PT1033975E - Processo para a preparacao de substancias biologicamente activas nao-cristalinas isentas de dissolventes - Google Patents
Processo para a preparacao de substancias biologicamente activas nao-cristalinas isentas de dissolventesInfo
- Publication number
- PT1033975E PT1033975E PT98965661T PT98965661T PT1033975E PT 1033975 E PT1033975 E PT 1033975E PT 98965661 T PT98965661 T PT 98965661T PT 98965661 T PT98965661 T PT 98965661T PT 1033975 E PT1033975 E PT 1033975E
- Authority
- PT
- Portugal
- Prior art keywords
- dissolvents
- nao
- preparation
- biologically active
- crystalline substances
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19752895 | 1997-11-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1033975E true PT1033975E (pt) | 2002-07-31 |
Family
ID=7850166
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT98965661T PT1033975E (pt) | 1997-11-28 | 1998-11-09 | Processo para a preparacao de substancias biologicamente activas nao-cristalinas isentas de dissolventes |
Country Status (11)
Country | Link |
---|---|
US (1) | US6547997B1 (pt) |
EP (1) | EP1033975B1 (pt) |
JP (1) | JP2001524503A (pt) |
CN (1) | CN1150891C (pt) |
AT (1) | ATE214595T1 (pt) |
CA (1) | CA2310847C (pt) |
DE (1) | DE59803468D1 (pt) |
DK (1) | DK1033975T3 (pt) |
ES (1) | ES2174538T3 (pt) |
PT (1) | PT1033975E (pt) |
WO (1) | WO1999027891A2 (pt) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60028754T2 (de) * | 1999-11-12 | 2007-05-31 | Abbott Laboratories, Abbott Park | Feste dispersion mit ritonavir, fenofibrat oder griseofulvin |
US7364752B1 (en) | 1999-11-12 | 2008-04-29 | Abbott Laboratories | Solid dispersion pharamaceutical formulations |
DE10026698A1 (de) * | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
DE102004020220A1 (de) * | 2004-04-22 | 2005-11-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
US8075872B2 (en) * | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE102004032051A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
PL1842533T3 (pl) * | 2003-08-06 | 2013-08-30 | Gruenenthal Gmbh | Postać aplikacyjna zabezpieczona przed nadużyciem |
DE10361596A1 (de) * | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
US20070048228A1 (en) * | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
DE102004032049A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102004032103A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
WO2009085828A2 (en) * | 2007-12-20 | 2009-07-09 | Mutual Pharmaceutical Company, Inc. | Quinine sulfate polymorphs, processes of preparing, compositions and uses thereof |
BRPI0906467C1 (pt) | 2008-01-25 | 2021-05-25 | Gruenenthal Gmbh | forma de dosagem farmacêutica com formato exterior modificado resistente à ruptura e com liberação controlada |
WO2009135680A1 (en) | 2008-05-09 | 2009-11-12 | Grünenthal GmbH | Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step |
EP2456427B1 (en) | 2009-07-22 | 2015-03-04 | Grünenthal GmbH | Hot-melt extruded controlled release dosage form |
CN102639118B (zh) | 2009-07-22 | 2015-07-29 | 格吕伦塔尔有限公司 | 氧化稳定的抗干扰剂型 |
US9579285B2 (en) * | 2010-02-03 | 2017-02-28 | Gruenenthal Gmbh | Preparation of a powdery pharmaceutical composition by means of an extruder |
EP2611426B1 (en) | 2010-09-02 | 2014-06-25 | Grünenthal GmbH | Tamper resistant dosage form comprising inorganic salt |
WO2012028318A1 (en) | 2010-09-02 | 2012-03-08 | Grünenthal GmbH | Tamper resistant dosage form comprising an anionic polymer |
HUE034710T2 (hu) | 2011-07-29 | 2018-02-28 | Gruenenthal Gmbh | Visszaéléssel szemben ellenálló, azonnali hatóanyagfelszabadulást biztosító tabletta |
DK2736495T3 (da) | 2011-07-29 | 2017-11-13 | Gruenenthal Gmbh | Misbrugsbestandig tablet som tilvejebringer øjeblikkelig frigivelse af lægemiddel |
CA2864949A1 (en) | 2012-02-28 | 2013-09-06 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
WO2013156453A1 (en) | 2012-04-18 | 2013-10-24 | Grünenthal GmbH | Tamper resistant and dose-dumping resistant pharmaceutical dosage form |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
AU2014273226B2 (en) | 2013-05-29 | 2019-06-27 | Grunenthal Gmbh | Tamper resistant dosage form with bimodal release profile |
EP3003279A1 (en) | 2013-05-29 | 2016-04-13 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
KR20160031526A (ko) | 2013-07-12 | 2016-03-22 | 그뤼넨탈 게엠베하 | 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형 |
EP3073994A1 (en) | 2013-11-26 | 2016-10-05 | Grünenthal GmbH | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
AU2015261060A1 (en) | 2014-05-12 | 2016-11-03 | Grunenthal Gmbh | Tamper resistant immediate release capsule formulation comprising Tapentadol |
CN106456550A (zh) | 2014-05-26 | 2017-02-22 | 格吕伦塔尔有限公司 | 避免乙醇剂量倾泻的多颗粒 |
CA2983642A1 (en) | 2015-04-24 | 2016-10-27 | Grunenthal Gmbh | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
US10842750B2 (en) | 2015-09-10 | 2020-11-24 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
GB201801415D0 (en) * | 2018-01-29 | 2018-03-14 | Univ Limerick | Method and apparatus |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3310676A1 (de) | 1983-03-24 | 1984-09-27 | Basf Ag, 6700 Ludwigshafen | Verfahren und vorrichtung zum entfernen von fluechtigen anteilen aus polymerenschmelzen oder paste |
US5811547A (en) | 1992-10-14 | 1998-09-22 | Nippon Shinyaju Co., Ltd. | Method for inducing crystalline state transition in medicinal substance |
ES2145063T3 (es) * | 1992-10-14 | 2000-07-01 | Nippon Shinyaku Co Ltd | Procedimiento de dislocacion del estado cristalino. |
US5466865A (en) | 1993-07-02 | 1995-11-14 | Ibah, Inc. | Neomorphic ibuprofen and methods of using same |
EP0791589B1 (en) * | 1994-04-11 | 2002-03-06 | Chugai Seiyaku Kabushiki Kaisha | 4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENES WHICH INHIBIT LDL OXIDATION |
DE4418837A1 (de) * | 1994-05-30 | 1995-12-07 | Bayer Ag | Thermisches Granulierverfahren |
AU725204B2 (en) | 1995-11-23 | 2000-10-05 | Janssen Pharmaceutica N.V. | Solid mixtures of cyclodextrins prepared via melt-extrusion |
DE19624607A1 (de) | 1996-06-20 | 1998-01-02 | Basf Ag | Verfahren zur Herstellung von Salzen von Säuregruppen tragenden pharmazeutischen Wirkstoffen |
DE19801073A1 (de) * | 1998-01-14 | 1999-07-15 | Bayer Ag | Mischvorrichtung |
-
1998
- 1998-11-09 ES ES98965661T patent/ES2174538T3/es not_active Expired - Lifetime
- 1998-11-09 EP EP98965661A patent/EP1033975B1/de not_active Expired - Lifetime
- 1998-11-09 CA CA002310847A patent/CA2310847C/en not_active Expired - Lifetime
- 1998-11-09 WO PCT/EP1998/007141 patent/WO1999027891A2/de active IP Right Grant
- 1998-11-09 DK DK98965661T patent/DK1033975T3/da active
- 1998-11-09 JP JP2000522879A patent/JP2001524503A/ja active Pending
- 1998-11-09 PT PT98965661T patent/PT1033975E/pt unknown
- 1998-11-09 US US09/554,215 patent/US6547997B1/en not_active Expired - Lifetime
- 1998-11-09 CN CNB988115999A patent/CN1150891C/zh not_active Expired - Lifetime
- 1998-11-09 DE DE59803468T patent/DE59803468D1/de not_active Expired - Lifetime
- 1998-11-09 AT AT98965661T patent/ATE214595T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1999027891A2 (de) | 1999-06-10 |
DE59803468D1 (de) | 2002-04-25 |
ES2174538T3 (es) | 2002-11-01 |
JP2001524503A (ja) | 2001-12-04 |
CA2310847C (en) | 2007-03-13 |
EP1033975B1 (de) | 2002-03-20 |
EP1033975A2 (de) | 2000-09-13 |
CN1280491A (zh) | 2001-01-17 |
US6547997B1 (en) | 2003-04-15 |
WO1999027891A3 (de) | 1999-08-12 |
DK1033975T3 (da) | 2002-05-27 |
CA2310847A1 (en) | 1999-06-10 |
ATE214595T1 (de) | 2002-04-15 |
CN1150891C (zh) | 2004-05-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT1033975E (pt) | Processo para a preparacao de substancias biologicamente activas nao-cristalinas isentas de dissolventes | |
AU7259196A (en) | Moldable, hand-shapable biodegradable implant material | |
AU4757496A (en) | Biodegradable implant for fracture nonunions | |
AU2018801A (en) | Cellular matrix | |
BR0107942A (pt) | Polìmeros de proteìna de liberação lenta | |
AU5106996A (en) | Process for producing active agent preparations in the form of a solid solution of the active agent in a polymer matrix and active agent preparations obtained thereby | |
AU3203800A (en) | A method for the preparation of uhmwpe doped with an antioxidant and an implant made thereof | |
DK0703786T3 (da) | Anvendelse af nona- og dekapeptider til fremstilling af et lægemiddel til behandling af AIDS | |
ES2138271T3 (es) | Compuestos de 6-dimetil-amino-metil-1-fenil-ciclohexano como principio activo farmaceutico. | |
AU2339997A (en) | Diode laser irradiation system for biological tissue stimulation | |
ES2094359T3 (es) | Formulaciones farmaceuticas de proteinas osteogenicas. | |
AR004357A1 (es) | Compuestos de 1-fenil-2-dimetilaminometil-ciclohexan-1-ol, y procedimiento de preparacion para dichos compuestos. | |
BR9506305A (pt) | Aparelho e processo para preparação de formas sólidas com desprendimento controlado do ingrediente ativo | |
AU697005B2 (en) | Implantable molded articles for the administration of active substances to plants | |
HK1019404A1 (en) | Injection formulations of avermectins or milbemycins based on castor oil, their preparation, and use of castor for preparing the same | |
AU8148494A (en) | Bandages | |
IT1287174B1 (it) | Diaril-ciclometilenpirazoli farmacologicamente attivi,procedimento per prepararli e composizioni farmaceutiche che li contengono | |
AU4428597A (en) | Iontophoretic drug delivery system, including method for activating same | |
AU7236394A (en) | Optically active 1-(4-nitrophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5h -2,3-benzodiazepine and process for preparing same | |
AU7552098A (en) | Physiologically active substances tkr2449, process for producing the same, and microorganism | |
PT1017681E (pt) | Derivados de hidrazono-benzazuleno composicoes farmaceuticas e intermediarios | |
AU6700996A (en) | Somatostatin-analogous cyclic peptides with inhibitory activity on growth hormone | |
IT1290910B1 (it) | 2-amminotetralina otticamente attiva, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono, attive | |
AU1411200A (en) | Novel physiologically active substance, process for producing the same and utilization thereof | |
GR960100431A (el) | Μηχανη διαμορφωσης και κοπης κολοδων γλυκισματων και αλλων ομοιογενων υλικων |