BR112012030625A2 - uso de inibidores de tirosina quinase de bruton (btk) - Google Patents
uso de inibidores de tirosina quinase de bruton (btk)Info
- Publication number
- BR112012030625A2 BR112012030625A2 BR112012030625A BR112012030625A BR112012030625A2 BR 112012030625 A2 BR112012030625 A2 BR 112012030625A2 BR 112012030625 A BR112012030625 A BR 112012030625A BR 112012030625 A BR112012030625 A BR 112012030625A BR 112012030625 A2 BR112012030625 A2 BR 112012030625A2
- Authority
- BR
- Brazil
- Prior art keywords
- btk
- tyrosine kinase
- kinase inhibitors
- bruton tyrosine
- expression profile
- Prior art date
Links
- 102000001714 Agammaglobulinaemia Tyrosine Kinase Human genes 0.000 title abstract 2
- 108010029445 Agammaglobulinaemia Tyrosine Kinase Proteins 0.000 title abstract 2
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 title abstract 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 title abstract 2
- 229940124291 BTK inhibitor Drugs 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000000090 biomarker Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000013394 immunophenotyping Methods 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 210000000207 lymphocyte subset Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
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US35165510P | 2010-06-04 | 2010-06-04 | |
US35176210P | 2010-06-04 | 2010-06-04 | |
US35179310P | 2010-06-04 | 2010-06-04 | |
US41976410P | 2010-12-03 | 2010-12-03 | |
US201161472138P | 2011-04-05 | 2011-04-05 | |
PCT/US2011/039190 WO2011153514A2 (en) | 2010-06-03 | 2011-06-03 | The use of inhibitors of bruton's tyrosine kinase (btk) |
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BR112012030625A2 true BR112012030625A2 (pt) | 2017-06-27 |
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BR112012030625A BR112012030625A2 (pt) | 2010-06-03 | 2011-06-03 | uso de inibidores de tirosina quinase de bruton (btk) |
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JP (8) | JP5841998B2 (pt) |
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CN (2) | CN103153311A (pt) |
AU (1) | AU2011261185A1 (pt) |
BR (1) | BR112012030625A2 (pt) |
CA (6) | CA3154024C (pt) |
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SG (2) | SG186077A1 (pt) |
WO (1) | WO2011153514A2 (pt) |
ZA (1) | ZA201209381B (pt) |
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Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021 |
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B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
B25G | Requested change of headquarter approved |
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