JP2015044834A5 - - Google Patents
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- Publication number
- JP2015044834A5 JP2015044834A5 JP2014220816A JP2014220816A JP2015044834A5 JP 2015044834 A5 JP2015044834 A5 JP 2015044834A5 JP 2014220816 A JP2014220816 A JP 2014220816A JP 2014220816 A JP2014220816 A JP 2014220816A JP 2015044834 A5 JP2015044834 A5 JP 2015044834A5
- Authority
- JP
- Japan
- Prior art keywords
- sustained release
- pharmaceutical dosage
- dosage form
- solid oral
- oral pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000012730 sustained-release form Substances 0.000 claims 20
- 238000013268 sustained release Methods 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 14
- 239000011159 matrix material Substances 0.000 claims 11
- 239000002552 dosage form Substances 0.000 claims 10
- 239000000014 opioid analgesic Substances 0.000 claims 10
- 238000009472 formulation Methods 0.000 claims 9
- 239000007787 solid Substances 0.000 claims 9
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims 7
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 claims 6
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims 6
- 229960000240 hydrocodone Drugs 0.000 claims 6
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 2
- 239000007942 layered tablet Substances 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 238000000518 rheometry Methods 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- WRRSFOZOETZUPG-FFHNEAJVSA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;hydrate Chemical compound O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC WRRSFOZOETZUPG-FFHNEAJVSA-N 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims 1
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 229960004126 codeine Drugs 0.000 claims 1
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Natural products C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000007888 film coating Substances 0.000 claims 1
- 238000009501 film coating Methods 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims 1
- 229960001410 hydromorphone Drugs 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- -1 organic acid salt Chemical class 0.000 claims 1
- 229960002085 oxycodone Drugs 0.000 claims 1
- 229960005118 oxymorphone Drugs 0.000 claims 1
- 230000002688 persistence Effects 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 150000003892 tartrate salts Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84024406P | 2006-08-25 | 2006-08-25 | |
| US60/840,244 | 2006-08-25 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012157157A Division JP5642736B2 (ja) | 2006-08-25 | 2012-07-13 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016146843A Division JP6286491B2 (ja) | 2006-08-25 | 2016-07-27 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015044834A JP2015044834A (ja) | 2015-03-12 |
| JP2015044834A5 true JP2015044834A5 (enExample) | 2015-06-11 |
| JP5980881B2 JP5980881B2 (ja) | 2016-08-31 |
Family
ID=38754532
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009525126A Active JP5069300B2 (ja) | 2006-08-25 | 2007-08-24 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
| JP2012045261A Active JP5373133B2 (ja) | 2006-08-25 | 2012-03-01 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
| JP2012096011A Withdrawn JP2012167102A (ja) | 2006-08-25 | 2012-04-19 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
| JP2012157157A Active JP5642736B2 (ja) | 2006-08-25 | 2012-07-13 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
| JP2012157158A Withdrawn JP2012229249A (ja) | 2006-08-25 | 2012-07-13 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
| JP2012157159A Withdrawn JP2012229250A (ja) | 2006-08-25 | 2012-07-13 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
| JP2014220816A Active JP5980881B2 (ja) | 2006-08-25 | 2014-10-29 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
| JP2016146843A Active JP6286491B2 (ja) | 2006-08-25 | 2016-07-27 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
Family Applications Before (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009525126A Active JP5069300B2 (ja) | 2006-08-25 | 2007-08-24 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
| JP2012045261A Active JP5373133B2 (ja) | 2006-08-25 | 2012-03-01 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
| JP2012096011A Withdrawn JP2012167102A (ja) | 2006-08-25 | 2012-04-19 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
| JP2012157157A Active JP5642736B2 (ja) | 2006-08-25 | 2012-07-13 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
| JP2012157158A Withdrawn JP2012229249A (ja) | 2006-08-25 | 2012-07-13 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
| JP2012157159A Withdrawn JP2012229250A (ja) | 2006-08-25 | 2012-07-13 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016146843A Active JP6286491B2 (ja) | 2006-08-25 | 2016-07-27 | オピオイド鎮痛薬を含む不正改変抵抗性経口医薬剤形 |
Country Status (41)
Families Citing this family (158)
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- 2013-05-23 US US13/901,142 patent/US20130251800A1/en not_active Abandoned
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2014
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2015
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2016
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2017
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- 2017-07-24 US US15/657,852 patent/US20170319496A1/en not_active Abandoned
- 2017-07-24 US US15/657,761 patent/US20170319493A1/en not_active Abandoned
- 2017-07-24 US US15/657,895 patent/US20170319497A1/en not_active Abandoned
- 2017-07-24 US US15/657,793 patent/US20170319494A1/en not_active Abandoned
- 2017-07-24 US US15/657,643 patent/US20170319491A1/en not_active Abandoned
- 2017-07-24 US US15/657,424 patent/US20170319488A1/en not_active Abandoned
- 2017-07-24 US US15/657,818 patent/US20170319495A1/en not_active Abandoned
- 2017-07-24 US US15/657,599 patent/US20170354607A1/en not_active Abandoned
- 2017-07-24 US US15/657,717 patent/US20170319492A1/en not_active Abandoned
- 2017-07-24 US US15/657,521 patent/US20170319490A1/en not_active Abandoned
- 2017-08-22 US US15/683,436 patent/US20170348240A1/en not_active Abandoned
- 2017-08-22 US US15/683,472 patent/US20170348241A1/en not_active Abandoned
- 2017-10-04 AR ARP170102762A patent/AR109796A2/es not_active Application Discontinuation
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2018
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2020
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2022
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2023
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2024
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2025
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