JP2009517466A5 - - Google Patents
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- Publication number
- JP2009517466A5 JP2009517466A5 JP2008543231A JP2008543231A JP2009517466A5 JP 2009517466 A5 JP2009517466 A5 JP 2009517466A5 JP 2008543231 A JP2008543231 A JP 2008543231A JP 2008543231 A JP2008543231 A JP 2008543231A JP 2009517466 A5 JP2009517466 A5 JP 2009517466A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- acetylsalicylic acid
- proton pump
- pump inhibitor
- form according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002552 dosage form Substances 0.000 description 33
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 30
- 229960001138 acetylsalicylic acid Drugs 0.000 description 30
- 229940126409 proton pump inhibitor Drugs 0.000 description 16
- 239000000612 proton pump inhibitor Substances 0.000 description 16
- 229960004770 esomeprazole Drugs 0.000 description 9
- SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 239000010410 layer Substances 0.000 description 7
- 238000010306 acid treatment Methods 0.000 description 6
- 239000002702 enteric coating Substances 0.000 description 6
- 238000009505 enteric coating Methods 0.000 description 6
- 230000002496 gastric effect Effects 0.000 description 6
- 208000010125 myocardial infarction Diseases 0.000 description 6
- 230000006441 vascular event Effects 0.000 description 6
- 239000002775 capsule Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 150000001447 alkali salts Chemical class 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- ZBFDAUIVDSSISP-UHFFFAOYSA-N 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]-1H-imidazo[4,5-b]pyridine Chemical compound N=1C2=NC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C ZBFDAUIVDSSISP-UHFFFAOYSA-N 0.000 description 1
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- HRRXCXABAPSOCP-UHFFFAOYSA-N ilaprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC(=CC=C3N=2)N2C=CC=C2)=C1C HRRXCXABAPSOCP-UHFFFAOYSA-N 0.000 description 1
- 229950008491 ilaprazole Drugs 0.000 description 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
- 229960003174 lansoprazole Drugs 0.000 description 1
- MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 description 1
- 229960000381 omeprazole Drugs 0.000 description 1
- 229960005019 pantoprazole Drugs 0.000 description 1
- 229960004157 rabeprazole Drugs 0.000 description 1
- YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 description 1
- 230000009861 stroke prevention Effects 0.000 description 1
- 238000009498 subcoating Methods 0.000 description 1
- 229950008375 tenatoprazole Drugs 0.000 description 1
- 230000009424 thromboembolic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74098105P | 2005-11-30 | 2005-11-30 | |
| US81888606P | 2006-07-06 | 2006-07-06 | |
| PCT/SE2006/001349 WO2007064274A1 (en) | 2005-11-30 | 2006-11-28 | Oral pharmaceutical dosage form comprising as active ingredients a proton pump inhibitor together with acetyl salicyclic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009517466A JP2009517466A (ja) | 2009-04-30 |
| JP2009517466A5 true JP2009517466A5 (enExample) | 2010-01-28 |
Family
ID=38092508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008543231A Pending JP2009517466A (ja) | 2005-11-30 | 2006-11-28 | 活性成分として、アセチルサリチル酸と一緒にプロトンポンプ阻害剤を含む経口医薬剤形 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20070122470A1 (enExample) |
| EP (1) | EP1957081A4 (enExample) |
| JP (1) | JP2009517466A (enExample) |
| KR (1) | KR20080070841A (enExample) |
| AR (1) | AR057181A1 (enExample) |
| AU (1) | AU2006321007A1 (enExample) |
| CA (1) | CA2628907A1 (enExample) |
| EC (1) | ECSP088490A (enExample) |
| IL (1) | IL191312A0 (enExample) |
| NO (1) | NO20082744L (enExample) |
| RU (1) | RU2008121767A (enExample) |
| TW (1) | TW200803871A (enExample) |
| UY (1) | UY29975A1 (enExample) |
| WO (1) | WO2007064274A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9600070D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
| SE510650C2 (sv) * | 1997-05-30 | 1999-06-14 | Astra Ab | Ny förening |
| US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
| AR057181A1 (es) * | 2005-11-30 | 2007-11-21 | Astra Ab | Nueva forma de dosificacion de combinacion |
| US9265732B2 (en) * | 2006-03-06 | 2016-02-23 | Pozen Inc. | Dosage forms for administering combinations of drugs |
| WO2009147178A2 (en) * | 2008-06-04 | 2009-12-10 | Nycomed Gmbh | Novel medical use of substituted pyridin-2-ylmethylsulphinyl-1h-benzimidazoles |
| KR20110079641A (ko) | 2008-09-09 | 2011-07-07 | 아스트라제네카 아베 | 제약 조성물을 이를 필요로 하는 환자에게 전달하는 방법 |
| WO2010041276A1 (en) * | 2008-10-06 | 2010-04-15 | Jubilant Organosys Limited | Pharmaceutical compositions comprising amorphous esomeprazole, dosage forms and process thereof |
| WO2010122583A2 (en) * | 2009-04-24 | 2010-10-28 | Rubicon Research Private Limited | Oral pharmaceutical compositions of acid labile substances |
| US20100305163A1 (en) * | 2009-05-20 | 2010-12-02 | Pramod Dattatray Yedurkar | Pharmaceutical formulations comprising nsaid and proton pump inhibitor drugs |
| MX2011013467A (es) | 2009-06-25 | 2012-02-13 | Astrazeneca Ab | Metodo para tratar un paciente que corre el riesgo de desarollar una ulcera asociada a antiinflamatorio no esteroide (aine). |
| NZ597534A (en) * | 2009-06-25 | 2013-09-27 | Pozen Inc | Method for treating a patient in need of aspirin therapy |
| WO2011025673A1 (en) * | 2009-08-26 | 2011-03-03 | Aptapharma, Inc. | Multilayer minitablets |
| WO2011144994A1 (en) * | 2010-05-21 | 2011-11-24 | Lupin Limited | Pharmaceutical compositions of nsaid and acid inhibitor |
| US20130243859A1 (en) * | 2010-12-03 | 2013-09-19 | Takeda Pharmaceutical Company Limited | Orally disintegrating tablet |
| CN103781478A (zh) * | 2011-06-24 | 2014-05-07 | 艾森达制药有限公司 | 用以改善酯类前药吸收率的方法与改良的药学组合物 |
| CN104080446B (zh) | 2011-11-30 | 2018-06-29 | 武田药品工业株式会社 | 干包衣片 |
| US9539214B2 (en) | 2011-12-28 | 2017-01-10 | Pozen Inc. | Compositions and methods for delivery of omeprazole plus acetylsalicylic acid |
| TW201532635A (zh) | 2013-05-21 | 2015-09-01 | Takeda Pharmaceutical | 口腔內崩解錠 |
| WO2015150943A1 (en) * | 2014-03-29 | 2015-10-08 | Wockhardt Limited | Pharmaceutical composition of nsaid and ppi or salt thereof |
| JP6778680B2 (ja) | 2015-07-30 | 2020-11-04 | 武田薬品工業株式会社 | 錠剤 |
| JP7321744B2 (ja) * | 2019-03-22 | 2023-08-07 | キョーリンリメディオ株式会社 | 安定化されたエソメプラゾールマグネシウム水和物含有腸溶性固形製剤 |
| MX2024012534A (es) * | 2022-04-19 | 2025-04-02 | Hanmi Pharmaceutical Co Ltd | Composicion farmaceutica que comprende acido acetilsalicilico e inhibidor de la bomba de protones |
| KR20240043707A (ko) | 2022-09-27 | 2024-04-03 | 한미약품 주식회사 | 아세틸살리실산 및 프로톤 펌프 저해제를 포함하는 약학적 조성물 |
| KR102850540B1 (ko) * | 2022-10-12 | 2025-08-26 | 일양약품주식회사 | 클로피도그렐 및 일라프라졸을 포함하는 복합제제 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4016744A (en) * | 1975-05-28 | 1977-04-12 | Hoffmann-La Roche Inc. | Applied instrumentation providing tabletting compression force |
| US4263328A (en) * | 1979-10-26 | 1981-04-21 | General Foods Corporation | Tableted gasified candy |
| IL75400A (en) * | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
| GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
| US4948581A (en) * | 1989-02-17 | 1990-08-14 | Dojin Iyaku-Kako Co., Ltd. | Long acting diclofenac sodium preparation |
| US5204118A (en) * | 1989-11-02 | 1993-04-20 | Mcneil-Ppc, Inc. | Pharmaceutical compositions and methods for treating the symptoms of overindulgence |
| DK1078628T3 (da) * | 1994-07-08 | 2009-02-23 | Astrazeneca Ab | Tabletteret flerenhedsdoseringsform |
| SE9600070D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
| GB2361185A (en) * | 2000-04-10 | 2001-10-17 | Nicholas J Wald | Pharmaceutical formulation for the prevention of cardiovascular disease |
| US7029701B2 (en) * | 2000-09-11 | 2006-04-18 | Andrx Pharmaceuticals, Llc | Composition for the treatment and prevention of ischemic events |
| US6544556B1 (en) * | 2000-09-11 | 2003-04-08 | Andrx Corporation | Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor |
| DK1411900T4 (da) * | 2001-06-01 | 2014-01-27 | Pozen Inc | Farmaceutiske sammensætninger til den koordinerede frigørelse af NSAIDs |
| US8206741B2 (en) * | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
| US6930099B2 (en) * | 2001-09-07 | 2005-08-16 | Advanced Medical Instruments | Composition for the treatment and prevention of endothelial dysfunction |
| FR2845917B1 (fr) * | 2002-10-21 | 2006-07-07 | Negma Gild | Composition pharmaceutique associant le tenatoprazole et un anti-inflammatoire |
| US20040121004A1 (en) * | 2002-12-20 | 2004-06-24 | Rajneesh Taneja | Dosage forms containing a PPI, NSAID, and buffer |
| US20040131676A1 (en) * | 2002-12-20 | 2004-07-08 | Rajneesh Taneja | Dosage forms containing a PPI, NSAID, and buffer |
| WO2004062552A2 (en) * | 2003-01-09 | 2004-07-29 | Galephar M/F | Pharmaceutical composition containing a nsaid and a benzimidazole derivative |
| JP2005145894A (ja) * | 2003-11-17 | 2005-06-09 | Takeda Chem Ind Ltd | 固形製剤 |
| US20050163847A1 (en) * | 2004-01-21 | 2005-07-28 | Andrx Pharmaceuticals, Llc | Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and an antiulcerative drug |
| EP1718303A4 (en) * | 2004-02-10 | 2010-09-01 | Santarus Inc | COMBINATION OF INHIBITOR OF PROTON PUMP, BUFFER AND NON-STEROIDAL ANTI-INFLAMMATORY DRUG |
| US20050227949A1 (en) * | 2004-04-07 | 2005-10-13 | Nasrola Edalatpour | Compositions and methods for treatment of viral and bacterial infections |
| US20060177504A1 (en) * | 2005-02-08 | 2006-08-10 | Renjit Sundharadas | Combination pain medication |
| AR057181A1 (es) * | 2005-11-30 | 2007-11-21 | Astra Ab | Nueva forma de dosificacion de combinacion |
| EP1965774A2 (en) * | 2005-12-30 | 2008-09-10 | Cogentus Pharmaceuticals, Inc. | Oral pharmaceutical formulations containing non-steroidal anti-inflammatory drugs and acid inhibitors |
| PE20090387A1 (es) * | 2007-05-24 | 2009-04-28 | Novartis Ag | Formulacion de pasireotida |
-
2006
- 2006-11-27 AR ARP060105217A patent/AR057181A1/es not_active Application Discontinuation
- 2006-11-28 WO PCT/SE2006/001349 patent/WO2007064274A1/en not_active Ceased
- 2006-11-28 RU RU2008121767/15A patent/RU2008121767A/ru not_active Application Discontinuation
- 2006-11-28 JP JP2008543231A patent/JP2009517466A/ja active Pending
- 2006-11-28 CA CA002628907A patent/CA2628907A1/en not_active Abandoned
- 2006-11-28 US US11/563,812 patent/US20070122470A1/en not_active Abandoned
- 2006-11-28 US US12/094,519 patent/US20100178334A1/en not_active Abandoned
- 2006-11-28 AU AU2006321007A patent/AU2006321007A1/en not_active Abandoned
- 2006-11-28 KR KR1020087012976A patent/KR20080070841A/ko not_active Withdrawn
- 2006-11-28 TW TW095144028A patent/TW200803871A/zh unknown
- 2006-11-28 EP EP06824483A patent/EP1957081A4/en not_active Withdrawn
- 2006-11-29 UY UY29975A patent/UY29975A1/es not_active Application Discontinuation
-
2008
- 2008-05-07 IL IL191312A patent/IL191312A0/en unknown
- 2008-05-30 EC EC2008008490A patent/ECSP088490A/es unknown
- 2008-06-17 NO NO20082744A patent/NO20082744L/no not_active Application Discontinuation
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