DK2140867T4 - Farmaceutisk sammensætning - Google Patents

Farmaceutisk sammensætning Download PDF

Info

Publication number
DK2140867T4
DK2140867T4 DK08720658.7T DK08720658T DK2140867T4 DK 2140867 T4 DK2140867 T4 DK 2140867T4 DK 08720658 T DK08720658 T DK 08720658T DK 2140867 T4 DK2140867 T4 DK 2140867T4
Authority
DK
Denmark
Prior art keywords
pharmaceutical composition
pharmaceutical
composition
Prior art date
Application number
DK08720658.7T
Other languages
English (en)
Other versions
DK2140867T3 (da
Inventor
Masazumi Kojima
Yoshio Kuno
Hiroaki Nakagami
Shinji Sagasaki
Koichi Ishidoh
Gaku Sekiguchi
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39875378&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2140867(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Application granted granted Critical
Publication of DK2140867T3 publication Critical patent/DK2140867T3/da
Publication of DK2140867T4 publication Critical patent/DK2140867T4/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
DK08720658.7T 2007-03-29 2008-03-28 Farmaceutisk sammensætning DK2140867T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007087327 2007-03-29
PCT/JP2008/000791 WO2008129846A1 (ja) 2007-03-29 2008-03-28 医薬組成物

Publications (2)

Publication Number Publication Date
DK2140867T3 DK2140867T3 (da) 2017-10-09
DK2140867T4 true DK2140867T4 (da) 2023-09-25

Family

ID=39875378

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08720658.7T DK2140867T4 (da) 2007-03-29 2008-03-28 Farmaceutisk sammensætning

Country Status (28)

Country Link
US (3) US20100081685A1 (da)
EP (1) EP2140867B2 (da)
JP (2) JP4463875B2 (da)
KR (1) KR101424843B1 (da)
CN (2) CN101652139A (da)
AU (1) AU2008241982B2 (da)
BR (1) BRPI0809205B8 (da)
CA (1) CA2680039C (da)
CO (1) CO6220955A2 (da)
CY (1) CY1119377T1 (da)
DK (1) DK2140867T4 (da)
ES (1) ES2644803T5 (da)
FI (1) FI2140867T4 (da)
HR (1) HRP20171384T4 (da)
HU (2) HUE035990T2 (da)
IL (2) IL200790A (da)
LT (2) LT2140867T (da)
MX (2) MX2009010474A (da)
MY (1) MY149356A (da)
NO (1) NO20093008L (da)
NZ (2) NZ597109A (da)
PL (1) PL2140867T5 (da)
PT (1) PT2140867T (da)
SG (1) SG179497A1 (da)
SI (1) SI2140867T2 (da)
TW (1) TWI409064B (da)
WO (1) WO2008129846A1 (da)
ZA (2) ZA200906182B (da)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG179497A1 (en) 2007-03-29 2012-04-27 Daiichi Sankyo Co Ltd Pharmaceutical composition
SI2371830T1 (sl) 2008-12-17 2014-01-31 Daiichi Sankyo Company, Limited Postopek za pridobivanje diaminskih derivatov
EP2374456B1 (en) * 2008-12-19 2016-08-03 Daiichi Sankyo Company, Limited Edoxaban dosage regime
WO2010082531A1 (ja) 2009-01-13 2010-07-22 第一三共株式会社 活性化血液凝固因子阻害剤
JP5666424B2 (ja) 2009-03-10 2015-02-12 第一三共株式会社 ジアミン誘導体の製造方法
JP5652879B2 (ja) 2009-03-13 2015-01-14 第一三共株式会社 光学活性なジアミン誘導体の製造方法
EA201171329A1 (ru) * 2009-04-30 2012-05-30 Такеда Фармасьютикал Компани Лимитед Твердый препарат
ES2605034T3 (es) * 2009-06-18 2017-03-10 Daiichi Sankyo Company, Limited Composición farmacéutica con solubilidad mejorada
ES2706880T3 (es) 2010-02-22 2019-04-01 Daiichi Sankyo Co Ltd Preparación sólida de liberación sostenida para uso oral
TW201132646A (en) * 2010-02-22 2011-10-01 Daiichi Sankyo Co Ltd Oral solid extended release dosage form
TW201200165A (en) * 2010-02-22 2012-01-01 Daiichi Sankyo Co Ltd Oral solid extended release dosage form
JP5390014B2 (ja) * 2010-03-19 2014-01-15 第一三共株式会社 抗凝固剤の溶出改善方法
JP5692873B2 (ja) * 2010-03-19 2015-04-01 第一三共株式会社 ジアミン誘導体の結晶およびその製造方法
WO2012002538A1 (ja) * 2010-07-02 2012-01-05 第一三共株式会社 光学活性ジアミン誘導体の塩の製造方法
US9402907B2 (en) 2011-08-10 2016-08-02 Daiichi Sankyo Company, Limited Pharmaceutical composition containing diamine derivative
WO2013026553A1 (en) 2011-08-22 2013-02-28 Ratiopharm Gmbh Composition comprising edoxaban
KR102127625B1 (ko) 2012-09-03 2020-06-29 다이이찌 산쿄 가부시키가이샤 하이드로모르폰염산염 함유의 경구용 서방성 의약 조성물
JP6227352B2 (ja) * 2012-09-27 2017-11-08 株式会社三和化学研究所 アナグリプチン又はその塩を含有する固形製剤
EP2952196A4 (en) * 2013-01-31 2016-08-03 Sawai Seiyaku Kk MULTILAYER TABLET CONTAINING TELMISARTAN AND HYDROCHLOROTHIAZIDE
TW201521794A (zh) * 2013-11-12 2015-06-16 Daiichi Sankyo Co Ltd 錠劑
WO2015129603A1 (ja) * 2014-02-25 2015-09-03 第一三共株式会社 活性化血液凝固第Ｘ因子（ＦＸａ）阻害剤の高純度結晶
US20170368037A1 (en) * 2014-12-26 2017-12-28 Daiichi Sankyo Company, Limited Pharmaceutical composition for promotion of fibrinolysis
CN107405342B (zh) * 2015-12-24 2021-05-14 江苏恒瑞医药股份有限公司 一种含有二胺衍生物或其盐的固体药物组合物
US20190364946A1 (en) * 2016-03-16 2019-12-05 Omegatri As Powders and tablets comprising omega-3 fatty acid derivatives and methods for their production
JP6673798B2 (ja) * 2016-10-12 2020-03-25 日本化薬株式会社 カペシタビンを有効成分とするフィルムコート医薬製剤
TWI812602B (zh) 2016-12-01 2023-08-21 日商第一三共股份有限公司 含二胺衍生物之口腔崩散錠及其製造方法
TWI826474B (zh) 2018-06-27 2023-12-21 日商第一三共股份有限公司 包含二胺衍生物之顆粒劑、以及其用途及製造方法
KR102222774B1 (ko) * 2018-07-27 2021-03-04 보령제약 주식회사 에독사반을 포함하는 약학적 제제 및 이의 제조방법
KR20200079957A (ko) 2018-12-26 2020-07-06 한국콜마주식회사 에독사반을 함유한 경구용 의약 조성물 및 그의 제조방법
KR102514961B1 (ko) 2019-03-05 2023-03-28 주식회사 파마코스텍 에독사반 벤젠술폰산염 1 수화물 결정형 및 그 제조방법
EP3744320A1 (en) 2019-05-29 2020-12-02 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising edoxaban
KR20210048632A (ko) 2019-10-23 2021-05-04 한미약품 주식회사 에독사반 유리 염기 함유 제약 조성물
KR102333564B1 (ko) 2019-11-28 2021-12-01 동방에프티엘(주) 광학 활성 다이아민 유도체 및 티아졸 유도체의 생산을 위한 새로운 합성경로
KR102090912B1 (ko) 2019-12-18 2020-03-18 유니셀랩 주식회사 신규한 결정형 형태의 에독사반 및 이의 제조방법
EP3838267A1 (en) 2019-12-19 2021-06-23 Biohorm, S.L. Edoxaban tablets
KR102513519B1 (ko) 2020-06-08 2023-03-23 주식회사 파마코스텍 신규한 에독사반 벤젠술폰산염 1 수화물의 제조방법
KR102222784B1 (ko) 2020-09-17 2021-03-04 유니셀랩 주식회사 신규한 에독사반 헤미에틸렌다이설퍼닉산 염 일수화물
EP4262760A1 (en) 2020-12-18 2023-10-25 KRKA, d.d., Novo mesto Edoxaban formulation containing no sugar alcohols
KR102518204B1 (ko) 2022-02-18 2023-04-05 주식회사 엔비피헬스케어 신규한 에독사반 프로필렌글리콜 용매화물

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361545A (en) * 1979-05-21 1982-11-30 Rowell Laboratories, Inc. Solid pharmaceutical formulations for slow, zero order release via controlled surface erosion
JP2814513B2 (ja) * 1988-02-03 1998-10-22 吉富製薬株式会社 溶出性の改良された製剤組成物
JP2642486B2 (ja) * 1989-08-04 1997-08-20 田辺製薬株式会社 難溶性薬物の超微粒子化法
US5149855A (en) 1989-12-26 1992-09-22 Mitsubishi Rayon Co., Ltd. Process for racemizing optically active carboxylic acid esters
US5055600A (en) 1990-04-24 1991-10-08 Rockwell International Corporation Glycidyl azide polymer (gap) synthesis by molten salt method
US5506248A (en) 1993-08-02 1996-04-09 Bristol-Myers Squibb Company Pharmaceutical compositions having good dissolution properties
IL110376A (en) * 1993-08-02 1998-08-16 Bristol Myers Squibb Co Pharmaceutical preparations containing iftroban and methods for their preparation
US5677469A (en) 1995-05-18 1997-10-14 Sepracor, Inc. Process for resolving chiral acids with 1-aminoindan-2-ols
JPH09309829A (ja) * 1996-05-22 1997-12-02 Taiyo Yakuhin Kogyo Kk ニトレンジピン含有経口投与製剤およびその製造法
US5958453A (en) * 1996-10-31 1999-09-28 Takeda Chemical Industries, Ltd. Solid pharmaceutical preparation with improved buccal disintegrability and/or dissolubility
JPH11180899A (ja) 1997-12-15 1999-07-06 Mitsui Chem Inc 活性メチレンアルキル化化合物の製造法
JP3680203B2 (ja) 1999-06-01 2005-08-10 東洋化成工業株式会社 ４−アセチルアミノベンゼンスルホニルアジドの製造方法
JP4044709B2 (ja) * 1999-11-19 2008-02-06 信越化学工業株式会社 水系フィルムコーティング剤及び経口固形製剤
JP2001151724A (ja) 1999-11-19 2001-06-05 Kuraray Co Ltd 光学活性な２，２，４−トリメチル−３−シクロヘキセンカルボン酸の製造方法
TWI288745B (en) 2000-04-05 2007-10-21 Daiichi Seiyaku Co Ethylenediamine derivatives
RU2271805C2 (ru) 2000-10-24 2006-03-20 Адзиномото Ко., Инк. Препарат, содержащий натеглинид
DE10106971A1 (de) * 2001-02-15 2002-08-29 Boehringer Ingelheim Pharma Arzneimittelformulierung die einen muskarinischen Agonisten enthält
US20020160048A1 (en) * 2001-02-15 2002-10-31 Karoline Bechtold-Peters Medical formulation containing a muscarinic agonist
KR100908418B1 (ko) * 2001-06-20 2009-07-21 액티버스 파마 컴퍼니 리미티드 퀴놀리논 유도체 의약 조성물 및 그의 제조 방법
JP3939601B2 (ja) * 2001-06-20 2007-07-04 株式会社アクティバスファーマ キノリノン誘導体医薬組成物及びその製造方法
EP1405852B9 (en) 2001-06-20 2013-03-27 Daiichi Sankyo Company, Limited Diamine derivatives
US7365205B2 (en) 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives
ES2383749T3 (es) 2001-08-09 2012-06-26 Daiichi Sankyo Company, Limited Derivados de diamina
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
TW200306868A (en) * 2002-05-22 2003-12-01 Shionogi & Co Composition of hardly soluble medicine with improved solubility
JP4109288B2 (ja) 2002-12-25 2008-07-02 第一三共株式会社 ジアミン誘導体
PE20131352A1 (es) * 2003-04-08 2013-11-14 Novartis Ag Composicion farmaceutica que contiene un agonista del receptor s1p y un alcohol de azucar
KR101060885B1 (ko) * 2003-06-17 2011-08-31 교와 핫꼬 기린 가부시키가이샤 염산 베니디핀 함유 의약 조성물
JP4606258B2 (ja) * 2003-06-17 2011-01-05 協和発酵キリン株式会社 塩酸ベニジピン含有医薬組成物
JP4759388B2 (ja) 2003-11-12 2011-08-31 第一三共株式会社 チアゾール誘導体の製造法
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
US8686189B2 (en) 2005-09-16 2014-04-01 Daiichi Sankyo Company, Limited Optically active diamine derivative and process for producing the same
JP4703333B2 (ja) 2005-09-26 2011-06-15 エヌ・ティ・ティ・ソフトウェア株式会社 電子メール処理プログラム
SG179497A1 (en) 2007-03-29 2012-04-27 Daiichi Sankyo Co Ltd Pharmaceutical composition
TW200909437A (en) 2007-06-21 2009-03-01 Daiichi Sankyo Co Ltd Process for the preparation of diamine-derivatives
EP2368870A1 (en) 2008-12-12 2011-09-28 Daiichi Sankyo Company, Limited Process for producing optically active carboxylic acid
SI2371830T1 (sl) 2008-12-17 2014-01-31 Daiichi Sankyo Company, Limited Postopek za pridobivanje diaminskih derivatov
EP2374456B1 (en) 2008-12-19 2016-08-03 Daiichi Sankyo Company, Limited Edoxaban dosage regime
WO2010082531A1 (ja) 2009-01-13 2010-07-22 第一三共株式会社 活性化血液凝固因子阻害剤
JP5666424B2 (ja) 2009-03-10 2015-02-12 第一三共株式会社 ジアミン誘導体の製造方法
JP5652879B2 (ja) 2009-03-13 2015-01-14 第一三共株式会社 光学活性なジアミン誘導体の製造方法
WO2010131663A1 (ja) 2009-05-15 2010-11-18 第一三共株式会社 オキサミド誘導体
ES2605034T3 (es) 2009-06-18 2017-03-10 Daiichi Sankyo Company, Limited Composición farmacéutica con solubilidad mejorada
JP2011051672A (ja) 2009-08-31 2011-03-17 Ihi Corp ラック棚及びラック棚の組立て方法
JP5692873B2 (ja) 2010-03-19 2015-04-01 第一三共株式会社 ジアミン誘導体の結晶およびその製造方法
US20130158069A1 (en) 2011-12-14 2013-06-20 Daiichi Sankyo Company, Limited Preventive and/or therapeutic agent for thromboembolism in thromboembolism patient with severe renal impairment

Also Published As

Publication number Publication date
CN101652139A (zh) 2010-02-17
KR20090122950A (ko) 2009-12-01
MY149356A (en) 2013-08-30
PT2140867T (pt) 2017-10-04
NO20093008L (no) 2009-09-30
HRP20171384T4 (hr) 2024-02-16
SI2140867T2 (sl) 2023-10-30
TWI409064B (zh) 2013-09-21
NZ579725A (en) 2012-02-24
EP2140867B2 (en) 2023-08-16
HRP20171384T1 (hr) 2017-11-17
ZA200906182B (en) 2010-11-24
BRPI0809205B1 (pt) 2019-09-03
RU2470637C2 (ru) 2012-12-27
JP4463875B2 (ja) 2010-05-19
CN104324015B (zh) 2018-08-28
BRPI0809205A2 (pt) 2014-09-02
EP2140867B1 (en) 2017-08-30
ES2644803T5 (es) 2024-02-26
PL2140867T3 (pl) 2017-12-29
CA2680039A1 (en) 2008-10-30
US9149532B2 (en) 2015-10-06
AU2008241982A1 (en) 2008-10-30
EP2140867A4 (en) 2013-07-03
SI2140867T1 (sl) 2017-12-29
RU2009139917A (ru) 2011-05-10
FI2140867T4 (fi) 2023-09-14
EP2140867A1 (en) 2010-01-06
CY1119377T1 (el) 2018-02-14
IL219829A0 (en) 2012-06-28
LTC2140867I2 (lt) 2018-11-12
US9707296B2 (en) 2017-07-18
SG179497A1 (en) 2012-04-27
MX2009010474A (es) 2009-10-19
MX351987B (es) 2017-11-03
NZ597109A (en) 2013-01-25
HUE035990T2 (en) 2018-05-28
TW200845972A (en) 2008-12-01
BRPI0809205B8 (pt) 2021-05-25
WO2008129846A1 (ja) 2008-10-30
LTPA2018005I1 (lt) 2018-02-12
CN104324015A (zh) 2015-02-04
IL200790A (en) 2014-06-30
AU2008241982B2 (en) 2013-02-21
DK2140867T3 (da) 2017-10-09
CA2680039C (en) 2015-05-26
ZA201005906B (en) 2012-05-30
IL200790A0 (en) 2010-05-17
LT2140867T (lt) 2017-12-11
US20150342938A1 (en) 2015-12-03
CO6220955A2 (es) 2010-11-19
PL2140867T5 (pl) 2023-10-30
ES2644803T3 (es) 2017-11-30
US20130337064A1 (en) 2013-12-19
JP2010090168A (ja) 2010-04-22
US20100081685A1 (en) 2010-04-01
KR101424843B1 (ko) 2014-08-13
JPWO2008129846A1 (ja) 2010-07-22
HUS1800007I1 (hu) 2018-03-28

Similar Documents

Publication Publication Date Title
LTC2140867I2 (lt) Farmacinė kompozicija
LTPA2018014I1 (lt) Farmacinė kompozicija 514
BRPI0721651A2 (pt) Composição farmacêutica
BRPI0715712A2 (pt) Composição farmacêutica
RU2493831C3 (ru) Фармацевтические композиции
BRPI0719393A2 (pt) Composição farmacêutica
DK2120884T3 (da) Farmaceutisk sammensætning
BRPI0820381A2 (pt) Formulações farmacêuticas
BRPI0813775A2 (pt) Composição
BRPI0920521A2 (pt) combinação farmacêutica
DK2041139T3 (da) Farmaceutiske forbindelser
ATE528048T1 (de) Schweisshemmende/desodorierende zusammensetzung
BRPI0716445A2 (pt) composiÇço farmacÊutica
BRPI0720234A2 (pt) Composição farmacêutica
DK2285413T3 (da) Farmaceutisk sammensætning
BRPI0810557A2 (pt) composição
BRPI0811274A2 (pt) Composição
BRPI0921313A2 (pt) composição farmaucêutica
BRPI0817833A2 (pt) Composição farmacêutica antimalárica
BRPI0820198A2 (pt) composições farmacêuticas
DK2966175T3 (da) Farmaceutiske sammensætninger indeholdende cortexolon-17-alpha-propionat
DK2271618T3 (da) Farmaceutiske forbindelser
BRPI0811002A2 (pt) Composição biofertilizante
BRPI0912171A2 (pt) composição farmacêutica
BRPI0820960A2 (pt) composição