JP2012529267A5 - - Google Patents
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- JP2012529267A5 JP2012529267A5 JP2012514213A JP2012514213A JP2012529267A5 JP 2012529267 A5 JP2012529267 A5 JP 2012529267A5 JP 2012514213 A JP2012514213 A JP 2012514213A JP 2012514213 A JP2012514213 A JP 2012514213A JP 2012529267 A5 JP2012529267 A5 JP 2012529267A5
- Authority
- JP
- Japan
- Prior art keywords
- coa
- dehydrogenase
- hydroxybutyryl
- reductase
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000004316 Oxidoreductases Human genes 0.000 claims description 71
- 108090000854 Oxidoreductases Proteins 0.000 claims description 71
- 101710088194 Dehydrogenase Proteins 0.000 claims description 43
- BAMBWCGEVIAQBF-CITAKDKDSA-N 4-hydroxybutyryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCO)O[C@H]1N1C2=NC=NC(N)=C2N=C1 BAMBWCGEVIAQBF-CITAKDKDSA-N 0.000 claims description 33
- 230000000813 microbial effect Effects 0.000 claims description 33
- 230000037361 pathway Effects 0.000 claims description 28
- 102000004357 Transferases Human genes 0.000 claims description 26
- 108090000992 Transferases Proteins 0.000 claims description 26
- 108090000623 proteins and genes Proteins 0.000 claims description 23
- PIAOXUVIBAKVSP-UHFFFAOYSA-N γ-hydroxybutyraldehyde Chemical compound OCCCC=O PIAOXUVIBAKVSP-UHFFFAOYSA-N 0.000 claims description 18
- 229930029653 phosphoenolpyruvate Natural products 0.000 claims description 12
- DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 claims description 12
- 108010030844 2-methylcitrate synthase Proteins 0.000 claims description 10
- 108010071536 Citrate (Si)-synthase Proteins 0.000 claims description 10
- 102000006732 Citrate synthase Human genes 0.000 claims description 10
- SJZRECIVHVDYJC-UHFFFAOYSA-M 4-hydroxybutyrate Chemical compound OCCCC([O-])=O SJZRECIVHVDYJC-UHFFFAOYSA-M 0.000 claims description 9
- 108010093796 4-hydroxybutyrate dehydrogenase Proteins 0.000 claims description 9
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims description 9
- 108010021680 2-oxoglutarate decarboxylase Proteins 0.000 claims description 8
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims description 8
- 101150106096 gltA gene Proteins 0.000 claims description 8
- 101150042350 gltA2 gene Proteins 0.000 claims description 8
- 244000005700 microbiome Species 0.000 claims description 8
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims description 8
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims description 8
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims description 7
- 102000011929 Succinate-CoA Ligases Human genes 0.000 claims description 6
- 108010075728 Succinate-CoA Ligases Proteins 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 230000000241 respiratory effect Effects 0.000 claims description 6
- 108010008221 formate C-acetyltransferase Proteins 0.000 claims description 5
- 230000001105 regulatory effect Effects 0.000 claims description 5
- ZSLZBFCDCINBPY-ZSJPKINUSA-N Acetyl-CoA Natural products O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims description 4
- 108700024126 Butyrate kinases Proteins 0.000 claims description 4
- 241000606768 Haemophilus influenzae Species 0.000 claims description 4
- 102000013460 Malate Dehydrogenase Human genes 0.000 claims description 4
- 108010026217 Malate Dehydrogenase Proteins 0.000 claims description 4
- 101150117498 arcA gene Proteins 0.000 claims description 4
- 238000012239 gene modification Methods 0.000 claims description 4
- 230000005017 genetic modification Effects 0.000 claims description 4
- 235000013617 genetically modified food Nutrition 0.000 claims description 4
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims description 3
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims description 3
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 claims 75
- 102000003960 Ligases Human genes 0.000 claims 21
- 108090000364 Ligases Proteins 0.000 claims 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 13
- 230000015572 biosynthetic process Effects 0.000 claims 13
- MMTYWJNSFWVPPS-UHFFFAOYSA-N 5-hydroxy-2-oxopentanoic acid Chemical compound OCCCC(=O)C(O)=O MMTYWJNSFWVPPS-UHFFFAOYSA-N 0.000 claims 11
- 108090000340 Transaminases Proteins 0.000 claims 11
- 230000009615 deamination Effects 0.000 claims 11
- 238000006481 deamination reaction Methods 0.000 claims 11
- 102000014898 transaminase activity proteins Human genes 0.000 claims 11
- 230000026731 phosphorylation Effects 0.000 claims 10
- 238000006366 phosphorylation reaction Methods 0.000 claims 10
- 108091000080 Phosphotransferase Proteins 0.000 claims 7
- 108010084086 Succinate-Semialdehyde Dehydrogenase Proteins 0.000 claims 7
- 102000005566 Succinate-Semialdehyde Dehydrogenase Human genes 0.000 claims 7
- 102000020233 phosphotransferase Human genes 0.000 claims 7
- 108090000489 Carboxy-Lyases Proteins 0.000 claims 6
- 102000004031 Carboxy-Lyases Human genes 0.000 claims 6
- 102000001253 Protein Kinase Human genes 0.000 claims 6
- 230000001419 dependent effect Effects 0.000 claims 6
- 108060006633 protein kinase Proteins 0.000 claims 6
- KPGXRSRHYNQIFN-UHFFFAOYSA-L 2-oxoglutarate(2-) Chemical compound [O-]C(=O)CCC(=O)C([O-])=O KPGXRSRHYNQIFN-UHFFFAOYSA-L 0.000 claims 5
- BLFRQYKZFKYQLO-UHFFFAOYSA-N 4-aminobutan-1-ol Chemical compound NCCCCO BLFRQYKZFKYQLO-UHFFFAOYSA-N 0.000 claims 5
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims 5
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims 5
- 102000004190 Enzymes Human genes 0.000 claims 5
- 108090000790 Enzymes Proteins 0.000 claims 5
- KABXUUFDPUOJMW-BYPYZUCNSA-N L-glutamic 5-semialdehyde Chemical compound OC(=O)[C@@H](N)CCC=O KABXUUFDPUOJMW-BYPYZUCNSA-N 0.000 claims 5
- 229930195712 glutamate Natural products 0.000 claims 5
- VHKNBDIQDAXGBL-UHFFFAOYSA-N 2,5-dioxopentanoic acid Chemical compound OC(=O)C(=O)CCC=O VHKNBDIQDAXGBL-UHFFFAOYSA-N 0.000 claims 4
- HHFBTTVZSVBPFP-CITAKDKDSA-N 4-aminobutanoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCN)O[C@H]1N1C2=NC=NC(N)=C2N=C1 HHFBTTVZSVBPFP-CITAKDKDSA-N 0.000 claims 4
- QYHKIXYHXCJHTR-CITAKDKDSA-N 5-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-4,5-dioxopentanoic acid Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C(=O)CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 QYHKIXYHXCJHTR-CITAKDKDSA-N 0.000 claims 4
- 108091022930 Glutamate decarboxylase Proteins 0.000 claims 4
- 102000008214 Glutamate decarboxylase Human genes 0.000 claims 4
- 230000001580 bacterial effect Effects 0.000 claims 4
- 238000006114 decarboxylation reaction Methods 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 108010060511 4-Aminobutyrate Transaminase Proteins 0.000 claims 3
- 102100035923 4-aminobutyrate aminotransferase, mitochondrial Human genes 0.000 claims 3
- 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 claims 3
- 102100034013 Gamma-glutamyl phosphate reductase Human genes 0.000 claims 3
- 101710198928 Gamma-glutamyl phosphate reductase Proteins 0.000 claims 3
- 102000005133 Glutamate 5-kinase Human genes 0.000 claims 3
- 102000016901 Glutamate dehydrogenase Human genes 0.000 claims 3
- 108010016106 Glutamate-5-semialdehyde dehydrogenase Proteins 0.000 claims 3
- CZWARROQQFCFJB-UHFFFAOYSA-N L-2-Amino-5-hydroxypentanoic acid Chemical compound OC(=O)C(N)CCCO CZWARROQQFCFJB-UHFFFAOYSA-N 0.000 claims 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 3
- 150000001299 aldehydes Chemical class 0.000 claims 3
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical group NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- VNOYUJKHFWYWIR-ITIYDSSPSA-N succinyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 VNOYUJKHFWYWIR-ITIYDSSPSA-N 0.000 claims 3
- AECJCRHEUUKQRT-SJOXLDEWSA-N (2S)-2-amino-4-hydroxybutanoic acid [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate Chemical compound OC(=O)[C@@H](N)CCO.O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 AECJCRHEUUKQRT-SJOXLDEWSA-N 0.000 claims 2
- UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 claims 2
- DZQLQEYLEYWJIB-UHFFFAOYSA-N 4-aminobutanal Chemical compound NCCCC=O DZQLQEYLEYWJIB-UHFFFAOYSA-N 0.000 claims 2
- CNXHSMPAOQXDRE-BLPRJPCASA-N 4-aminobutanoic acid;[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3r)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate Chemical group NCCCC(O)=O.O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CNXHSMPAOQXDRE-BLPRJPCASA-N 0.000 claims 2
- RMQJECWPWQIIPW-UHFFFAOYSA-N 4-hydroxycrotonic acid Chemical compound OCC=CC(O)=O RMQJECWPWQIIPW-UHFFFAOYSA-N 0.000 claims 2
- 101150021974 Adh1 gene Proteins 0.000 claims 2
- 102000006589 Alpha-ketoglutarate dehydrogenase Human genes 0.000 claims 2
- 108020004306 Alpha-ketoglutarate dehydrogenase Proteins 0.000 claims 2
- 101100446530 Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) fhaE gene Proteins 0.000 claims 2
- 241000193403 Clostridium Species 0.000 claims 2
- 241000193401 Clostridium acetobutylicum Species 0.000 claims 2
- 102000020018 Cystathionine gamma-Lyase Human genes 0.000 claims 2
- 108010045283 Cystathionine gamma-lyase Proteins 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 241000626621 Geobacillus Species 0.000 claims 2
- 201000008225 Klebsiella pneumonia Diseases 0.000 claims 2
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 2
- UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical compound OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 claims 2
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 2
- 206010035717 Pneumonia klebsiella Diseases 0.000 claims 2
- 241000986839 Porphyromonas gingivalis W83 Species 0.000 claims 2
- FQFRDDVZPBFYST-CITAKDKDSA-N S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 4-hydroxybut-2-enethioate Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C=CCO)O[C@H]1N1C2=NC=NC(N)=C2N=C1 FQFRDDVZPBFYST-CITAKDKDSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 101150049512 ald gene Proteins 0.000 claims 2
- 101150031417 buk1 gene Proteins 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 238000004821 distillation Methods 0.000 claims 2
- 101150093898 fimD gene Proteins 0.000 claims 2
- WHUUTDBJXJRKMK-VKHMYHEASA-L glutamate group Chemical group N[C@@H](CCC(=O)[O-])C(=O)[O-] WHUUTDBJXJRKMK-VKHMYHEASA-L 0.000 claims 2
- 229940047650 haemophilus influenzae Drugs 0.000 claims 2
- 238000002955 isolation Methods 0.000 claims 2
- 101150003321 lpdA gene Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 2
- XGAWKWCCTIEGRI-UHFFFAOYSA-N phosphono 4-hydroxybutanoate Chemical compound OCCCC(=O)OP(O)(O)=O XGAWKWCCTIEGRI-UHFFFAOYSA-N 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 101150111745 sucA gene Proteins 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims 2
- UIKQNMXWCYQNCS-UHFFFAOYSA-N 2-hydroxybutanal Chemical compound CCC(O)C=O UIKQNMXWCYQNCS-UHFFFAOYSA-N 0.000 claims 1
- XDAOHSVZXQBFMP-UHFFFAOYSA-N 3-hydroxy-2-oxopentanoic acid Chemical compound CCC(O)C(=O)C(O)=O XDAOHSVZXQBFMP-UHFFFAOYSA-N 0.000 claims 1
- 108030005660 3-hydroxybutyryl-CoA dehydratases Proteins 0.000 claims 1
- 108010055682 3-hydroxybutyryl-CoA dehydrogenase Proteins 0.000 claims 1
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical group OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 claims 1
- 108010035023 4-hydroxybutyryl-CoA dehydratase Proteins 0.000 claims 1
- 101000695175 Bacillus subtilis (strain 168) Probable phosphate butyryltransferase Proteins 0.000 claims 1
- 102100039894 Hemoglobin subunit delta Human genes 0.000 claims 1
- 101710181816 Pyruvate-formate-lyase deactivase Proteins 0.000 claims 1
- 108010093991 Vinylacetyl-CoA Delta-isomerase Proteins 0.000 claims 1
- 230000004103 aerobic respiration Effects 0.000 claims 1
- 239000013592 cell lysate Substances 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- UIUJIQZEACWQSV-UHFFFAOYSA-N succinic semialdehyde Chemical compound OC(=O)CCC=O UIUJIQZEACWQSV-UHFFFAOYSA-N 0.000 claims 1
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- ZGSGBCBFJJASJA-UHFFFAOYSA-N 2-[3-(methylamino)propylamino]ethylsulfanylphosphonic acid Chemical compound CNCCCNCCSP(O)(O)=O ZGSGBCBFJJASJA-UHFFFAOYSA-N 0.000 description 1
- UIUJIQZEACWQSV-UHFFFAOYSA-M 4-oxobutanoate Chemical compound [O-]C(=O)CCC=O UIUJIQZEACWQSV-UHFFFAOYSA-M 0.000 description 1
- 101100398785 Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) ldhD gene Proteins 0.000 description 1
- 101100386830 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) ddh gene Proteins 0.000 description 1
- 101150014383 adhE gene Proteins 0.000 description 1
- 101150026107 ldh1 gene Proteins 0.000 description 1
- 101150041530 ldha gene Proteins 0.000 description 1
- 101150111581 pflB gene Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18431109P | 2009-06-04 | 2009-06-04 | |
| US61/184,311 | 2009-06-04 | ||
| PCT/US2010/037544 WO2010141920A2 (en) | 2009-06-04 | 2010-06-04 | Microorganisms for the production of 1,4-butanediol and related methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016001512A Division JP2016105716A (ja) | 2009-06-04 | 2016-01-07 | １，４−ブタンジオールの生成のための微生物体及び関連する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012529267A JP2012529267A (ja) | 2012-11-22 |
| JP2012529267A5 true JP2012529267A5 (enExample) | 2016-02-25 |
| JP5964747B2 JP5964747B2 (ja) | 2016-08-03 |
Family
ID=43298584
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514213A Active JP5964747B2 (ja) | 2009-06-04 | 2010-06-04 | １，４−ブタンジオールの生成のための微生物体及び関連する方法 |
| JP2016001512A Pending JP2016105716A (ja) | 2009-06-04 | 2016-01-07 | １，４−ブタンジオールの生成のための微生物体及び関連する方法 |
| JP2017211474A Pending JP2018046843A (ja) | 2009-06-04 | 2017-11-01 | １，４−ブタンジオールの生成のための微生物体及び関連する方法 |
| JP2019157532A Pending JP2020005647A (ja) | 2009-06-04 | 2019-08-30 | １，４−ブタンジオールの生成のための微生物体及び関連する方法 |
| JP2021174364A Withdrawn JP2022031648A (ja) | 2009-06-04 | 2021-10-26 | １，４－ブタンジオールの生成のための微生物体及び関連する方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016001512A Pending JP2016105716A (ja) | 2009-06-04 | 2016-01-07 | １，４−ブタンジオールの生成のための微生物体及び関連する方法 |
| JP2017211474A Pending JP2018046843A (ja) | 2009-06-04 | 2017-11-01 | １，４−ブタンジオールの生成のための微生物体及び関連する方法 |
| JP2019157532A Pending JP2020005647A (ja) | 2009-06-04 | 2019-08-30 | １，４−ブタンジオールの生成のための微生物体及び関連する方法 |
| JP2021174364A Withdrawn JP2022031648A (ja) | 2009-06-04 | 2021-10-26 | １，４－ブタンジオールの生成のための微生物体及び関連する方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US8129169B2 (enExample) |
| EP (3) | EP4056706A1 (enExample) |
| JP (5) | JP5964747B2 (enExample) |
| KR (1) | KR102041627B1 (enExample) |
| CN (3) | CN113528417A (enExample) |
| AU (1) | AU2010256428B2 (enExample) |
| BR (1) | BRPI1010581A2 (enExample) |
| CA (1) | CA2764379A1 (enExample) |
| ES (1) | ES2680905T3 (enExample) |
| MY (2) | MY187676A (enExample) |
| PL (1) | PL2438178T3 (enExample) |
| SG (1) | SG176656A1 (enExample) |
| SI (1) | SI3392340T1 (enExample) |
| VN (1) | VN29801A1 (enExample) |
| WO (1) | WO2010141920A2 (enExample) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7947483B2 (en) * | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| CA2712779C (en) * | 2008-01-22 | 2021-03-16 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
| SI2265709T1 (en) * | 2008-03-27 | 2018-03-30 | Genomatica, Inc. | MICROORGANISMS FOR PREPARATION OF ADYPIC ACID AND OTHER COMPOUNDS |
| JP2011519561A (ja) | 2008-05-01 | 2011-07-14 | ジェノマティカ， インコーポレイテッド | メタクリル酸の産生のための微生物 |
| US8129154B2 (en) | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| EP2313491A4 (en) * | 2008-07-08 | 2011-12-07 | Opx Biotechnologies Inc | METHODS, COMPOSITIONS AND SYSTEMS FOR BIOSYNTHETIC BIOPRODUCTION OF 1,4-BUTANEDIOL |
| CA2735883C (en) * | 2008-09-10 | 2020-05-05 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol |
| KR20110097951A (ko) * | 2008-12-16 | 2011-08-31 | 게노마티카 인코포레이티드 | 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법 |
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