JP2013527249A5 - - Google Patents
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- JP2013527249A5 JP2013527249A5 JP2013513403A JP2013513403A JP2013527249A5 JP 2013527249 A5 JP2013527249 A5 JP 2013527249A5 JP 2013513403 A JP2013513403 A JP 2013513403A JP 2013513403 A JP2013513403 A JP 2013513403A JP 2013527249 A5 JP2013527249 A5 JP 2013527249A5
- Authority
- JP
- Japan
- Prior art keywords
- relapsed
- refractory
- compound
- treating
- lymphoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 80
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 68
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 50
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 46
- 239000003112 inhibitor Substances 0.000 claims 28
- 208000003837 Second Primary Neoplasms Diseases 0.000 claims 14
- 238000011269 treatment regimen Methods 0.000 claims 14
- 229960004641 rituximab Drugs 0.000 claims 9
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 8
- 229960002450 ofatumumab Drugs 0.000 claims 8
- -1 4-phenoxyphenyl Chemical group 0.000 claims 7
- 210000004698 lymphocyte Anatomy 0.000 claims 7
- 108091008875 B cell receptors Proteins 0.000 claims 6
- 239000002246 antineoplastic agent Substances 0.000 claims 6
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 6
- 206010025323 Lymphomas Diseases 0.000 claims 5
- 229960004679 doxorubicin Drugs 0.000 claims 5
- 102100031162 Collagen alpha-1(XVIII) chain Human genes 0.000 claims 4
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 4
- 108010079505 Endostatins Proteins 0.000 claims 4
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 4
- 239000012828 PI3K inhibitor Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 229960004397 cyclophosphamide Drugs 0.000 claims 4
- 230000007547 defect Effects 0.000 claims 4
- 229960005167 everolimus Drugs 0.000 claims 4
- 230000037361 pathway Effects 0.000 claims 4
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 claims 4
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 3
- 229960002707 bendamustine Drugs 0.000 claims 3
- YTKUWDBFDASYHO-UHFFFAOYSA-N bendamustine Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 YTKUWDBFDASYHO-UHFFFAOYSA-N 0.000 claims 3
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 claims 3
- 229960004630 chlorambucil Drugs 0.000 claims 3
- 229960000390 fludarabine Drugs 0.000 claims 3
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims 3
- 230000000306 recurrent effect Effects 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 229960004528 vincristine Drugs 0.000 claims 3
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 3
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 3
- FPVKHBSQESCIEP-UHFFFAOYSA-N (8S)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol Natural products C1C(O)C(CO)OC1N1C(NC=NCC2O)=C2N=C1 FPVKHBSQESCIEP-UHFFFAOYSA-N 0.000 claims 2
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 2
- KIWODJBCHRADND-UHFFFAOYSA-N 3-anilino-4-[1-[3-(1-imidazolyl)propyl]-3-indolyl]pyrrole-2,5-dione Chemical compound O=C1NC(=O)C(C=2C3=CC=CC=C3N(CCCN3C=NC=C3)C=2)=C1NC1=CC=CC=C1 KIWODJBCHRADND-UHFFFAOYSA-N 0.000 claims 2
- 102100027205 B-cell antigen receptor complex-associated protein alpha chain Human genes 0.000 claims 2
- 102100027203 B-cell antigen receptor complex-associated protein beta chain Human genes 0.000 claims 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 2
- 101150051290 BLNK gene Proteins 0.000 claims 2
- 239000012623 DNA damaging agent Substances 0.000 claims 2
- 241000289669 Erinaceus europaeus Species 0.000 claims 2
- 102000003964 Histone deacetylase Human genes 0.000 claims 2
- 108090000353 Histone deacetylase Proteins 0.000 claims 2
- 101000914489 Homo sapiens B-cell antigen receptor complex-associated protein alpha chain Proteins 0.000 claims 2
- 101000914491 Homo sapiens B-cell antigen receptor complex-associated protein beta chain Proteins 0.000 claims 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- 206010052178 Lymphocytic lymphoma Diseases 0.000 claims 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
- 239000012661 PARP inhibitor Substances 0.000 claims 2
- 229930012538 Paclitaxel Natural products 0.000 claims 2
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 claims 2
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 2
- 229940079156 Proteasome inhibitor Drugs 0.000 claims 2
- 108090000315 Protein Kinase C Proteins 0.000 claims 2
- 102000003923 Protein Kinase C Human genes 0.000 claims 2
- 229940123582 Telomerase inhibitor Drugs 0.000 claims 2
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims 2
- 229960000548 alemtuzumab Drugs 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 229960001467 bortezomib Drugs 0.000 claims 2
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 2
- 210000000349 chromosome Anatomy 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 230000002950 deficient Effects 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229960003668 docetaxel Drugs 0.000 claims 2
- 229960005420 etoposide Drugs 0.000 claims 2
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 2
- 201000003444 follicular lymphoma Diseases 0.000 claims 2
- 239000003481 heat shock protein 90 inhibitor Substances 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims 2
- 229960001101 ifosfamide Drugs 0.000 claims 2
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 229940043355 kinase inhibitor Drugs 0.000 claims 2
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 2
- 229960004942 lenalidomide Drugs 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 210000002751 lymph Anatomy 0.000 claims 2
- 230000000527 lymphocytic effect Effects 0.000 claims 2
- 229940124302 mTOR inhibitor Drugs 0.000 claims 2
- 238000009115 maintenance therapy Methods 0.000 claims 2
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims 2
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 claims 2
- 229960004963 mesalazine Drugs 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 229960001592 paclitaxel Drugs 0.000 claims 2
- 229960002340 pentostatin Drugs 0.000 claims 2
- FPVKHBSQESCIEP-JQCXWYLXSA-N pentostatin Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC[C@H]2O)=C2N=C1 FPVKHBSQESCIEP-JQCXWYLXSA-N 0.000 claims 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 2
- 239000003207 proteasome inhibitor Substances 0.000 claims 2
- 239000003909 protein kinase inhibitor Substances 0.000 claims 2
- 238000011363 radioimmunotherapy Methods 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- 238000002626 targeted therapy Methods 0.000 claims 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
- 239000003277 telomerase inhibitor Substances 0.000 claims 2
- 229960000235 temsirolimus Drugs 0.000 claims 2
- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 claims 2
- 229960003433 thalidomide Drugs 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 claims 1
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 1
- 229960004618 prednisone Drugs 0.000 claims 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35113010P | 2010-06-03 | 2010-06-03 | |
| US61/351,130 | 2010-06-03 | ||
| US35165510P | 2010-06-04 | 2010-06-04 | |
| US35176210P | 2010-06-04 | 2010-06-04 | |
| US35179310P | 2010-06-04 | 2010-06-04 | |
| US61/351,793 | 2010-06-04 | ||
| US61/351,655 | 2010-06-04 | ||
| US61/351,762 | 2010-06-04 | ||
| US41976410P | 2010-12-03 | 2010-12-03 | |
| US61/419,764 | 2010-12-03 | ||
| US201161472138P | 2011-04-05 | 2011-04-05 | |
| US61/472,138 | 2011-04-05 | ||
| PCT/US2011/039190 WO2011153514A2 (en) | 2010-06-03 | 2011-06-03 | The use of inhibitors of bruton's tyrosine kinase (btk) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015222455A Division JP6057309B2 (ja) | 2010-06-03 | 2015-11-12 | ブルトン型チロシンキナーゼ（Ｂｔｋ）の阻害剤の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013527249A JP2013527249A (ja) | 2013-06-27 |
| JP2013527249A5 true JP2013527249A5 (enExample) | 2014-02-20 |
| JP5841998B2 JP5841998B2 (ja) | 2016-01-13 |
Family
ID=45067334
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013513403A Active JP5841998B2 (ja) | 2010-06-03 | 2011-06-03 | ブルトン型チロシンキナーゼ（Ｂｔｋ）の阻害剤の使用 |
| JP2015222455A Active JP6057309B2 (ja) | 2010-06-03 | 2015-11-12 | ブルトン型チロシンキナーゼ（Ｂｔｋ）の阻害剤の使用 |
| JP2016209070A Active JP6376416B2 (ja) | 2010-06-03 | 2016-10-25 | ブルトン型チロシンキナーゼ（Ｂｔｋ）の阻害剤の使用 |
| JP2018131092A Active JP6580760B2 (ja) | 2010-06-03 | 2018-07-10 | ブルトン型チロシンキナーゼ（Ｂｔｋ）の阻害剤の使用 |
| JP2019155084A Ceased JP2020063231A (ja) | 2010-06-03 | 2019-08-27 | ブルトン型チロシンキナーゼ（Ｂｔｋ）の阻害剤の使用 |
| JP2021096028A Active JP7042950B2 (ja) | 2010-06-03 | 2021-06-08 | ブルトン型チロシンキナーゼ（Ｂｔｋ）の阻害剤の使用 |
| JP2022033735A Ceased JP2022088408A (ja) | 2010-06-03 | 2022-03-04 | ブルトン型チロシンキナーゼ（Ｂｔｋ）の阻害剤の使用 |
| JP2023203240A Pending JP2024028806A (ja) | 2010-06-03 | 2023-11-30 | ブルトン型チロシンキナーゼ（Ｂｔｋ）の阻害剤の使用 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015222455A Active JP6057309B2 (ja) | 2010-06-03 | 2015-11-12 | ブルトン型チロシンキナーゼ（Ｂｔｋ）の阻害剤の使用 |
| JP2016209070A Active JP6376416B2 (ja) | 2010-06-03 | 2016-10-25 | ブルトン型チロシンキナーゼ（Ｂｔｋ）の阻害剤の使用 |
| JP2018131092A Active JP6580760B2 (ja) | 2010-06-03 | 2018-07-10 | ブルトン型チロシンキナーゼ（Ｂｔｋ）の阻害剤の使用 |
| JP2019155084A Ceased JP2020063231A (ja) | 2010-06-03 | 2019-08-27 | ブルトン型チロシンキナーゼ（Ｂｔｋ）の阻害剤の使用 |
| JP2021096028A Active JP7042950B2 (ja) | 2010-06-03 | 2021-06-08 | ブルトン型チロシンキナーゼ（Ｂｔｋ）の阻害剤の使用 |
| JP2022033735A Ceased JP2022088408A (ja) | 2010-06-03 | 2022-03-04 | ブルトン型チロシンキナーゼ（Ｂｔｋ）の阻害剤の使用 |
| JP2023203240A Pending JP2024028806A (ja) | 2010-06-03 | 2023-11-30 | ブルトン型チロシンキナーゼ（Ｂｔｋ）の阻害剤の使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (24) | US20120087915A1 (enExample) |
| EP (1) | EP2575818A4 (enExample) |
| JP (8) | JP5841998B2 (enExample) |
| KR (1) | KR101580714B1 (enExample) |
| CN (2) | CN107898791A (enExample) |
| AU (1) | AU2011261185A1 (enExample) |
| BR (1) | BR112012030625A2 (enExample) |
| CA (7) | CA2800913C (enExample) |
| CL (1) | CL2012003381A1 (enExample) |
| EA (2) | EA031737B1 (enExample) |
| IL (3) | IL300955A (enExample) |
| MX (4) | MX342405B (enExample) |
| MY (1) | MY191929A (enExample) |
| NZ (7) | NZ604040A (enExample) |
| PH (3) | PH12012502356A1 (enExample) |
| SG (2) | SG186077A1 (enExample) |
| WO (1) | WO2011153514A2 (enExample) |
| ZA (1) | ZA201209381B (enExample) |
Families Citing this family (186)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009001636A (es) * | 2006-08-16 | 2009-02-23 | Novartis Ag | Metodo para elaborar dispersiones solidas de compuestos terapeuticos altamente cristalinos. |
| CA2663116C (en) | 2006-09-22 | 2014-06-10 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| US8809273B2 (en) | 2007-03-28 | 2014-08-19 | Pharmacyclics, Inc. | Inhibitors of Bruton's tyrosine kinase |
| PL2176296T3 (pl) | 2007-07-16 | 2012-07-31 | Genentech Inc | Przeciwciała anty-CD79B i immunokoniugaty i sposoby stosowania |
| CN101802013B (zh) | 2007-07-16 | 2014-07-02 | 健泰科生物技术公司 | 人源化抗cd79b抗体和免疫偶联物及使用方法 |
| CN101965335B (zh) | 2008-01-04 | 2015-01-14 | 英特利凯恩有限责任公司 | 某些化学实体、组合物和方法 |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| EP2300022A2 (en) | 2008-04-25 | 2011-03-30 | Duke University | Regulatory b cells and their uses |
| US20100101977A1 (en) * | 2008-06-05 | 2010-04-29 | United Comb & Novelty Corporation | Stackable Packaging For Lipped Containers |
| CA3031835C (en) | 2008-06-27 | 2021-09-07 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
| US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| CN102159214A (zh) | 2008-07-16 | 2011-08-17 | 药品循环公司 | 用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂 |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| PE20120602A1 (es) | 2009-03-24 | 2012-05-21 | Gilead Calistoga Llc | ATROPISOMEROS DE 2-[(6-AMINO-9H-PURIN-9-IL)METIL]-5-METIL-3-o-TOLILQUINAZOLIN-4(3H)-ONA |
| CN102482277B (zh) | 2009-05-05 | 2017-09-19 | 达纳-法伯癌症研究所有限公司 | 表皮生长因子受体抑制剂及治疗障碍的方法 |
| MX342405B (es) | 2010-06-03 | 2016-09-28 | Pharmacyclics Inc | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
| US10131875B2 (en) | 2010-08-04 | 2018-11-20 | Duke University | Regulatory B cells and their uses |
| CN105566229A (zh) | 2010-08-10 | 2016-05-11 | 西建阿维拉米斯研究公司 | Btk抑制剂的苯磺酸盐及其用途和制备方法 |
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