PT744941E - Processo para preparar formulacoes farmaceuticas de particulas finas - Google Patents

Processo para preparar formulacoes farmaceuticas de particulas finas

Info

Publication number
PT744941E
PT744941E PT95909559T PT95909559T PT744941E PT 744941 E PT744941 E PT 744941E PT 95909559 T PT95909559 T PT 95909559T PT 95909559 T PT95909559 T PT 95909559T PT 744941 E PT744941 E PT 744941E
Authority
PT
Portugal
Prior art keywords
pharmaceutical formulations
fine particles
preparing pharmaceutical
extrusion
spheronization
Prior art date
Application number
PT95909559T
Other languages
English (en)
Inventor
Pramod K Gupta
Susan J Semla
Jacqueline E Briskin
Claud Loyd
Robert W Kohler
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of PT744941E publication Critical patent/PT744941E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
PT95909559T 1994-02-16 1995-02-14 Processo para preparar formulacoes farmaceuticas de particulas finas PT744941E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19702594A 1994-02-16 1994-02-16

Publications (1)

Publication Number Publication Date
PT744941E true PT744941E (pt) 2003-10-31

Family

ID=22727703

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95909559T PT744941E (pt) 1994-02-16 1995-02-14 Processo para preparar formulacoes farmaceuticas de particulas finas

Country Status (11)

Country Link
US (1) US6063313A (pt)
EP (1) EP0744941B1 (pt)
JP (1) JP4040084B2 (pt)
AT (1) ATE241962T1 (pt)
CA (1) CA2182282C (pt)
DE (1) DE69530973T2 (pt)
DK (1) DK0744941T3 (pt)
ES (1) ES2199981T3 (pt)
MX (1) MX9603480A (pt)
PT (1) PT744941E (pt)
WO (1) WO1995022319A1 (pt)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19531277A1 (de) 1995-08-25 1997-02-27 Basf Ag Verwendung von Lipiden als Hilfsmittel bei der Herstellung von festen Arzneiformen nach dem Schmelzextrusionsverfahren
AU3508097A (en) 1996-06-26 1998-01-14 Board Of Regents, The University Of Texas System Hot-melt extrudable pharmaceutical formulation
US6139872A (en) * 1996-08-14 2000-10-31 Henkel Corporation Method of producing a vitamin product
FR2753904B1 (fr) * 1996-10-01 1998-10-30 Gattefosse Ets Sa Composition pharmaceutique a liberation modifiee de principe actif, comportant une matrice, et procede de fabrication
IT1298574B1 (it) * 1998-02-06 2000-01-12 Vectorpharma Int Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione
ES2207211T3 (es) * 1998-04-24 2004-05-16 Basf Corporation Procedimiento mejorado para la extrusion.
JP2000128774A (ja) * 1998-10-26 2000-05-09 Tanabe Seiyaku Co Ltd 薬物を含有する球形微粒子の製法
SI20150A (sl) * 1999-02-19 2000-08-31 Lek, Tovarna Farmacevtskih In Direktno stisljivi matriks za nadzorovano sproščanje celodnevne doze klaritromicina
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
EP1164872A1 (en) 1999-03-26 2002-01-02 The NutraSweet Company PARTICLES OF N- N-(3,3-DIMETHYLBUTYL)-L-$g(a)-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER
DE19916383A1 (de) * 1999-03-31 2000-10-05 Schering Ag Pharmazeutische Zusammensetzung mit einem Extrusionsstoff
DE60028754T2 (de) 1999-11-12 2007-05-31 Abbott Laboratories, Abbott Park Feste dispersion mit ritonavir, fenofibrat oder griseofulvin
MXPA02009587A (es) * 2000-03-28 2003-05-14 Biochemie Gmbh Particulas granuladas con sabor enmascarado.
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
CA2423172A1 (en) * 2000-09-22 2002-03-28 Galephar M/F Sustained release composition containing clarithromycin
FR2816507B1 (fr) 2000-11-16 2003-02-28 Ethypharm Lab Prod Ethiques Microgranules a base de principe actif, procede de fabrication et compositons pharmaceutiques integrant lesdits microgranules
ITRN20000051A1 (it) 2000-12-22 2002-06-22 Ascor Chimici Srl Metodo e apparecchiatura per formare sferule composite contenenti principi attivi del tipo farmaceutico e/o integratori alimentari o cosmeti
EP1390383B1 (en) 2001-05-11 2012-02-29 Isis Pharmaceuticals, Inc. Antisense permeation enhancers
US20030203019A1 (en) * 2002-04-30 2003-10-30 Cornelius John Mark Coated conditioners for use in foods and pharmaceuticals
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US20040162333A1 (en) * 2003-02-19 2004-08-19 Naima Mezaache Rapid absorption selective 5-HT agonist formulations
CA2675724C (en) 2003-06-16 2012-12-04 Andrx Pharmaceuticals, Llc Oral extended-release composition
US20060165790A1 (en) * 2003-06-27 2006-07-27 Malcolm Walden Multiparticulates
TWI357815B (en) * 2003-06-27 2012-02-11 Euro Celtique Sa Multiparticulates
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
WO2005023221A1 (en) * 2003-09-05 2005-03-17 Ranbaxy Laboratories Limited Clarithromycin formulations having improved biovailability
GB2411355B (en) 2004-02-27 2006-02-22 Niche Generics Ltd Pharmaceutical composition
US7491263B2 (en) * 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
GB2418854B (en) 2004-08-31 2009-12-23 Euro Celtique Sa Multiparticulates
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102006006532B4 (de) * 2006-02-10 2007-11-08 Biogenerics Pharma Gmbh Pharmazeutische Zubereitung
RU2437662C2 (ru) 2006-04-07 2011-12-27 Меррион Рисерч Iii Лимитед Твердая пероральная лекарственная форма, содержащая усилитель
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
US20080131504A1 (en) * 2006-12-01 2008-06-05 Mission Pharmacal Co. Short Term Slow Release Drug Delivery System
BRPI0906467C1 (pt) 2008-01-25 2021-05-25 Gruenenthal Gmbh forma de dosagem farmacêutica com formato exterior modificado resistente à ruptura e com liberação controlada
CA2723558A1 (en) 2008-05-07 2009-11-12 Merrion Research Iii Limited Compositions of gnrh related compounds and processes of preparation
WO2009135680A1 (en) 2008-05-09 2009-11-12 Grünenthal GmbH Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
EP2456427B1 (en) 2009-07-22 2015-03-04 Grünenthal GmbH Hot-melt extruded controlled release dosage form
CN102639118B (zh) 2009-07-22 2015-07-29 格吕伦塔尔有限公司 氧化稳定的抗干扰剂型
EP2516494B1 (en) * 2009-12-23 2016-06-01 Essilor International (Compagnie Générale D'Optique) Method of converting a polymerizable composition into thermoplastic polyurethane of improved yellowness index and article obtained by this method
US9089484B2 (en) 2010-03-26 2015-07-28 Merrion Research Iii Limited Pharmaceutical compositions of selective factor Xa inhibitors for oral administration
WO2012028318A1 (en) 2010-09-02 2012-03-08 Grünenthal GmbH Tamper resistant dosage form comprising an anionic polymer
EP2611426B1 (en) 2010-09-02 2014-06-25 Grünenthal GmbH Tamper resistant dosage form comprising inorganic salt
CA2819234A1 (en) 2011-01-07 2012-07-12 Merrion Research Iii Limited Pharmaceutical compositions of iron for oral administration
HUE034710T2 (hu) 2011-07-29 2018-02-28 Gruenenthal Gmbh Visszaéléssel szemben ellenálló, azonnali hatóanyagfelszabadulást biztosító tabletta
DK2736495T3 (da) 2011-07-29 2017-11-13 Gruenenthal Gmbh Misbrugsbestandig tablet som tilvejebringer øjeblikkelig frigivelse af lægemiddel
CA2864949A1 (en) 2012-02-28 2013-09-06 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
WO2013156453A1 (en) 2012-04-18 2013-10-24 Grünenthal GmbH Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
AU2014273226B2 (en) 2013-05-29 2019-06-27 Grunenthal Gmbh Tamper resistant dosage form with bimodal release profile
EP3003279A1 (en) 2013-05-29 2016-04-13 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
KR20160031526A (ko) 2013-07-12 2016-03-22 그뤼넨탈 게엠베하 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형
EP3073994A1 (en) 2013-11-26 2016-10-05 Grünenthal GmbH Preparation of a powdery pharmaceutical composition by means of cryo-milling
AU2015261060A1 (en) 2014-05-12 2016-11-03 Grunenthal Gmbh Tamper resistant immediate release capsule formulation comprising Tapentadol
CN106456550A (zh) 2014-05-26 2017-02-22 格吕伦塔尔有限公司 避免乙醇剂量倾泻的多颗粒
WO2016120378A1 (en) 2015-01-29 2016-08-04 Novo Nordisk A/S Tablets comprising glp-1 agonist and enteric coating
CA2983642A1 (en) 2015-04-24 2016-10-27 Grunenthal Gmbh Tamper-resistant dosage form with immediate release and resistance against solvent extraction
US10842750B2 (en) 2015-09-10 2020-11-24 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB757165A (en) * 1953-10-30 1956-09-12 Abbott Lab Compositions of erythromycin for combating bacterial infections
US4374082A (en) * 1981-08-18 1983-02-15 Richard Hochschild Method for making a pharmaceutical and/or nutritional dosage form
FR2581541B1 (fr) * 1985-05-09 1988-05-20 Rhone Poulenc Sante Nouvelles compositions pharmaceutiques permettant la liberation prolongee d'un principe actif et leur procede de preparation
DE3524572A1 (de) * 1985-07-10 1987-01-15 Thomae Gmbh Dr K Feste arzneimittelformen zur peroralen anwendung enthaltend 9-deoxo-11-deoxy-9,11-(imino(2-(2-methoxyethoxy)ethyliden)-oxy)-(9s)-erythromycin und verfahren zu ihrer herstellung
US4686231A (en) * 1985-12-12 1987-08-11 Smithkline Beckman Corporation Inhibition of 5-lipoxygenase products
US4800087A (en) * 1986-11-24 1989-01-24 Mehta Atul M Taste-masked pharmaceutical compositions
IL84944A (en) * 1987-01-19 1992-02-16 Ici Plc Pharmaceutical compositions containing 1,2-dihydro-3h-indazolone derivatives,some new such compounds and their preparation
IT1226549B (it) * 1988-07-12 1991-01-24 Resa Farma Composizioni farmaceutiche ad attivita' analgesica ed antiinfiammatoria per uso orale, dotate di ottima palatabilita' ed esenti da effetti irritanti sulle mucose.
US5126145A (en) * 1989-04-13 1992-06-30 Upsher Smith Laboratories Inc Controlled release tablet containing water soluble medicament
US5002774A (en) * 1989-06-08 1991-03-26 Erbamont, Inc. Sustained release pharmaceutical tablet
US5169645A (en) * 1989-10-31 1992-12-08 Duquesne University Of The Holy Ghost Directly compressible granules having improved flow properties
FR2657257B1 (fr) * 1990-01-19 1994-09-02 Rhone Poulenc Sante Procede de preparation de medicaments sous forme de perles.
FR2663818B1 (fr) * 1990-06-29 1993-07-09 Rhone Poulenc Nutrition Animale Procede de preparation de granules de principes actifs par extrusion.
JP3265680B2 (ja) * 1992-03-12 2002-03-11 大正製薬株式会社 経口製剤用組成物
US5292900A (en) * 1992-12-18 1994-03-08 Abbott Laboratories O-substituted N-hydroxyurea derivatives

Also Published As

Publication number Publication date
WO1995022319A1 (en) 1995-08-24
JPH09509176A (ja) 1997-09-16
EP0744941A1 (en) 1996-12-04
DK0744941T3 (da) 2003-09-29
DE69530973T2 (de) 2004-05-19
MX9603480A (es) 1997-12-31
DE69530973D1 (de) 2003-07-10
CA2182282A1 (en) 1995-08-24
US6063313A (en) 2000-05-16
EP0744941B1 (en) 2003-06-04
ATE241962T1 (de) 2003-06-15
CA2182282C (en) 2006-04-18
JP4040084B2 (ja) 2008-01-30
ES2199981T3 (es) 2004-03-01

Similar Documents

Publication Publication Date Title
PT744941E (pt) Processo para preparar formulacoes farmaceuticas de particulas finas
ES524518A0 (es) Un procedimiento para preparar un agente anti-inflamatorio
AR011080A1 (es) Composicion en polvo seco, proceso para su preparacion y uso de dicha composicion para la fabricacion del medicamento
LV12231A (lv) Dispersa makromolekulu kompozicija
MX9602515A (es) Procedimiento para preparar formas de dosis farmaceuticas de substancias hidrofobicas.
HUP0004050A2 (hu) Javított oldódású itrakonazol, eljárás ennek előállítására és ezt tartalmazó orális gyógyszerkészítmény
NO990790L (no) Blandinger omfattende mikropartikler av vann-ul°selige forbindelser og fremgangsmÕte for fremstilling av samme
BR9912023B1 (pt) processo para a fabricaÇço de partÍculas de produto de reaÇço de amina, produto de reaÇço de amina processada, mÉtodo de incorporaÇço da mesma, composiÇço final, mÉtodo para distribuiÇço de fragrÂncia residual a uma superfÍcie, uso de produto e composiÇço acondicionada.
AU2793397A (en) Fine ultraviolet screening particles, process for preparing the same, and cosmetic preparation
PE21891A1 (es) Sistemas excipientes para uso en composiciones cosmeticas
ATE331783T1 (de) Trockene mikroorganismenkulturen und verfahren zu deren herstellung
PL299753A1 (en) Method of obtaining large-size emulsion polymer particles, polymer and application thereof
CA2269134A1 (en) A novel polymorphic crystalline form of fluticasone propionate, a method for its production and pharmaceutical compositions thereof
EP0412706A3 (en) Vehicle systems for use in cosmetic compostions
BR9003858A (pt) Composicao cosmetica,composicao para o cuidado de cabelos,composicao condicionadora de cabelo e processo para a producao de uma composicao condicionadora de cabelos
PT1496865E (pt) Processo para a preparacao de cristais, cristais assim obtidos e sua utilizacao em formulacoes farmaceuticas
PT861084E (pt) Processo e composicao melhorados para cisplatina (cddp) terapeutica
ATE269057T1 (de) Arzneizubereitungen und deren herstellungsverfahren
GB0027880D0 (en) Method for the production of particles
NO303715B1 (no) Stabilt, vandig apparat
ZA200409401B (en) Method for producing steroid crystals, crystals obtained by said method and their use in pharmaceutical formulations.
CL2004000976A1 (es) Procedimiento de preparacion de preformulaciones farmaceuticas homogeneas que contienen elevada concentracion de esteroides, utiles para la obtencion de preparaciones farmaceuticas solidas o semisolidas de dosis reducida con una concentracion final d
BR9102130A (pt) Material aglomerado,processo para producao de particulas duras e arredondadas,e particulas duras e arredondadas
HUT45502A (en) Process for producing new 2,6-diamino-3-(halogen-benzyl)-pyridines and pharmaceutics comprising the same as active ingredient
DE69013765T2 (de) Harte Schleifmittelteilchen und Verfahren zu deren Herstellung.