JP2013527167A5 - - Google Patents
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- Publication number
- JP2013527167A5 JP2013527167A5 JP2013508152A JP2013508152A JP2013527167A5 JP 2013527167 A5 JP2013527167 A5 JP 2013527167A5 JP 2013508152 A JP2013508152 A JP 2013508152A JP 2013508152 A JP2013508152 A JP 2013508152A JP 2013527167 A5 JP2013527167 A5 JP 2013527167A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- nicotine
- composition according
- levulinic acid
- levulinate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 15
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 claims 15
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 15
- 229960002715 nicotine Drugs 0.000 claims 14
- JOOXCMJARBKPKM-UHFFFAOYSA-M 4-oxopentanoate Chemical compound CC(=O)CCC([O-])=O JOOXCMJARBKPKM-UHFFFAOYSA-M 0.000 claims 8
- 125000005523 4-oxopentanoic acid group Chemical group 0.000 claims 8
- 229940040102 levulinic acid Drugs 0.000 claims 8
- 229940058352 levulinate Drugs 0.000 claims 7
- -1 nicotine compound Chemical class 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 239000012458 free base Substances 0.000 claims 4
- 229910052783 alkali metal Inorganic materials 0.000 claims 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- RFEJUZJILGIRHQ-OMDKHLBYSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 RFEJUZJILGIRHQ-OMDKHLBYSA-N 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- 230000002164 acetylcholinergic effect Effects 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 229960001698 nicotine polacrilex Drugs 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 229940124535 smoking cessation aid Drugs 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/769,335 US20110268809A1 (en) | 2010-04-28 | 2010-04-28 | Nicotine-Containing Pharmaceutical Compositions |
| US12/769,335 | 2010-04-28 | ||
| PCT/US2011/033928 WO2011139684A2 (en) | 2010-04-28 | 2011-04-26 | Nicotine-containing pharmaceutical compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013527167A JP2013527167A (ja) | 2013-06-27 |
| JP2013527167A5 true JP2013527167A5 (enExample) | 2014-05-29 |
| JP5981416B2 JP5981416B2 (ja) | 2016-08-31 |
Family
ID=44626142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013508152A Active JP5981416B2 (ja) | 2010-04-28 | 2011-04-26 | ニコチン含有医薬組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110268809A1 (enExample) |
| EP (1) | EP2563330A2 (enExample) |
| JP (1) | JP5981416B2 (enExample) |
| CN (1) | CN102933199A (enExample) |
| WO (1) | WO2011139684A2 (enExample) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10244793B2 (en) | 2005-07-19 | 2019-04-02 | Juul Labs, Inc. | Devices for vaporization of a substance |
| AT507187B1 (de) | 2008-10-23 | 2010-03-15 | Helmut Dr Buchberger | Inhalator |
| US8752545B2 (en) | 2011-02-11 | 2014-06-17 | Batmark Limited | Inhaler component |
| SE535587C2 (sv) * | 2011-03-29 | 2012-10-02 | Chill Of Sweden Ab | Produkt innehållande ett fritt nikotinsalt och en ej vattenlöslig påse |
| WO2013006643A1 (en) * | 2011-07-06 | 2013-01-10 | The Parkinson's Institute | Compositions and methods for treatment of symptoms in parkinson's disease patients |
| US9084439B2 (en) | 2011-09-22 | 2015-07-21 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9629392B2 (en) | 2011-09-22 | 2017-04-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US20130078307A1 (en) | 2011-09-22 | 2013-03-28 | Niconovum Usa, Inc. | Nicotine-containing pharmaceutical composition |
| US9474303B2 (en) | 2011-09-22 | 2016-10-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9907748B2 (en) | 2011-10-21 | 2018-03-06 | Niconovum Usa, Inc. | Excipients for nicotine-containing therapeutic compositions |
| US20130177646A1 (en) * | 2012-01-05 | 2013-07-11 | Mcneil Ab | Solid Nicotine-Comprising Dosage Form with Reduced Organoleptic Disturbance |
| CN108271909A (zh) * | 2012-02-06 | 2018-07-13 | 加优有限责任公司 | 包括三维物体的口腔递送产品 |
| US9763928B2 (en) | 2012-02-10 | 2017-09-19 | Niconovum Usa, Inc. | Multi-layer nicotine-containing pharmaceutical composition |
| US10517530B2 (en) | 2012-08-28 | 2019-12-31 | Juul Labs, Inc. | Methods and devices for delivering and monitoring of tobacco, nicotine, or other substances |
| US20140255452A1 (en) | 2013-03-11 | 2014-09-11 | Niconovum Usa, Inc. | Method and apparatus for differentiating oral pouch products |
| US10279934B2 (en) | 2013-03-15 | 2019-05-07 | Juul Labs, Inc. | Fillable vaporizer cartridge and method of filling |
| AU2014262808B2 (en) * | 2013-05-06 | 2018-12-13 | Juul Labs, Inc. | Nicotine salt formulations for aerosol devices and methods thereof |
| CN111642812A (zh) | 2013-06-14 | 2020-09-11 | 尤尔实验室有限公司 | 电子汽化设备中的具有单独的可汽化材料的多个加热元件 |
| US10357054B2 (en) | 2013-10-16 | 2019-07-23 | R.J. Reynolds Tobacco Company | Smokeless tobacco pastille |
| KR20240070710A (ko) | 2013-12-05 | 2024-05-21 | 쥴 랩스, 인크. | 에어로졸 장치를 위한 니코틴 액제 및 그 방법 |
| US10159282B2 (en) | 2013-12-23 | 2018-12-25 | Juul Labs, Inc. | Cartridge for use with a vaporizer device |
| US9549573B2 (en) | 2013-12-23 | 2017-01-24 | Pax Labs, Inc. | Vaporization device systems and methods |
| US10076139B2 (en) | 2013-12-23 | 2018-09-18 | Juul Labs, Inc. | Vaporizer apparatus |
| USD842536S1 (en) | 2016-07-28 | 2019-03-05 | Juul Labs, Inc. | Vaporizer cartridge |
| US10058129B2 (en) | 2013-12-23 | 2018-08-28 | Juul Labs, Inc. | Vaporization device systems and methods |
| PT3504991T (pt) | 2013-12-23 | 2021-03-01 | Juul Labs Int Inc | Sistemas de dispositivo e métodos de vaporização |
| US20160366947A1 (en) | 2013-12-23 | 2016-12-22 | James Monsees | Vaporizer apparatus |
| USD825102S1 (en) | 2016-07-28 | 2018-08-07 | Juul Labs, Inc. | Vaporizer device with cartridge |
| US11478021B2 (en) | 2014-05-16 | 2022-10-25 | Juul Labs, Inc. | Systems and methods for aerosolizing a vaporizable material |
| US20150335070A1 (en) | 2014-05-20 | 2015-11-26 | R.J. Reynolds Tobacco Company | Electrically-powered aerosol delivery system |
| US10508096B2 (en) | 2014-05-27 | 2019-12-17 | R.J. Reynolds Tobacco Company | Nicotine salts, co-crystals, and salt co-crystal complexes |
| EP3148982A1 (en) | 2014-05-27 | 2017-04-05 | R. J. Reynolds Tobacco Company | Nicotine salts, co-crystals, and salt co-crystal complexes |
| US9896429B2 (en) | 2014-05-27 | 2018-02-20 | R.J. Reynolds Tobacco Company | Nicotine salts, co-crystals, and salt co-crystal complexes |
| US11019840B2 (en) | 2014-07-02 | 2021-06-01 | R.J. Reynolds Tobacco Company | Oral pouch products |
| US10959456B2 (en) | 2014-09-12 | 2021-03-30 | R.J. Reynolds Tobacco Company | Nonwoven pouch comprising heat sealable binder fiber |
| EA201700155A1 (ru) * | 2014-10-20 | 2017-10-31 | Товарищество С Ограниченной Ответственностью "Фармацевтическая Компания "Ромат" | Фармацевтическая композиция для лечения туберкулеза |
| GB2535427A (en) | 2014-11-07 | 2016-08-24 | Nicoventures Holdings Ltd | Solution |
| US20160157515A1 (en) | 2014-12-05 | 2016-06-09 | R.J. Reynolds Tobacco Company | Smokeless tobacco pouch |
| CA2969728C (en) | 2014-12-05 | 2023-06-13 | Pax Labs, Inc. | Calibrated dose control |
| US9968125B2 (en) | 2015-01-09 | 2018-05-15 | Philip Morris Products S.A. | Nicotine—diketopiperazine microparticle formulations and methods of making the same |
| US10213586B2 (en) | 2015-01-28 | 2019-02-26 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
| AU2016228779A1 (en) | 2015-03-12 | 2017-09-07 | Chrono Therapeutics Inc. | Craving input and support system |
| US10154689B2 (en) | 2015-06-30 | 2018-12-18 | R.J. Reynolds Tobacco Company | Heat generation segment for an aerosol-generation system of a smoking article |
| US11224594B2 (en) | 2015-09-16 | 2022-01-18 | Philip Morris Products S.A. | Nicotine formulations and methods of making and using the same |
| US10149844B2 (en) | 2015-09-16 | 2018-12-11 | Philip Morris Products S.A. | Inhalable nicotine formulations, and methods of making and using thereof |
| US20170071248A1 (en) | 2015-09-16 | 2017-03-16 | Sansa Corporation (Barbados) Inc. | System and Method for Controlling the Harshness of Nicotine-Based Dry Powder Formulations |
| US9585835B1 (en) | 2015-09-16 | 2017-03-07 | Sansa Corporation (Barbados) Inc. | Inhalable nicotine formulations and methods of making and using the same |
| GB2542838B (en) | 2015-10-01 | 2022-01-12 | Nicoventures Trading Ltd | Aerosol provision system |
| RU2733625C2 (ru) | 2015-11-24 | 2020-10-05 | Р. Дж. Рейнолдс Тобакко Компани | Система подачи аэрозоля с электрическим питанием |
| PL3379952T3 (pl) * | 2015-11-25 | 2024-03-18 | R. J. Reynolds Tobacco Company | Kompleksy soli, kokryształów i kokryształów soli nikotyny |
| US20170165252A1 (en) | 2015-12-10 | 2017-06-15 | Niconovum Usa Inc. | Protein-enriched therapeutic composition |
| KR20250058060A (ko) * | 2015-12-24 | 2025-04-29 | 필립모리스 프로덕츠 에스.에이. | 가향된 니코틴 분말 |
| AU2016381372B2 (en) * | 2015-12-30 | 2021-07-22 | Next Generation Labs, LLC | Nicotine replacement therapy products comprising synthetic nicotine |
| CO2018009342A2 (es) | 2016-02-11 | 2018-09-20 | Juul Labs Inc | Cartuchos de fijación segura para dispositivos vaporizadores |
| MX377347B (es) | 2016-02-11 | 2025-03-07 | Juul Labs Inc | Cartucho rellenable de vaporizador y metodo de relleno |
| CN109069497A (zh) * | 2016-02-29 | 2018-12-21 | 尼古珍有限公司 | 尼古丁制剂和气雾剂 |
| US10405582B2 (en) | 2016-03-10 | 2019-09-10 | Pax Labs, Inc. | Vaporization device with lip sensing |
| US10292977B2 (en) | 2016-04-11 | 2019-05-21 | Neurocea, LLC | Compositions and methods for treatment related to fall and fall frequency in neurodegenerative diseases |
| US10143687B2 (en) | 2016-04-11 | 2018-12-04 | Neurocea, LLC | Compositions and methods for treatment related to fall and fall frequency in neurodegenerative diseases |
| USD849996S1 (en) | 2016-06-16 | 2019-05-28 | Pax Labs, Inc. | Vaporizer cartridge |
| USD848057S1 (en) | 2016-06-23 | 2019-05-07 | Pax Labs, Inc. | Lid for a vaporizer |
| USD836541S1 (en) | 2016-06-23 | 2018-12-25 | Pax Labs, Inc. | Charging device |
| USD851830S1 (en) | 2016-06-23 | 2019-06-18 | Pax Labs, Inc. | Combined vaporizer tamp and pick tool |
| US10602775B2 (en) | 2016-07-21 | 2020-03-31 | Rai Strategic Holdings, Inc. | Aerosol delivery device with a unitary reservoir and liquid transport element comprising a porous monolith and related method |
| US10617151B2 (en) | 2016-07-21 | 2020-04-14 | Rai Strategic Holdings, Inc. | Aerosol delivery device with a liquid transport element comprising a porous monolith and related method |
| US11660403B2 (en) | 2016-09-22 | 2023-05-30 | Juul Labs, Inc. | Leak-resistant vaporizer device |
| US10080387B2 (en) | 2016-09-23 | 2018-09-25 | Rai Strategic Holdings, Inc. | Aerosol delivery device with replaceable wick and heater assembly |
| EP3565617A1 (en) | 2017-01-06 | 2019-11-13 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| WO2018197454A1 (en) | 2017-04-24 | 2018-11-01 | Swedish Match North Europe Ab | A flavoured moist oral pouched nicotine product comprising triglyceride |
| WO2019049049A1 (en) | 2017-09-05 | 2019-03-14 | R. J. Reynolds Tobacco Company | SALTS, CO-CRYSTALS, AND CO-CRYSTAL COMPLEXES OF NICOTINE SALTS |
| USD887632S1 (en) | 2017-09-14 | 2020-06-16 | Pax Labs, Inc. | Vaporizer cartridge |
| US10786010B2 (en) | 2017-12-15 | 2020-09-29 | Rai Strategic Holdings, Inc. | Aerosol delivery device with multiple aerosol delivery pathways |
| US10555558B2 (en) | 2017-12-29 | 2020-02-11 | Rai Strategic Holdings, Inc. | Aerosol delivery device providing flavor control |
| AU2019279884B2 (en) | 2018-05-29 | 2025-01-30 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| EP3807260B1 (en) | 2018-06-15 | 2024-09-18 | R. J. Reynolds Tobacco Company | Purification of nicotine |
| US20200077703A1 (en) | 2018-09-11 | 2020-03-12 | Rai Strategic Holdings, Inc. | Wicking element for aerosol delivery device |
| CA3119992A1 (en) | 2018-11-16 | 2020-05-22 | Morningside Venture Investments Limited | Thermally regulated transdermal drug delivery system |
| US12213510B2 (en) | 2019-09-11 | 2025-02-04 | Nicoventures Trading Limited | Pouched products with enhanced flavor stability |
| US12342847B2 (en) | 2019-09-11 | 2025-07-01 | Nicoventures Trading Limited | Oral product with cellulosic flavor stabilizer |
| US11617744B2 (en) | 2019-12-09 | 2023-04-04 | Nico Ventures Trading Limited | Moist oral compositions |
| US12171872B2 (en) | 2019-12-09 | 2024-12-24 | Nicoventures Trading Limited | Oral compositions and methods of manufacture |
| JP2023505797A (ja) | 2019-12-09 | 2023-02-13 | ニコベンチャーズ トレーディング リミテッド | 放出可能成分を含む経口製品用フリース |
| US20210169138A1 (en) | 2019-12-09 | 2021-06-10 | Nicoventures Trading Limited | Fibrous fleece material |
| JP2023504756A (ja) | 2019-12-09 | 2023-02-06 | ニコベンチャーズ トレーディング リミテッド | カンナビノイドを含む口腔用製品 |
| CA3160044A1 (en) | 2019-12-09 | 2021-06-17 | Savannah JOHNSON | Oral product in a pourous pouch comprising a fleece material |
| CA3160454A1 (en) | 2019-12-09 | 2021-06-17 | Savannah JOHNSON | Stimulus-responsive pouch |
| US12439952B2 (en) | 2019-12-09 | 2025-10-14 | Nicoventures Trading Limited | Moist oral compositions |
| US11826462B2 (en) | 2019-12-09 | 2023-11-28 | Nicoventures Trading Limited | Oral product with sustained flavor release |
| US11883527B2 (en) | 2019-12-09 | 2024-01-30 | Nicoventures Trading Limited | Oral composition and method of manufacture |
| EP4072317A1 (en) | 2019-12-09 | 2022-10-19 | Nicoventures Trading Limited | Pouched products with heat sealable binder |
| US11872231B2 (en) | 2019-12-09 | 2024-01-16 | Nicoventures Trading Limited | Moist oral product comprising an active ingredient |
| US11889856B2 (en) | 2019-12-09 | 2024-02-06 | Nicoventures Trading Limited | Oral foam composition |
| US12433321B2 (en) | 2019-12-09 | 2025-10-07 | Nicoventures Trading Limited | Oral composition with beet material |
| US12439949B2 (en) | 2019-12-09 | 2025-10-14 | Nicoventures Trading Limited | Oral compositions with reduced water activity |
| US11672862B2 (en) | 2019-12-09 | 2023-06-13 | Nicoventures Trading Limited | Oral products with reduced irritation |
| US12310959B2 (en) | 2019-12-09 | 2025-05-27 | Nicoventures Trading Limited | Oral compositions with reduced water content |
| US12137723B2 (en) | 2019-12-09 | 2024-11-12 | Nicoventures Trading Limited | Oral products with active ingredient combinations |
| US12151023B2 (en) | 2019-12-09 | 2024-11-26 | Nicoventures Trading Limited | Oral composition with beet material |
| US11793230B2 (en) | 2019-12-09 | 2023-10-24 | Nicoventures Trading Limited | Oral products with improved binding of active ingredients |
| JP2023505351A (ja) | 2019-12-09 | 2023-02-08 | ニコベンチャーズ トレーディング リミテッド | 口腔用組成物のための薬剤 |
| US12520867B2 (en) | 2019-12-09 | 2026-01-13 | Nicoventures Trading Limited | Buffered oral compositions |
| US12491250B2 (en) | 2019-12-09 | 2025-12-09 | Nicoventures Trading Limited | Oral composition with nanocrystalline cellulose |
| EP4072334A1 (en) | 2019-12-09 | 2022-10-19 | Nicoventures Trading Limited | Oral product with dissolvable component |
| US11969502B2 (en) | 2019-12-09 | 2024-04-30 | Nicoventures Trading Limited | Oral products |
| JP2023530239A (ja) | 2020-06-08 | 2023-07-14 | ニコベンチャーズ トレーディング リミテッド | 発泡性口腔組成物 |
| US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
| US20240000808A1 (en) * | 2020-11-16 | 2024-01-04 | Orcosa Inc. | Improved use of cannabinoids in the treatment of alzheimer's disease |
| US11839602B2 (en) | 2020-11-25 | 2023-12-12 | Nicoventures Trading Limited | Oral cannabinoid product with lipid component |
| EP4284972A1 (en) | 2021-01-28 | 2023-12-06 | Nicoventures Trading Limited | Method for sealing pouches |
| CA3223902A1 (en) | 2021-06-25 | 2022-12-29 | Richard Svensson | Oral products and method of manufacture |
| WO2023007440A1 (en) | 2021-07-30 | 2023-02-02 | Nicoventures Trading Limited | Aerosol generating substrate comprising microcrystalline cellulose |
| CA3131364A1 (en) * | 2021-09-20 | 2023-03-20 | Apotex Inc. | Novel salts of nintedanib and crystalline forms thereof |
| JP2024546044A (ja) | 2021-11-15 | 2024-12-17 | ニコベンチャーズ トレーディング リミテッド | 感覚特性が増強された製品 |
| EP4503974A1 (en) | 2022-04-06 | 2025-02-12 | Nicoventures Trading Limited | Pouched products with heat sealable binder |
| KR102848894B1 (ko) * | 2022-10-26 | 2025-08-21 | 한국원자력연구원 | 합성 니코틴의 감별 방법 |
| CN115997965A (zh) * | 2023-02-09 | 2023-04-25 | 东莞市吉纯生物技术有限公司 | 一种尼古丁缓释型口含烟及其制备方法 |
Family Cites Families (122)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2033909A (en) | 1934-12-19 | 1936-03-17 | Niacet Chemicals Corp | Manufacture of calcium levulinate |
| US3901248A (en) | 1970-07-22 | 1975-08-26 | Leo Ab | Chewable smoking substitute composition |
| US3877468A (en) | 1970-07-22 | 1975-04-15 | Leo Ab | Chewable tobacco substitute composition |
| US3845217A (en) | 1972-11-16 | 1974-10-29 | Helsingborg L Ab | Buffered smoking substitute compositions |
| US4284809A (en) | 1979-04-02 | 1981-08-18 | The Upjohn Company | 13,14-Didehydro-inter-oxa-19-oxo-PGF1 compounds |
| GB8301659D0 (en) | 1983-01-21 | 1983-02-23 | Leo Ab | Smoking substitutes |
| US4655231A (en) | 1984-01-09 | 1987-04-07 | Advanced Tobacco Products, Inc. | Snuff and preparation thereof |
| US4597961A (en) | 1985-01-23 | 1986-07-01 | Etscorn Frank T | Transcutaneous application of nicotine |
| US4800903A (en) | 1985-05-24 | 1989-01-31 | Ray Jon P | Nicotine dispenser with polymeric reservoir of nicotine |
| GB8615676D0 (en) | 1986-06-26 | 1986-07-30 | Stoppers Co Ltd | Nicotine containing lozenge |
| EP0283672B1 (en) * | 1987-02-10 | 1993-09-22 | R.J. Reynolds Tobacco Company | Cigarette |
| US4830028A (en) | 1987-02-10 | 1989-05-16 | R. J. Reynolds Tobacco Company | Salts provided from nicotine and organic acid as cigarette additives |
| IL86170A (en) | 1987-05-01 | 1992-12-01 | Elan Transdermal Ltd | Preparations and compositions comprising nicotine for percutaneous administration |
| US5834011A (en) | 1988-02-19 | 1998-11-10 | The Regents Of The University Of California | Method for aiding in the reduction of incidence of tobacco smoking |
| US5004610A (en) | 1988-06-14 | 1991-04-02 | Alza Corporation | Subsaturated nicotine transdermal therapeutic system |
| US5154927A (en) | 1989-01-19 | 1992-10-13 | Wm. Wrigley Jr. Company | Gum composition containing dispersed porous beads containing active chewing gum ingredients and method |
| US5525351A (en) | 1989-11-07 | 1996-06-11 | Dam; Anders | Nicotine containing stimulant unit |
| SE8904295D0 (sv) | 1989-12-21 | 1989-12-21 | Pharmacia Ab | Smoking substitute |
| US5512306A (en) | 1992-06-19 | 1996-04-30 | Pharmica Ab | Smoking substitute |
| US5031646A (en) | 1990-01-16 | 1991-07-16 | R. J. Reynolds Tobacco Company | Cigarette |
| US5167242A (en) | 1990-06-08 | 1992-12-01 | Kabi Pharmacia Aktiebolaq | Nicotine-impermeable container and method of fabricating the same |
| US5147654A (en) | 1990-07-23 | 1992-09-15 | Alza Corporation | Oral osmotic device for delivering nicotine |
| US5110605A (en) | 1990-08-21 | 1992-05-05 | Oramed, Inc. | Calcium polycarbophil-alginate controlled release composition and method |
| GB9200047D0 (en) | 1992-01-03 | 1992-02-26 | Univ Alberta | Nicotine-containing nasal spray |
| US6024097A (en) | 1992-02-20 | 2000-02-15 | J Mom Trust | Product for assisting a smoker in giving up the habit |
| US6098632A (en) | 1992-11-25 | 2000-08-08 | Pharmacia & Upjohn Ab | Nicotine-impermeable container and method of fabricating the same |
| US6602892B1 (en) | 1993-06-10 | 2003-08-05 | David P. L. Sachs | Methods for nicotine replacement dosage determination |
| WO1995001766A1 (en) | 1993-07-09 | 1995-01-19 | Cygnus Therapeutic Systems | Method and device for providing nicotine replacement therapy transdermally/transbuccally |
| US5549906A (en) | 1993-07-26 | 1996-08-27 | Pharmacia Ab | Nicotine lozenge and therapeutic method for smoking cessation |
| US5362496A (en) | 1993-08-04 | 1994-11-08 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
| SE9303574D0 (sv) | 1993-11-01 | 1993-11-01 | Kabi Pharmacia Ab | Composition for drug delivery and method the manufacturing thereof |
| IT1274034B (it) | 1994-07-26 | 1997-07-14 | Applied Pharma Res | Composizioni farmaceutiche a base di gomma da masticare e procedimento per la loro preparazione |
| US5723477A (en) | 1994-11-10 | 1998-03-03 | Sibia Neurosciences, Inc. | Modulators of acetylcholine receptors |
| US5604231A (en) | 1995-01-06 | 1997-02-18 | Smith; Carr J. | Pharmaceutical compositions for prevention and treatment of ulcerative colitis |
| US5583140A (en) | 1995-05-17 | 1996-12-10 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of central nervous system disorders |
| US5811126A (en) | 1995-10-02 | 1998-09-22 | Euro-Celtique, S.A. | Controlled release matrix for pharmaceuticals |
| ATE260646T1 (de) | 1996-04-16 | 2004-03-15 | Novartis Consumer Health Sa | Schnell zerfallende orale dosierungsform |
| US6166048A (en) | 1999-04-20 | 2000-12-26 | Targacept, Inc. | Pharmaceutical compositions for inhibition of cytokine production and secretion |
| GB9614902D0 (en) | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
| DE19646392A1 (de) | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
| US5811442A (en) | 1997-02-21 | 1998-09-22 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of conditions associated with decreased blood flow |
| US6024981A (en) | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
| US7214686B2 (en) | 1997-06-30 | 2007-05-08 | Targacept, Inc. | Pharmaceutical compositions and methods for effecting dopamine release |
| US20030176467A1 (en) | 1997-09-25 | 2003-09-18 | Sven Andersson | Nicotine compositions |
| US6268386B1 (en) | 1998-06-25 | 2001-07-31 | Marshall Anlauf Thompson | Nicotine beverage |
| US6234169B1 (en) | 1998-08-14 | 2001-05-22 | Arthur Slutsky | Inhaler |
| US6344222B1 (en) | 1998-09-03 | 2002-02-05 | Jsr Llc | Medicated chewing gum delivery system for nicotine |
| US6358060B2 (en) | 1998-09-03 | 2002-03-19 | Jsr Llc | Two-stage transmucosal medicine delivery system for symptom relief |
| US20020098264A1 (en) | 1998-11-27 | 2002-07-25 | Cherukuri Subraman R. | Medicated chewing gum delivery system for nicotine |
| US6596298B2 (en) | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
| SE9803986D0 (sv) | 1998-11-23 | 1998-11-23 | Pharmacia & Upjohn Ab | New compositions |
| GB9826192D0 (en) | 1998-12-01 | 1999-01-20 | Controlled Theraputics Scotlan | Oral transmucosal delivery |
| US7163705B2 (en) | 1998-12-15 | 2007-01-16 | Wm. Wrigley Jr. Company | Coated chewing gum product and method of making |
| PT1061900E (pt) | 1999-01-14 | 2005-04-29 | Noven Pharma | Composicoes e metodos para libertacao de uma droga |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US7374779B2 (en) | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
| US6090401A (en) | 1999-03-31 | 2000-07-18 | Mcneil-Ppc, Inc. | Stable foam composition |
| US6773716B2 (en) | 1999-04-06 | 2004-08-10 | Wm. Wrigley Jr. Company | Over-coated chewing gum formulations |
| US6355265B1 (en) | 1999-04-06 | 2002-03-12 | Wm. Wrigley Jr. Company | Over-coated chewing gum formulations |
| US6426090B1 (en) | 1999-04-06 | 2002-07-30 | Wm. Wrigley Jr. Company | Over-coated product including tableted center and medicament |
| US6322806B1 (en) | 1999-04-06 | 2001-11-27 | Wm. Wrigley Jr. Company | Over-coated chewing gum formulations including tableted center |
| US6583160B2 (en) | 1999-04-14 | 2003-06-24 | Steve Smith | Nicotine therapy method and oral carrier for assuaging tobacco-addiction |
| US6248760B1 (en) | 1999-04-14 | 2001-06-19 | Paul C Wilhelmsen | Tablet giving rapid release of nicotine for transmucosal administration |
| US20010016593A1 (en) | 1999-04-14 | 2001-08-23 | Wilhelmsen Paul C. | Element giving rapid release of nicotine for transmucosal administration |
| US6319510B1 (en) | 1999-04-20 | 2001-11-20 | Alayne Yates | Gum pad for delivery of medication to mucosal tissues |
| GB9911037D0 (en) | 1999-05-13 | 1999-07-14 | Micap Limited | Nicotine delivery service |
| US20080138398A1 (en) | 1999-07-16 | 2008-06-12 | Aradigm Corporation | Dual release nicotine formulations, and systems and methods for their use |
| US8256433B2 (en) | 1999-07-16 | 2012-09-04 | Aradigm Corporation | Systems and methods for effecting cessation of tobacco use |
| US6799576B2 (en) | 1999-07-16 | 2004-10-05 | Aradigm Corporation | System for effecting smoking cessation |
| US6322828B1 (en) | 1999-09-13 | 2001-11-27 | Deseret Laboratories, Inc. | Process for manufacturing a pharmaceutical chewing gum |
| US6660754B1 (en) | 2000-02-15 | 2003-12-09 | Smithkline Beecham Corporation | Method for reducing or eliminating smoking |
| US7115297B2 (en) | 2000-02-22 | 2006-10-03 | Suzanne Jaffe Stillman | Nutritionally fortified liquid composition with added value delivery systems/elements/additives |
| US7067116B1 (en) | 2000-03-23 | 2006-06-27 | Warner-Lambert Company Llc | Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1 |
| CA2359813C (en) | 2000-10-24 | 2008-04-22 | Richard L. Jones | Nicotine mucosal spray |
| SE0102197D0 (sv) | 2001-06-20 | 2001-06-20 | Pharmacia Ab | New product and use and manufacture thereof |
| US6585997B2 (en) | 2001-08-16 | 2003-07-01 | Access Pharmaceuticals, Inc. | Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds |
| US7208186B2 (en) | 2001-09-18 | 2007-04-24 | Spi Pharma, Inc. | Chewing gum formulation and method of making the same |
| CN1602193A (zh) | 2001-12-10 | 2005-03-30 | 约瑟夫·罗伯特·奈特 | 用烟碱处理的饮料 |
| SE0104388D0 (sv) | 2001-12-27 | 2001-12-27 | Pharmacia Ab | New formulation and use and manufacture thereof |
| US20030159702A1 (en) | 2002-01-21 | 2003-08-28 | Lindell Katarina E.A. | Formulation and use manufacture thereof |
| DK1471890T3 (da) | 2002-02-07 | 2007-01-08 | Pharmacia Corp | Farmaceutisk doseringsform til mukös afgivelse |
| AU2003214936A1 (en) | 2002-02-20 | 2003-09-09 | Pharmacia And Upjohn Company | Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity |
| US7105173B1 (en) | 2002-03-21 | 2006-09-12 | Rolling Kenneth J | Nicotine replacement applique |
| US20040101543A1 (en) | 2002-03-22 | 2004-05-27 | John Liu | Nicotine-containing oral dosage form |
| US7767698B2 (en) | 2002-06-03 | 2010-08-03 | Mcneil Ab | Formulation and use thereof |
| US8216609B2 (en) | 2002-08-05 | 2012-07-10 | Torrent Pharmaceuticals Limited | Modified release composition of highly soluble drugs |
| US7135484B2 (en) | 2002-08-14 | 2006-11-14 | Abbott Laboratories | Azabicyclic compounds are central nervous system active agents |
| WO2004028267A1 (en) | 2002-09-24 | 2004-04-08 | Gumlink A/S | Chewing gum having improved release of chewing gum ingredients |
| JP4287817B2 (ja) | 2002-09-24 | 2009-07-01 | ガムリンク エー／エス | 少なくとも１種の高分子量生物分解性ポリマーを含む生物分解性チューインガム |
| DE60234884D1 (de) | 2002-09-24 | 2010-02-04 | Gumlink As | Kaugummi mit niedrigem Feuchtigkeitsgehalt |
| AU2002342580B2 (en) | 2002-09-24 | 2008-05-15 | Gumlink A/S | Degradable chewing gum polymer |
| US6886557B2 (en) * | 2002-10-31 | 2005-05-03 | Hewlett-Packard Development Company, L.P. | Inhalation device and method for delivering variable amounts of different components |
| WO2004056363A2 (en) * | 2002-12-20 | 2004-07-08 | Niconovum Ab | A physically and chemically stable nicotine-containing particulate material |
| EP1449525A1 (en) | 2003-02-20 | 2004-08-25 | Cross Chem Llc | chewing gum in the form of multi-layer tablets |
| US20040182403A1 (en) | 2003-02-28 | 2004-09-23 | Sven-Borje Andersson | Container comprising nicotine and the use and manufacture thereof |
| CN100381083C (zh) | 2003-04-29 | 2008-04-16 | 韩力 | 一种非可燃性电子喷雾香烟 |
| RU2351315C2 (ru) | 2003-07-24 | 2009-04-10 | Смитклайн Бичам Корпорейшн | Пленки, растворяющиеся в полости рта |
| PL1663168T3 (pl) | 2003-09-08 | 2009-07-31 | Mcneil Ab | Preparaty nikotyny i ich zastosowanie |
| US20050123502A1 (en) | 2003-10-07 | 2005-06-09 | Chan Shing Y. | Nicotine containing oral compositions |
| WO2005053691A2 (en) | 2003-12-02 | 2005-06-16 | Fertin Pharma A/S | Nicotine delivery product and method for producing it |
| WO2006004646A1 (en) * | 2004-06-28 | 2006-01-12 | Nektar Therapeutics | Aerosol formulation comprising nicotine salt |
| CN101090713A (zh) | 2004-11-30 | 2007-12-19 | 费尔廷制药公司 | 尼古丁口香糖对使用者提供快速缓解的方法 |
| WO2006100075A2 (en) | 2005-03-22 | 2006-09-28 | Niconovum Ab | Use of an artificial sweetener to enhance absorption of nicotine |
| US8323683B2 (en) | 2005-05-18 | 2012-12-04 | Mcneil-Ppc, Inc. | Flavoring of drug-containing chewing gums |
| ATE448786T1 (de) | 2005-06-01 | 2009-12-15 | Fertin Pharma As | Verfahren zur herstellung eines nikotinzuführenden produkts |
| US20070134169A1 (en) * | 2005-12-11 | 2007-06-14 | Rabinoff Michael D | Methods for smoking cessation or alcohol cessation or other addiction cessation |
| AU2007224586A1 (en) * | 2006-03-16 | 2007-09-20 | Niconovum Ab | Stable lozenge compositions providing rapid release of nicotine |
| CN101528199B (zh) * | 2006-03-16 | 2013-05-29 | 尼科诺瓦姆股份公司 | 改良的鼻烟组合物 |
| EP1998748B1 (en) | 2006-03-16 | 2015-01-14 | NicoNovum AB | Improved snuff composition |
| US20070269386A1 (en) | 2006-05-16 | 2007-11-22 | Per Steen | New product and use and manufacture thereof |
| US20070269492A1 (en) | 2006-05-16 | 2007-11-22 | Per Steen | New product and use and manufacture thereof |
| US8642016B2 (en) | 2006-07-21 | 2014-02-04 | Jsrnti, Llc | Medicinal delivery system, and related methods |
| RU2009115720A (ru) | 2006-09-27 | 2010-11-10 | Никоновум Аб (Se) | Направленное применение |
| MX2009005671A (es) * | 2006-12-01 | 2009-06-08 | Cima Labs Inc | Forma de dosificacion de nicotina transmucosal oral. |
| CN101563071A (zh) * | 2006-12-01 | 2009-10-21 | 赛福伦公司 | 尼古丁经口粘膜剂型 |
| US20080286340A1 (en) | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered nicotine containing products |
| US20080286341A1 (en) | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered coated nicotine containing products |
| US20080292683A1 (en) | 2007-05-24 | 2008-11-27 | Monosolrx, Llc. | Film shreds and delivery system incorporating same |
| US20090004248A1 (en) | 2007-06-29 | 2009-01-01 | Frank Bunick | Dual portion dosage lozenge form |
| US20090081291A1 (en) | 2007-09-26 | 2009-03-26 | Gin Jerry B | Sustained Release Dosage Forms For Delivery of Agents to an Oral Cavity of a User |
| US8039620B2 (en) | 2008-05-22 | 2011-10-18 | Teva Pharmaceutical Industries Ltd. | Varenicline tosylate, an intermediate in the preparation process of varenicline L-tartrate |
| US20100018539A1 (en) | 2008-07-28 | 2010-01-28 | Paul Andrew Brinkley | Smokeless tobacco products and processes |
-
2010
- 2010-04-28 US US12/769,335 patent/US20110268809A1/en not_active Abandoned
-
2011
- 2011-04-26 EP EP11717898A patent/EP2563330A2/en not_active Withdrawn
- 2011-04-26 CN CN2011800285443A patent/CN102933199A/zh active Pending
- 2011-04-26 JP JP2013508152A patent/JP5981416B2/ja active Active
- 2011-04-26 WO PCT/US2011/033928 patent/WO2011139684A2/en not_active Ceased
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