DE10075400T8 - Polyhydroxyalkanoatherstellung mittels Coenzym a-abhängigen Aldehyddehydrogenasepfaden - Google Patents
Polyhydroxyalkanoatherstellung mittels Coenzym a-abhängigen Aldehyddehydrogenasepfaden Download PDFInfo
- Publication number
- DE10075400T8 DE10075400T8 DE10075400T DE10075400T DE10075400T8 DE 10075400 T8 DE10075400 T8 DE 10075400T8 DE 10075400 T DE10075400 T DE 10075400T DE 10075400 T DE10075400 T DE 10075400T DE 10075400 T8 DE10075400 T8 DE 10075400T8
- Authority
- DE
- Germany
- Prior art keywords
- coa
- organism
- aldehyde dehydrogenase
- dependent aldehyde
- pha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 title abstract 6
- 230000001419 dependent effect Effects 0.000 title abstract 6
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 title abstract 5
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 title abstract 5
- 229920000903 polyhydroxyalkanoate Polymers 0.000 title abstract 3
- 230000037361 pathway Effects 0.000 title abstract 2
- RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 title 1
- 229940093530 coenzyme a Drugs 0.000 title 1
- 239000000178 monomer Substances 0.000 abstract 3
- 229920000642 polymer Polymers 0.000 abstract 3
- REKYPYSUBKSCAT-UHFFFAOYSA-N 3-hydroxypentanoic acid Chemical compound CCC(O)CC(O)=O REKYPYSUBKSCAT-UHFFFAOYSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- HPMGFDVTYHWBAG-UHFFFAOYSA-N 3-hydroxyhexanoic acid Chemical compound CCCC(O)CC(O)=O HPMGFDVTYHWBAG-UHFFFAOYSA-N 0.000 abstract 1
- ALRHLSYJTWAHJZ-UHFFFAOYSA-M 3-hydroxypropionate Chemical compound OCCC([O-])=O ALRHLSYJTWAHJZ-UHFFFAOYSA-M 0.000 abstract 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- FMHKPLXYWVCLME-UHFFFAOYSA-N 4-hydroxy-valeric acid Chemical compound CC(O)CCC(O)=O FMHKPLXYWVCLME-UHFFFAOYSA-N 0.000 abstract 1
- SJZRECIVHVDYJC-UHFFFAOYSA-M 4-hydroxybutyrate Chemical compound OCCCC([O-])=O SJZRECIVHVDYJC-UHFFFAOYSA-M 0.000 abstract 1
- PHOJOSOUIAQEDH-UHFFFAOYSA-N 5-hydroxypentanoic acid Chemical compound OCCCCC(O)=O PHOJOSOUIAQEDH-UHFFFAOYSA-N 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 206010064571 Gene mutation Diseases 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 101150041588 eutE gene Proteins 0.000 abstract 1
- 108010010718 poly(3-hydroxyalkanoic acid) synthase Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C12P7/625—Polyesters of hydroxy carboxylic acids
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Prostheses (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Adhesives Or Adhesive Processes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41008702P | 2002-09-12 | 2002-09-12 | |
| US410067P | 2002-09-12 | ||
| EP10075400.1A EP2365088B1 (de) | 2002-09-12 | 2003-09-12 | Polyhydroxyalkanoatherstellung mittels Coenzym a-abhängigen Aldehyddehydrogenasepfaden |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE10075400T1 DE10075400T1 (de) | 2012-10-11 |
| DE10075400T8 true DE10075400T8 (de) | 2013-04-25 |
Family
ID=31994056
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60336757T Expired - Lifetime DE60336757D1 (de) | 2002-09-12 | 2003-09-12 | Produktion von polyhydroxyalkanoat mittels coenzym-a-abhängiger aldehyd-dehydrogenase-wege |
| DE10075400T Active DE10075400T8 (de) | 2002-09-12 | 2003-09-12 | Polyhydroxyalkanoatherstellung mittels Coenzym a-abhängigen Aldehyddehydrogenasepfaden |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60336757T Expired - Lifetime DE60336757D1 (de) | 2002-09-12 | 2003-09-12 | Produktion von polyhydroxyalkanoat mittels coenzym-a-abhängiger aldehyd-dehydrogenase-wege |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8071355B2 (de) |
| EP (2) | EP2365088B1 (de) |
| JP (2) | JP4628103B2 (de) |
| AT (1) | ATE505559T1 (de) |
| AU (1) | AU2003267185A1 (de) |
| DE (2) | DE60336757D1 (de) |
| ES (1) | ES2395053T3 (de) |
| WO (1) | WO2004024876A2 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100979694B1 (ko) | 2005-05-24 | 2010-09-02 | 한국과학기술원 | 폴리락테이트 또는 그 공중합체 생성능을 가지는 세포 또는식물 및 이를 이용한 폴리락테이트 또는 그 공중합체의제조방법 |
| PL2137315T3 (pl) | 2007-03-16 | 2015-02-27 | Genomatica Inc | Kompozycje i sposoby do biosyntezy 1,4-butanodiolu i jego prekursorów |
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| CN102164986B (zh) * | 2008-06-24 | 2013-12-25 | Lg化学株式会社 | 用具有提高聚乳酸酯及其共聚物生产能力的微生物突变体制备聚乳酸酯及其共聚物的方法 |
| JP5912529B2 (ja) | 2008-09-10 | 2016-04-27 | ゲノマチカ， インク． | １，４−ブタンジオールの生成のための微生物体 |
| WO2010057022A1 (en) * | 2008-11-14 | 2010-05-20 | Genomatica, Inc. | Microorganisms for the production of methyl ethyl ketone and 2-butanol |
| KR101886012B1 (ko) | 2008-12-12 | 2018-08-06 | 씨제이제일제당 (주) | 폴리（5ｈｖ）및 5 탄소 화학물질의 생산을 위한 녹색 공정 및 조성물 |
| KR101293886B1 (ko) * | 2009-02-05 | 2013-08-07 | 주식회사 엘지화학 | 폴리락틱산 또는 폴리락틱산 공중합체 생성능을 지닌 재조합 랄스토니아 유트로파 및 이것을 이용하여 폴리락틱산 또는 폴리락틱산 공중합체를 제조하는 방법 |
| EP3392340B1 (de) | 2009-06-04 | 2022-01-05 | Genomatica, Inc. | Mikroorganismen zur herstellung von 1,4-butandiol und entsprechende verfahren |
| WO2010141780A1 (en) * | 2009-06-04 | 2010-12-09 | Genomatica, Inc. | Process of separating components of a fermentation broth |
| CN105441374A (zh) * | 2009-10-13 | 2016-03-30 | 基因组股份公司 | 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法 |
| US8530210B2 (en) | 2009-11-25 | 2013-09-10 | Genomatica, Inc. | Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone |
| US8445244B2 (en) | 2010-02-23 | 2013-05-21 | Genomatica, Inc. | Methods for increasing product yields |
| US8048661B2 (en) * | 2010-02-23 | 2011-11-01 | Genomatica, Inc. | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes |
| FR2964014B1 (fr) * | 2010-08-31 | 2013-04-05 | Ifremer | Nucleus enrobe d'un revetement filmogene aux proprietes antibacteriennes et cicatrisantes et procede d'obtention. |
| FR2968506B1 (fr) * | 2010-12-14 | 2013-02-08 | Ifremer | Nucleus recouvert de pha |
| CN102212501B (zh) * | 2011-03-31 | 2013-06-12 | 山东大学 | 一种重组大肠杆菌及应用其以单一碳源生产phbv的方法 |
| BR112013027641A2 (pt) * | 2011-04-29 | 2016-11-29 | Metabolix Inc | processo verde para produzir poli-hidroxialcanoatos e produtos químicos com o uso de uma matéria-prima renovável |
| EP3591056A1 (de) | 2011-08-19 | 2020-01-08 | Genomatica, Inc. | Mikroorganismen und verfahren zur herstellung von 2,4-pentadienoat, butadien, propylen, 1,3-butanedol und zugehörige alkohole |
| MY171760A (en) | 2011-11-02 | 2019-10-28 | Genomatica Inc | Microorganisms and methods for the production of caprolactone |
| EP2855687B1 (de) | 2012-06-04 | 2020-04-22 | Genomatica, Inc. | Mikroorganismen und verfahren zur herstellung von 4-hydroxybutyrat, 1,4-butandiol und verwandten verbindungen |
| CN115960720A (zh) | 2012-10-15 | 2023-04-14 | 基因组股份公司 | 用于生产特定长度脂肪醇及相关化合物的微生物和方法 |
| BR112015020904A2 (pt) | 2013-03-15 | 2017-10-10 | Genomatica Inc | microrganismos e métodos para produção de butadieno e compostos relacionados por assimilação de formiato |
| EP3074504B1 (de) | 2013-11-25 | 2024-12-25 | Genomatica, Inc. | Verfahren zur verbesserung der mikrobiellen herstellung von fettalkoholen mit bestimmter länge in gegenwart von methanol |
| WO2016007365A1 (en) | 2014-07-11 | 2016-01-14 | Genomatica, Inc. | Microorganisms and methods for the production of butadiene using acetyl-coa |
| EP3741865B1 (de) | 2014-09-18 | 2024-03-13 | Genomatica, Inc. | Nicht-natürliche mikrobielle organismen mit verbesserter energieeffizienz |
| US10941454B2 (en) | 2015-05-30 | 2021-03-09 | Genomatica, Inc. | Vinylisomerase-dehydratases, alkenol dehydratases, linalool dehydratases and crotyl alcohol dehydratases and methods for making and using them |
| US11566250B2 (en) | 2017-10-26 | 2023-01-31 | Noroo Ic Co., Ltd. | Production and separation of 3-hydroxypropionic acid |
| KR20200072543A (ko) | 2017-10-26 | 2020-06-22 | 노루 아이씨 코포레이션 엘티디 | 3-히드록시프로피온산의 생산 및 분리 |
| JP7209434B2 (ja) * | 2019-10-31 | 2023-01-20 | 株式会社カネカ | ポリヒドロキシアルカン酸の製造方法およびその利用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4477654A (en) | 1981-07-07 | 1984-10-16 | Imperial Chemical Industries Plc | 3-Hydroxybutyrate polymers |
| EP0145233B2 (de) | 1983-11-23 | 1991-11-06 | Imperial Chemical Industries Plc | Trennungsverfahrenfür ein 3-hydroxybutyrat-Polymer |
| US5229279A (en) | 1987-06-29 | 1993-07-20 | Massachusetts Institute Of Technology | Method for producing novel polyester biopolymers |
| US5480794A (en) | 1987-06-29 | 1996-01-02 | Massachusetts Institute Of Technology And Metabolix, Inc. | Overproduction and purification of soluble PHA synthase |
| US5245023A (en) | 1987-06-29 | 1993-09-14 | Massachusetts Institute Of Technology | Method for producing novel polyester biopolymers |
| US5250430A (en) | 1987-06-29 | 1993-10-05 | Massachusetts Institute Of Technology | Polyhydroxyalkanoate polymerase |
| GB9325952D0 (en) * | 1993-12-20 | 1994-02-23 | Zeneca Ltd | Process for preparing films and coatings |
| RU2144047C1 (ru) | 1994-01-28 | 2000-01-10 | Дзе Проктер Энд Гэмбл Компани | Биоразлагаемые сополимеры, пластмассовые и впитывающие изделия, содержащие биоразлагаемые сополимеры |
| ZA95627B (en) | 1994-01-28 | 1995-10-05 | Procter & Gamble | Biodegradable copolymers and plastic articles comprising biodegradable copolymers |
| FR2719012B1 (fr) | 1994-04-22 | 1996-07-12 | Pomagalski Sa | Pince débrayable d'un véhicule tracté par câble. |
| US5563239A (en) | 1994-11-09 | 1996-10-08 | Eastman Chemical Company | Composition and process for the production of poly(3-hydroxyalkanoates) |
| DE69733490T2 (de) | 1997-03-03 | 2006-03-16 | Metabolix, Inc., Cambridge | Verfahren zur polyestern-biosynthese |
| US6316262B1 (en) * | 1997-09-19 | 2001-11-13 | Metabolix, Inc. | Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids |
| US7455999B2 (en) | 1998-01-22 | 2008-11-25 | Metabolix, Inc. | Transgenic systems for the manufacture of poly (3-hydroxy-butyrate-co-3-hydroxyhexanoate) |
| CA2339351C (en) * | 1998-08-04 | 2007-07-03 | Metabolix, Inc. | Polyhydroxyalkanoate production from polyols |
| ATE319835T1 (de) * | 1998-08-18 | 2006-03-15 | Metabolix Inc | Transgene polyhydroxyalkanoat produzierende mikroben |
| PT1163019E (pt) * | 1999-03-25 | 2007-12-06 | Metabolix Inc | Dispositivos médicos e aplicações de polímeros de poli-hidroxialcanoato |
| EP1305439B1 (de) * | 2000-07-21 | 2006-06-07 | Metabolix, Inc. | Herstellung von polyhydroxyalkanoaten aus polyolen |
| US7094840B2 (en) * | 2000-10-27 | 2006-08-22 | Metabolix, Inc. | Compositions comprising low molecular weight polyhydroxyalkanoates and methods employing same |
-
2003
- 2003-09-12 JP JP2004536287A patent/JP4628103B2/ja not_active Expired - Lifetime
- 2003-09-12 EP EP10075400.1A patent/EP2365088B1/de not_active Expired - Lifetime
- 2003-09-12 ES ES10075400.1T patent/ES2395053T3/es not_active Expired - Lifetime
- 2003-09-12 AT AT03749656T patent/ATE505559T1/de not_active IP Right Cessation
- 2003-09-12 WO PCT/US2003/028842 patent/WO2004024876A2/en active Search and Examination
- 2003-09-12 EP EP03749656A patent/EP1581619B1/de not_active Expired - Lifetime
- 2003-09-12 US US10/661,939 patent/US8071355B2/en active Active
- 2003-09-12 AU AU2003267185A patent/AU2003267185A1/en not_active Abandoned
- 2003-09-12 DE DE60336757T patent/DE60336757D1/de not_active Expired - Lifetime
- 2003-09-12 DE DE10075400T patent/DE10075400T8/de active Active
-
2010
- 2010-06-16 JP JP2010137010A patent/JP2010268797A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ATE505559T1 (de) | 2011-04-15 |
| US8071355B2 (en) | 2011-12-06 |
| AU2003267185A8 (en) | 2004-04-30 |
| JP2006507811A (ja) | 2006-03-09 |
| ES2395053T3 (es) | 2015-10-08 |
| EP1581619A2 (de) | 2005-10-05 |
| WO2004024876A3 (en) | 2006-05-26 |
| EP1581619A4 (de) | 2007-02-14 |
| EP1581619B1 (de) | 2011-04-13 |
| JP4628103B2 (ja) | 2011-02-09 |
| ES2395053T1 (es) | 2013-02-07 |
| JP2010268797A (ja) | 2010-12-02 |
| EP2365088A3 (de) | 2012-01-11 |
| US20040106176A1 (en) | 2004-06-03 |
| DE10075400T1 (de) | 2012-10-11 |
| EP2365088B1 (de) | 2015-05-27 |
| WO2004024876A2 (en) | 2004-03-25 |
| DE60336757D1 (de) | 2011-05-26 |
| AU2003267185A1 (en) | 2004-04-30 |
| EP2365088A2 (de) | 2011-09-14 |
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