JP2010090168A5 - - Google Patents
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- JP2010090168A5 JP2010090168A5 JP2010007969A JP2010007969A JP2010090168A5 JP 2010090168 A5 JP2010090168 A5 JP 2010090168A5 JP 2010007969 A JP2010007969 A JP 2010007969A JP 2010007969 A JP2010007969 A JP 2010007969A JP 2010090168 A5 JP2010090168 A5 JP 2010090168A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- formula
- dissolution test
- compound represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 9
- 238000007922 dissolution test Methods 0.000 claims 9
- 239000011248 coating agent Substances 0.000 claims 7
- -1 5-chloropyridin-2-yl Chemical group 0.000 claims 6
- 239000000654 additive Substances 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 4
- 229960003943 hypromellose Drugs 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 150000005846 sugar alcohols Chemical class 0.000 claims 4
- 229920002554 vinyl polymer Polymers 0.000 claims 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 3
- 239000001856 Ethyl cellulose Substances 0.000 claims 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 3
- 229930195725 Mannitol Natural products 0.000 claims 3
- 230000000996 additive effect Effects 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 229920002678 cellulose Polymers 0.000 claims 3
- 239000001913 cellulose Substances 0.000 claims 3
- 238000004090 dissolution Methods 0.000 claims 3
- 229920001249 ethyl cellulose Polymers 0.000 claims 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims 3
- 239000000594 mannitol Substances 0.000 claims 3
- 235000010355 mannitol Nutrition 0.000 claims 3
- 239000012085 test solution Substances 0.000 claims 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- 229920000881 Modified starch Polymers 0.000 claims 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 2
- 238000010828 elution Methods 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 229920000609 methyl cellulose Polymers 0.000 claims 2
- 239000001923 methylcellulose Substances 0.000 claims 2
- 235000010981 methylcellulose Nutrition 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 241000255925 Diptera Species 0.000 claims 1
- 239000004386 Erythritol Substances 0.000 claims 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 1
- KWSAYQLNHUMQLP-ROSVLZJBSA-N N'-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide 4-methylbenzenesulfonic acid hydrate Chemical compound O.Cc1ccc(cc1)S(O)(=O)=O.CN(C)C(=O)[C@H]1CC[C@H](NC(=O)C(N)=O)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 KWSAYQLNHUMQLP-ROSVLZJBSA-N 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- YIKSCQDJHCMVMK-UHFFFAOYSA-N Oxamide Chemical compound NC(=O)C(N)=O YIKSCQDJHCMVMK-UHFFFAOYSA-N 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229920003144 amino alkyl methacrylate copolymer Polymers 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 235000019414 erythritol Nutrition 0.000 claims 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims 1
- 229940009714 erythritol Drugs 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 229960001855 mannitol Drugs 0.000 claims 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 1
- INYJGWAMAOSZQJ-UHFFFAOYSA-N oxamide;hydrochloride Chemical compound Cl.NC(=O)C(N)=O INYJGWAMAOSZQJ-UHFFFAOYSA-N 0.000 claims 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229940069328 povidone Drugs 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
- 229960002675 xylitol Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010007969A JP2010090168A (ja) | 2007-03-29 | 2010-01-18 | 医薬組成物 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007087327 | 2007-03-29 | ||
| JP2010007969A JP2010090168A (ja) | 2007-03-29 | 2010-01-18 | 医薬組成物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009510780A Division JP4463875B2 (ja) | 2007-03-29 | 2008-03-28 | 医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010090168A JP2010090168A (ja) | 2010-04-22 |
| JP2010090168A5 true JP2010090168A5 (enExample) | 2011-03-10 |
Family
ID=39875378
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009510780A Active JP4463875B2 (ja) | 2007-03-29 | 2008-03-28 | 医薬組成物 |
| JP2010007969A Pending JP2010090168A (ja) | 2007-03-29 | 2010-01-18 | 医薬組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009510780A Active JP4463875B2 (ja) | 2007-03-29 | 2008-03-28 | 医薬組成物 |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US20100081685A1 (enExample) |
| EP (1) | EP2140867B2 (enExample) |
| JP (2) | JP4463875B2 (enExample) |
| KR (1) | KR101424843B1 (enExample) |
| CN (2) | CN101652139A (enExample) |
| AU (1) | AU2008241982B2 (enExample) |
| BR (1) | BRPI0809205B8 (enExample) |
| CA (1) | CA2680039C (enExample) |
| CO (1) | CO6220955A2 (enExample) |
| CY (1) | CY1119377T1 (enExample) |
| DK (1) | DK2140867T4 (enExample) |
| ES (1) | ES2644803T5 (enExample) |
| FI (1) | FI2140867T4 (enExample) |
| HR (1) | HRP20171384T4 (enExample) |
| HU (2) | HUE035990T2 (enExample) |
| IL (2) | IL200790A (enExample) |
| LT (2) | LT2140867T (enExample) |
| MX (2) | MX2009010474A (enExample) |
| MY (1) | MY149356A (enExample) |
| NO (1) | NO20093008L (enExample) |
| NZ (2) | NZ597109A (enExample) |
| PL (1) | PL2140867T5 (enExample) |
| PT (1) | PT2140867T (enExample) |
| SG (1) | SG179497A1 (enExample) |
| SI (1) | SI2140867T2 (enExample) |
| TW (1) | TWI409064B (enExample) |
| WO (1) | WO2008129846A1 (enExample) |
| ZA (2) | ZA200906182B (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2644803T5 (es) | 2007-03-29 | 2024-02-26 | Daiichi Sankyo Co Ltd | Composición farmacéutica |
| CN102256984B (zh) | 2008-12-17 | 2014-09-03 | 第一三共株式会社 | 制备二胺衍生物的方法 |
| EP2374456B1 (en) * | 2008-12-19 | 2016-08-03 | Daiichi Sankyo Company, Limited | Edoxaban dosage regime |
| JPWO2010082531A1 (ja) | 2009-01-13 | 2012-07-05 | 第一三共株式会社 | 活性化血液凝固因子阻害剤 |
| EP2407457B1 (en) | 2009-03-10 | 2015-04-22 | Daiichi Sankyo Company, Limited | Process for producing diamine derivative |
| JP5652879B2 (ja) | 2009-03-13 | 2015-01-14 | 第一三共株式会社 | 光学活性なジアミン誘導体の製造方法 |
| CA2760073A1 (en) * | 2009-04-30 | 2010-11-04 | Takeda Pharmaceutical Company Limited | Solid preparation |
| KR20120037396A (ko) * | 2009-06-18 | 2012-04-19 | 다이이찌 산쿄 가부시키가이샤 | 용출성이 개선된 의약 조성물 |
| TW201132646A (en) * | 2010-02-22 | 2011-10-01 | Daiichi Sankyo Co Ltd | Oral solid extended release dosage form |
| ES2706880T3 (es) * | 2010-02-22 | 2019-04-01 | Daiichi Sankyo Co Ltd | Preparación sólida de liberación sostenida para uso oral |
| TW201200165A (en) * | 2010-02-22 | 2012-01-01 | Daiichi Sankyo Co Ltd | Oral solid extended release dosage form |
| KR101792299B1 (ko) * | 2010-03-19 | 2017-10-31 | 다이이찌 산쿄 가부시키가이샤 | 항응고제의 용출 개선 방법 |
| CN102791719B (zh) | 2010-03-19 | 2015-07-29 | 第一三共株式会社 | 二胺衍生物的晶体及其制备方法 |
| CN103080078B (zh) * | 2010-07-02 | 2015-02-11 | 第一三共株式会社 | 光学活性二胺衍生物盐的制备方法 |
| KR101940840B1 (ko) * | 2011-08-10 | 2019-01-21 | 다이이찌 산쿄 가부시키가이샤 | 디아민 유도체 함유 의약 조성물 |
| WO2013026553A1 (en) | 2011-08-22 | 2013-02-28 | Ratiopharm Gmbh | Composition comprising edoxaban |
| RU2665372C2 (ru) | 2012-09-03 | 2018-08-29 | Дайити Санкио Компани, Лимитед | Пероральная фармацевтическая композиция замедленного высвобождения, содержащая гидрохлорид гидроморфона |
| JP6227352B2 (ja) * | 2012-09-27 | 2017-11-08 | 株式会社三和化学研究所 | アナグリプチン又はその塩を含有する固形製剤 |
| EP2952196A4 (en) * | 2013-01-31 | 2016-08-03 | Sawai Seiyaku Kk | MULTILAYER TABLET WITH TELMISARTAN AND HYDROCHLOROTHIAZIDE |
| TW201521794A (zh) * | 2013-11-12 | 2015-06-16 | Daiichi Sankyo Co Ltd | 錠劑 |
| WO2015129603A1 (ja) * | 2014-02-25 | 2015-09-03 | 第一三共株式会社 | 活性化血液凝固第Ｘ因子（ＦＸａ）阻害剤の高純度結晶 |
| JPWO2016104678A1 (ja) * | 2014-12-26 | 2017-10-12 | 第一三共株式会社 | 線溶を促進するための医薬組成物 |
| WO2017107857A1 (zh) * | 2015-12-24 | 2017-06-29 | 江苏恒瑞医药股份有限公司 | 一种含有二胺衍生物或其盐的固体药物组合物 |
| JP6738477B2 (ja) * | 2016-03-16 | 2020-08-12 | ゴールデン オメガ ノルウェー アーエス | ω−３脂肪酸誘導体を含む粉末及び錠剤、ならびにその製造方法 |
| JP6673798B2 (ja) * | 2016-10-12 | 2020-03-25 | 日本化薬株式会社 | カペシタビンを有効成分とするフィルムコート医薬製剤 |
| TWI812602B (zh) | 2016-12-01 | 2023-08-21 | 日商第一三共股份有限公司 | 含二胺衍生物之口腔崩散錠及其製造方法 |
| TWI826474B (zh) * | 2018-06-27 | 2023-12-21 | 日商第一三共股份有限公司 | 包含二胺衍生物之顆粒劑、以及其用途及製造方法 |
| KR102222774B1 (ko) * | 2018-07-27 | 2021-03-04 | 보령제약 주식회사 | 에독사반을 포함하는 약학적 제제 및 이의 제조방법 |
| KR20200079957A (ko) | 2018-12-26 | 2020-07-06 | 한국콜마주식회사 | 에독사반을 함유한 경구용 의약 조성물 및 그의 제조방법 |
| KR102514961B1 (ko) | 2019-03-05 | 2023-03-28 | 주식회사 파마코스텍 | 에독사반 벤젠술폰산염 1 수화물 결정형 및 그 제조방법 |
| EP3744320A1 (en) | 2019-05-29 | 2020-12-02 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising edoxaban |
| KR20210048632A (ko) | 2019-10-23 | 2021-05-04 | 한미약품 주식회사 | 에독사반 유리 염기 함유 제약 조성물 |
| KR102333564B1 (ko) | 2019-11-28 | 2021-12-01 | 동방에프티엘(주) | 광학 활성 다이아민 유도체 및 티아졸 유도체의 생산을 위한 새로운 합성경로 |
| KR102090912B1 (ko) | 2019-12-18 | 2020-03-18 | 유니셀랩 주식회사 | 신규한 결정형 형태의 에독사반 및 이의 제조방법 |
| EP3838267A1 (en) | 2019-12-19 | 2021-06-23 | Biohorm, S.L. | Edoxaban tablets |
| KR102513519B1 (ko) | 2020-06-08 | 2023-03-23 | 주식회사 파마코스텍 | 신규한 에독사반 벤젠술폰산염 1 수화물의 제조방법 |
| KR102222784B1 (ko) | 2020-09-17 | 2021-03-04 | 유니셀랩 주식회사 | 신규한 에독사반 헤미에틸렌다이설퍼닉산 염 일수화물 |
| WO2022129535A1 (en) | 2020-12-18 | 2022-06-23 | Krka, D.D., Novo Mesto | Edoxaban formulation containing no sugar alcohols |
| JP2022113667A (ja) * | 2021-01-25 | 2022-08-04 | 全星薬品工業株式会社 | エドキサバン含有医薬組成物 |
| JP2023056113A (ja) * | 2021-10-07 | 2023-04-19 | 日医工株式会社 | エドキサバン含有医薬組成物 |
| KR102518204B1 (ko) | 2022-02-18 | 2023-04-05 | 주식회사 엔비피헬스케어 | 신규한 에독사반 프로필렌글리콜 용매화물 |
| WO2024121413A1 (en) | 2022-12-09 | 2024-06-13 | Synthon B.V. | Formulation comprising edoxaban and preparation thereof |
| JP7352248B1 (ja) * | 2023-03-27 | 2023-09-28 | 学校法人藤田学園 | 抗がん剤 |
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| CA2773066A1 (en) | 2003-11-12 | 2005-05-26 | Daiichi Sankyo Company, Limited | Process for producing thiazole derivative |
| DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
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| JP4703333B2 (ja) | 2005-09-26 | 2011-06-15 | エヌ・ティ・ティ・ソフトウェア株式会社 | 電子メール処理プログラム |
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| CN102256984B (zh) | 2008-12-17 | 2014-09-03 | 第一三共株式会社 | 制备二胺衍生物的方法 |
| EP2374456B1 (en) | 2008-12-19 | 2016-08-03 | Daiichi Sankyo Company, Limited | Edoxaban dosage regime |
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| EP2407457B1 (en) | 2009-03-10 | 2015-04-22 | Daiichi Sankyo Company, Limited | Process for producing diamine derivative |
| JP5652879B2 (ja) | 2009-03-13 | 2015-01-14 | 第一三共株式会社 | 光学活性なジアミン誘導体の製造方法 |
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