AR076540A1 - Composiciones de comprimidos de desintegracion oral que comprenden combinaciones de analgesicos no- opioides y opioides, forma de dosificacion. metodo de preparacion. metodo para tratar dolor - Google Patents
Composiciones de comprimidos de desintegracion oral que comprenden combinaciones de analgesicos no- opioides y opioides, forma de dosificacion. metodo de preparacion. metodo para tratar dolorInfo
- Publication number
- AR076540A1 AR076540A1 ARP100101500A ARP100101500A AR076540A1 AR 076540 A1 AR076540 A1 AR 076540A1 AR P100101500 A ARP100101500 A AR P100101500A AR P100101500 A ARP100101500 A AR P100101500A AR 076540 A1 AR076540 A1 AR 076540A1
- Authority
- AR
- Argentina
- Prior art keywords
- coating
- opioid analgesic
- pharmaceutical composition
- water insoluble
- insoluble polymer
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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- A61K31/60—Salicylic acid; Derivatives thereof
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
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- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
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- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
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Abstract
Reivindicacion 1: Una composicion farmacéutica, caracterizada porque comprende multiples micropartículas que contienen droga analgésica no opioide/droga analgésica opioide, en donde las micropartículas que contienen droga comprenden: (a) un nucleo que comprende una droga analgésica no opioide; (b) un primer recubrimiento dispuesto sobre el nucleo, que comprende una droga analgésica opioide; y (c) un segundo recubrimiento dispuesto sobre el nucleo, que comprende un polímero insoluble en agua. Reivindicacion 10: La composicion farmacéutica de la reivindicacion 1, caracterizada porque el segundo recubrimiento enmascara sustancialmente el sabor del analgésico no opioide y/o del analgésico opioide. Reivindicacion 12: La composicion farmacéutica de la reivindicacion 10, caracterizada porque el segundo recubrimiento comprende además un polímero gastrosoluble o un formador de poros gastrosoluble. Reivindicacion 15: La composicion farmacéutica de la reivindicacion 1, caracterizada porque el segundo recubrimiento modifica sustancialmente la liberacion del analgésico no opioide. Reivindicacion 18: La composicion farmacéutica de la reivindicacion 15, caracterizada porque el segundo recubrimiento se dispone entre el nucleo y el primer recubrimiento. Reivindicacion 19: La composicion farmacéutica de la reivindicacion 18, caracterizada porque además comprende un tercer recubrimiento dispuesto sobre el primer recubrimiento, en donde el tercer recubrimiento comprende un polímero insoluble en agua que es el mismo polímero insoluble en agua del segundo recubrimiento, o uno diferente. Reivindicacion 21: La composicion farmacéutica de la reivindicacion 11, caracterizada porque además comprende un tercer recubrimiento dispuesto entre el nucleo y el primer recubrimiento, en donde el tercer recubrimiento comprende un polímero insoluble en agua que es igual, diferente, del polímero insoluble en agua, y un segundo recubrimiento. Reivindicacion 31: La composicion farmacéutica de la reivindicacion 30, caracterizada porque la droga analgésica no opioide se selecciona del grupo que consiste de acetaminofeno, aspirina, ibuprofeno, ketoprofeno, meloxicam, diclofenac potásico, etodolac, sulindac, indometacina y celecoxib; y el analgésico opioide se selecciona del grupo que consiste de hidrocodona, oximorfona, buprenorfina, fentanilo e hidromorfona. Reivindicacion 32: La composicion farmacéutica de la reivindicacion 31, caracterizada porque el analgésico no opioide comprende acetaminofeno, y el analgésico opioide comprende hidrocodona. Reivindicacion 35: La composicion farmacéutica de la reivindicacion 1, caracterizada porque además comprende una segunda poblacion de partículas que contienen droga analgésica no opioide, en donde la segunda poblacion de partículas que contienen droga analgésica no opioide comprende: (i) un segundo nucleo que comprende la droga analgésica no opioide; y (ii) un cuarto recubrimiento que comprende un polímero insoluble en agua dispuesto sobre el segundo nucleo, en donde el polímero insoluble en agua del cuarto recubrimiento es el mismo, o es diferente, polímero insoluble en agua del segundo recubrimiento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US17478009P | 2009-05-01 | 2009-05-01 | |
US17478809P | 2009-05-01 | 2009-05-01 |
Publications (1)
Publication Number | Publication Date |
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AR076540A1 true AR076540A1 (es) | 2011-06-22 |
Family
ID=43032597
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100101500A AR076540A1 (es) | 2009-05-01 | 2010-05-03 | Composiciones de comprimidos de desintegracion oral que comprenden combinaciones de analgesicos no- opioides y opioides, forma de dosificacion. metodo de preparacion. metodo para tratar dolor |
ARP100101499A AR076835A1 (es) | 2009-05-01 | 2010-05-03 | Composiciones de comprimidos de desintegracion oral que comprenden combinaciones de drogas en dosis elevadas y reducidas. metodo. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100101499A AR076835A1 (es) | 2009-05-01 | 2010-05-03 | Composiciones de comprimidos de desintegracion oral que comprenden combinaciones de drogas en dosis elevadas y reducidas. metodo. |
Country Status (14)
Country | Link |
---|---|
US (2) | US20100330150A1 (es) |
EP (2) | EP2424504A4 (es) |
JP (2) | JP5845172B2 (es) |
KR (2) | KR101752014B1 (es) |
CN (3) | CN102458360A (es) |
AR (2) | AR076540A1 (es) |
AU (2) | AU2010242749B2 (es) |
BR (1) | BRPI1007636A2 (es) |
CA (2) | CA2760614A1 (es) |
MX (2) | MX2011011480A (es) |
RU (2) | RU2567032C2 (es) |
TW (2) | TW201041608A (es) |
WO (2) | WO2010127346A1 (es) |
ZA (2) | ZA201108780B (es) |
Families Citing this family (58)
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US7201920B2 (en) | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
BRPI0811319A2 (pt) | 2007-05-25 | 2015-02-10 | Tolmar Therapeutics Inc | Composição fluida, método de formação de uma composição fluida, implante biodegrádavel formado in situ, método de formação de um implante biodegradável in situ, kit, implante e método de trataento |
MX2011011480A (es) * | 2009-05-01 | 2012-02-28 | Aptalis Pharmatech Inc | Composicines de tabletas que se desintegran oralmente que comprenden combinaciones de analgesicos no opioides y opioides. |
CA2775890C (en) | 2009-09-30 | 2016-06-21 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse |
AU2010324835B2 (en) | 2009-11-30 | 2015-06-18 | Adare Pharmaceuticals, Inc. | Compressible-coated pharmaceutical compositions and tablets and methods of manufacture |
US9271939B2 (en) * | 2010-03-15 | 2016-03-01 | Inventia Healthcare Private Limited | Stabilized prolonged release pharmaceutical composition comprising atypical antipsychotic |
GB2481017B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
PL2593081T3 (pl) * | 2010-07-15 | 2014-08-29 | Tedec Meiji Farma S A | Kompozycja tabletki żelazo-mannitol-owoalbumina |
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- 2010-05-03 US US12/772,770 patent/US20100330150A1/en not_active Abandoned
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