
(en)
|
2012-12-06 |
2019-11-27 |
Sigma Aldrich Co. LLC |
Crispr-based genome modification and regulation
|
|
AU2013359262C1
(en)
*
|
2012-12-12 |
2021-05-13 |
Massachusetts Institute Of Technology |
CRISPR-Cas component systems, methods and compositions for sequence manipulation
|
|
DK2931897T3
(en)
|
2012-12-12 |
2018-02-05 |
Broad Inst Inc |
CONSTRUCTION, MODIFICATION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTICAL APPLICATIONS
|
|
WO2014093709A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
DK2931898T3
(en)
|
2012-12-12 |
2016-06-20 |
Massachusetts Inst Technology |
CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS
|
|
WO2014093694A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes
|
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
CA2894684A1
(en)
*
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Engineering and optimization of improved crispr-cas systems, methods and enzyme compositions for sequence manipulation in eukaryotes
|
|
CN105121648B
(zh)
*
|
2012-12-12 |
2021-05-07 |
布罗德研究所有限公司 |
用于序列操纵的系统、方法和优化的指导组合物的工程化
|
|
WO2014093718A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
CA2895155C
(en)
*
|
2012-12-17 |
2021-07-06 |
President And Fellows Of Harvard College |
Rna-guided human genome engineering
|
|
WO2014131833A1
(en)
|
2013-02-27 |
2014-09-04 |
Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) |
Gene editing in the oocyte by cas9 nucleases
|
|
EP3578666A1
(en)
|
2013-03-12 |
2019-12-11 |
President and Fellows of Harvard College |
Method of generating a three-dimensional nucleic acid containing matrix
|
|
MX374090B
(es)
|
2013-03-14 |
2025-03-05 |
Caribou Biosciences Inc |
Composiciones y métodos de ácidos nucleicos dirigidos al ácido nucleico.
|
|
WO2014204578A1
(en)
|
2013-06-21 |
2014-12-24 |
The General Hospital Corporation |
Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
|
|
US20140273230A1
(en)
*
|
2013-03-15 |
2014-09-18 |
Sigma-Aldrich Co., Llc |
Crispr-based genome modification and regulation
|
|
AU2014227653B2
(en)
|
2013-03-15 |
2017-04-20 |
The General Hospital Corporation |
Using RNA-guided foki nucleases (RFNs) to increase specificity for RNA-guided genome editing
|
|
US20140273235A1
(en)
*
|
2013-03-15 |
2014-09-18 |
Regents Of The University Of Minnesota |
ENGINEERING PLANT GENOMES USING CRISPR/Cas SYSTEMS
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
US20160186208A1
(en)
*
|
2013-04-16 |
2016-06-30 |
Whitehead Institute For Biomedical Research |
Methods of Mutating, Modifying or Modulating Nucleic Acid in a Cell or Nonhuman Mammal
|
|
SI2986729T1
(sl)
|
2013-04-16 |
2019-02-28 |
Regeneron Pharmaceuticals, Inc. |
Ciljana sprememba genoma podgane
|
|
CN105683376A
(zh)
*
|
2013-05-15 |
2016-06-15 |
桑格摩生物科学股份有限公司 |
用于治疗遗传病状的方法和组合物
|
|
US20160122774A1
(en)
*
|
2013-05-29 |
2016-05-05 |
Cellectis |
A method for producing precise dna cleavage using cas9 nickase activity
|
|
EP4596565A3
(en)
|
2013-06-04 |
2025-11-05 |
President And Fellows Of Harvard College |
Rna-guided transcriptional regulation
|
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
|
EP3004370B1
(en)
*
|
2013-06-05 |
2024-08-21 |
Duke University |
Rna-guided gene editing and gene regulation
|
|
CN105531372A
(zh)
|
2013-06-14 |
2016-04-27 |
塞尔克蒂斯股份有限公司 |
植物中非转基因基因组编辑方法
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
MX2015017312A
(es)
*
|
2013-06-17 |
2017-04-10 |
Broad Inst Inc |
Suministro y uso de composiciones, vectores y sistemas crispr-cas para la modificación dirigida y terapia hepáticas.
|
|
KR20160019553A
(ko)
*
|
2013-06-17 |
2016-02-19 |
더 브로드 인스티튜트, 인코퍼레이티드 |
유사분열 후 세포의 질병 및 장애를 표적화하고 모델링하기 위한 시스템, 방법 및 조성물의 전달, 유전자 조작 및 최적화
|
|
EP3011030B1
(en)
*
|
2013-06-17 |
2023-11-08 |
The Broad Institute, Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
KR20250012194A
(ko)
*
|
2013-06-17 |
2025-01-23 |
더 브로드 인스티튜트, 인코퍼레이티드 |
바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용
|
|
WO2014204724A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
WO2015006294A2
(en)
*
|
2013-07-10 |
2015-01-15 |
President And Fellows Of Harvard College |
Orthogonal cas9 proteins for rna-guided gene regulation and editing
|
|
US10563225B2
(en)
*
|
2013-07-26 |
2020-02-18 |
President And Fellows Of Harvard College |
Genome engineering
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
CA3109801C
(en)
|
2013-08-22 |
2024-01-09 |
Andrew Cigan |
Plant genome modification using guide rna/cas endonuclease systems and methods of use
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
EP3418379B1
(en)
|
2013-09-18 |
2020-12-09 |
Kymab Limited |
Methods, cells & organisms
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
WO2015066119A1
(en)
|
2013-10-30 |
2015-05-07 |
North Carolina State University |
Compositions and methods related to a type-ii crispr-cas system in lactobacillus buchneri
|
|
AU2014346559B2
(en)
|
2013-11-07 |
2020-07-09 |
Editas Medicine,Inc. |
CRISPR-related methods and compositions with governing gRNAs
|
|
US9546384B2
(en)
|
2013-12-11 |
2017-01-17 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for the targeted modification of a mouse genome
|
|
SMT201800653T1
(it)
|
2013-12-11 |
2019-01-11 |
Regeneron Pharma |
Metodi e composizioni per la modificazione indirizzata a bersaglio di un genoma
|
|
JP6793547B2
(ja)
|
2013-12-12 |
2020-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
最適化機能ＣＲＩＳＰＲ−Ｃａｓ系による配列操作のための系、方法および組成物
|
|
EP3080259B1
(en)
|
2013-12-12 |
2023-02-01 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
US20150165054A1
(en)
*
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
MX2016007325A
(es)
|
2013-12-12 |
2017-07-19 |
Broad Inst Inc |
Composiciones y metodos de uso de sistemas crispr-cas en desordenes debidos a repeticion de nucleotidos.
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
AU2014361834B2
(en)
|
2013-12-12 |
2020-10-22 |
Massachusetts Institute Of Technology |
CRISPR-Cas systems and methods for altering expression of gene products, structural information and inducible modular Cas enzymes
|
|
BR112016013207A2
(pt)
|
2013-12-12 |
2017-09-26 |
Massachusetts Inst Technology |
administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para o hbv e distúrbios e doenças virais
|
|
AU2014361781B2
(en)
|
2013-12-12 |
2021-04-01 |
Massachusetts Institute Of Technology |
Delivery, use and therapeutic applications of the CRISPR -Cas systems and compositions for genome editing
|
|
US10787654B2
(en)
*
|
2014-01-24 |
2020-09-29 |
North Carolina State University |
Methods and compositions for sequence guiding Cas9 targeting
|
|
EP4063503A1
(en)
|
2014-02-11 |
2022-09-28 |
The Regents of the University of Colorado, a body corporate |
Crispr enabled multiplexed genome engineering
|
|
JP2017506893A
(ja)
|
2014-02-18 |
2017-03-16 |
デューク ユニバーシティ |
ウイルス複製不活化組成物並びにその製造方法及び使用
|
|
WO2015134812A1
(en)
|
2014-03-05 |
2015-09-11 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
WO2015138510A1
(en)
|
2014-03-10 |
2015-09-17 |
Editas Medicine., Inc. |
Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
CA2943622A1
(en)
*
|
2014-03-25 |
2015-10-01 |
Editas Medicine Inc. |
Crispr/cas-related methods and compositions for treating hiv infection and aids
|
|
US11242525B2
(en)
|
2014-03-26 |
2022-02-08 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating sickle cell disease
|
|
US12460231B2
(en)
|
2014-04-02 |
2025-11-04 |
Editas Medicine, Inc. |
Crispr/CAS-related methods and compositions for treating primary open angle glaucoma
|
|
US11439712B2
(en)
|
2014-04-08 |
2022-09-13 |
North Carolina State University |
Methods and compositions for RNA-directed repression of transcription using CRISPR-associated genes
|
|
WO2015168125A1
(en)
|
2014-04-28 |
2015-11-05 |
Recombinetics, Inc. |
Multiplex gene editing in swine
|
|
EP3152319A4
(en)
*
|
2014-06-05 |
2017-12-27 |
Sangamo BioSciences, Inc. |
Methods and compositions for nuclease design
|
|
RS60359B1
(sr)
|
2014-06-06 |
2020-07-31 |
Regeneron Pharma |
Postupci i kompozicije za modifikovanje ciljanog lokusa
|
|
DK3155101T3
(da)
|
2014-06-16 |
2020-05-04 |
Univ Johns Hopkins |
Sammensætninger og fremgangsmåder til ekspression af CRISPR-leder-RNA´er under anvendelse af H1-promotoren
|
|
EP3157328B1
(en)
*
|
2014-06-17 |
2021-08-04 |
Poseida Therapeutics, Inc. |
A method for directing proteins to specific loci in the genome and uses thereof
|
|
HUE049405T2
(hu)
*
|
2014-06-23 |
2020-09-28 |
Regeneron Pharma |
Nukleáz-közvetített DNS-összeállítás
|
|
KR102386101B1
(ko)
|
2014-06-26 |
2022-04-14 |
리제너론 파마슈티칼스 인코포레이티드 |
표적화된 유전자 변형을 위한 방법 및 그 조성물, 및 사용 방법
|
|
WO2016007604A1
(en)
*
|
2014-07-09 |
2016-01-14 |
Gen9, Inc. |
Compositions and methods for site-directed dna nicking and cleaving
|
|
WO2016007839A1
(en)
|
2014-07-11 |
2016-01-14 |
President And Fellows Of Harvard College |
Methods for high-throughput labelling and detection of biological features in situ using microscopy
|
|
ES3047792T3
(en)
*
|
2014-07-14 |
2025-12-04 |
Univ California |
Crispr/cas transcriptional modulation
|
|
WO2016022363A2
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
CN106922154B
(zh)
|
2014-08-06 |
2022-01-07 |
基因工具股份有限公司 |
使用空肠弯曲杆菌crispr/cas系统衍生的rna引导的工程化核酸酶的基因编辑
|
|
EP3633032A3
(en)
|
2014-08-28 |
2020-07-29 |
North Carolina State University |
Novel cas9 proteins and guiding features for dna targeting and genome editing
|
|
WO2016036754A1
(en)
|
2014-09-02 |
2016-03-10 |
The Regents Of The University Of California |
Methods and compositions for rna-directed target dna modification
|
|
CN108064129A
(zh)
|
2014-09-12 |
2018-05-22 |
纳幕尔杜邦公司 |
玉米和大豆中复合性状基因座的位点特异性整合位点的产生和使用方法
|
|
WO2016057951A2
(en)
*
|
2014-10-09 |
2016-04-14 |
Life Technologies Corporation |
Crispr oligonucleotides and gene editing
|
|
DK3204399T3
(da)
*
|
2014-10-09 |
2025-02-24 |
Seattle Childrens Hospital Dba Seattle Childrens Res Inst |
Lange poly (a)-plasmider og fremgangsmåder til indføring af lange poly (a)-sekvenser i plasmidet
|
|
EP3204496A1
(en)
|
2014-10-10 |
2017-08-16 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
DK3207124T3
(da)
|
2014-10-15 |
2019-08-12 |
Regeneron Pharma |
Fremgangsmåder og sammensætninger til generering eller bevaring af pluripotente celler
|
|
GB201418965D0
(https=)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
|
US20170306306A1
(en)
*
|
2014-10-24 |
2017-10-26 |
Life Technologies Corporation |
Compositions and Methods for Enhancing Homologous Recombination
|
|
CN107429246B
(zh)
*
|
2014-10-31 |
2021-06-01 |
麻省理工学院 |
用于crispr的大规模并行组合遗传学
|
|
CN107406838A
(zh)
*
|
2014-11-06 |
2017-11-28 |
纳幕尔杜邦公司 |
Rna引导的内切核酸酶向细胞中的肽介导的递送
|
|
CA2963820A1
(en)
|
2014-11-07 |
2016-05-12 |
Editas Medicine, Inc. |
Methods for improving crispr/cas-mediated genome-editing
|
|
CN107532142A
(zh)
*
|
2014-11-11 |
2018-01-02 |
应用干细胞有限公司 |
使用同源重组改造间充质干细胞
|
|
US10858662B2
(en)
|
2014-11-19 |
2020-12-08 |
Institute For Basic Science |
Genome editing with split Cas9 expressed from two vectors
|
|
ES2731437T3
(es)
|
2014-11-21 |
2019-11-15 |
Regeneron Pharma |
Métodos y composiciones para la modificación genética dirigida mediante el uso de pares de ARN guías
|
|
GB201421096D0
(en)
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
|
US10900034B2
(en)
|
2014-12-03 |
2021-01-26 |
Agilent Technologies, Inc. |
Guide RNA with chemical modifications
|
|
AU2015360502A1
(en)
|
2014-12-10 |
2017-06-29 |
Regents Of The University Of Minnesota |
Genetically modified cells, tissues, and organs for treating disease
|
|
EP3889260A1
(en)
|
2014-12-12 |
2021-10-06 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
CN112877327B
(zh)
*
|
2014-12-18 |
2024-11-22 |
综合基因技术公司 |
基于crispr的组合物和使用方法
|
|
WO2016100857A1
(en)
|
2014-12-19 |
2016-06-23 |
Regeneron Pharmaceuticals, Inc. |
Stem cells for modeling type 2 diabetes
|
|
KR102530821B1
(ko)
|
2014-12-19 |
2023-05-10 |
리제너론 파마슈티칼스 인코포레이티드 |
단일 단계 다중 표적화를 통한 표적화된 유전자 변형을 위한 방법 및 조성물
|
|
WO2016106244A1
(en)
|
2014-12-24 |
2016-06-30 |
The Broad Institute Inc. |
Crispr having or associated with destabilization domains
|
|
US11248240B2
(en)
|
2015-01-29 |
2022-02-15 |
Meiogenix |
Method for inducing targeted meiotic recombinations
|
|
US10676726B2
(en)
|
2015-02-09 |
2020-06-09 |
Duke University |
Compositions and methods for epigenome editing
|
|
EP3280803B1
(en)
|
2015-04-06 |
2021-05-26 |
The Board of Trustees of the Leland Stanford Junior University |
Chemically modified guide rnas for crispr/cas-mediated gene regulation
|
|
CA2982966C
(en)
|
2015-04-24 |
2024-02-20 |
Editas Medicine, Inc. |
Evaluation of cas9 molecule/guide rna molecule complexes
|
|
WO2016176617A2
(en)
|
2015-04-29 |
2016-11-03 |
New York University |
Method for treating high-grade gliomas
|
|
EP3292219B9
(en)
|
2015-05-04 |
2022-05-18 |
Ramot at Tel-Aviv University Ltd. |
Methods and kits for fragmenting dna
|
|
AU2016261358B2
(en)
|
2015-05-11 |
2021-09-16 |
Editas Medicine, Inc. |
Optimized CRISPR/Cas9 systems and methods for gene editing in stem cells
|
|
MX382223B
(es)
*
|
2015-05-12 |
2025-03-13 |
Sangamo Therapeutics Inc |
Regulacion de expresion genica mediada por nucleasa.
|
|
KR20220139447A
(ko)
|
2015-05-29 |
2022-10-14 |
노쓰 캐롤라이나 스테이트 유니버시티 |
크리스퍼 핵산을 사용하여 박테리아, 고세균, 조류 및 효모를 스크리닝하는 방법
|
|
WO2016196887A1
(en)
|
2015-06-03 |
2016-12-08 |
Board Of Regents Of The University Of Nebraska |
Dna editing using single-stranded dna
|
|
EP3307887A1
(en)
|
2015-06-09 |
2018-04-18 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for improving transplantation
|
|
KR102468240B1
(ko)
|
2015-06-15 |
2022-11-17 |
노쓰 캐롤라이나 스테이트 유니버시티 |
핵산 및 rna-기반 항미생물제를 효율적으로 전달하기 위한 방법 및 조성물
|
|
EP3929286A1
(en)
*
|
2015-06-17 |
2021-12-29 |
Poseida Therapeutics, Inc. |
Compositions and methods for directing proteins to specific loci in the genome
|
|
TWI813532B
(zh)
|
2015-06-18 |
2023-09-01 |
美商博得學院股份有限公司 |
降低脱靶效應的ｃｒｉｓｐｒ酶突變
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
WO2016210271A1
(en)
*
|
2015-06-24 |
2016-12-29 |
Sigma-Aldrich Co. Llc |
Cell cycle dependent genome regulation and modification
|
|
GB2592821B
(en)
|
2015-07-31 |
2022-01-12 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
CA3033909A1
(en)
|
2015-08-14 |
2017-02-23 |
The University Of Sydney |
Connexin 45 inhibition for therapy
|
|
EP3341727B1
(en)
|
2015-08-25 |
2022-08-10 |
Duke University |
Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
AU2016316845B2
(en)
|
2015-08-28 |
2022-03-10 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
AU2016326711B2
(en)
|
2015-09-24 |
2022-11-03 |
Editas Medicine, Inc. |
Use of exonucleases to improve CRISPR/Cas-mediated genome editing
|
|
KR101745863B1
(ko)
|
2015-09-25 |
2017-06-12 |
전남대학교산학협력단 |
Crispr/cas9 시스템을 이용한 프로히비틴2 유전자 제거용 시발체
|
|
KR101795999B1
(ko)
|
2015-09-25 |
2017-11-09 |
전남대학교산학협력단 |
Crispr/cas9 시스템을 이용한 베타2-마이크로글로불린 유전자 제거용 시발체
|
|
WO2017058751A1
(en)
|
2015-09-28 |
2017-04-06 |
North Carolina State University |
Methods and compositions for sequence specific antimicrobials
|
|
EP4089175A1
(en)
*
|
2015-10-13 |
2022-11-16 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
|
JP2018537891A
(ja)
|
2015-10-22 |
2018-12-20 |
テレフオンアクチーボラゲット エルエム エリクソン（パブル） |
無線信号の選択的な強化に関する方法および装置
|
|
JP7109784B2
(ja)
*
|
2015-10-23 |
2022-08-01 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
遺伝子編集のための進化したＣａｓ９蛋白質
|
|
US20180230489A1
(en)
|
2015-10-28 |
2018-08-16 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
|
JP6882282B2
(ja)
|
2015-11-03 |
2021-06-02 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
三次元核酸含有マトリックスの立体撮像のための方法と装置
|
|
CN106893739A
(zh)
|
2015-11-17 |
2017-06-27 |
香港中文大学 |
用于靶向基因操作的新方法和系统
|
|
US10240145B2
(en)
*
|
2015-11-25 |
2019-03-26 |
The Board Of Trustees Of The Leland Stanford Junior University |
CRISPR/Cas-mediated genome editing to treat EGFR-mutant lung cancer
|
|
EA201891317A3
(ru)
|
2015-11-30 |
2019-04-30 |
Дьюк Юниверсити |
Терапевтические мишени для коррекции гена дистрофина человека с помощью редактирования генов и способы их применения
|
|
US11542466B2
(en)
|
2015-12-22 |
2023-01-03 |
North Carolina State University |
Methods and compositions for delivery of CRISPR based antimicrobials
|
|
WO2017123559A2
(en)
|
2016-01-11 |
2017-07-20 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric proteins and methods of regulating gene expression
|
|
ES2875747T3
(es)
|
2016-01-11 |
2021-11-11 |
Univ Leland Stanford Junior |
Proteínas quiméricas y métodos de inmunoterapia
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
WO2017165862A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
EP3433363A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
US20190127713A1
(en)
|
2016-04-13 |
2019-05-02 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
WO2017180694A1
(en)
|
2016-04-13 |
2017-10-19 |
Editas Medicine, Inc. |
Cas9 fusion molecules gene editing systems, and methods of use thereof
|
|
WO2017180926A1
(en)
*
|
2016-04-14 |
2017-10-19 |
Boco Silicon Valley. Inc. |
Genome editing of human neural stem cells using nucleases
|
|
US11499168B2
(en)
*
|
2016-04-25 |
2022-11-15 |
Universitat Basel |
Allele editing and applications thereof
|
|
CN109415761B
(zh)
|
2016-04-25 |
2022-09-20 |
哈佛学院董事及会员团体 |
用于原位分子检测的杂交链反应方法
|
|
CN116850305A
(zh)
*
|
2016-05-06 |
2023-10-10 |
朱诺治疗学股份有限公司 |
基因工程化细胞及其制备方法
|
|
IL323024A
(en)
|
2016-05-20 |
2025-10-01 |
Regeneron Pharma |
Methods for breaking immunological tolerance using multiple guide RNAs
|
|
LT3604527T
(lt)
*
|
2016-06-02 |
2021-06-25 |
Sigma-Aldrich Co., Llc |
Programuojamų, dnr surišančių baltymų panaudojimas tiksliniam genomo modifikavimui pagerinti
|
|
CA3026332A1
(en)
*
|
2016-06-03 |
2017-12-14 |
Temple University - Of The Commonwealth System Of Higher Education |
Negative feedback regulation of hiv-1 by gene editing strategy
|
|
CN116064534A
(zh)
*
|
2016-06-03 |
2023-05-05 |
国家医疗保健研究所 |
编码Cas9核酸酶的核酸的饮食控制的表达及其用途
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
US10337051B2
(en)
|
2016-06-16 |
2019-07-02 |
The Regents Of The University Of California |
Methods and compositions for detecting a target RNA
|
|
US11293021B1
(en)
|
2016-06-23 |
2022-04-05 |
Inscripta, Inc. |
Automated cell processing methods, modules, instruments, and systems
|
|
US10017760B2
(en)
|
2016-06-24 |
2018-07-10 |
Inscripta, Inc. |
Methods for generating barcoded combinatorial libraries
|
|
US11603533B2
(en)
|
2016-07-12 |
2023-03-14 |
Washington University |
Incorporation of internal polya-encoded poly-lysine sequence tags and their variations for the tunable control of protein synthesis in bacterial and eukaryotic cells
|
|
WO2018017754A1
(en)
|
2016-07-19 |
2018-01-25 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
JP7556688B2
(ja)
|
2016-07-28 |
2024-09-26 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Ｇｐｒ１５６変異体及びその使用
|
|
JP2019523009A
(ja)
|
2016-07-29 |
2019-08-22 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． |
Ｃ末端切断型フィブリリン−１の発現をもたらす変異を有するマウス
|
|
WO2018026976A1
(en)
|
2016-08-02 |
2018-02-08 |
Editas Medicine, Inc. |
Compositions and methods for treating cep290 associated disease
|
|
KR102547316B1
(ko)
|
2016-08-03 |
2023-06-23 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
|
US11661590B2
(en)
|
2016-08-09 |
2023-05-30 |
President And Fellows Of Harvard College |
Programmable CAS9-recombinase fusion proteins and uses thereof
|
|
JP2019524149A
(ja)
*
|
2016-08-20 |
2019-09-05 |
アベリノ ラボ ユーエスエー インコーポレイテッドＡｖｅｌｌｉｎｏ Ｌａｂ ＵＳＡ， Ｉｎｃ． |
一本鎖ガイドＲＮＡ、ＣＲＩＳＰＲ／Ｃａｓ９システム、及びそれらの使用方法
|
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
CN109923216B
(zh)
|
2016-08-31 |
2024-08-02 |
哈佛学院董事及会员团体 |
将生物分子的检测组合到使用荧光原位测序的单个试验的方法
|
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
|
WO2018048827A1
(en)
*
|
2016-09-07 |
2018-03-15 |
Massachusetts Institute Of Technology |
Rna-guided endonuclease-based dna assembly
|
|
CN106636197B
(zh)
*
|
2016-09-22 |
2019-09-03 |
南京市妇幼保健院 |
一种定向敲降斑马鱼基因组中多拷贝基因的方法
|
|
US20190225974A1
(en)
|
2016-09-23 |
2019-07-25 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome optimization in plants
|
|
JP7306696B2
(ja)
|
2016-09-30 |
2023-07-11 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Ｒｎａ誘導型核酸修飾酵素及びその使用方法
|
|
CA3038960A1
(en)
|
2016-09-30 |
2018-04-05 |
The Regents Of The University Of California |
Rna-guided nucleic acid modifying enzymes and methods of use thereof
|
|
EP3525831A4
(en)
*
|
2016-10-11 |
2020-06-03 |
Stemgenics, Inc. |
NANOPARTICLES FUNCTIONALIZED WITH GENE EDITING TOOLS AND RELATED METHODS
|
|
AU2017341926B2
(en)
|
2016-10-14 |
2022-06-30 |
The General Hospital Corporation |
Epigenetically regulated site-specific nucleases
|
|
EP3526320A1
(en)
|
2016-10-14 |
2019-08-21 |
President and Fellows of Harvard College |
Aav delivery of nucleobase editors
|
|
GB201617559D0
(en)
|
2016-10-17 |
2016-11-30 |
University Court Of The University Of Edinburgh The |
Swine comprising modified cd163 and associated methods
|
|
JP7181862B2
(ja)
|
2016-10-18 |
2022-12-01 |
リージェンツ オブ ザ ユニバーシティ オブ ミネソタ |
腫瘍浸潤リンパ球および治療の方法
|
|
AU2017355218B2
(en)
*
|
2016-11-02 |
2024-02-22 |
Universität Basel |
Immunologically discernible cell surface variants for use in cell therapy
|
|
WO2018119010A1
(en)
|
2016-12-19 |
2018-06-28 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
AU2017379073B2
(en)
*
|
2016-12-22 |
2023-12-14 |
Intellia Therapeutics, Inc. |
Compositions and methods for treating alpha-1 antitrypsin deficiency
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
KR102151065B1
(ko)
*
|
2016-12-23 |
2020-09-02 |
기초과학연구원 |
동물 배아의 염기 교정용 조성물 및 염기 교정 방법
|
|
US11859219B1
(en)
|
2016-12-30 |
2024-01-02 |
Flagship Pioneering Innovations V, Inc. |
Methods of altering a target nucleotide sequence with an RNA-guided nuclease and a single guide RNA
|
|
EP3565907B1
(en)
|
2017-01-06 |
2022-05-04 |
Editas Medicine, Inc. |
Methods of assessing nuclease cleavage
|
|
IL314915B1
(en)
|
2017-01-23 |
2026-02-01 |
Regeneron Pharma |
Variants of 17-beta-hydroxysteroid dehydrogenase and their uses
|
|
WO2018140497A1
(en)
|
2017-01-25 |
2018-08-02 |
Efimov Igor R |
Apparatus and methods for in vitro preclinical human trials
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
CN106978438B
(zh)
*
|
2017-02-27 |
2020-08-28 |
北京大北农生物技术有限公司 |
提高同源重组效率的方法
|
|
JP2020510038A
(ja)
|
2017-03-09 |
2020-04-02 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
がんワクチン
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
EP3596217A1
(en)
|
2017-03-14 |
2020-01-22 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
CA3057192A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
US11913015B2
(en)
|
2017-04-17 |
2024-02-27 |
University Of Maryland, College Park |
Embryonic cell cultures and methods of using the same
|
|
US11834670B2
(en)
|
2017-04-19 |
2023-12-05 |
Global Life Sciences Solutions Usa Llc |
Site-specific DNA modification using a donor DNA repair template having tandem repeat sequences
|
|
WO2018195402A1
(en)
|
2017-04-20 |
2018-10-25 |
Egenesis, Inc. |
Methods for generating genetically modified animals
|
|
WO2018195545A2
(en)
|
2017-04-21 |
2018-10-25 |
The General Hospital Corporation |
Variants of cpf1 (cas12a) with altered pam specificity
|
|
US11499151B2
(en)
|
2017-04-28 |
2022-11-15 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide RNA molecules
|
|
EP3622070A2
(en)
|
2017-05-10 |
2020-03-18 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
|
US20200172895A1
(en)
|
2017-05-25 |
2020-06-04 |
The General Hospital Corporation |
Using split deaminases to limit unwanted off-target base editor deamination
|
|
MX2019014661A
(es)
|
2017-06-05 |
2020-07-29 |
Regeneron Pharma |
Variantes de b4galt1 y usos de estas.
|
|
WO2018227114A1
(en)
|
2017-06-09 |
2018-12-13 |
Editas Medicine, Inc. |
Engineered cas9 nucleases
|
|
CA3067382A1
(en)
|
2017-06-15 |
2018-12-20 |
The Regents Of The University Of California |
Targeted non-viral dna insertions
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
EP4484562A3
(en)
|
2017-06-27 |
2025-03-26 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized asgr1 locus
|
|
MX2019015505A
(es)
|
2017-06-30 |
2020-07-28 |
Inscripta Inc |
Metodos, modulos, instrumentos y sistemas de procesamiento de celulas automatizados.
|
|
WO2019006418A2
(en)
|
2017-06-30 |
2019-01-03 |
Intima Bioscience, Inc. |
ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
|
|
KR102523217B1
(ko)
|
2017-07-11 |
2023-04-20 |
시그마-알드리치 컴퍼니., 엘엘씨 |
표적된 게놈 변형을 개선하기 위한 뉴클레오솜 상호작용 단백질 도메인 사용
|
|
US11866726B2
(en)
|
2017-07-14 |
2024-01-09 |
Editas Medicine, Inc. |
Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
|
|
WO2019023680A1
(en)
|
2017-07-28 |
2019-01-31 |
President And Fellows Of Harvard College |
METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE)
|
|
BR112019028146A2
(pt)
*
|
2017-07-31 |
2020-07-07 |
Sigma-Aldrich Co. Llc |
rna guia sintético para sistemas ativadores de crispr/cas
|
|
WO2019028032A1
(en)
|
2017-07-31 |
2019-02-07 |
Regeneron Pharmaceuticals, Inc. |
EMBRYONIC STEM CELLS OF TRANSGENIC MOUSE CASES AND MICE AND USES THEREOF
|
|
CN111182790A
(zh)
|
2017-07-31 |
2020-05-19 |
瑞泽恩制药公司 |
Crispr报告体非人类动物及其用途
|
|
CN110891419A
(zh)
|
2017-07-31 |
2020-03-17 |
瑞泽恩制药公司 |
评价crispr/cas-诱导的与外源供体核酸的体内重组
|
|
JP7355730B2
(ja)
*
|
2017-08-09 |
2023-10-03 |
ベンソン ヒル，インコーポレイティド |
ゲノムを修飾するための組成物及び方法
|
|
US10738327B2
(en)
|
2017-08-28 |
2020-08-11 |
Inscripta, Inc. |
Electroporation cuvettes for automation
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
WO2019050948A1
(en)
*
|
2017-09-05 |
2019-03-14 |
Regeneron Pharmaceuticals, Inc. |
ADMINISTRATION OF A GENE EDITION SYSTEM HAVING ONLY ONE RETROVIRAL PARTICLE AND METHODS OF GENERATING AND USING
|
|
CA3074652A1
(en)
|
2017-09-06 |
2019-03-14 |
Regeneron Pharmaceuticals, Inc. |
Single immunoglobulin interleukin-1 receptor related (sigirr) variants and uses thereof
|
|
JP2020536500A
(ja)
|
2017-09-07 |
2020-12-17 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． |
溶質キャリアファミリー１４メンバー１（ｓｌｃ１４ａ１）の変異型及びその使用
|
|
MX394999B
(es)
|
2017-09-29 |
2025-03-24 |
Regeneron Pharma |
Animales no humanos que comprenden un locus ttr humanizado y metodos de uso
|
|
EP3687621A4
(en)
|
2017-09-30 |
2021-08-11 |
Inscripta, Inc. |
Flow through electroporation instrumentation
|
|
EP3697807A1
(en)
|
2017-10-16 |
2020-08-26 |
Regeneron Pharmaceuticals, Inc. |
Cornulin (crnn) variants and uses thereof
|
|
KR20250107288A
(ko)
|
2017-10-16 |
2025-07-11 |
더 브로드 인스티튜트, 인코퍼레이티드 |
아데노신 염기 편집제의 용도
|
|
US11634716B2
(en)
|
2017-10-16 |
2023-04-25 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Genetically modified mesenchymal stem cells for use in cardiovascular prosthetics
|
|
KR102503130B1
(ko)
|
2017-10-27 |
2023-02-24 |
더 리전트 오브 더 유니버시티 오브 캘리포니아 |
내인성 t 세포 수용체의 표적화된 대체
|
|
WO2019089804A1
(en)
|
2017-11-01 |
2019-05-09 |
The Regents Of The University Of California |
Casy compositions and methods of use
|
|
JP2021503278A
(ja)
|
2017-11-01 |
2021-02-12 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
ＣａｓＺ組成物及び使用方法
|
|
WO2019089808A1
(en)
|
2017-11-01 |
2019-05-09 |
The Regents Of The University Of California |
Class 2 crispr/cas compositions and methods of use
|
|
WO2019090261A1
(en)
|
2017-11-03 |
2019-05-09 |
University Of Florida Research Foundation, Inc. |
Methods and compositions for plant pathogen resistance in plants
|
|
ES2911249T3
(es)
|
2017-11-10 |
2022-05-18 |
Regeneron Pharma |
Animales no humanos que comprenden una mutación de slc30a8 y métodos de uso
|
|
CN111448313A
(zh)
*
|
2017-11-16 |
2020-07-24 |
阿斯利康(瑞典)有限公司 |
用于改善基于Cas9的敲入策略的有效性的组合物和方法
|
|
IL310006A
(en)
|
2017-11-30 |
2024-03-01 |
Regeneron Pharma |
Non-human animals containing a humanized TRKB locus
|
|
WO2019118949A1
(en)
|
2017-12-15 |
2019-06-20 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
WO2019126578A1
(en)
*
|
2017-12-20 |
2019-06-27 |
Poseida Therapeutics, Inc. |
Compositions and methods for directing proteins to specific loci in the genome
|
|
KR20210152597A
(ko)
|
2017-12-22 |
2021-12-15 |
(주)지플러스생명과학 |
키메라 게놈 조작 분자 및 방법
|
|
CA3086620A1
(en)
|
2018-01-12 |
2019-07-18 |
Basf Se |
Gene underlying the number of spikelets per spike qtl in wheat on chromosome 7a
|
|
WO2019144061A1
(en)
|
2018-01-19 |
2019-07-25 |
Duke University |
Genome engineering with crispr-cas systems in eukaryotes
|
|
US12098363B2
(en)
*
|
2018-01-26 |
2024-09-24 |
The Children's Medical Center Corporation |
Targeting BCL11A distal regulatory elements with a CAS9-CAS9 fusion for fetal hemoglobin reinduction
|
|
CN111902536B
(zh)
*
|
2018-02-15 |
2024-07-30 |
西格马-奥尔德里奇有限责任公司 |
用于真核基因组修饰的改造的cas9系统
|
|
KR20200124702A
(ko)
|
2018-02-23 |
2020-11-03 |
파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 |
신규한 cas9 오르소로그
|
|
WO2019178426A1
(en)
|
2018-03-14 |
2019-09-19 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
CN111885915B
(zh)
|
2018-03-19 |
2023-04-28 |
瑞泽恩制药公司 |
使用crispr/cas系统对动物进行转录调制
|
|
WO2019190874A1
(en)
|
2018-03-29 |
2019-10-03 |
Inscripta, Inc. |
Automated control of cell growth rates for induction and transformation
|
|
US10376889B1
(en)
|
2018-04-13 |
2019-08-13 |
Inscripta, Inc. |
Automated cell processing instruments comprising reagent cartridges
|
|
JP7555822B2
(ja)
|
2018-04-19 |
2024-09-25 |
ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア |
ゲノム編集のための組成物および方法
|
|
US10858761B2
(en)
|
2018-04-24 |
2020-12-08 |
Inscripta, Inc. |
Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells
|
|
US10526598B2
(en)
|
2018-04-24 |
2020-01-07 |
Inscripta, Inc. |
Methods for identifying T-cell receptor antigens
|
|
US10508273B2
(en)
|
2018-04-24 |
2019-12-17 |
Inscripta, Inc. |
Methods for identifying selective binding pairs
|
|
US20210324381A1
(en)
*
|
2018-04-27 |
2021-10-21 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Therapeutic genome editing in x-linked hyper igm syndrome
|
|
WO2019213430A1
(en)
*
|
2018-05-03 |
2019-11-07 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods for nicking target dna sequences
|
|
WO2019217803A1
(en)
|
2018-05-10 |
2019-11-14 |
Auxolytic Ltd. |
Gene therapy methods and compositions using auxotrophic regulatable cells
|
|
CN112105732A
(zh)
*
|
2018-05-10 |
2020-12-18 |
先正达参股股份有限公司 |
用于多核苷酸的靶向编辑的方法和组合物
|
|
CN121555430A
(zh)
|
2018-05-11 |
2026-02-24 |
比姆医疗股份有限公司 |
使用可编程碱基编辑器系统取代病原性氨基酸的方法
|
|
CN108624622A
(zh)
*
|
2018-05-16 |
2018-10-09 |
湖南艾佳生物科技股份有限公司 |
一种基于CRISPR-Cas9系统构建的能分泌小鼠白细胞介素-6的基因工程细胞株
|
|
KR20210045360A
(ko)
|
2018-05-16 |
2021-04-26 |
신테고 코포레이션 |
가이드 rna 설계 및 사용을 위한 방법 및 시스템
|
|
EP3797160A1
(en)
|
2018-05-23 |
2021-03-31 |
The Broad Institute Inc. |
Base editors and uses thereof
|
|
EP3575402A1
(en)
*
|
2018-06-01 |
2019-12-04 |
Algentech SAS |
Gene targeting
|
|
EP3800998A1
(en)
|
2018-06-07 |
2021-04-14 |
The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) |
Methods of regenerating and transforming cannabis
|
|
EP3802839A1
(en)
|
2018-06-07 |
2021-04-14 |
The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) |
Nucleic acid constructs and methods of using same
|
|
EP4159872B1
(en)
*
|
2018-06-25 |
2024-09-11 |
Bionano Genomics, Inc. |
Labeling of dna
|
|
EP3823633A4
(en)
|
2018-06-29 |
2023-05-03 |
Editas Medicine, Inc. |
SYNTHETIC LEAD MOLECULES, COMPOSITIONS AND METHODS RELATED THERETO
|
|
AU2019292919A1
(en)
|
2018-06-30 |
2021-03-11 |
Inscripta, Inc. |
Instruments, modules, and methods for improved detection of edited sequences in live cells
|
|
US12522807B2
(en)
|
2018-07-09 |
2026-01-13 |
The Broad Institute, Inc. |
RNA programmable epigenetic RNA modifiers and uses thereof
|
|
AU2019316094B2
(en)
*
|
2018-08-03 |
2026-02-19 |
Beam Therapeutics Inc. |
Multi-effector nucleobase editors and methods of using same to modify a nucleic acid target sequence
|
|
GB201813011D0
(en)
|
2018-08-10 |
2018-09-26 |
Vib Vzw |
Means and methods for drought tolerance in crops
|
|
US10532324B1
(en)
|
2018-08-14 |
2020-01-14 |
Inscripta, Inc. |
Instruments, modules, and methods for improved detection of edited sequences in live cells
|
|
US11142740B2
(en)
|
2018-08-14 |
2021-10-12 |
Inscripta, Inc. |
Detection of nuclease edited sequences in automated modules and instruments
|
|
US10752874B2
(en)
|
2018-08-14 |
2020-08-25 |
Inscripta, Inc. |
Instruments, modules, and methods for improved detection of edited sequences in live cells
|
|
KR102103103B1
(ko)
|
2018-08-16 |
2020-04-21 |
(주)라트바이오 |
인위적 뉴클레아제를 생산하는 형질전환 동물 및 형질전환 배아
|
|
US20210246472A1
(en)
*
|
2018-08-21 |
2021-08-12 |
Sigma-Aldrich Co. Llc |
Down-regulation of the cytosolic dna sensor pathway
|
|
US11965154B2
(en)
|
2018-08-30 |
2024-04-23 |
Inscripta, Inc. |
Detection of nuclease edited sequences in automated modules and instruments
|
|
EP3850088A4
(en)
|
2018-09-07 |
2023-07-19 |
Beam Therapeutics, Inc. |
Compositions and methods for improving base editing
|
|
KR20210055733A
(ko)
|
2018-09-07 |
2021-05-17 |
빔 테라퓨틱스, 인크. |
핵염기 편집 시스템을 전달하기 위한 조성물 및 방법
|
|
CN109055379B
(zh)
*
|
2018-09-10 |
2022-04-15 |
石铭 |
一种转基因鸡输卵管生物反应器的制备方法
|
|
KR102121817B1
(ko)
*
|
2018-09-12 |
2020-06-26 |
한국화학연구원 |
Crispr 편집 기술을 이용한 재조합 항원을 발현시키는 벡터 및 이를 동시에 다중 삽입시키는 방법
|
|
JP7222075B2
(ja)
|
2018-09-13 |
2023-02-14 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Ｃ３糸球体症のモデルとしての補体因子ｈ遺伝子ノックアウトラット
|
|
WO2020072248A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system
|
|
WO2020072250A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for genome modification and alteration of expression
|
|
US12264330B2
(en)
|
2018-10-01 |
2025-04-01 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for killing target cells
|
|
WO2020072253A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for screening for variant cells
|
|
WO2020076976A1
(en)
|
2018-10-10 |
2020-04-16 |
Readcoor, Inc. |
Three-dimensional spatial molecular indexing
|
|
JP7460643B2
(ja)
|
2018-10-16 |
2024-04-02 |
ブルーアレル， エルエルシー |
遺伝子へのｄｎａの標的化挿入のための方法
|
|
JP7578590B2
(ja)
|
2018-10-18 |
2024-11-06 |
インテリア セラピューティクス，インコーポレーテッド |
第ｉｘ因子を発現するための組成物及び方法
|
|
AU2019368215B2
(en)
|
2018-10-22 |
2023-05-18 |
Inscripta, Inc. |
Engineered enzymes
|
|
US11214781B2
(en)
|
2018-10-22 |
2022-01-04 |
Inscripta, Inc. |
Engineered enzyme
|
|
WO2020086908A1
(en)
*
|
2018-10-24 |
2020-04-30 |
The Broad Institute, Inc. |
Constructs for improved hdr-dependent genomic editing
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
KR20200071198A
(ko)
|
2018-12-10 |
2020-06-19 |
네오이뮨텍, 인코퍼레이티드 |
Nrf2 발현 조절 기반 T 세포 항암면역치료법
|
|
US12365888B2
(en)
|
2018-12-14 |
2025-07-22 |
Pioneer Hi-Bred International, Inc. |
CRISPR-Cas systems for genome editing
|
|
WO2020128478A1
(en)
|
2018-12-19 |
2020-06-25 |
King's College London |
Immunotherapeutic methods and compositions
|
|
CA3120799A1
(en)
|
2018-12-20 |
2020-06-25 |
Regeneron Pharmaceuticals, Inc. |
Nuclease-mediated repeat expansion
|
|
WO2020142676A1
(en)
*
|
2019-01-04 |
2020-07-09 |
The University Of Chicago |
Systems and methods for modulating rna
|
|
WO2020146899A1
(en)
*
|
2019-01-11 |
2020-07-16 |
Chan Zuckerberg Biohub, Inc. |
Targeted in vivo genome modification
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
US11946040B2
(en)
|
2019-02-04 |
2024-04-02 |
The General Hospital Corporation |
Adenine DNA base editor variants with reduced off-target RNA editing
|
|
WO2020168122A1
(en)
|
2019-02-13 |
2020-08-20 |
Beam Therapeutics Inc. |
Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence
|
|
US20220298494A1
(en)
*
|
2019-02-14 |
2022-09-22 |
Metagenomi Ip Technologies, Llc |
Enzymes with ruvc domains
|
|
US10913941B2
(en)
|
2019-02-14 |
2021-02-09 |
Metagenomi Ip Technologies, Llc |
Enzymes with RuvC domains
|
|
CA3129835A1
(en)
*
|
2019-02-15 |
2020-08-20 |
Sigma-Aldrich Co. Llc |
Crispr/cas fusion proteins and systems
|
|
GB201902277D0
(en)
|
2019-02-19 |
2019-04-03 |
King S College London |
Therapeutic agents
|
|
CA3130789A1
(en)
|
2019-03-07 |
2020-09-10 |
The Regents Of The University Of California |
Crispr-cas effector polypeptides and methods of use thereof
|
|
EP3768826B1
(en)
|
2019-03-18 |
2023-12-13 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas screening platform to identify genetic modifiers of tau seeding or aggregation
|
|
CA3127814C
(en)
|
2019-03-18 |
2024-05-14 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
|
|
JP7657726B2
(ja)
|
2019-03-19 |
2025-04-07 |
ザ ブロード インスティテュート，インコーポレーテッド |
編集ヌクレオチド配列を編集するための方法および組成物
|
|
US11001831B2
(en)
|
2019-03-25 |
2021-05-11 |
Inscripta, Inc. |
Simultaneous multiplex genome editing in yeast
|
|
CN113631713A
(zh)
|
2019-03-25 |
2021-11-09 |
因思科瑞普特公司 |
酵母中的同时多重基因组编辑
|
|
WO2020206162A1
(en)
|
2019-04-03 |
2020-10-08 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for insertion of antibody coding sequences into a safe harbor locus
|
|
ES2966625T3
(es)
|
2019-04-04 |
2024-04-23 |
Regeneron Pharma |
Roedores que comprenden un locus del factor de coagulación 12 humanizado
|
|
WO2020206134A1
(en)
|
2019-04-04 |
2020-10-08 |
Regeneron Pharmaceuticals, Inc. |
Methods for scarless introduction of targeted modifications into targeting vectors
|
|
GB201905360D0
(en)
|
2019-04-16 |
2019-05-29 |
Univ Nottingham |
Fungal strains, production and uses thereof
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CN113825838A
(zh)
|
2019-05-10 |
2021-12-21 |
巴斯夫欧洲公司 |
增强植物中基因表达的调节性核酸分子
|
|
US11891618B2
(en)
|
2019-06-04 |
2024-02-06 |
Regeneron Pharmaceuticals, Inc. |
Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use
|
|
AU2020288623A1
(en)
|
2019-06-06 |
2022-01-06 |
Inscripta, Inc. |
Curing for recursive nucleic acid-guided cell editing
|
|
US11622547B2
(en)
|
2019-06-07 |
2023-04-11 |
Regeneran Pharmaceuticals, Inc. |
Genetically modified mouse that expresses human albumin
|
|
US11845957B2
(en)
|
2019-06-14 |
2023-12-19 |
Regeneron Pharmaceuticals, Inc. |
Models of tauopathy
|
|
US10907125B2
(en)
|
2019-06-20 |
2021-02-02 |
Inscripta, Inc. |
Flow through electroporation modules and instrumentation
|
|
US10920189B2
(en)
|
2019-06-21 |
2021-02-16 |
Inscripta, Inc. |
Genome-wide rationally-designed mutations leading to enhanced lysine production in E. coli
|
|
US10927385B2
(en)
|
2019-06-25 |
2021-02-23 |
Inscripta, Inc. |
Increased nucleic-acid guided cell editing in yeast
|
|
EP3783104A1
(en)
*
|
2019-08-20 |
2021-02-24 |
Kemijski Institut |
Coiled-coil mediated tethering of crispr-cas and exonucleases for enhanced genome editing
|
|
WO2021050398A1
(en)
*
|
2019-09-10 |
2021-03-18 |
The Regents Of The University Of California |
Synthetic lethality screening platform for cells undergoing alt
|
|
WO2021048316A1
(en)
|
2019-09-12 |
2021-03-18 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
|
CN114616002A
(zh)
|
2019-09-13 |
2022-06-10 |
瑞泽恩制药公司 |
使用由脂质纳米颗粒递送的crispr/cas系统在动物中进行的转录调控
|
|
EP4034138A4
(en)
|
2019-09-27 |
2024-07-31 |
Beam Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS
|
|
WO2021069387A1
(en)
|
2019-10-07 |
2021-04-15 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
CN110628825A
(zh)
*
|
2019-10-14 |
2019-12-31 |
上海捷易生物科技有限公司 |
一种依赖nhej的报告基因敲入组合物及其使用方法
|
|
US12521451B2
(en)
|
2019-11-08 |
2026-01-13 |
Regeneron Pharmaceuticals, Inc. |
CRISPR and AAV strategies for x-linked juvenile retinoschisis therapy
|
|
US11203762B2
(en)
|
2019-11-19 |
2021-12-21 |
Inscripta, Inc. |
Methods for increasing observed editing in bacteria
|
|
WO2021108363A1
(en)
|
2019-11-25 |
2021-06-03 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-mediated upregulation of humanized ttr allele
|
|
CN114787365A
(zh)
|
2019-12-03 |
2022-07-22 |
巴斯夫欧洲公司 |
用于在植物中增强基因表达的调节性核酸分子
|
|
KR102776469B1
(ko)
|
2019-12-10 |
2025-03-05 |
인스크립타 인코포레이티드 |
신규 mad 뉴클레아제
|
|
US10704033B1
(en)
|
2019-12-13 |
2020-07-07 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
KR20220116485A
(ko)
|
2019-12-16 |
2022-08-23 |
바스프 아그리컬쳐럴 솔루션즈 시드 유에스 엘엘씨 |
쌍을 형성한 닉카제를 이용하는 개선된 게놈 편집
|
|
EP4069851A4
(en)
|
2019-12-18 |
2023-11-22 |
Inscripta, Inc. |
Cascade/dcas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells
|
|
WO2021141890A1
(en)
*
|
2020-01-09 |
2021-07-15 |
Pioneer Hi-Bred International, Inc. |
Two-step gene swap
|
|
US10689669B1
(en)
|
2020-01-11 |
2020-06-23 |
Inscripta, Inc. |
Automated multi-module cell processing methods, instruments, and systems
|
|
AU2021213705A1
(en)
|
2020-01-27 |
2022-06-16 |
Inscripta, Inc. |
Electroporation modules and instrumentation
|
|
EP4096396A1
(en)
|
2020-01-28 |
2022-12-07 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized pnpla3 locus and methods of use
|
|
WO2021155063A1
(en)
|
2020-01-29 |
2021-08-05 |
Readcoor, Llc |
Compositions and methods for analyte detection
|
|
EP4099821A1
(en)
|
2020-02-07 |
2022-12-14 |
Regeneron Pharmaceuticals, Inc. |
<smallcaps/>? ? ?klkb1? ? ? ? ?non-human animals comprising a humanizedlocus and methods of use
|
|
CN115485385A
(zh)
|
2020-03-04 |
2022-12-16 |
瑞泽恩制药公司 |
用于使肿瘤细胞对免疫疗法敏感的方法和组合物
|
|
EP4114952A4
(en)
*
|
2020-03-05 |
2024-05-08 |
Board of Regents of the University of Nebraska |
Crispr/cas9 system for multistrain hiv-1 treatment
|
|
WO2021195079A1
(en)
|
2020-03-23 |
2021-09-30 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
|
|
GB2608292B
(en)
|
2020-03-31 |
2024-02-14 |
Metagenomi Inc |
Class II, type II CRISPR systems
|
|
WO2021202938A1
(en)
|
2020-04-03 |
2021-10-07 |
Creyon Bio, Inc. |
Oligonucleotide-based machine learning
|
|
US20210332388A1
(en)
|
2020-04-24 |
2021-10-28 |
Inscripta, Inc. |
Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
|
|
DE112021002672T5
(de)
|
2020-05-08 |
2023-04-13 |
President And Fellows Of Harvard College |
Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz
|
|
US11787841B2
(en)
|
2020-05-19 |
2023-10-17 |
Inscripta, Inc. |
Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli
|
|
US20230232796A1
(en)
|
2020-06-26 |
2023-07-27 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ace2 locus
|
|
CN111849986A
(zh)
*
|
2020-07-24 |
2020-10-30 |
江苏集萃药康生物科技有限公司 |
一种减少CRISPR-Cas9基因编辑中双链DNA片段串联的方法及其应用
|
|
US20220049303A1
(en)
|
2020-08-17 |
2022-02-17 |
Readcoor, Llc |
Methods and systems for spatial mapping of genetic variants
|
|
WO2022060749A1
(en)
|
2020-09-15 |
2022-03-24 |
Inscripta, Inc. |
Crispr editing to embed nucleic acid landing pads into genomes of live cells
|
|
AU2021347359A1
(en)
|
2020-09-25 |
2023-05-18 |
Beam Therapeutics Inc. |
Fratricide resistant modified immune cells and methods of using the same
|
|
US11512297B2
(en)
|
2020-11-09 |
2022-11-29 |
Inscripta, Inc. |
Affinity tag for recombination protein recruitment
|
|
US20240002839A1
(en)
|
2020-12-02 |
2024-01-04 |
Decibel Therapeutics, Inc. |
Crispr sam biosensor cell lines and methods of use thereof
|
|
US20240058390A1
(en)
*
|
2020-12-16 |
2024-02-22 |
The Administrators Of The Tulane Educational Fund |
Wnt+ adipocytes, exosomes from wnt+ adipocytes, and methods of making and using them
|
|
AU2021415461A1
(en)
|
2021-01-04 |
2023-08-17 |
Inscripta, Inc. |
Mad nucleases
|
|
US20240376451A1
(en)
|
2021-01-07 |
2024-11-14 |
Inscripta, Inc. |
Mad nucleases
|
|
BR112023014719A2
(pt)
*
|
2021-01-22 |
2023-12-05 |
Metagenomi Inc |
Novas nucleases quiméricas e manipuladas
|
|
EP4288541A1
(en)
|
2021-02-05 |
2023-12-13 |
Christiana Care Gene Editing Institute, Inc. |
Methods of and compositions for reducing gene expression and/or activity
|
|
US11884924B2
(en)
|
2021-02-16 |
2024-01-30 |
Inscripta, Inc. |
Dual strand nucleic acid-guided nickase editing
|
|
GB202103131D0
(en)
|
2021-03-05 |
2021-04-21 |
Biosystems Tech Limited |
Method for preparation of research organisms
|
|
WO2022240846A1
(en)
|
2021-05-10 |
2022-11-17 |
Sqz Biotechnologies Company |
Methods for delivering genome editing molecules to the nucleus or cytosol of a cell and uses thereof
|
|
WO2022251644A1
(en)
|
2021-05-28 |
2022-12-01 |
Lyell Immunopharma, Inc. |
Nr4a3-deficient immune cells and uses thereof
|
|
KR20240027676A
(ko)
|
2021-06-02 |
2024-03-04 |
라이엘 이뮤노파마, 인크. |
Nr4a3-결핍 면역 세포 및 이의 용도
|
|
CA3225082A1
(en)
|
2021-08-27 |
2023-03-02 |
Brian C. Thomas |
Enzymes with ruvc domains
|
|
JP2024534945A
(ja)
|
2021-09-10 |
2024-09-26 |
アジレント・テクノロジーズ・インク |
化学修飾を有するプライム編集のためのガイドｒｎａ
|
|
AU2022366987A1
(en)
|
2021-10-14 |
2024-05-16 |
Arsenal Biosciences, Inc. |
Immune cells having co-expressed shrnas and logic gate systems
|
|
US20240336896A1
(en)
|
2021-10-14 |
2024-10-10 |
Lonza Sales Ag |
Modified producer cells for extracellular vesicle production
|
|
EP4423271A2
(en)
|
2021-10-28 |
2024-09-04 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-related methods and compositions for knocking out c5
|
|
KR20240099393A
(ko)
|
2021-11-01 |
2024-06-28 |
톰 바이오사이언시스, 인코포레이티드 |
유전자 편집 기구와 핵산 카고의 동시 전달을 위한 단일 작제물 플랫폼
|
|
CN118488784A
(zh)
|
2021-11-04 |
2024-08-13 |
瑞泽恩制药公司 |
包含经修饰的cacng1基因座的非人动物
|
|
MX2024006257A
(es)
|
2021-11-24 |
2024-07-29 |
Metagenomi Inc |
Sistemas de endonucleasas.
|
|
CN118632622A
(zh)
|
2021-12-08 |
2024-09-10 |
瑞泽恩制药公司 |
突变型肌纤蛋白疾病模型及其用途
|
|
GB202118058D0
(en)
|
2021-12-14 |
2022-01-26 |
Univ Warwick |
Methods to increase yields in crops
|
|
US20230279442A1
(en)
|
2021-12-15 |
2023-09-07 |
Versitech Limited |
Engineered cas9-nucleases and method of use thereof
|
|
WO2023122506A1
(en)
|
2021-12-20 |
2023-06-29 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising humanized ace2 and tmprss loci
|
|
WO2023122764A1
(en)
|
2021-12-22 |
2023-06-29 |
Tome Biosciences, Inc. |
Co-delivery of a gene editor construct and a donor template
|
|
KR20240128067A
(ko)
|
2021-12-29 |
2024-08-23 |
브리스톨-마이어스 스큅 컴퍼니 |
랜딩 패드 세포주의 생성
|
|
WO2023150181A1
(en)
|
2022-02-01 |
2023-08-10 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
|
EP4473103A2
(en)
|
2022-02-02 |
2024-12-11 |
Regeneron Pharmaceuticals, Inc. |
Anti-tfr:gaa and anti-cd63:gaa insertions for treatment of pompe disease
|
|
US20250194571A1
(en)
|
2022-02-07 |
2025-06-19 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for defining optimal treatment timeframes in lysosomal disease
|
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
|
WO2023212677A2
(en)
|
2022-04-29 |
2023-11-02 |
Regeneron Pharmaceuticals, Inc. |
Identification of tissue-specific extragenic safe harbors for gene therapy approaches
|
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
|
US20250302998A1
(en)
|
2022-05-09 |
2025-10-02 |
Regeneron Pharmaceuticals, Inc. |
Vectors and methods for in vivo antibody production
|
|
KR20250027283A
(ko)
|
2022-05-19 |
2025-02-25 |
라이엘 이뮤노파마, 인크. |
nr4a3을 표적하는 폴리뉴클레오타이드 및 이의 용도
|
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
|
CN119421951A
(zh)
|
2022-05-31 |
2025-02-11 |
瑞泽恩制药公司 |
用于c9orf72重复序列扩增疾病的crispr干扰疗法
|
|
WO2023235725A2
(en)
|
2022-05-31 |
2023-12-07 |
Regeneron Pharmaceuticals, Inc. |
Crispr-based therapeutics for c9orf72 repeat expansion disease
|
|
WO2023250384A2
(en)
*
|
2022-06-22 |
2023-12-28 |
The Regents Of The University Of California |
Crispr-cas effector polypeptides and methods of use thereof
|
|
IL317874A
(en)
|
2022-06-24 |
2025-02-01 |
Tune Therapeutics Inc |
Compounds, systems and methods for reducing low density lipoproteins through targeted gene suppression
|
|
GB2621813A
(en)
|
2022-06-30 |
2024-02-28 |
Univ Newcastle |
Preventing disease recurrence in Mitochondrial replacement therapy
|
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
|
IL318625A
(en)
|
2022-07-29 |
2025-03-01 |
Regeneron Pharma |
Compositions and methods for transferrin receptor (TFR)-mediated delivery to brain and muscle
|
|
AU2023316646A1
(en)
|
2022-07-29 |
2024-12-12 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a modified transferrin receptor locus
|
|
IL318553A
(en)
|
2022-08-05 |
2025-03-01 |
Regeneron Pharma |
Aggregation-resistant TDP-43 variants
|
|
WO2024064952A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells overexpressing c-jun
|
|
WO2024064958A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
|
CN120265314A
(zh)
|
2022-09-28 |
2025-07-04 |
瑞泽恩制药公司 |
抗体抗性修饰受体以增强基于细胞的疗法
|
|
WO2024077174A1
(en)
|
2022-10-05 |
2024-04-11 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
|
WO2024083579A1
(en)
|
2022-10-20 |
2024-04-25 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
|
IL320016A
(en)
|
2022-11-04 |
2025-06-01 |
Regeneron Pharma |
Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
|
|
AU2023379457A1
(en)
|
2022-11-14 |
2025-05-15 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|
|
EP4619420A1
(en)
|
2022-11-16 |
2025-09-24 |
Regeneron Pharmaceuticals, Inc. |
Chimeric proteins comprising membrane bound il-12 with protease cleavable linkers
|
|
US12415172B2
(en)
|
2022-12-22 |
2025-09-16 |
Synthego Corporation |
Systems and method for automated oligonucleotide synthesis
|
|
WO2024138194A1
(en)
|
2022-12-22 |
2024-06-27 |
Tome Biosciences, Inc. |
Platforms, compositions, and methods for in vivo programmable gene insertion
|
|
EP4654982A1
(en)
|
2023-01-27 |
2025-12-03 |
Regeneron Pharmaceuticals, Inc. |
Modified rhabdovirus glycoproteins and uses thereof
|
|
WO2024234006A1
(en)
|
2023-05-11 |
2024-11-14 |
Tome Biosciences, Inc. |
Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs)
|
|
CN121568725A
(zh)
|
2023-06-15 |
2026-02-24 |
里珍纳龙药品有限公司 |
用于听力病症的基因疗法
|
|
AU2024309884A1
(en)
|
2023-06-30 |
2025-12-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for increasing homology-directed repair
|
|
AU2024315073A1
(en)
|
2023-07-28 |
2026-01-22 |
Regeneron Pharmaceuticals, Inc. |
Use of bgh-sv40l tandem polya to enhance transgene expression during unidirectional gene insertion
|
|
AU2024317483A1
(en)
|
2023-07-28 |
2026-01-29 |
Regeneron Pharmaceuticals, Inc. |
Anti-tfr:gaa and anti-cd63:gaa insertion for treatment of pompe disease
|
|
US20250049896A1
(en)
|
2023-07-28 |
2025-02-13 |
Regeneron Pharmaceuticals, Inc. |
Anti-tfr:acid sphingomyelinase for treatment of acid sphingomyelinase deficiency
|
|
WO2025038750A2
(en)
|
2023-08-14 |
2025-02-20 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
|
WO2025049524A1
(en)
|
2023-08-28 |
2025-03-06 |
Regeneron Pharmaceuticals, Inc. |
Cxcr4 antibody-resistant modified receptors
|
|
WO2025050069A1
(en)
|
2023-09-01 |
2025-03-06 |
Tome Biosciences, Inc. |
Programmable gene insertion using engineered integration enzymes
|
|
GB202314578D0
(en)
|
2023-09-22 |
2023-11-08 |
Univ Manchester |
Methods of producing homoplasmic modified plants or parts thereof
|
|
WO2025122754A1
(en)
|
2023-12-07 |
2025-06-12 |
Regeneron Pharmaceuticals, Inc. |
Gaa knockout non-human animals
|
|
WO2025184567A1
(en)
|
2024-03-01 |
2025-09-04 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response
|
|
WO2025217398A1
(en)
|
2024-04-10 |
2025-10-16 |
Lyell Immunopharma, Inc. |
Methods for culturing cells with improved culture medium
|
|
EP4677108A1
(en)
|
2024-04-22 |
2026-01-14 |
Basecamp Research Ltd |
Method and compositions for detecting off-target editing
|
|
WO2025224182A2
(en)
|
2024-04-23 |
2025-10-30 |
Basecamp Research Ltd |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
WO2025235388A1
(en)
|
2024-05-06 |
2025-11-13 |
Regeneron Pharmaceuticals, Inc. |
Transgene genomic identification by nuclease-mediated long read sequencing
|
|
WO2025259669A1
(en)
|
2024-06-10 |
2025-12-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and systems for characterizing modified oligonucleotides
|
|
WO2025265017A1
(en)
|
2024-06-20 |
2025-12-26 |
Regeneron Pharmaceuticals, Inc. |
Ass1 gene insertion for the treatment of citrullinemia type i
|
|
WO2026006542A2
(en)
|
2024-06-26 |
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