JP2011137020A5 - - Google Patents
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- Publication number
- JP2011137020A5 JP2011137020A5 JP2011033064A JP2011033064A JP2011137020A5 JP 2011137020 A5 JP2011137020 A5 JP 2011137020A5 JP 2011033064 A JP2011033064 A JP 2011033064A JP 2011033064 A JP2011033064 A JP 2011033064A JP 2011137020 A5 JP2011137020 A5 JP 2011137020A5
- Authority
- JP
- Japan
- Prior art keywords
- oral dosage
- dosage form
- sustained release
- oxycodone
- release oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000006186 oral dosage form Substances 0.000 claims 21
- 238000013268 sustained release Methods 0.000 claims 18
- 239000012730 sustained-release form Substances 0.000 claims 18
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims 15
- 229960002085 oxycodone Drugs 0.000 claims 15
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 claims 13
- 229960004127 naloxone Drugs 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 9
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 8
- 239000012458 free base Substances 0.000 claims 7
- 208000005793 Restless legs syndrome Diseases 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 229960005181 morphine Drugs 0.000 claims 4
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims 3
- WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 claims 3
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 claims 3
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 claims 3
- 229960002428 fentanyl Drugs 0.000 claims 3
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 3
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims 3
- 229960000240 hydrocodone Drugs 0.000 claims 3
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims 3
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims 3
- 229960001410 hydromorphone Drugs 0.000 claims 3
- 229960001797 methadone Drugs 0.000 claims 3
- 229960005297 nalmefene Drugs 0.000 claims 3
- 229960003086 naltrexone Drugs 0.000 claims 3
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims 3
- 239000003402 opiate agonist Substances 0.000 claims 3
- 239000003401 opiate antagonist Substances 0.000 claims 3
- 229960005118 oxymorphone Drugs 0.000 claims 3
- GGCSSNBKKAUURC-UHFFFAOYSA-N sufentanil Chemical compound C1CN(CCC=2SC=CC=2)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 GGCSSNBKKAUURC-UHFFFAOYSA-N 0.000 claims 3
- 229960004739 sufentanil Drugs 0.000 claims 3
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04013469.4 | 2004-06-08 | ||
| EP04013469A EP1604667A1 (en) | 2004-06-08 | 2004-06-08 | Opioids for the treatment of the restless leg syndrome |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007526247A Division JP2008501742A (ja) | 2004-06-08 | 2005-06-01 | 下肢静止不能症候群の治療用オピオイド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011137020A JP2011137020A (ja) | 2011-07-14 |
| JP2011137020A5 true JP2011137020A5 (enExample) | 2012-02-16 |
| JP5774865B2 JP5774865B2 (ja) | 2015-09-09 |
Family
ID=34925286
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007526247A Withdrawn JP2008501742A (ja) | 2004-06-08 | 2005-06-01 | 下肢静止不能症候群の治療用オピオイド |
| JP2011033064A Expired - Fee Related JP5774865B2 (ja) | 2004-06-08 | 2011-02-18 | 下肢静止不能症候群の治療用オピオイド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007526247A Withdrawn JP2008501742A (ja) | 2004-06-08 | 2005-06-01 | 下肢静止不能症候群の治療用オピオイド |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US20070185147A1 (enExample) |
| EP (3) | EP1604667A1 (enExample) |
| JP (2) | JP2008501742A (enExample) |
| KR (2) | KR101200869B1 (enExample) |
| CN (2) | CN103394090A (enExample) |
| AT (1) | ATE486603T1 (enExample) |
| AU (1) | AU2005251445C1 (enExample) |
| BR (1) | BRPI0511300A (enExample) |
| CA (1) | CA2569742C (enExample) |
| CY (1) | CY1111512T1 (enExample) |
| DE (1) | DE602005024571D1 (enExample) |
| DK (1) | DK1781291T3 (enExample) |
| ES (1) | ES2355247T3 (enExample) |
| HR (1) | HRP20110049T2 (enExample) |
| IL (1) | IL179896A (enExample) |
| ME (1) | ME01238B (enExample) |
| MX (1) | MXPA06014391A (enExample) |
| NO (1) | NO337890B1 (enExample) |
| NZ (1) | NZ552430A (enExample) |
| PL (1) | PL1781291T3 (enExample) |
| PT (1) | PT1781291E (enExample) |
| RS (1) | RS51573B (enExample) |
| SI (1) | SI1781291T1 (enExample) |
| WO (1) | WO2005120506A1 (enExample) |
| ZA (1) | ZA200610477B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
| EP2266564B1 (en) | 1997-12-22 | 2013-03-13 | Euro-Celtique S.A. | Pharmaceutical oral dosage form comprising a combination of an opioid agonist and an opioid antagonist |
| JP4522652B2 (ja) | 2001-05-11 | 2010-08-11 | エンドー ファーマシューティカルズ， インコーポレイティド | 乱用防止制御放出オピオイド投薬形態 |
| LT2425824T (lt) | 2002-04-05 | 2017-07-25 | Euro-Celtique S.A. | Farmacinis preparatas, turintis oksikodono ir naloksono |
| EP1604666A1 (en) | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD) |
| EP1702558A1 (en) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Method and device for the assessment of bowel function |
| US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
| US7794750B2 (en) * | 2008-06-20 | 2010-09-14 | Mutual Pharmaceutical Company, Inc. | Controlled-release formulations, method of manufacture, and use thereof |
| US8632805B2 (en) * | 2008-06-20 | 2014-01-21 | Mutual Pharmaceutical Company, Inc. | Controlled-release formulations, method of manufacture, and use thereof |
| HUE042105T2 (hu) | 2009-03-10 | 2019-06-28 | Euro Celtique Sa | Oxikodont és naloxont tartalmazó azonnali hatóanyagleadású orális gyógyászati készítmények |
| AU2011252040C1 (en) | 2010-05-10 | 2015-04-02 | Euro-Celtique S.A. | Manufacturing of active-free granules and tablets comprising the same |
| BR112012028773A2 (pt) | 2010-05-10 | 2016-07-19 | Euro Celtique Sa | composições farmacêuticas compreendendo hidromorfona e naloxona |
| CA2798885C (en) | 2010-05-10 | 2014-11-18 | Euro-Celtique S.A. | Combination of active loaded granules with additional actives |
| US20180264013A1 (en) * | 2010-07-08 | 2018-09-20 | Wellesley Pharmaceuticals, Llc | Composition and methods for treating sleep disorders |
| PH12013500172A1 (en) * | 2010-08-13 | 2022-10-24 | Euro Celtique Sa | Use of binders for manufacturing storage stable formulations |
| EP3024461B1 (en) | 2013-07-23 | 2020-05-13 | Euro-Celtique S.A. | A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
| EP3068397A1 (en) | 2013-11-13 | 2016-09-21 | Euro-Celtique S.A. | Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome |
Family Cites Families (69)
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|---|---|---|---|---|
| US3173876A (en) | 1960-05-27 | 1965-03-16 | John C Zobrist | Cleaning methods and compositions |
| NL271831A (enExample) | 1960-11-29 | |||
| US3276586A (en) | 1963-08-30 | 1966-10-04 | Rosaen Filter Co | Indicating means for fluid filters |
| NL6714885A (enExample) | 1967-11-02 | 1969-05-06 | ||
| US3541006A (en) | 1968-07-03 | 1970-11-17 | Amicon Corp | Ultrafiltration process |
| US3541005A (en) | 1969-02-05 | 1970-11-17 | Amicon Corp | Continuous ultrafiltration of macromolecular solutions |
| US3773955A (en) * | 1970-08-03 | 1973-11-20 | Bristol Myers Co | Analgetic compositions |
| FR2183546B1 (enExample) * | 1972-05-10 | 1975-06-20 | Servier Lab | |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US3916889A (en) | 1973-09-28 | 1975-11-04 | Sandoz Ag | Patient ventilator apparatus |
| GB1478759A (en) | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
| US3966040A (en) * | 1975-03-05 | 1976-06-29 | Hazelwood John E | Combined vibratory feeder drive unit, vibratory feeder bowl, and parts separator |
| US4077407A (en) | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
| US4126684A (en) * | 1976-02-11 | 1978-11-21 | Ciba-Geigy Corporation | 4-amino-3-p-halophenylbutyric acids and their derivatives used in the control of narcotic abuse |
| US4063064A (en) | 1976-02-23 | 1977-12-13 | Coherent Radiation | Apparatus for tracking moving workpiece by a laser beam |
| US4285987A (en) | 1978-10-23 | 1981-08-25 | Alza Corporation | Process for manufacturing device with dispersion zone |
| US4200098A (en) | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
| US4457933A (en) * | 1980-01-24 | 1984-07-03 | Bristol-Myers Company | Prevention of analgesic abuse |
| GB8332556D0 (en) * | 1983-12-06 | 1984-01-11 | Reckitt & Colmann Prod Ltd | Analgesic compositions |
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| US4769372A (en) * | 1986-06-18 | 1988-09-06 | The Rockefeller University | Method of treating patients suffering from chronic pain or chronic cough |
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| NZ260408A (en) * | 1993-05-10 | 1996-05-28 | Euro Celtique Sa | Controlled release preparation comprising tramadol |
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| US5411745A (en) | 1994-05-25 | 1995-05-02 | Euro-Celtique, S.A. | Powder-layered morphine sulfate formulations |
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| BR9813826A (pt) * | 1997-12-22 | 2000-10-10 | Euro Celtique Sa | Potencial de uso abusivo de administração oral de opióide analgésico |
| EP2266564B1 (en) * | 1997-12-22 | 2013-03-13 | Euro-Celtique S.A. | Pharmaceutical oral dosage form comprising a combination of an opioid agonist and an opioid antagonist |
| CZ297284B6 (cs) * | 1998-03-27 | 2006-10-11 | Pharmacia & Upjohn Company | Farmaceutiký prostredek pro lécbu syndromu neklidných nohou |
| SE9803760D0 (sv) * | 1998-11-04 | 1998-11-04 | Jan Hedner | Sätt att behandla och diagnostisera syndromet restless legs och motsvarande medel |
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| EP2517710B1 (en) * | 2000-02-08 | 2015-03-25 | Euro-Celtique S.A. | Tamper-resistant oral opioid agonist formulations |
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| JP4522652B2 (ja) * | 2001-05-11 | 2010-08-11 | エンドー ファーマシューティカルズ， インコーポレイティド | 乱用防止制御放出オピオイド投薬形態 |
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| CA2454328C (en) * | 2001-07-18 | 2008-03-18 | Christopher D. Breder | Pharmaceutical combinations of oxycodone and naloxone |
| US20030044458A1 (en) * | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
| JP2005512965A (ja) * | 2001-09-24 | 2005-05-12 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 不穏四肢症候群および定期的四肢運動障害の処置に有用な抗痙攣誘導体 |
| LT2425824T (lt) * | 2002-04-05 | 2017-07-25 | Euro-Celtique S.A. | Farmacinis preparatas, turintis oksikodono ir naloksono |
| US20030191147A1 (en) * | 2002-04-09 | 2003-10-09 | Barry Sherman | Opioid antagonist compositions and dosage forms |
| EP1364649A1 (en) * | 2002-05-23 | 2003-11-26 | Cilag AG | Adduct of topiramate and tramadol hydrochioride and uses thereof |
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| EP1604666A1 (en) * | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD) |
| EP1695700A1 (en) * | 2005-02-28 | 2006-08-30 | Euro-Celtique S.A. | Dosage form containing oxycodone and naloxone |
-
2004
- 2004-06-08 EP EP04013469A patent/EP1604667A1/en not_active Withdrawn
-
2005
- 2005-06-01 BR BRPI0511300-8A patent/BRPI0511300A/pt not_active Application Discontinuation
- 2005-06-01 KR KR1020097016692A patent/KR101200869B1/ko not_active Expired - Lifetime
- 2005-06-01 DK DK05754710.1T patent/DK1781291T3/da active
- 2005-06-01 CN CN2013102699069A patent/CN103394090A/zh active Pending
- 2005-06-01 KR KR1020077000489A patent/KR20070037485A/ko not_active Ceased
- 2005-06-01 EP EP05754710A patent/EP1781291B9/en not_active Expired - Lifetime
- 2005-06-01 RS RS20110030A patent/RS51573B/sr unknown
- 2005-06-01 JP JP2007526247A patent/JP2008501742A/ja not_active Withdrawn
- 2005-06-01 NZ NZ552430A patent/NZ552430A/en not_active IP Right Cessation
- 2005-06-01 AT AT05754710T patent/ATE486603T1/de active
- 2005-06-01 HR HR20110049A patent/HRP20110049T2/hr unknown
- 2005-06-01 ES ES05754710T patent/ES2355247T3/es not_active Expired - Lifetime
- 2005-06-01 WO PCT/EP2005/005888 patent/WO2005120506A1/en not_active Ceased
- 2005-06-01 ME MEP-2011-18A patent/ME01238B/me unknown
- 2005-06-01 CN CNA2005800231113A patent/CN1984659A/zh active Pending
- 2005-06-01 DE DE602005024571T patent/DE602005024571D1/de not_active Expired - Lifetime
- 2005-06-01 SI SI200531198T patent/SI1781291T1/sl unknown
- 2005-06-01 CA CA2569742A patent/CA2569742C/en not_active Expired - Fee Related
- 2005-06-01 PT PT05754710T patent/PT1781291E/pt unknown
- 2005-06-01 US US11/570,222 patent/US20070185147A1/en not_active Abandoned
- 2005-06-01 PL PL05754710T patent/PL1781291T3/pl unknown
- 2005-06-01 EP EP10175878A patent/EP2255808A3/en not_active Withdrawn
- 2005-06-01 MX MXPA06014391A patent/MXPA06014391A/es active IP Right Grant
- 2005-06-01 AU AU2005251445A patent/AU2005251445C1/en not_active Expired
-
2006
- 2006-12-06 IL IL179896A patent/IL179896A/en active IP Right Grant
- 2006-12-14 ZA ZA200610477A patent/ZA200610477B/en unknown
-
2007
- 2007-01-08 NO NO20070113A patent/NO337890B1/no not_active IP Right Cessation
-
2011
- 2011-02-03 CY CY20111100121T patent/CY1111512T1/el unknown
- 2011-02-18 JP JP2011033064A patent/JP5774865B2/ja not_active Expired - Fee Related
- 2011-12-21 US US13/333,719 patent/US20120172387A1/en not_active Abandoned
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