AR076540A1 - Composiciones de comprimidos de desintegracion oral que comprenden combinaciones de analgesicos no- opioides y opioides, forma de dosificacion. metodo de preparacion. metodo para tratar dolor - Google Patents

Composiciones de comprimidos de desintegracion oral que comprenden combinaciones de analgesicos no- opioides y opioides, forma de dosificacion. metodo de preparacion. metodo para tratar dolor

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Publication number
AR076540A1
AR076540A1 ARP100101500A ARP100101500A AR076540A1 AR 076540 A1 AR076540 A1 AR 076540A1 AR P100101500 A ARP100101500 A AR P100101500A AR P100101500 A ARP100101500 A AR P100101500A AR 076540 A1 AR076540 A1 AR 076540A1
Authority
AR
Argentina
Prior art keywords
coating
opioid analgesic
pharmaceutical composition
water insoluble
insoluble polymer
Prior art date
Application number
ARP100101500A
Other languages
English (en)
Inventor
Michael Grossellin
Jin Wang Lai
James Clevenger
Gopi M Venkatesh
Original Assignee
Eurand Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand Inc filed Critical Eurand Inc
Publication of AR076540A1 publication Critical patent/AR076540A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
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  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Neurology (AREA)
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  • Rheumatology (AREA)
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  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reivindicacion 1: Una composicion farmacéutica, caracterizada porque comprende multiples micropartículas que contienen droga analgésica no opioide/droga analgésica opioide, en donde las micropartículas que contienen droga comprenden: (a) un nucleo que comprende una droga analgésica no opioide; (b) un primer recubrimiento dispuesto sobre el nucleo, que comprende una droga analgésica opioide; y (c) un segundo recubrimiento dispuesto sobre el nucleo, que comprende un polímero insoluble en agua. Reivindicacion 10: La composicion farmacéutica de la reivindicacion 1, caracterizada porque el segundo recubrimiento enmascara sustancialmente el sabor del analgésico no opioide y/o del analgésico opioide. Reivindicacion 12: La composicion farmacéutica de la reivindicacion 10, caracterizada porque el segundo recubrimiento comprende además un polímero gastrosoluble o un formador de poros gastrosoluble. Reivindicacion 15: La composicion farmacéutica de la reivindicacion 1, caracterizada porque el segundo recubrimiento modifica sustancialmente la liberacion del analgésico no opioide. Reivindicacion 18: La composicion farmacéutica de la reivindicacion 15, caracterizada porque el segundo recubrimiento se dispone entre el nucleo y el primer recubrimiento. Reivindicacion 19: La composicion farmacéutica de la reivindicacion 18, caracterizada porque además comprende un tercer recubrimiento dispuesto sobre el primer recubrimiento, en donde el tercer recubrimiento comprende un polímero insoluble en agua que es el mismo polímero insoluble en agua del segundo recubrimiento, o uno diferente. Reivindicacion 21: La composicion farmacéutica de la reivindicacion 11, caracterizada porque además comprende un tercer recubrimiento dispuesto entre el nucleo y el primer recubrimiento, en donde el tercer recubrimiento comprende un polímero insoluble en agua que es igual, diferente, del polímero insoluble en agua, y un segundo recubrimiento. Reivindicacion 31: La composicion farmacéutica de la reivindicacion 30, caracterizada porque la droga analgésica no opioide se selecciona del grupo que consiste de acetaminofeno, aspirina, ibuprofeno, ketoprofeno, meloxicam, diclofenac potásico, etodolac, sulindac, indometacina y celecoxib; y el analgésico opioide se selecciona del grupo que consiste de hidrocodona, oximorfona, buprenorfina, fentanilo e hidromorfona. Reivindicacion 32: La composicion farmacéutica de la reivindicacion 31, caracterizada porque el analgésico no opioide comprende acetaminofeno, y el analgésico opioide comprende hidrocodona. Reivindicacion 35: La composicion farmacéutica de la reivindicacion 1, caracterizada porque además comprende una segunda poblacion de partículas que contienen droga analgésica no opioide, en donde la segunda poblacion de partículas que contienen droga analgésica no opioide comprende: (i) un segundo nucleo que comprende la droga analgésica no opioide; y (ii) un cuarto recubrimiento que comprende un polímero insoluble en agua dispuesto sobre el segundo nucleo, en donde el polímero insoluble en agua del cuarto recubrimiento es el mismo, o es diferente, polímero insoluble en agua del segundo recubrimiento.
ARP100101500A 2009-05-01 2010-05-03 Composiciones de comprimidos de desintegracion oral que comprenden combinaciones de analgesicos no- opioides y opioides, forma de dosificacion. metodo de preparacion. metodo para tratar dolor AR076540A1 (es)

Applications Claiming Priority (2)

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US17478809P 2009-05-01 2009-05-01
US17478009P 2009-05-01 2009-05-01

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AR076540A1 true AR076540A1 (es) 2011-06-22

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ARP100101500A AR076540A1 (es) 2009-05-01 2010-05-03 Composiciones de comprimidos de desintegracion oral que comprenden combinaciones de analgesicos no- opioides y opioides, forma de dosificacion. metodo de preparacion. metodo para tratar dolor
ARP100101499A AR076835A1 (es) 2009-05-01 2010-05-03 Composiciones de comprimidos de desintegracion oral que comprenden combinaciones de drogas en dosis elevadas y reducidas. metodo.

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ARP100101499A AR076835A1 (es) 2009-05-01 2010-05-03 Composiciones de comprimidos de desintegracion oral que comprenden combinaciones de drogas en dosis elevadas y reducidas. metodo.

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US (2) US9572781B2 (es)
EP (2) EP2424365A4 (es)
JP (2) JP5845173B2 (es)
KR (2) KR101752014B1 (es)
CN (3) CN106390129A (es)
AR (2) AR076540A1 (es)
AU (2) AU2010242749B2 (es)
BR (1) BRPI1007636A2 (es)
CA (2) CA2760614A1 (es)
MX (2) MX345942B (es)
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