MX2024003998A - Producto oral con una amina basica y un agente de emparejamiento ionico. - Google Patents

Producto oral con una amina basica y un agente de emparejamiento ionico.

Info

Publication number
MX2024003998A
MX2024003998A MX2024003998A MX2024003998A MX2024003998A MX 2024003998 A MX2024003998 A MX 2024003998A MX 2024003998 A MX2024003998 A MX 2024003998A MX 2024003998 A MX2024003998 A MX 2024003998A MX 2024003998 A MX2024003998 A MX 2024003998A
Authority
MX
Mexico
Prior art keywords
organic acid
basic amine
oral product
ion pairing
pairing agent
Prior art date
Application number
MX2024003998A
Other languages
English (en)
Inventor
Steven Lee Alderman
Thomas H Poole
Michael Zawadzki
Kai Tang
Original Assignee
Nicoventures Trading Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicoventures Trading Ltd filed Critical Nicoventures Trading Ltd
Publication of MX2024003998A publication Critical patent/MX2024003998A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Manufacture Of Tobacco Products (AREA)

Abstract

La presente invención refiere a una composición configurada para uso oral, la cual incluye al menos un excipiente, agua, una amina básica y un ácido orgánico, una sal de metal alcalino de un ácido orgánico, o una combinación de los mismos, en donde el ácido orgánico tiene un valor de logP de aproximadamente 1 a aproximadamente 12. Al menos una parte de la amina básica está asociada con al menos una parte del ácido orgánico o la sal de metal alcalino del mismo. La asociación se encuentra en forma de una sal de amina básica-ácido orgánico, un par iónico entre la amina básica y una base conjugada del ácido orgánico, o una combinación de ambos. El ácido orgánico es un monoéster de un ácido dicarboxílico o es un derivado de carotenoide que tiene uno o más ácidos carboxílicos.
MX2024003998A 2021-09-30 2022-09-29 Producto oral con una amina basica y un agente de emparejamiento ionico. MX2024003998A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163250631P 2021-09-30 2021-09-30
PCT/IB2022/059305 WO2023053062A1 (en) 2021-09-30 2022-09-29 Oral product with a basic amine and an ion pairing agent

Publications (1)

Publication Number Publication Date
MX2024003998A true MX2024003998A (es) 2024-06-03

Family

ID=83693121

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2024003998A MX2024003998A (es) 2021-09-30 2022-09-29 Producto oral con una amina basica y un agente de emparejamiento ionico.

Country Status (6)

Country Link
US (1) US20230138306A1 (es)
EP (1) EP4408183A1 (es)
JP (1) JP2024536230A (es)
CA (1) CA3233375A1 (es)
MX (1) MX2024003998A (es)
WO (1) WO2023053062A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220071984A1 (en) * 2019-09-11 2022-03-10 Nicoventures Trading Limited Oral product with nicotine and ion pairing agent

Family Cites Families (187)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US787611A (en) 1903-06-17 1905-04-18 American Cigar Company Treating tobacco.
US1086306A (en) 1912-11-11 1914-02-03 Theodor Oelenheinz Process of bleaching tobacco-leaves.
US1376586A (en) 1918-04-06 1921-05-03 Schwartz Francis Tobacco-tablet
US1437095A (en) 1920-06-01 1922-11-28 August Wasmuth Process of bleaching tobacco
US1757477A (en) 1927-07-11 1930-05-06 Rosenhoch Samuel Process and device for ozonizing tobacco
US2148147A (en) 1933-12-30 1939-02-21 Degussa Process for bleaching tobacco
US2170107A (en) 1935-01-28 1939-08-22 Degussa Process for bleaching tobacco
US2274649A (en) 1935-01-28 1942-03-03 Degussa Process for bleaching tobacco
US2122421A (en) 1937-07-30 1938-07-05 Du Pont Tobacco treatment
US2770239A (en) 1952-02-04 1956-11-13 Prats Jose Romero Process of treating tobacco
US3612065A (en) 1970-03-09 1971-10-12 Creative Enterprises Inc Method of puffing tobacco and reducing nicotine content thereof
US3943945A (en) 1971-09-20 1976-03-16 Rosen Enterprises, Inc. Process for preparation of reconstituted tobacco sheet
US3889689A (en) 1971-12-20 1975-06-17 Rosen Enterprise Inc Method of treating tobacco with catalase and hydrogen peroxide
US3851653A (en) 1972-10-11 1974-12-03 Rosen Enterprises Inc Method of puffing tobacco and reducing nicotine content thereof
US4340073A (en) 1974-02-12 1982-07-20 Philip Morris, Incorporated Expanding tobacco
GB1489761A (en) 1974-03-08 1977-10-26 Amf Inc Process of treating tobacco
US3943940A (en) 1974-09-13 1976-03-16 Isao Minami Method of removing nicotine in smoking and a smoking filter to be used therefor
US4034764A (en) 1975-08-15 1977-07-12 Philip Morris Incorporated Smoking material and method for its preparation
GB1550835A (en) 1975-08-18 1979-08-22 British American Tobacco Co Treatment of tobacco
US4194514A (en) 1976-09-27 1980-03-25 Stauffer Chemical Company Removal of radioactive lead and polonium from tobacco
US4150677A (en) 1977-01-24 1979-04-24 Philip Morris Incorporated Treatment of tobacco
US4267847A (en) 1978-05-12 1981-05-19 British-American Tobacco Company Limited Tobacco additives
US4289147A (en) 1979-11-15 1981-09-15 Leaf Proteins, Inc. Process for obtaining deproteinized tobacco freed of nicotine and green pigment, for use as a smoking product
US4589428A (en) 1980-02-21 1986-05-20 Philip Morris Incorporated Tobacco treatment
DE3009031C2 (de) 1980-03-08 1983-04-21 B.A.T. Cigaretten-Fabriken Gmbh, 2000 Hamburg Verfahren zur Herstellung von Aromastoffen für Rauchprodukte
DE3009032C2 (de) 1980-03-08 1983-11-24 B.A.T. Cigaretten-Fabriken Gmbh, 2000 Hamburg Verfahren zur Herstellung von Aromastoffen für Rauchprodukte
US4388933A (en) 1981-06-25 1983-06-21 Philip Morris, Inc. Tobacco stem treatment and expanded tobacco product
US4366823A (en) 1981-06-25 1983-01-04 Philip Morris, Incorporated Process for expanding tobacco
US4366824A (en) 1981-06-25 1983-01-04 Philip Morris Incorporated Process for expanding tobacco
IN158943B (es) 1981-12-07 1987-02-21 Mueller Adam
GB2122892B (en) 1982-07-02 1986-01-29 Squibb & Sons Inc Nystantin pastille formulation
US4528993A (en) 1982-08-20 1985-07-16 R. J. Reynolds Tobacco Company Process for producing moist snuff
US4660577A (en) 1982-08-20 1987-04-28 R.J. Reynolds Tobacco Company Dry pre-mix for moist snuff
US4513756A (en) 1983-04-28 1985-04-30 The Pinkerton Tobacco Company Process of making tobacco pellets
JPS6024172A (ja) 1983-07-21 1985-02-06 日本たばこ産業株式会社 たばこ用香料の製造方法
DE3344554A1 (de) 1983-12-09 1985-06-20 B.A.T. Cigaretten-Fabriken Gmbh, 2000 Hamburg Rauchprodukt, enthaltend nicotin-n' -oxid
US5092352A (en) 1983-12-14 1992-03-03 American Brands, Inc. Chewing tobacco product
US4624269A (en) 1984-09-17 1986-11-25 The Pinkerton Tobacco Company Chewable tobacco based product
US4716911A (en) 1986-04-08 1988-01-05 Genencor, Inc. Method for protein removal from tobacco
GB8615676D0 (en) 1986-06-26 1986-07-30 Stoppers Co Ltd Nicotine containing lozenge
US4727889A (en) 1986-12-22 1988-03-01 R. J. Reynolds Tobacco Company Tobacco processing
US5018540A (en) 1986-12-29 1991-05-28 Philip Morris Incorporated Process for removal of basic materials
US5005593A (en) 1988-01-27 1991-04-09 R. J. Reynolds Tobacco Company Process for providing tobacco extracts
US5435325A (en) 1988-04-21 1995-07-25 R. J. Reynolds Tobacco Company Process for providing tobacco extracts using a solvent in a supercritical state
US4887618A (en) 1988-05-19 1989-12-19 R. J. Reynolds Tobacco Company Tobacco processing
US4987907A (en) 1988-06-29 1991-01-29 Helme Tobacco Company Chewing tobacco composition and process for producing same
US4967771A (en) 1988-12-07 1990-11-06 R. J. Reynolds Tobacco Company Process for extracting tobacco
US4986286A (en) 1989-05-02 1991-01-22 R. J. Reynolds Tobacco Company Tobacco treatment process
US4941484A (en) 1989-05-30 1990-07-17 R. J. Reynolds Tobacco Company Tobacco processing
US5525351A (en) 1989-11-07 1996-06-11 Dam; Anders Nicotine containing stimulant unit
US5121757A (en) 1989-12-18 1992-06-16 R. J. Reynolds Tobacco Company Tobacco treatment process
US5060669A (en) 1989-12-18 1991-10-29 R. J. Reynolds Tobacco Company Tobacco treatment process
US4991599A (en) 1989-12-20 1991-02-12 Tibbetts Hubert M Fiberless tobacco product for smoking and chewing
US5167244A (en) 1990-01-19 1992-12-01 Kjerstad Randy E Tobacco substitute
US5065775A (en) 1990-02-23 1991-11-19 R. J. Reynolds Tobacco Company Tobacco processing
US5131414A (en) 1990-02-23 1992-07-21 R. J. Reynolds Tobacco Company Tobacco processing
US5234008A (en) 1990-02-23 1993-08-10 R. J. Reynolds Tobacco Company Tobacco processing
US5099862A (en) 1990-04-05 1992-03-31 R. J. Reynolds Tobacco Company Tobacco extraction process
US5074319A (en) 1990-04-19 1991-12-24 R. J. Reynolds Tobacco Company Tobacco extraction process
US5110605A (en) 1990-08-21 1992-05-05 Oramed, Inc. Calcium polycarbophil-alginate controlled release composition and method
US5668295A (en) 1990-11-14 1997-09-16 Philip Morris Incorporated Protein involved in nicotine synthesis, DNA encoding, and use of sense and antisense DNAs corresponding thereto to affect nicotine content in transgenic tobacco cells and plants
US5131415A (en) 1991-04-04 1992-07-21 R. J. Reynolds Tobacco Company Tobacco extraction process
US5318050A (en) 1991-06-04 1994-06-07 R. J. Reynolds Tobacco Company Tobacco treatment process
US5197494A (en) 1991-06-04 1993-03-30 R.J. Reynolds Tobacco Company Tobacco extraction process
US5343879A (en) 1991-06-21 1994-09-06 R. J. Reynolds Tobacco Company Tobacco treatment process
US5360022A (en) 1991-07-22 1994-11-01 R. J. Reynolds Tobacco Company Tobacco processing
US5148819A (en) 1991-08-15 1992-09-22 R. J. Reynolds Tobacco Company Process for extracting tobacco
US5230354A (en) 1991-09-03 1993-07-27 R. J. Reynolds Tobacco Company Tobacco processing
US5243999A (en) 1991-09-03 1993-09-14 R. J. Reynolds Tobacco Company Tobacco processing
US5301694A (en) 1991-11-12 1994-04-12 Philip Morris Incorporated Process for isolating plant extract fractions
US5259403A (en) 1992-03-18 1993-11-09 R. J. Reynolds Tobacco Company Process and apparatus for expanding tobacco cut filler
US5445169A (en) 1992-08-17 1995-08-29 R. J. Reynolds Tobacco Company Process for providing a tobacco extract
US5387416A (en) 1993-07-23 1995-02-07 R. J. Reynolds Tobacco Company Tobacco composition
US5549906A (en) 1993-07-26 1996-08-27 Pharmacia Ab Nicotine lozenge and therapeutic method for smoking cessation
DE4415999A1 (de) 1994-05-06 1995-11-09 Bolder Arzneimittel Gmbh Magensäurebindende Kaupastillen
US5539093A (en) 1994-06-16 1996-07-23 Fitzmaurice; Wayne P. DNA sequences encoding enzymes useful in carotenoid biosynthesis
US5637785A (en) 1994-12-21 1997-06-10 The Salk Institute For Biological Studies Genetically modified plants having modulated flower development
GR1002575B (el) 1995-04-07 1997-02-06 Μεθοδος και συσκευη αφαιρεσεως βλαπτικων ουσιων εκ των σιγαρεττων προ της καταναλωσεως.
US5725865A (en) * 1995-08-29 1998-03-10 V. Mane Fils S.A. Coolant compositions
US5705624A (en) 1995-12-27 1998-01-06 Fitzmaurice; Wayne Paul DNA sequences encoding enzymes useful in phytoene biosynthesis
US5713376A (en) 1996-05-13 1998-02-03 Berger; Carl Non-addictive tobacco products
US5908032A (en) 1996-08-09 1999-06-01 R.J. Reynolds Tobacco Company Method of and apparatus for expanding tobacco
US6298859B1 (en) 1998-07-08 2001-10-09 Novozymes A/S Use of a phenol oxidizing enzyme in the treatment of tobacco
US6596298B2 (en) 1998-09-25 2003-07-22 Warner-Lambert Company Fast dissolving orally comsumable films
US6083527A (en) 1998-11-05 2000-07-04 Thistle; Robert Breath mint with tooth decay and halitosis prevention characteristics
SE9803986D0 (sv) 1998-11-23 1998-11-23 Pharmacia & Upjohn Ab New compositions
US7374779B2 (en) 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US20010016593A1 (en) 1999-04-14 2001-08-23 Wilhelmsen Paul C. Element giving rapid release of nicotine for transmucosal administration
US6248760B1 (en) 1999-04-14 2001-06-19 Paul C Wilhelmsen Tablet giving rapid release of nicotine for transmucosal administration
US6131584A (en) 1999-04-15 2000-10-17 Brown & Williamson Tobacco Corporation Tobacco treatment process
US6805134B2 (en) 1999-04-26 2004-10-19 R. J. Reynolds Tobacco Company Tobacco processing
GB9911037D0 (en) 1999-05-13 1999-07-14 Micap Limited Nicotine delivery service
DE60020716T2 (de) 1999-07-22 2005-12-15 Warner-Lambert Co. Llc Filmbildende zusammensetzungen aus pullulan
US6371126B1 (en) 2000-03-03 2002-04-16 Brown & Williamson Tobacco Corporation Tobacco recovery system
EP1313868B1 (en) 2000-08-30 2006-07-19 North Carolina State University Transgenic plants containing molecular decoys that alter protein content therein
ES2380178T3 (es) 2001-03-08 2012-05-09 Michigan State University Reguladores del metabolismo de lípidos en plantas
US6834654B2 (en) 2001-05-01 2004-12-28 Regent Court Technologies, Llc Smokeless tobacco product
US20040020503A1 (en) 2001-05-01 2004-02-05 Williams Jonnie R. Smokeless tobacco product
US6668839B2 (en) 2001-05-01 2003-12-30 Jonnie R. Williams Smokeless tobacco product
US7208659B2 (en) 2001-05-02 2007-04-24 Conopco Inc. Process for increasing the flavonoid content of a plant and plants obtainable thereby
US6730832B1 (en) 2001-09-10 2004-05-04 Luis Mayan Dominguez High threonine producing lines of Nicotiana tobacum and methods for producing
US7032601B2 (en) 2001-09-28 2006-04-25 U.S. Smokeless Tobacco Company Encapsulated materials
US6953040B2 (en) 2001-09-28 2005-10-11 U.S. Smokeless Tobacco Company Tobacco mint plant material product
US20040101543A1 (en) 2002-03-22 2004-05-27 John Liu Nicotine-containing oral dosage form
US6772767B2 (en) 2002-09-09 2004-08-10 Brown & Williamson Tobacco Corporation Process for reducing nitrogen containing compounds and lignin in tobacco
US7025066B2 (en) 2002-10-31 2006-04-11 Jerry Wayne Lawson Method of reducing the sucrose ester concentration of a tobacco mixture
US7556047B2 (en) 2003-03-20 2009-07-07 R.J. Reynolds Tobacco Company Method of expanding tobacco using steam
SE0301244D0 (sv) 2003-04-29 2003-04-29 Swedish Match North Europe Ab Smokeless tobacco product user package
US7014039B2 (en) 2003-06-19 2006-03-21 R.J. Reynolds Tobacco Company Sliding shell package for smoking articles
SE527350C8 (sv) 2003-08-18 2006-03-21 Gallaher Snus Ab Lock till snusdosa
BRPI0415682A (pt) 2003-11-03 2006-12-19 Us Smokeless Tobacco Co tabaco sem fumaça aromatizado e métodos de fabricação
US8627828B2 (en) 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
WO2005063060A1 (en) 2003-12-22 2005-07-14 U.S. Smokeless Tobacco Company Conditioning process for tobacco and/or snuff compositions
WO2006004480A1 (en) 2004-07-02 2006-01-12 Radi Medical Systems Ab Smokeless toabacco product
US7337782B2 (en) 2004-08-18 2008-03-04 R.J. Reynolds Tobacco Company Process to remove protein and other biomolecules from tobacco extract or slurry
WO2006022784A1 (en) 2004-08-23 2006-03-02 U.S. Smokeless Tobacco Company Nicotiana compositions
US7650891B1 (en) 2004-09-03 2010-01-26 Rosswil Llc Ltd. Tobacco precursor product
US20060210488A1 (en) 2005-03-19 2006-09-21 Jakubowski Henryk P Teeth whitening candy with tartar removal and breath freshening properties
US7537110B2 (en) 2005-06-02 2009-05-26 Philip Morris Usa Inc. Container for consumer article
US7584843B2 (en) 2005-07-18 2009-09-08 Philip Morris Usa Inc. Pocket-size hand-held container for consumer items
US7861728B2 (en) 2006-02-10 2011-01-04 R.J. Reynolds Tobacco Company Smokeless tobacco composition having an outer and inner pouch
US20070062549A1 (en) 2005-09-22 2007-03-22 Holton Darrell E Jr Smokeless tobacco composition
US7819124B2 (en) 2006-01-31 2010-10-26 U.S. Smokeless Tobacco Company Tobacco articles and methods
US7810507B2 (en) 2006-02-10 2010-10-12 R. J. Reynolds Tobacco Company Smokeless tobacco composition
JP2009529561A (ja) 2006-03-16 2009-08-20 ニコノヴァム エービー ニコチンの速やかな放出をもたらす安定なロゼンジ組成物
SE529886C2 (sv) 2006-04-28 2007-12-18 Swedish Match North Europe Ab En ny metod för framställning av en fuktsnuskomposition som inte innehåller tobak
US8642016B2 (en) 2006-07-21 2014-02-04 Jsrnti, Llc Medicinal delivery system, and related methods
US20080029116A1 (en) 2006-08-01 2008-02-07 John Howard Robinson Smokeless tobacco
US20080173317A1 (en) 2006-08-01 2008-07-24 John Howard Robinson Smokeless tobacco
EP2089294A4 (en) 2006-12-12 2010-01-20 Meadwestvaco Corp PACKING WITH ROTATABLE LID
US20080166395A1 (en) * 2007-01-04 2008-07-10 Roush Steven H Article for delivering substrates to the oral cavity
CN101686731B (zh) 2007-02-23 2013-05-08 美国无烟烟草有限责任公司 新型烟草组合物及制备方法
US8186360B2 (en) 2007-04-04 2012-05-29 R.J. Reynolds Tobacco Company Cigarette comprising dark air-cured tobacco
US8393465B2 (en) 2007-05-07 2013-03-12 Philip Morris Usa Inc. Pocket-size hybrid container for consumer items
WO2009004488A2 (en) 2007-06-08 2009-01-08 Philip Morris Products S.A. Capsule clusters for oral consumption
US8061362B2 (en) 2007-07-23 2011-11-22 R. J. Reynolds Tobacco Company Smokeless tobacco composition
US20090081291A1 (en) 2007-09-26 2009-03-26 Gin Jerry B Sustained Release Dosage Forms For Delivery of Agents to an Oral Cavity of a User
USD594154S1 (en) 2007-11-13 2009-06-09 R.J. Reynolds Tobacco Company Container with bottom compartment
US8336557B2 (en) 2007-11-28 2012-12-25 Philip Morris Usa Inc. Smokeless compressed tobacco product for oral consumption
US7878324B2 (en) 2007-11-30 2011-02-01 Philip Morris Usa Inc. Pocket-size container for consumer items
USD592956S1 (en) 2008-02-08 2009-05-26 Philip Morris Usa Inc. Container
US20090230003A1 (en) 2008-02-08 2009-09-17 Philip Morris Usa Inc. Pocket-sized container
US8033425B2 (en) 2008-03-04 2011-10-11 R.J. Reynolds Tobacco Company Dispensing container
US7946450B2 (en) 2008-04-25 2011-05-24 R.J. Reynolds Tobacco Company Dispensing container
US9248935B2 (en) 2008-12-01 2016-02-02 R.J. Reynolds Tobacco Company Dual cavity sliding dispenser
US9155772B2 (en) 2008-12-08 2015-10-13 Philip Morris Usa Inc. Soft, chewable and orally dissolvable and/or disintegrable products
US20120067361A1 (en) 2009-04-03 2012-03-22 X-International Aps Plant fiber product and method for its manufacture
USD625178S1 (en) 2009-04-16 2010-10-12 R.J. Reynolds Tobacco Company, Inc. Container with hinged insert
US8087540B2 (en) 2009-04-16 2012-01-03 R.J. Reynolds Tabacco Company Dispensing container for metered dispensing of product
RU2536214C2 (ru) 2009-05-11 2014-12-20 Ю.С. Смоуклис Тобэкоу Компани Ллк Способ и устройство для ароматизации бездымного табака
US8991403B2 (en) 2009-06-02 2015-03-31 R.J. Reynolds Tobacco Company Thermal treatment process for tobacco materials
US8944072B2 (en) 2009-06-02 2015-02-03 R.J. Reynolds Tobacco Company Thermal treatment process for tobacco materials
US8434496B2 (en) 2009-06-02 2013-05-07 R. J. Reynolds Tobacco Company Thermal treatment process for tobacco materials
US20110139164A1 (en) 2009-12-15 2011-06-16 R. J. Reynolds Tobacco Company Tobacco Product And Method For Manufacture
US8096411B2 (en) 2010-01-12 2012-01-17 R. J. Reynolds Tabacco Company Dispensing container
US8397945B2 (en) 2010-02-23 2013-03-19 R.J. Reynolds Tobacco Company Dispensing container
US9039839B2 (en) 2010-04-08 2015-05-26 R.J. Reynolds Tobacco Company Smokeless tobacco composition comprising tobacco-derived material and non-tobacco plant material
US11116237B2 (en) 2010-08-11 2021-09-14 R.J. Reynolds Tobacco Company Meltable smokeless tobacco composition
US9675102B2 (en) 2010-09-07 2017-06-13 R. J. Reynolds Tobacco Company Smokeless tobacco product comprising effervescent composition
US8931493B2 (en) 2010-11-01 2015-01-13 R.J. Reynolds Tobacco Co. Smokeless tobacco products
US9775376B2 (en) 2010-12-01 2017-10-03 R.J. Reynolds Tobacco Company Smokeless tobacco pastille and moulding process for forming smokeless tobacco products
US9204667B2 (en) 2010-12-01 2015-12-08 R.J. Reynolds Tobacco Company Smokeless tobacco pastille and injection molding process for forming smokeless tobacco products
US9474303B2 (en) 2011-09-22 2016-10-25 R.J. Reynolds Tobacco Company Translucent smokeless tobacco product
US9084439B2 (en) 2011-09-22 2015-07-21 R.J. Reynolds Tobacco Company Translucent smokeless tobacco product
US10881132B2 (en) 2011-12-14 2021-01-05 R.J. Reynolds Tobacco Company Smokeless tobacco product comprising effervescent composition
US9420825B2 (en) 2012-02-13 2016-08-23 R.J. Reynolds Tobacco Company Whitened tobacco composition
US9044035B2 (en) 2012-04-17 2015-06-02 R.J. Reynolds Tobacco Company Remelted ingestible products
US9339058B2 (en) 2012-04-19 2016-05-17 R. J. Reynolds Tobacco Company Method for producing microcrystalline cellulose from tobacco and related tobacco product
US10093058B2 (en) * 2013-03-15 2018-10-09 Altria Client Services Llc Methods and machines for making oral products
US11202470B2 (en) * 2013-05-22 2021-12-21 Njoy, Inc. Compositions, devices, and methods for nicotine aerosol delivery
US11503853B2 (en) 2013-09-09 2022-11-22 R.J. Reynolds Tobacco Company Smokeless tobacco composition incorporating a botanical material
US10357054B2 (en) 2013-10-16 2019-07-23 R.J. Reynolds Tobacco Company Smokeless tobacco pastille
US9375033B2 (en) 2014-02-14 2016-06-28 R.J. Reynolds Tobacco Company Tobacco-containing gel composition
SE538741C2 (sv) 2014-04-04 2016-11-08 X-International Aps Tobaksråvara
US11019840B2 (en) 2014-07-02 2021-06-01 R.J. Reynolds Tobacco Company Oral pouch products
US10959456B2 (en) 2014-09-12 2021-03-30 R.J. Reynolds Tobacco Company Nonwoven pouch comprising heat sealable binder fiber
US20160073686A1 (en) 2014-09-12 2016-03-17 R.J. Reynolds Tobacco Company Tobacco-derived filter element
US20160157515A1 (en) 2014-12-05 2016-06-09 R.J. Reynolds Tobacco Company Smokeless tobacco pouch
US20160192703A1 (en) 2015-01-07 2016-07-07 R.J. Reynolds Tobacco Company Oral pouch products
US9950858B2 (en) 2015-01-16 2018-04-24 R.J. Reynolds Tobacco Company Tobacco-derived cellulose material and products formed thereof
SE541198C2 (en) 2016-11-02 2019-04-30 Winnington Ab Defibrated tobacco raw material
KR20200037220A (ko) * 2017-06-26 2020-04-08 누드 니코틴 인코포레이티드 니코틴 염 및 이의 제조 및 사용 방법
US11388924B2 (en) * 2018-02-02 2022-07-19 10150703 Canada Inc. Nicotine ion pair formulation neutralized with CO2 and process therefor
US11889856B2 (en) * 2019-12-09 2024-02-06 Nicoventures Trading Limited Oral foam composition
US20210169788A1 (en) * 2019-12-09 2021-06-10 Nicoventures Trading Limited Oral product and method of manufacture
US20210169126A1 (en) * 2019-12-09 2021-06-10 Nicoventures Trading Limited Oral composition with salt inclusion
SE544672C2 (en) * 2020-05-07 2022-10-11 Liw Innovation Ab New compositions for oral or nasal use

Also Published As

Publication number Publication date
US20230138306A1 (en) 2023-05-04
JP2024536230A (ja) 2024-10-04
CA3233375A1 (en) 2023-04-06
WO2023053062A1 (en) 2023-04-06
EP4408183A1 (en) 2024-08-07

Similar Documents

Publication Publication Date Title
MX2022002990A (es) Producto oral con una amina basica y un agente de apareamiento de iones.
PH12021550328A1 (en) Methods of reducing the need for peripheral arterial revascularization in a statin-treated subject
MX2019014181A (es) Nuevas composiciones de acidos modificados como alternativas a los acidos convencionales en la industria del petroleo y el gas.
HU9401391D0 (en) Substituted salicylic acid derivatives, process for producing them and use of them
MX2024003998A (es) Producto oral con una amina basica y un agente de emparejamiento ionico.
ATE475415T1 (de) Neue salze des wirkstoffs rasagilin
UY26839A1 (es) Productos de derivados de la 4 - fenil - piridina
EP4248968A3 (en) Tlr7/8 antagonists and uses thereof
MX2021000093A (es) Antagonistas del receptor de tipo toll 7/8 (tlr7/8) y usos de los mismos.
EP2392566A4 (en) PROCESS FOR THE PREPARATION OF A DICHLOROPYRAZINE DERIVATIVE
UA6301A1 (uk) Спосіб одержання похідних ціс-4-феніл-1,2,3,4-тетрагідра-1-нафтіламіна або його солей
MX2016004992A (es) Cocristales de (s)-n-metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il ) amino)propan-2-il)quinolina-4-carboxamida y sus derivados deuterados como inhibidores de proteínas cinasa dependientes de adn (adn-pk).
TNSN07148A1 (en) (biphenyl) carboxylic acids and derivatives thereof
MY192462A (en) Composition of mannuronic dicarboxylic acid
MX2023012537A (es) Composiciónes orales y metodos de fabricacion.
MY148953A (en) Substituted biphenyl carboxylic acids and derivatives thereof
MX2021007161A (es) Agente que contiene acido ursodesoxicolico para tratar o prevenir la presbicia.
MX2024003130A (es) Amida 1,4-dihidro-1,6-naftiridina sustituida y uso de la misma.
MX2024003997A (es) Composicion de goma oral.
MX2020002986A (es) Composicion herbicida a base de acido acetico.
NZ600577A (en) Stable aqueous compositions of prostglandin agonist prodrugs and methods for use thereof
MX2023012905A (es) Barra de jabon.
HRP20070025A2 (en) New pseudopolymorph of desloratadine formed with carbon dioxide
MX2023003245A (es) Derivados de amina novedosos.
ES2135693T3 (es) Procedimiento para la obtencion de acidos glicinicos o esteres de acidos glicinicos n-substituidos y empleo del procedimiento para la sintesis del indigo.