MX2020004438A - El uso de inhibidores de la tirosina quinasa de bruton (btk). - Google Patents
El uso de inhibidores de la tirosina quinasa de bruton (btk).Info
- Publication number
- MX2020004438A MX2020004438A MX2020004438A MX2020004438A MX2020004438A MX 2020004438 A MX2020004438 A MX 2020004438A MX 2020004438 A MX2020004438 A MX 2020004438A MX 2020004438 A MX2020004438 A MX 2020004438A MX 2020004438 A MX2020004438 A MX 2020004438A
- Authority
- MX
- Mexico
- Prior art keywords
- btk
- bruton
- inhibitors
- tyrosine kinase
- subpopulation
- Prior art date
Links
- 102000001714 Agammaglobulinaemia Tyrosine Kinase Human genes 0.000 title 1
- 108010029445 Agammaglobulinaemia Tyrosine Kinase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 2
- 229940124291 BTK inhibitor Drugs 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000000090 biomarker Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000013394 immunophenotyping Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract
Se divulgan aquí métodos para tratar un cáncer que comprenden: a. administrar un inhibidor de Btk a un sujeto suficiente para dar como resultado un incremento o aparición en la sangre de una subpoblación de linfocitos definida por inmunofenotipificación; b. determinar el perfil de expresión de uno o más biomarcadores a partir de una o más subpoblaciones de linfocitos; y c. administrar un segundo agente con base en el perfil de expresión determinado.
Applications Claiming Priority (7)
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US35113010P | 2010-06-03 | 2010-06-03 | |
US35165510P | 2010-06-04 | 2010-06-04 | |
US35179310P | 2010-06-04 | 2010-06-04 | |
US35176210P | 2010-06-04 | 2010-06-04 | |
US41976410P | 2010-12-03 | 2010-12-03 | |
US201161472138P | 2011-04-05 | 2011-04-05 | |
PCT/US2011/039190 WO2011153514A2 (en) | 2010-06-03 | 2011-06-03 | The use of inhibitors of bruton's tyrosine kinase (btk) |
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MX2020004438A true MX2020004438A (es) | 2021-03-25 |
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ID=45067334
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Application Number | Title | Priority Date | Filing Date |
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MX2020004438A MX2020004438A (es) | 2010-06-03 | 2011-06-03 | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
MX2020004501A MX2020004501A (es) | 2010-06-03 | 2011-06-03 | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
MX2012014049A MX342405B (es) | 2010-06-03 | 2011-06-03 | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
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Application Number | Title | Priority Date | Filing Date |
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MX2020004501A MX2020004501A (es) | 2010-06-03 | 2011-06-03 | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
MX2012014049A MX342405B (es) | 2010-06-03 | 2011-06-03 | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
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US (24) | US20120087915A1 (es) |
EP (1) | EP2575818A4 (es) |
JP (8) | JP5841998B2 (es) |
KR (1) | KR101580714B1 (es) |
CN (2) | CN103153311A (es) |
AU (1) | AU2011261185A1 (es) |
BR (1) | BR112012030625A2 (es) |
CA (7) | CA3113343A1 (es) |
CL (1) | CL2012003381A1 (es) |
EA (2) | EA031737B1 (es) |
IL (3) | IL300955A (es) |
MX (3) | MX2020004438A (es) |
MY (1) | MY191929A (es) |
NZ (7) | NZ753024A (es) |
PH (2) | PH12016501206A1 (es) |
SG (2) | SG186077A1 (es) |
WO (1) | WO2011153514A2 (es) |
ZA (1) | ZA201209381B (es) |
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