ES2138271T3 - Compuestos de 6-dimetil-amino-metil-1-fenil-ciclohexano como principio activo farmaceutico. - Google Patents
Compuestos de 6-dimetil-amino-metil-1-fenil-ciclohexano como principio activo farmaceutico.Info
- Publication number
- ES2138271T3 ES2138271T3 ES96110104T ES96110104T ES2138271T3 ES 2138271 T3 ES2138271 T3 ES 2138271T3 ES 96110104 T ES96110104 T ES 96110104T ES 96110104 T ES96110104 T ES 96110104T ES 2138271 T3 ES2138271 T3 ES 2138271T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- cyclhexan
- dimethyl
- phenyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
SE DESCRIBEN COMPUESTOS DE 6-DIMETILAMINOMETIL-1-FENILCICLOHEXANO, PROCEDIMIENTO PARA SU OBTENCION Y LA UTILIZACION DE ESTOS COMPUESTOS EN MEDICAMENTOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19525137A DE19525137C2 (de) | 1995-07-11 | 1995-07-11 | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2138271T3 true ES2138271T3 (es) | 2000-01-01 |
Family
ID=7766487
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96110104T Expired - Lifetime ES2138271T3 (es) | 1995-07-11 | 1996-06-22 | Compuestos de 6-dimetil-amino-metil-1-fenil-ciclohexano como principio activo farmaceutico. |
Country Status (23)
Country | Link |
---|---|
US (2) | US5733936A (es) |
EP (1) | EP0753506B1 (es) |
JP (1) | JP3982853B2 (es) |
KR (1) | KR100470013B1 (es) |
CN (1) | CN1122018C (es) |
AR (1) | AR003449A1 (es) |
AT (1) | ATE183495T1 (es) |
AU (1) | AU703890B2 (es) |
CA (1) | CA2180816C (es) |
CO (1) | CO4700427A1 (es) |
DE (2) | DE19525137C2 (es) |
DK (1) | DK0753506T3 (es) |
ES (1) | ES2138271T3 (es) |
GR (1) | GR3031304T3 (es) |
HK (1) | HK1010364A1 (es) |
HU (1) | HU223341B1 (es) |
IL (1) | IL118825A (es) |
MX (1) | MX9602683A (es) |
PE (1) | PE11698A1 (es) |
PL (1) | PL185803B1 (es) |
RU (1) | RU2178409C2 (es) |
SI (1) | SI0753506T1 (es) |
ZA (1) | ZA965866B (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2383255A1 (en) | 2010-04-28 | 2011-11-02 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
EP2530072A1 (en) | 2011-06-03 | 2012-12-05 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4426245A1 (de) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
DE19712398A1 (de) * | 1997-03-25 | 1998-10-01 | Gruenenthal Gmbh | Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel |
DE19732928C2 (de) * | 1997-07-31 | 2000-05-18 | Gruenenthal Gmbh | Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel |
DE19830105C1 (de) * | 1998-07-06 | 2000-02-17 | Gruenenthal Gmbh | Acridinderivate |
ES2141688B1 (es) * | 1998-11-06 | 2001-02-01 | Vita Invest Sa | Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos. |
EP1313460A2 (en) * | 1999-11-09 | 2003-05-28 | Darwin Discovery Limited | Therapeutic use and formulation of (-)-tramadol |
ES2160534B1 (es) * | 1999-12-30 | 2002-04-16 | Vita Invest Sa | Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo. |
DE10000311A1 (de) * | 2000-01-05 | 2001-07-12 | Gruenenthal Gmbh | Aminomethyl-Phonyl-Cyclohexanonderivate |
DE10000312A1 (de) * | 2000-01-05 | 2001-07-12 | Gruenenthal Gmbh | Substituierte Aminomethyl-Phenyl-Cyclohexanderivate |
DE10004926A1 (de) * | 2000-02-04 | 2001-08-09 | Gruenenthal Gmbh | Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten |
DE10049483A1 (de) * | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte 1-Aminobutan-3-ol-Derivate |
DE10049481A1 (de) | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte C-Cyclohexylmethylamin-Derivate |
AU2002212959A1 (en) | 2000-10-13 | 2002-04-29 | Eli Lilly And Company | Cycloalkylfluorosulfonamide derivatives |
DE10059411A1 (de) | 2000-11-30 | 2002-06-13 | Gruenenthal Gmbh | Verwendung von 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz |
DE10059413A1 (de) * | 2000-11-30 | 2002-06-20 | Gruenenthal Gmbh | Verwendung von substituierten 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz |
DE10109763A1 (de) * | 2001-02-28 | 2002-09-05 | Gruenenthal Gmbh | Pharmazeutische Salze |
US20050176790A1 (en) * | 2001-02-28 | 2005-08-11 | Johannes Bartholomaus | Pharmaceutical salts |
PE20030320A1 (es) * | 2001-07-17 | 2003-04-03 | Gruenenthal Chemie | Derivados sustituidos de 4-aminociclohexanol |
DE10146275A1 (de) | 2001-09-18 | 2003-04-24 | Gruenenthal Gmbh | Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz |
PE20030527A1 (es) | 2001-10-24 | 2003-07-26 | Gruenenthal Chemie | Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen |
DE10153345A1 (de) * | 2001-10-29 | 2003-05-08 | Gruenenthal Gmbh | Substituierte 1H-Chinoxalin-2-on-Verbindungen und substituierte 4-Aryl- und 4-Heteroarylcyclohexan-Verbindungen |
DE10153348A1 (de) * | 2001-10-29 | 2003-05-08 | Gruenenthal Gmbh | Substituierte Benzo(b)azepin-2-on-Verbindungen |
DE10153346A1 (de) | 2001-10-29 | 2004-04-22 | Grünenthal GmbH | Substituierte Indole |
DE10153347A1 (de) * | 2001-10-29 | 2003-05-08 | Gruenenthal Gmbh | Substituierte 1H-Chinolin-2-on-Verbindungen |
DE10206405A1 (de) * | 2002-02-14 | 2003-08-28 | Gruenenthal Gmbh | Synthese von substituierten Carbamidestern |
DE10206403A1 (de) * | 2002-02-14 | 2003-08-28 | Gruenenthal Gmbh | Synthese von Beta-Aminoketonen |
DE10218862A1 (de) * | 2002-04-26 | 2003-11-06 | Gruenenthal Gmbh | Verfahren zur Chlorierung tertiärer Alkohole |
US20050137194A1 (en) * | 2002-05-29 | 2005-06-23 | Gruenenthal Gmbh | Combination of selected opioids with other active compounds for treatment of urinary incontinence |
DE10233048A1 (de) * | 2002-07-19 | 2004-01-29 | Grünenthal GmbH | Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken |
US20050182131A1 (en) * | 2002-07-19 | 2005-08-18 | Gruenenthal Gmbh | 1-Phenyl-2-dimethylaminomethyl cyclohexane compounds and therapies for depressive symptoms, pain and incontinence |
US20110060053A1 (en) * | 2002-09-09 | 2011-03-10 | Gruenenthal Gmbh | Crystalline Modifications of 6-Dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol |
ES2640404T3 (es) * | 2002-11-22 | 2017-11-02 | Grünenthal GmbH | Combinación de analgésicos seleccionados con inhibidores de la COX II |
DE10333835A1 (de) * | 2003-07-24 | 2005-03-10 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol enthaltendes Arzneimittel mit verzögerter Wirkstofffreisetzung |
DE10356362A1 (de) * | 2003-11-28 | 2005-06-23 | Grünenthal GmbH | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen |
EP1695957A1 (en) * | 2005-02-25 | 2006-08-30 | Grünenthal GmbH | Crystalline forms of (1RS,3RS,6RS)-6-Dimethylaminomethyl-1-(3-methoxy-phenyl)cyclohexane-1,3-diol hydrochloride |
US20060211887A1 (en) * | 2005-02-25 | 2006-09-21 | Gruenenthal Gmbh | Phosphate salts of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexane compounds |
JP2008531511A (ja) * | 2005-02-25 | 2008-08-14 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | (1rs,3rs,6rs)−6−ジメチルアミノメチル−1−(3−メトキシ−フェニル)シクロヘキサン−1,3−ジオール塩酸塩の結晶形 |
DE102005009217A1 (de) * | 2005-02-25 | 2006-08-31 | Grünenthal GmbH | Phosphatsalze der 6-Dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexanverbindungen |
DE102005034973A1 (de) * | 2005-07-22 | 2007-02-15 | Grünenthal GmbH | Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen |
DE102005034974A1 (de) * | 2005-07-22 | 2007-04-19 | Grünenthal GmbH | Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen |
US7884247B2 (en) * | 2005-07-22 | 2011-02-08 | Gruenenthal Gmbh | Salt of dimethylaminomethyl-phenyl-cyclohexane and crystalline forms thereof |
JP5323480B2 (ja) * | 2005-07-22 | 2013-10-23 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 3−[2−(ジメチルアミノ)メチル−(シクロヘキシ−1−イル)]−フェノールのHCl多形体 |
US20090104266A1 (en) * | 2005-09-15 | 2009-04-23 | Tobias Jung | 3-(2-dimethylaminomethylcy clohexyl)phenol retard formulation |
DE102005061429A1 (de) * | 2005-12-22 | 2007-06-28 | Grünenthal GmbH | Substituierte Oxazol-Derivate |
DE602007009096D1 (de) * | 2006-05-24 | 2010-10-21 | Pfizer Ltd | Verfahren zur herstellung von benzopyran-2-olderivaten |
DE102007022790A1 (de) * | 2007-05-11 | 2008-11-20 | Grünenthal GmbH | Axomadol zur Schmerzbehandlung bei Arthrose |
EP2085081A1 (de) * | 2008-02-04 | 2009-08-05 | Grünenthal GmbH | 3-(2-Dimethylaminomethyl-cyclohexyl)-phenol gegen polyneuropathischen Schmerz |
ATE516261T1 (de) * | 2008-02-29 | 2011-07-15 | Gruenenthal Gmbh | Verfahren zur herstellung von 6- |
EP2262759A1 (de) | 2008-02-29 | 2010-12-22 | Grünenthal GmbH | Verfahren zur herstellung von (1rs,3rs,6rs)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexan-1,3-diol |
WO2010025930A1 (en) * | 2008-09-05 | 2010-03-11 | Grünenthal GmbH | Pharmaceutical combination comprising 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3 diol and paracetamol |
US20100063009A1 (en) * | 2008-09-05 | 2010-03-11 | Gruenenthal Gmbh | Pharmaceutical Combination Comprising 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1.3-diol and an NSAID |
US20110053914A1 (en) * | 2009-08-28 | 2011-03-03 | Gruenenthal Gmbh | Pharmaceutical Combination Comprising 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol or 6-Dimethylaminomethyl-1-(3-hydroxy-phenyl)-cyclohexane-1,3-diol and an Antiepileptic |
US20110295038A1 (en) * | 2010-05-28 | 2011-12-01 | Gruenenthal Gmbh | Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds |
US20120022294A1 (en) | 2010-06-30 | 2012-01-26 | Gruenenthal Gmbh | Axomadol or a Metabolite Thereof for Use in the Treatment of Irritable Bowel Syndrome |
CN103153971A (zh) | 2010-07-23 | 2013-06-12 | 格吕伦塔尔有限公司 | 3-(3-二甲基氨基-1-乙基-2-甲基-丙基)-苯酚的盐或共晶体 |
CN106190104A (zh) * | 2016-07-05 | 2016-12-07 | 太仓市东明化工有限公司 | 一种循环使用寿命长的荧光剂 |
JP7183196B2 (ja) * | 2018-02-06 | 2022-12-05 | 第一三共株式会社 | アミノアルキル化合物 |
CN118108610A (zh) * | 2024-04-30 | 2024-05-31 | 山东新华制药股份有限公司 | 盐酸去甲曲马多的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1199764B (de) * | 1963-04-02 | 1965-09-02 | Gruenenthal Chemie | Verfahren zur Herstellung von basisch substituierten Phenolaethern |
US3652589A (en) * | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
-
1995
- 1995-07-11 DE DE19525137A patent/DE19525137C2/de not_active Expired - Fee Related
-
1996
- 1996-06-22 AT AT96110104T patent/ATE183495T1/de active
- 1996-06-22 DE DE59602775T patent/DE59602775D1/de not_active Expired - Lifetime
- 1996-06-22 DK DK96110104T patent/DK0753506T3/da active
- 1996-06-22 EP EP96110104A patent/EP0753506B1/de not_active Expired - Lifetime
- 1996-06-22 SI SI9630087T patent/SI0753506T1/xx not_active IP Right Cessation
- 1996-06-22 ES ES96110104T patent/ES2138271T3/es not_active Expired - Lifetime
- 1996-07-04 PE PE1996000511A patent/PE11698A1/es not_active Application Discontinuation
- 1996-07-08 AR ARP960103493A patent/AR003449A1/es active IP Right Grant
- 1996-07-08 CO CO96035551A patent/CO4700427A1/es unknown
- 1996-07-09 CA CA002180816A patent/CA2180816C/en not_active Expired - Fee Related
- 1996-07-09 MX MX9602683A patent/MX9602683A/es unknown
- 1996-07-10 JP JP18085596A patent/JP3982853B2/ja not_active Expired - Fee Related
- 1996-07-10 US US08/679,756 patent/US5733936A/en not_active Ceased
- 1996-07-10 ZA ZA965866A patent/ZA965866B/xx unknown
- 1996-07-10 KR KR1019960027695A patent/KR100470013B1/ko not_active IP Right Cessation
- 1996-07-10 HU HU9601884A patent/HU223341B1/hu not_active IP Right Cessation
- 1996-07-10 IL IL11882596A patent/IL118825A/xx not_active IP Right Cessation
- 1996-07-10 AU AU59453/96A patent/AU703890B2/en not_active Ceased
- 1996-07-10 CN CN96110802A patent/CN1122018C/zh not_active Expired - Fee Related
- 1996-07-10 PL PL96315192A patent/PL185803B1/pl not_active IP Right Cessation
- 1996-07-11 RU RU96115331/04A patent/RU2178409C2/ru not_active IP Right Cessation
-
1998
- 1998-09-25 HK HK98110962A patent/HK1010364A1/xx unknown
-
1999
- 1999-09-22 GR GR990402404T patent/GR3031304T3/el unknown
-
2000
- 2000-03-30 US US09/539,528 patent/USRE37355E1/en not_active Expired - Lifetime
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2383255A1 (en) | 2010-04-28 | 2011-11-02 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
WO2011135007A1 (en) | 2010-04-28 | 2011-11-03 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
EP2530072A1 (en) | 2011-06-03 | 2012-12-05 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
WO2012164055A2 (en) | 2011-06-03 | 2012-12-06 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
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